Subretinal suspensions of hiPSC-derived retinal pigment epithelium cells form functional monolayers in NOD-SCID mice facilitating treatment of advanced retinal diseases by Xiaojing Song, Guanjie Gao, Ke Ye, Ping Xu, Yuan Wang, Suai Zhang, Dandan Zheng, Jian Ge, Xiufeng Zhong

“…Despite its therapeutic potential, this approach is encumbered by critical challenges, notably the survival of donor RPE cells post-transplantation and the successful reconstruction of a functional RPE layer. …”
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A glyoxal-specific aldehyde signaling axis in Pseudomonas aeruginosa that influences quorum sensing and infection by Christopher J. Corcoran, Bonnie J. Cuthbert, David G. Glanville, Mailyn Terrado, Diana Valverde Mendez, Benjamin P. Bratton, Daniel E. Schemenauer, Valerie L. Tokars, Thomas G. Martin, Lawrence W. Rasmussen, Matthew C. Madison, Andrew F. Maule, Joshua W. Shaevitz, Boo Shan Tseng, Julian P. Whitelegge, Catherine Putonti, Amit Gaggar, Jordan R. Beach, Jonathan A. Kirk, Alfonso Mondragón, Abby R. Kroken, Jonathan P. Allen, Celia W. Goulding, Andrew T. Ulijasz

“…An ArqI atomic structure revealed several unique features to the ABM family, including a ‘pinwheel’ hexamer harboring a GO-derived post-translational modification on a conserved arginine residue (Arg49). …”
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A randomized controlled trial adding behavioral counseling to supervised physical activity in people living with and beyond cancer (BOOST-UP-): a study protocol for a live remotely... by Linda Trinh, Ryan E. Rhodes, Shabbir M. H. Alibhai, Kristin L. Campbell, David M. Langelier, Eugene Chang, Tracey Colella, Brian Chan, Daniel Santa Mina, Paul Oh, Edward McAuley

“…People LWBC will complete measures at baseline, midpoint, post-intervention (6-months), at 6-months follow-up, and 1-year follow-up. …”
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Cannabinol (CBN; 30 and 300 mg) effects on sleep and next-day function in insomnia disorder (‘CUPID’ study): protocol for a randomised, double-blind, placebo-controlled, cross-over... by Ronald R Grunstein, Bandana Saini, Christopher J Gordon, Anastasia Suraev, Angela L D'Rozario, Chris Irwin, Camilla M Hoyos, Iain McGregor, Brendon Yee, Isobel Lavender, Danielle McCartney, Nathaniel Marshall

“…Safety-related and exploratory outcomes include changes to next-day simulated driving performance, subjective mood and drug effects, postural sway, alertness and reaction time, overnight memory consolidation, pre and post-sleep subjective and objective sleepiness; and plasma, urinary, and salivary cannabinoid concentrations. …”
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The effect of aerobic exercise along with living in enriched environment on spatial memory and brain-derived neurotrophic factor in the Hippocampal tissue of Elderly female Wistar... by Mozhgan Mozhgan Abdullahzadeh Nobejari, Behrouz Abdoli, Rana Rana Fayaz Milani

“…Therefore,  One-way analysis of variance with Tukey's post-hoc test (P<0.05) were used to analyze the data.Results: BDNF increased in all groups significantly (P<0.001), and comparisons between groups were significant except for control vs sham (P=0.27) and Alzheimer's vs Aerobic Alzheimer's (P=0.20) groups. …”
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Levodopa / opicapone as a complement to STN-DBS in clinical practice. A retrospective single-centre analysis. by Moritz A. Loeffler, Philipp Klocke, Idil Cebi, Alireza Gharabaghi, Daniel Weiss

“…Methods: A patient cohort treated with STN-DBS + levodopa + opicapone (n = 16) was compared to an age-matched control cohort without opicapone treatment at baseline before and ≥ 5 months post-surgery. As main outcomes we assessed the MDS-UPDRS III and IV scores and reduction of the cumulative dopaminergic medication quantified by the levodopa equivalent dosages (LED). …”
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Recurrence of tuberculosis and associated risk factors among Non-HIV patients in Taiwan: A retrospective cohort study by Che-min Hsu, Chia-Ju Wu, Chih-Jung Chang, Sheng-Wei Pan, Yen-Han Tseng, Jhong-Ru Huang, Wei-Juin Su, Jia-Yih Feng, Yuh-Min Chen

“…A notable decline in the recurrence rate was observed post-2017. The peak recurrence rate was observed during the second year following treatment completion. …”
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Fungal colonization before or after lung transplantation has no negative impact on survival or the development of chronic lung allograft dysfunction by Embla Bodén, Fanny Sveréus, Anna Niroomand, Hamid Akbarshahi, Richard Ingemansson, Hillevi Larsson, Sandra Lindstedt, Franziska Olm

“…Being colonized with fungus before or within the first 12 months post-LTx did not significantly affect survival or CLAD development. …”
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Analysis of the short-to-intermediate-term efficacy of autologous costochondral transplantation in treatment for Hepple V osteochondral lesion of talus by Jiazheng Wang, Jieyuan Zhang, Shaolin Fu, Xueqian Li, Cheng Wang, Chenglin Wu, Shutao Zhang, Xin Ma, Zhongmin Shi

“…There were no complications, such as neurovascular injury, nonunion or delayed union, and post-traumatic arthritis in both groups. Conclusion This study preliminarily validated that ACT could restore the defective talar articular cartilage shorten the operation time and hospitalization days, reduce the amount of intraoperative blood loss, achieve excellent outcomes and help patients return to work and recreational activities more quickly.…”
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Description of the combined evidence-based, theory-based and person-based approaches used to develop a behavioural intervention package to support non-allergist healthcare workers... by Sarah Tonkin-Crine, Neil Powell, Jonathan Sandoe, Bridie Kent, Mathew Upton

“…The identified HCW target behaviours were: taking a penA allergy focused history and to risk assess the patient’s penA history; to then either de-label the patient on history alone (direct de-label; DDL) or prescribe a direct oral challenge (DOC) dose; to perform baseline and post-test observations and counsel the patient on the risks of penA records and on the risks and the benefits of PADL. …”
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Å ALIES FINANSINIO SAUGUMO POVEIKIS PAJAMŲ NELYGYBEI by Rasa BartkutÄ—, Jurga GrikietytÄ—-ÄŒebataviÄienÄ—

“…VÄ—liau Å¡ios srities tyrimų proveržį paskatino 2020 m. pasaulinÄ— pandemija, o 2022 m. geopolitinÄ—s situacijos pokyÄiai ir su tuo įsisijÄ™ nauji iÅ¡Å¡Å«kiai tapo postÅ«miu daugiau dÄ—mesio skirti Å¡alies finansinio saugumo palaikymo priemonių efektyvumui. …”
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An ACE2-Fc decoy produced in glycoengineered plants neutralizes ancestral and newly emerging SARS-CoV-2 variants and demonstrates therapeutic efficacy in hamsters by Esther Föderl-Höbenreich, Shiva Izadi, Lara Hofacker, Nikolaus F. Kienzl, Alexandra Castilho, Richard Strasser, Ferran Tarrés-Freixas, Guillermo Cantero, Núria Roca, Mònica Pérez, Cristina Lorca-Oró, Carla Usai, Joaquim Segalés, Júlia Vergara-Alert, Lukas Mach, Kurt Zatloukal

“…In a golden Syrian hamster model, therapeutic intranasal delivery of ACE2-Fc effectively reduced weight loss and SARS-CoV-2 replication in the lungs when administered 24 h post-inoculation. This protective effect was not observed upon treatment of the infected animals with a non-binding ACE2-Fc mutant, demonstrating that the plant-derived ACE2-Fc decoy interferes specifically with the attachment of the virus to host cells. …”
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Using sputum and tongue swab specimens for in-home point-of-care targeted universal testing for tuberculosis of household contacts: an acceptability and feasibility analysis by Adam Penn-Nicholson, Andrew Medina-Marino, Charl Bezuidenhout, Gesine Meyer-Rath, Lawrence Long, Matthew P Fox, Grant Theron, Morten Ruhwald, Brooke Nichols, Sharon Olifant, Kuhle Fiphaza, Maria Pieruccini, Bernard Fourie

“…Household contacts of people with TB residing in the Buffalo City Metro Health District (Eastern Cape Province, South Africa) who received in-home POC TUTT through the TB Home Study were asked to complete a post-test acceptability survey. The survey assessed the level of comfort, confidence in the test results and perceived appropriateness of in-home POC TUTT. …”
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Comparative Analysis of Two Zika Virus Isolates in a Rhesus Macaque Pregnancy Model by Hannah K. Jaeger, Jessica L. Smith, Christopher J. Parkins, Nicole N. Haese, Craig N. Kreklywich, Michael Denton, Caralyn S. Labriola, Michael K. Axthelm, Aaron Barber-Axthelm, Kim Chun, Tonya Swanson, Rahul J. D’Mello, Terry K. Morgan, Duncan R. Smith, Jamie O. Lo, Alec J. Hirsch, Victoria H. J. Roberts, Daniel N. Streblow

“…Pregnant animals (<i>n</i> = 3 per group) were infected subcutaneously with either ZIKV-PR or ZIKV-TH at ~50 days gestation (GD) and monitored for 40 days post-infection (GD90). Similar courses of viremia and immune activation were observed for both viruses when compared to uninfected controls. …”
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Epidemic situation and features of accompanying therapy in the treatment of socially significant infectious diseases in penitentiary populations before, during, and after the COVID... by V. M. Kolomiets, N. A. Polshikova, A. Yu. Petrov, A. L. Kovalenko, E. V. Talikova

“…A further decrease in the incidence of the main SIDs was recorded in the post-Covid period (2020–2022). The exceptions were gonorrhea (a 1.8-fold increase — from 18.2 to 32.7 per 100 thousand) and tuberculosis (a 1.5-fold increase — from 364.8 to 552.1 per 100 thousand), P&gt;0.05. …”
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Dynamics of vector competence for dengue virus type 2 in rural and urban populations of Aedes albopictus: implications for infectious disease control by Jehangir Khan, Muhammad Adil, Zhang Junyan, Dongjing Zhang, Yidong Deng, Zhiyue Lv, Tao Chen

“…Three different bioassays (B1–B3) were conducted on 60 mosquitoes per population: B1 at 7 days post-exposure (dpe) to assess viral infection in the mosquito midgut, and B2 and B3 at 14 dpe to evaluate viral dissemination in the carcass and transmission via saliva. …”
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Molecular Mechanism for PACAP 38-Induced Neurite Outgrowth in PC12 Cells by Junko Shibato, Fumiko Takenoya, Takahiro Hirabayashi, Ai Kimura, Michio Yamashita, Ichiro Takasaki, Randeep Rakwal, Seiji Shioda

“…PC12 cells were treated with PACAP38 being added to the cell culture medium at concentrations of 10−7 M, 10−8 M, and 10−9 M. Post PACAP38 treatment, immunostaining was used to confirm protrusion elongation of the PC12 cells, while RT-PCR, two-dimensional gel electrophoresis in conjunction with Western blotting, and inhibition experiments were performed to confirm the expression of the PACAP gene, its receptors, and downstream signaling components. …”
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The effect of empagliflozin on peripheral microvascular dysfunction in patients with heart failure with preserved ejection fraction by Sanne G. J. Mourmans, Anouk Achten, Raquel Hermans, Marijne J. E. Scheepers, Elisa D’Alessandro, Geertje Swennen, Janneke Woudstra, Yolande Appelman, Harry van Goor, Casper Schalkwijk, Christian Knackstedt, Jerremy Weerts, Etto C. Eringa, Vanessa P. M. van Empel

“…Methods This is a pre-post intervention study in patients diagnosed with HFpEF who are eligible for treatment with empagliflozin. …”
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Clinical efficacy and regulatory mechanisms of Shi Pi Zeng Ye formula in treating functional constipation comorbid with depression: integrating clinical observation, mass spectrome... by Ling Yao, Xiaoqiang Jia, Yufei Li, Haixia Li, Zhuhui Zhang, Longfang Quan, Qiuling Liu, Jie Dai, Xuedi Lei, Huashang Li, Yonghai Li

“…Assessments were conducted at baseline, 4 weeks, and 12 weeks post-treatment. The study also explored the action mechanisms of SPZY through mass spectrometry, network pharmacology, and molecular docking to ascertain the binding affinities of SPZY’s active components to critical targets.ResultsThe study findings indicated significant improvements in WCS (p &lt; 0.0001), HAMD-17 (p &lt; 0.0001), PAC-QOL (p &lt; 0.0001), and HAMA (p &lt; 0.001) scores from baseline to 3 months. …”
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A pilot study investigating the effect of pembrolizumab on the tumoral immunoprofile of newly diagnosed mullerian cancers by Stéphanie L. Gaillard, Gloria Broadwater, Andrew Berchuck, William S. Andrews, Laura J. Havrilesky, Brittany A. Davidson, Rebecca A. Previs, Mark D. Starr, John S. Yi, Andrew B. Nixon, Jadee L. Neff, Jose Ramon Conejo-Garcia, Angeles Alvarez Secord

“…TIL levels changed in 4 of 11 paired sets, with 3 decreasing and 1 increasing post-treatment. PD-L1 modified proportion score increased in 7 cases, decreased in 2, and remained unchanged in 2. …”
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