A universal testing and treatment intervention to improve HIV control: One-year results from intervention communities in Zambia in the HPTN 071 (PopART) cluster-randomised trial. by Richard Hayes, Sian Floyd, Ab Schaap, Kwame Shanaube, Peter Bock, Kalpana Sabapathy, Sam Griffith, Deborah Donnell, Estelle Piwowar-Manning, Wafaa El-Sadr, Nulda Beyers, Helen Ayles, Sarah Fidler, HPTN 071 (PopART) Study Team

“…Data from four communities in Zambia receiving the full intervention (including immediate ART for all individuals with HIV) were used to determine proportions of participants who knew their HIV status after the CHiP visit; proportions linking to care and initiating ART following referral; and overall proportions of HIV-infected individuals who knew their status (first 90 target) and the proportion of these on ART (second 90 target), pre- and post-intervention. We are not able to assess progress towards the third 90 target at this stage of the study. …”
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Application of the Fitness and Nutrition Program for Seniors (FANS) to improve Physical Activity and Kinanthropometric Measures among Community-Dwelling Older Adults living with Fr... by Pei-Shan Li, Chia-Jung Hsieh, Nae-Fang Miao, Chuan-Hsiu Tsai, Chieh-Yu Liu, Hung-Ru Lin, Shu-Fang Vivienne Wu, Jordan Koh

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Optimizing High-Power Performance of [001]-Oriented Pb(Mg_1/3Nb_2/3)-PbTiO₃ Through Combined DC and AC Polarization Above Curie Temperature by Yuliang Zhu, Xiaobo Wang, Wenchao Xue, Xinran Wen, Chengtao Luo

“…Pb(Mg_1/3Nb_2/3)O₃-PbTiO₃ single crystals (PMN-PT SCs) are widely utilized in high-performance piezoelectric devices due to their exceptional piezoelectric properties. Among the various post-processing techniques for domain engineering in PMN-PT SCs, alternating current polarization (ACP) has become a widely adopted method for enhancing piezoelectric performance. …”
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Safety and effectiveness of multimodal opioid-free anaesthesia for pain and recovery after laparoscopic surgery: a systematic review and meta-analysis by Jiang Liu, Li Jing, Lin Cheng, Sifan Qin, Xinyan Geng, Shirong Fang

“…The secondary outcomes included the incidence of postoperative nausea and vomiting (PONV), antiemetic use, extubation time (measured in minutes), post-anaesthesia care unit discharge time (measured in minutes), shivering, bradycardia, hypotension and pruritus.Data extraction and synthesis Meta-analyses were performed using Stata16 software, using the DerSimonian and Laird’s method and inverse variance to summarise effect sizes for each outcome under a random effects model for all outcomes. …”
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Stationary Cycling Exercise With Virtual Reality to Reduce Depressive Symptoms Among People With Mild to Moderate Depression: Randomized Controlled Trial by Na Zhang, Chenlu Hong, Yuejia Wang, Haiqin Chen, Yueli Zhu, Miao Da, Zhongxia Shen, Xudong Zhao, Jiali Xu, Jiaxiu Sheng, Yanan Luo, Meiying Xu

“…Response rate, remission rate, satisfaction, compliance, and adverse events were assessed post intervention. Outcomes were analyzed using an ITT approach. …”
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Enhanced T-cell immunity and lower humoral responses following 5-dose SARS-CoV-2 vaccination in patients with inborn errors of immunity compared with healthy controls by Vitor Gabriel Lopes da Silva, Gabriela Justamante Händel Schmitz, Kathleen E. Sullivan, Júlia Barbate, Maria Izabel de Haro Azinar, Carolina Sanchez Aranda, Maria Isabel de Moraes-Pinto

“…T-cell responses to Spike were stronger in patients with IEI post-booster (405 vs. 149 spot-forming cells/million PBMC; p = 0.002). …”
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Polymorphisms in the GNAS Gene as Predictors of Ventricular Tachyarrhythmias and Sudden Cardiac Death: Results From the DISCOVERY Trial and Oregon Sudden Unexpected Death Study by Heinrich Wieneke, Jesper Hastrup Svendsen, Jeffrey Lande, Sebastian Spencker, Juan Gabriel Martinez, Bernhard Strohmer, Lauri Toivonen, Hervé Le Marec, F. Javier Garcia‐Fernandez, Domenico Corrado, Adriana Huertas‐Vazquez, Audrey Uy‐Evanado, Carmen Rusinaru, Kyndaron Reinier, Csaba Foldesi, Wieslaw Hulak, Sumeet S. Chugh, Winfried Siffert

“…In the DISCOVERY trial, genotypes of 2 SNPs in the GNAS gene were nominally significant in the prospective screening and significantly associated with VT when viewed as recessive traits in post hoc analyses (TT vs CC/CT in c.393C>T: HR 1.42 [CI 1.11‐1.80], P=0.005; TT vs CC/CT in c.2273C>T: HR 1.57 [CI 1.18‐2.09], P=0.002). …”
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Long‐Term Clinical Outcomes of Treatments for In‐Stent Chronic Total Occlusions: A Real‐World Study Based on Different Strategies of Revascularization by Zhuoran Yang, Jiasheng Yin, Yiqing Hu, Li Zhu, You Zhou, Yaqi Zhang, Nirupama Krishnamurthi, Jieyu Jiang, Wenxian Zhou, Nitin Barman, Hao Lu, Junbo Ge

“…In this single‐center retrospective cohort study of 198 patients with IS‐CTO post‐DES, 3‐year outcomes of DCB, DES, and plain old balloon angioplasty (POBA) were compared, focusing on target vessel failure (TVF). …”
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Theory-screened Prussian blue analogues-based nanozymes for promoting diabetic wound healing via ferroptosis inhibition by Qingrong Dong, Xiaomei Shen, Ge Fang, Jia Shi, Xiafeng Zhu, Jiangfeng Du, Hui Zhang, Cuicui Ge

“…Through computational and experimental methods, the optimized Prussian blue analogues (MPBs) with highest iron chelating efficiency and efficacy (CuPBs) are screened out and both the CuPBs and the post-chelated products have been demonstrated to exhibit reactive oxygen species (ROS)-scavenging activities. …”
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Diagnostic value of microRNA-27 and -339 in heart transplant recipients with myocardial fibrosis by O. P. Shevchenko, D. A. Velikiy, S. O. Sharapchenko, O. E. Gichkun, A. V. Marchenko, A. A. Ulybysheva, V. S. Pavlov, N. P. Моzheikо, N. N. Кoloskovа, A. O. Shevchenko

“…The combination of molecular-genetic and proteomic biomarkers in one test improves the diagnostic characteristics of these expressions with respect to post-transplant complications in heart recipients.…”
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Regulation of retinoic acid inducible gene I signal transduction by bluetongue virus through the ubiquitin-proteasome system by Danfeng LU, Zhenxing ZHANG, Zhanhong LI, Pei ZHU, Zhuoran LI

“…Treatment with the proteasome inhibitor MG-132 significantly suppressed RIG-I degradation induced by BTV infection; The nuclear translocation ratio of IRF3 in MG-132 treated SPAE cells increased by 9.67 and 8.66 percentage points compared with their untreated counterparts at 24 hours post-infection (24 hpi) and 48 hpi; The expression level of IFN-α increased by 2.18-fold comparing with that of the corresponding untreated group at 48 hpi; The genomic copy numbers of BTV decreased to 74% and 85% of those of the untreated counterparts at 24 and 48 hpi, respectively. …”
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Biochemical investigation of association of arsenic exposed polymorphic variants and disease susceptibility by Syed Muhammad Shoaib, Samina Afzal, Muhammad Sajid Hamid Akash, Kanwal Rehman, Amjad Hussain, Ahmed Nadeem, Asif Shahzad, Sabry M. Attia

“…The groundwater exhibited significantly elevated arsenic concentrations (68.18 ± 21.28 μg/L) in comparison to both water and sanitation agency Faisalabad (WASA)-supplied water (9.81 ± 1.2 μg/L) and locally filtered water (8.12 ± 1.42 μg/L), as determined by one-way ANOVA followed by Bonferroni's post-test at P < 0.05. An association was established between arsenic concentration and the incidence of disease, such as diabetes mellitus. …”
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Development and Validation of a Machine Learning Model for Predicting Long-Term Depression Risk in ACS Patients After PCI: A Retrospective Cohort Study by Lv H, Sun F, Zhang Y, Zhou X

“…Decision curve analysis demonstrated the clinical benefit of both models across a range of thresholds.Conclusion: The models demonstrated potential for early risk stratification of post-PCI depression and may inform targeted clinical interventions.Plain Language Summary: Depression is a common but often overlooked problem in people recovering from heart procedures. …”
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The role of ubiquitination and deubiquitination in urological tumours by Lifeng Gan, Lifeng Gan, Lifeng Gan, Peiyue Luo, Peiyue Luo, Peiyue Luo, Junrong Zou, Junrong Zou, Wei Li, Wei Li, Wei Li, Qi Chen, Qi Chen, Qi Chen, Le Cheng, Le Cheng, Le Cheng, Fangtao Zhang, Fangtao Zhang, Fangtao Zhang, Haidong Zhong, Haidong Zhong, Haidong Zhong, Liying Zheng, Biao Qian, Biao Qian

“…Ubiquitination, a form of post-translational modification, occurs in eukaryotic cells and involves several key components, such as Ub-activating enzymes, Ub-binding enzymes, and Ub-protein ligases. …”
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The ASSIST Trial: Acute Effects of Manipulating Strength Exercise Volume on Insulin Sensitivity in Adults Living With Obesity: A Randomized Controlled, Crossover, Clinical Trial by Luis Filipe Rocha Silva, Paulo H. Evangelista Silva, Jordan Ottoni do Carmo, Bruna Caroline Chaves Garcia, Elizabethe Adriana Esteves, Zachary Aaron Mang, Fabiano Trigueiro Amorim, Marco Fabrício Dias‐Peixoto, Fernando Gripp, Valmor Tricoli, Flavio de Castro Magalhaes

“…Results One‐way repeated measure analysis of variance followed by Tukey as post hoc showed that indexes of insulin sensitivity improved after the high‐volume session (p < 0.05) but not after the low‐volume session (p > 0.05) (effect size [EF] for high and low volume, respectively): insulin area under the curve (AUC) [−0.53 and −0.05], C‐peptide AUC [0.58 and 0.18], Cederholm index [0.59 and 0.11], skeletal muscle index [0.89 and 0.60], Gutt index [0.78 and 0.20], Stumvoll index [0.81 and 0.18], and the simple index [0.52 and 0.16]). β‐cell function showed a strong tendency to improve (p < 0.06) after the high‐volume session (EF for high and low volume, respectively): C‐peptidogenic index [0.58 and −0.20], C‐peptide oral disposition index [0.72, −0.33]. …”
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Newborn Screening for Gaucher Disease: The New Jersey Experience by Caitlin Menello, Shaney Pressley, Madeline Steffensen, Sarah Schmidt, Helio Pedro, Reena Jethva, Karen Valdez-Gonzalez, Darius J. Adams, Punita Gupta, Lorien Tambini King, Milen Velinov, Sharon Anderson, Peyman Bizargity, Beth Pletcher, Allysa Tuite, Christina Kresge, Debra Lynn Day-Salvatore, Ryan Kuehl, Can Ficicioglu

“…Three type I GD patients started enzyme replacement therapy, with the youngest starting at 28 months of age. Post-treatment data are available for these individuals. …”
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Effects of histone acetyltransferase and deacetylase inhibitors on the expression of S100A genes after TLR4 and TLR2 stimulation in human dental pulp cells by Holger Jungbluth, Dominik Kraus, Diana Lalaouni, Sarah Hossam Fahmy, Jochen Winter, Søren Jepsen

“…Analysis of variance (ANOVA) followed by tukey post-hoc-test was calculated. Results: HDAC and HAT inhibitors significantly altered the expression of S100A genes in hDPCs both in presence and absence of LPS and Pam3CSK4, respectively. …”
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A Retrospective Longitudinal Study on Venous Thromboembolisms: The Impact of Active Monitoring on the Venous Thromboembolism Management Practices of Healthcare Providers to Improve... by Rateb Abd Alrazak Daowd, Ateeq Mohamad Algarni, Majed Abdulhadi Almograbi, Sara Majed Saab, Naif Mansour Alrashed, Maryam Mohammad Harthi, Amira Fatmah Paguyo Quilapio, Ibrahim Numan Alnajjar, Shahzad Ahmad Mumtaz, Raed Fahad Albusayyis, Dalya Ali Aljumaiah, Yazeed Alsalamah, Huda Ibrahim Almulhim

“…Lastly, we recommend addressing the risk factors associated with the occurrence of hospital-acquired VTE and performing post-discharge follow-ups of patients.…”
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10-year experience in orthotopic heart transplantation in Kuzbass by L. S. Barbarash, O. L. Barbarash, E. V. Grigoriev, D. L. Shukevich, T. B. Pecherina, M. G. Zinets, A. V. Sotnikov, I. K. Khalivopulo, T. S. Golovina, E. M. Kurguzova, A. V. Ivanova, Yu. S. Ignatova, A. V. Yurkina, D. P. Golubovskaya, P. G. Parfenov, J. I. Gusel’nikova, E. V. Dren’

“…At the same time, there is lower perioperative mortality and higher survival in the post-OHT long-period.Objective: to analyze OHT outcomes in Kuzbass over a 10-year period.Material and methods. …”
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Senescence-associated alterations in histone H3 modifications, HP1 alpha levels and distribution, and in the transcriptome of vascular smooth muscle cells in different types of sen... by Agnieszka Gadecka, Marta Koblowska, Helena Kossowska, Roksana Iwanicka-Nowicka, Dorota Janiszewska, Grażyna Mosieniak, Krzysztof Bojakowski, Krzysztof Goryca, Anna Bielak-Zmijewska

“…Methods We investigated the level and distribution of HP1α and H3 modifications that are markers of hetero- and euchromatin (H3K9me3, H3K27me3, H3K4me3, H3K9Ac - WB and IF), alterations in the transcriptomic profile (DNA microarray, qPCR), H3K4me3, H3K9me3 and HP1α protein distribution in the genome (ChIP-seq), and expression of enzymes involved in histone post-translational modifications (DNA microarray, qPCR, WB, IF). …”
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