Biological maturation determines the beneficial effects of high-intensity functional training on cardiorespiratory fitness in male adolescents by Jarosław Domaradzki, Cristian Alvarez, Rafał Szafraniec, Dawid Koźlenia

“…The MO role in the HIFT intervention was tested by MANCOVA and ANCOVA with post hoc detailed comparisons. Results MO contributed to the studied model more than CA (Wilk’s Λ = 0.49, ηp2 = 0.24, p < 0.001; Wilk’s Λ = 0.83, ηp2 = 0.07, p < 0.063, respectively). …”
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Prediagnosis Insights Into Amyotrophic Lateral Sclerosis: Clinical Symptoms and Medication Use by Chunyang Pang, Wen Cao, Jiali Xie, Yaojia Li, Luyi Zhu, Huan Yu, Dongsheng Fan, Binbin Deng

“…In the ALS cohort, the male‐to‐female ratio was 2.9, with a median age at onset of 64.61 years (Interquartile range (IQR): 56.80–71.31) and a median survival time post‐diagnosis of 9.08 months (IQR: 3.18–18.98), while females (log‐rank p = 0.038) and individuals with earlier (< 64.61 years) disease onset (log‐rank p < 0.001) had longer survival periods. …”
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Dexamethasone-eluting cochlear implants reduce inflammation and foreign body response in human and murine cochleae by Muhammad Taifur Rahman, Brian J Mostaert, Peter Eckard, Shakila Mahmuda Fatima, Rachel Scheperle, Ibrahim Razu, Bryce Hunger, Rafal T. Olszewski, Shoujun Gu, Cristina L. Garcia, Nashwaan Ali Khan, Douglas M Bennion, Jacob Oleson, Jonathon R. Kirk, Ya Lang Enke, Robert D. Gay, Robert J. Morell, Keiko Hirose, Michael Hoa, Alexander D. Claussen, Marlan R. Hansen

“…This study aims to investigate the long-term efficacy of dexamethasone-eluting cochlear implant and locally delivered dexamethasone, a potent anti-inflammatory glucocorticoid, on the intracochlear FBR and electrical impedance post-implantation in a murine model. Preliminary impedance data in humans are also provided as a complement to the murine data to illustrate generalizability and reinforce implications related to clinical application. …”
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Cardiac protection of wogonin in mice with pulmonary fibrosis by regulating Sirt1/ γ-H2AX pathway by Libo Wang, Libo Wang, Fei Lin, Runran Miao, Tianhao Zhao, Yuan Liu, Lin Yang, Min Zhang, Min Zhang

“…This gap in understanding complicates the management and treatment of HF in patients with PF.ObjectivesTo investigate the effects of PF on cardiac function and myocardial fibrosis using a mouse PF model and evaluate the therapeutic potential of wogonin, a flavonoid compound known for its anti-PF properties.MethodsA PF mouse model was established via intratracheal administration of bleomycin (BLM). Starting on day 8 post-BLM treatment, wogonin (50 mg/kg) was intraperitoneally administered every 2 days for 2 weeks. …”
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AAV-shDUX4 provides short-term benefits but limited long-term efficacy in a DUX4 mouse model of FSHD by S. Sohn, S. Reid, M. Bowen, C. Hudon, E. Corbex, B. Morel, C. Hourde, V. Mariot, J. Dumonceaux

“…However, by 10 months post-treatment, the therapeutic effects had substantially diminished, with most pathological markers remaining uncorrected and no sustained improvement in muscle force. …”
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In Vitro Evaluation of the Antiviral Activity of Polyphenol (-)-Epigallocatechin-3-Gallate (EGCG) Against Mayaro Virus by Pâmela Jóyce Previdelli da Conceição, Gabriela Miranda Ayusso, Tamara Carvalho, Maria Leticia Duarte Lima, Mikaela dos Santos Marinho, Fábio Rogério Moraes, Paola Elaine Galán-Jurado, José González-Santamaría, Cíntia Bittar, Bo Zhang, Ana Carolina Gomes Jardim, Paula Rahal, Marilia Freitas Calmon

“…Finally, it also showed significant inhibition in the post-entry stages of the MAYV replication cycle, acting on the replication of the genetic material and late stages, such as assembly and release. …”
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The effect of infectious bursal disease virus infection on gut microbiota of broiler chicken and the role of prebiotics and probiotics on correction of gut dysbiosis using analysis... by M. I. Mosa, H. M. Salem, M. Hassan, M. A. El-Saied, M. A. Bastamy, M. M. Amer

“…The clinical signs, postmortem lesions (PM), mortality, bursal index (BI), immune response, body weight gain (BWG), feed intake (FI), feed con-version rate (FCR), caecum villi morphometry and gut microbiome profile were studied. At 3 days post infection (dpi), significant decrease in caecum total mucosal thickness (P<0.05) were observed in CP group (204±12.6 µm) compared to CN group (266±16 µm) while it was corrected in infected pro-phylaxis groups P1 (310±10.5 µm), P2 (320±13.4 µm), P3 (267±13.9 µm) and P4 (265±10.6 µm). …”

Safety and pharmacokinetics of dolutegravir in pregnant mothers with HIV infection and their neonates: A randomised trial (DolPHIN-1 study). by Catriona Waitt, Catherine Orrell, Stephen Walimbwa, Yashna Singh, Kenneth Kintu, Bryony Simmons, Julian Kaboggoza, Mary Sihlangu, Julie-Anne Coombs, Thoko Malaba, Josaphat Byamugisha, Alieu Amara, Joshua Gini, Laura Else, Christie Heiburg, Eva Maria Hodel, Helen Reynolds, Ushma Mehta, Pauline Byakika-Kibwika, Andrew Hill, Landon Myer, Mohammed Lamorde, Saye Khoo

“…<h4>Methods and findings</h4>In DolPHIN-1, HIV-infected treatment-naïve pregnant women (28-36 weeks of gestation, age 26 (19-42), weight 67kg (45-119), all Black African) in Uganda and South Africa were randomised 1:1 to dolutegravir (DTG) or efavirenz (EFV)-containing ART until 2 weeks post-partum (2wPP), between 9th March 2017 and 16th January 2018, with follow-up until six months postpartum. …”
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Comparative efficacy and safety of nitinol vs. novel fully biodegradable occluders for transcatheter patent foramen ovale closure in migraine treatment: a retrospective cohort stud... by Rui-lin Li, Jing-juan Huang, Jie Ming, Ying Hao, Wei Wen, Yun-li Shen, Li Lin, Lin-xiang Lu

“…Secondary outcomes included the incidence of safety-related events and the rate of residual right-to-left shunt.ResultsBoth the nitinol group and biodegradable groups showed significant reductions in MIDAS scores post-procedure with no significant difference in migraine relief between groups (P = 0.644, Kaplan-Meier analysis). …”
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Construction and multidimensional effect evaluation of a mindfulness-based second victim intervention support programme for intensive care unit nurses: a case–control study by Xiaolei Chen, Aiyan Du, Mei Yu, Cen Zhang, Xuefen Zhu, Yan Cao, Linghong Hua, Xiaodong Cao

“…Specifically, the PSQI score in the experimental group decreased from 12.94 ± 2.03 at baseline to 9.32 ± 2.13 post-intervention, whereas the control group’s score only decreased from 12.76 ± 2.21 to 10.72 ± 1.99. …”
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Self-injurious behavior in Greek adolescents: the role of mental health problems and COVID-19 trauma by Georgios Giannakopoulos, Foivos Zaravinos-Tsakos, Efrosyni Pilafa, Andre Sourander, Gerasimos Kolaitis

“…Participants completed the Strengths and Difficulties Questionnaire (SDQ) to assess emotional symptoms, conduct problems, hyperactivity, and peer difficulties, and the Children’s Revised Impact of Event Scale-8 (CRIES-8) to evaluate post-traumatic stress symptoms. SIB was assessed via self-report, and specific COVID-19–related experiences (e.g., quarantine, hospitalization) were recorded alongside measures of suicidal ideation and suicide attempts. …”
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U–Pb dating on calcite paleosol nodules: first absolute age constraints on the Miocene continental succession of the Paris Basin by V. Monchal, R. Rateau, K. Drost, C. Gagnaison, B. Mennecart, R. Toullec, K. Torremans, D. Chew

“…Recent progress in carbonate U–Pb dating can improve correlations between continental successions by providing absolute age constraints on carbonate deposition and/or on syn- to post-depositional processes such as pedogenesis.</p> <p>In this study, we analysed pedogenic calcite nodules within a continental Miocene succession in the southwestern Paris Basin (the important paleontological site at Mauvières quarry, France). …”
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Transient gray matter decline during antarctic isolation: Roles of sleep, exercise, and cognition by David Roalf, Mathias Basner, Joanne C. Beer, Russell T. Shinohara, Kosha Ruparel, Tyler M. Moore, David F. Dinges, Alexander C. Stahn, Jad Nasrini, Emanuel Hermosillo, Adrian J. Ecker, Karthik Prabhakaran, Mustafa M. Almuqbel, Michael G. Smith, Christopher W. Jones, Bernd Johannes, Darius A. Gerlach, Beth Healey, Floris P. van den Berg, Hanns-Christian Gunga, Tracy R. Melzer, Bruce V. Taylor, Ruben C. Gur

“…This study assessed brain structure changes in 25 crewmembers who spent 12 months at Concordia, with MRI scans conducted before, immediately after, and five months post-mission. The study included 25 controls scanned over a similar interval and 4 “flying phantom” individuals who were scanned at all sites. …”
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Cross-lineage 5-methylcytosine methylome profiling reveals methylated divergence among Toxoplasma gondii tachyzoites of the three major clonal lineages by Xiao-Nan Zheng, Hong-Yu Song, Hany M. Elsheikha, Chen-Ran Tian, Xing Tian, Qing Liu, Wen-Bin Zheng, Xing-Quan Zhu

“…Among the emerging layers of gene regulation, 5-methylcytosine (m5C) has emerged as a pivotal post-transcriptional modification in eukaryotes. …”
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Exploring the impact and mechanisms of behavioral activation on sleep disorders in colorectal cancer: a randomized controlled trial by Anlong Li, Runze Huang, Han Ge, Dajie Liu, Shaochun Liu, Yingxue Jia, Jiaying Chai, Xinyi Zheng, Lijun Liu, Chen Gan, Jian Xu, Ling Cheng, Mingjun Zhang, Huaidong Cheng

“…Assessments of quality of life, sleep disturbances, psychological distress, activation, avoidance, and physical activity levels were conducted at baseline (T0), four weeks later (T1), and post-intervention (T2). Generalized estimating equation (GEE) analysis was used to evaluate the intervention’s impact and potential mediating effects. …”
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OCTA changes of retinal microvessels and thickness in moyamoya disease by Xian-Zhe Qian, Cheng Chen, Hong-Liang Li, Lei Zhong, Hong Wei, Qian-Min Ge, Jin-Yu Hu, Qi Hong, Xiao-Yu Wang, Yan-Mei Zeng, Xu Chen, Yi-Xin Wang, Chong-Gang Pei, Yi Shao

“…Analyses of variance (ANOVA) and Bonferroni post hoc analysis were used to calculate statistical differences between the three groups. …”
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More Evidence that Surgical Intervention for Unstable Distal Radius Fracture in Elderly Does not Offer a Superior Patient Perceived Functional Advantage over Time Honored Conservat... by Raghavendra S Kulkarni, Sriram R Kulkarni

“…Introduction: In this study, elderly distal radius fracture treatment by both conservatively and surgical intervention was examined at 1 and 2 years post-injury and then reevaluated after a median of 10 (range 10–13) years. …”
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Aquificae overcomes competition by archaeal thermophiles, and crowding by bacterial mesophiles, to dominate the boiling vent-water of a Trans-Himalayan sulfur-borax spring. by Nibendu Mondal, Subhajit Dutta, Sumit Chatterjee, Jagannath Sarkar, Mahamadul Mondal, Chayan Roy, Ranadhir Chakraborty, Wriddhiman Ghosh

“…While members of this phylum accounted for 80% of all 16S rRNA-encoding reads within the metagenomic dataset, 14% of such reads were attributed to Proteobacteria. Post assembly, only 25% of all protein-coding genes identified were attributable to Aquificae, whereas 41% was ascribed to Proteobacteria. …”
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Consumers’ healthy lifestyle as a determinant of the influence of microcelebrities and microinfluencers by Mariola Palazón, María del Carmen Alarcón-del-Amo, Borja Martínez, Manuela López

“…Design/methodology/approach – An empirical study with a real healthy food brand was developed in which three real influencers from Instagram collaborated and posted a story showing the company’s products. A total of 148 individuals participated in the study. …”
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Carotid revascularization for ocular ischemic syndrome – a systematic review by Leonor Baldaia, Miguel Silva, Eduardo Silva, Celso Nunes, Luís Orelhas, Maria Carmona, Luís F. Antunes, Manuel Fonseca

“…We aim to study the potential improvement of visual symptoms post-carotid endarterectomy (CEA) in patients with carotid stenosis and hypoperfusion-related ocular issues. …”
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