RT-QuIC Reactivity in the Brain and Other Organs and Tissues in Early, Middle-early, Middle-late and Terminal Stages of Scrapie Agent 263K Intracerebral Infection in Hamsters by Donglin Liang, Chumou Liu, Kang Xiao, Yuan Wang, Donghua Zhou, Xiaoxi Jia, Yuezhang Wu, Xiaoping Dong, Qi Shi

“…-- named anchor --> </a> <h5 class="section-title" id="d1447294e225">Methods:</h5> <p dir="auto" id="d1447294e227">Brain, skin and other organ specimens were collected at approximately 20, 40, 60 and 80 (terminal stage) days post-inoculation, and homogenates were prepared. …”
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Single-cell transcriptomics reveals cellular dynamics and chemokine CXCL2-mediated smooth muscle cell proliferation in arterial repair by Xingxiao Huang, Xingxiao Huang, Yan Ping, Yan Ping, Qiuli Sun, Qiuli Sun, Mingjun Yu, Mingjun Yu, Chao Yang, Xiao Liu, Long Wang, Jinyu Huang, Jinyu Huang

“…BackgroundPercutaneous coronary intervention (PCI) remains the primary treatment for coronary artery disease (CAD), yet post-procedural arterial injury triggers cellular change and pathological inflammation, leading to thrombosis and restenosis. …”
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Indonesian Geriatrics Society Consensus on COVID-19 Management in Older Adults by IGP Suka Aryana, Siti Setiati, Roza Mulyana, Noto Dwimartutie, Aulia Rizka, Bayu Basuki Wijaya, Nur Riviati, Rensa Rensa, Dina Aprilia Ariestine, Bambang Joni Karjono, Eko Aribowo, Hildebrand Hanoch Victor Watupongoh, Ridzqie Dibyantari, Wayan Giri Semara Putra, Fandi Triansyah, Rahmi Istanti, Dian Daniella

“…In this consensus, we also discuss about management of older adults with special condition such as diabetes mellitus, kidney disease, malignancy, frailty, delirium, immobilization and dementia. In post COVID-19 phase, we believe that physical rehabilitation is important as it is done to improve fitness. …”
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Historical water environment changes in Chagan Lake (mid-19th to mid-20th century) inferred from sedimentary diatom records by Fengyang Sui, Fengyang Sui, Xinxin Du, Henglin Xiao, Henglin Xiao, Shuying Zang, Hongkuan Hui, Qi Lv, Yan Liu, Nannan Zhang, Yawen Fan

“…Sedimentological data further indicated accelerated sedimentation rates (0.34 cm·yr−1 pre-1950s vs. 1.31 cm·yr−1 post-1980s) and notable changes in grain-size characteristics, attributable to combined anthropogenic erosion, hydrological engineering, and climatic influences. …”
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Effect of an auxiliary device on scanning accuracy for multiple implants: an in vitro comparative study by Mingyue Lyu, Dingyi Xu, Yizhou Li, Shiwen Zhang, Heling Zhao, Quan Yuan

“…The data were statistically analyzed using two-way ANOVA and post hoc multiple comparison tests. Results The impression method (p <.001) and scanning range (p <.001) significantly influenced the trueness and precision of implant impressions for complete edentulous arches. …”
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Right atrial remodelling and prognosis in patients with severe atrial functional tricuspid regurgitation by Soongu Kwak, Dong‐Jae Han, Seung‐Pyo Lee, Ho Young Hwang, Hyung‐Kwan Kim, Yong‐Jin Kim, Kyung Hwan Kim, Jae Woong Choi, Jun‐Bean Park

“…In the surgical intervention group, four post‐surgical deaths (11.8%) occurred exclusively in patients with both high RA area and RV end‐diastolic area indices. …”
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Association of serum insulin-like growth factor-1 and adrenocorticotropic hormone therapeutic response in patients with infantile epileptic spasms syndrome by Ka-Na Lin, Ka-Na Lin, Feng Han, Ying-Yan Wang, Wei Zhao, Ji-Wen Wang, Hao Li, Hao Li, Yun-Qing Zhou, Yun-Qing Zhou

“…Within the hypsarrhythmia population, responders (n = 9) showed higher IGF-1, IGFBP-3 levels, and IGF-1/IGFBP-3 ratios than non-responders (n = 5) before ACTH treatment (p &lt; 0.05). Post-ACTH treatment, serum IGF-1 and IGFBP-3 levels increased in all patients, with greater elevation observed in responders.ConclusionOur findings demonstrate that serum IGF-1, IGFBP-3 levels, and their ratio correlate with both hypsarrhythmia severity and short-term ACTH response in IESS patients. …”
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The effect of aerobic exercise and crocin consumption on the gene expression of BDNF, TrkB, dopamine, and serotonin in the cerebral cortex of rats induced with methamphetamine by Soudabeh Nourolapour, Asieh Abbassi Daloii, Seyyed Javad Ziaolhagh, Alireza Barari

“…The data were analyzed by using one-way analysis of variance and Tukey's post hoc-test at the significance level of P≤0.05.   …”
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Zingerone Attenuates Cadmium-Induced Neuroinflammation, Oxidative Stress and Cognitive Deficit on the Prefrontal Cortex of Adult Wistar Rats by Oviosun A, Oviosun EC, Nto NJ, Memudu AE, Anyanwu EG

“…Data from this study was analysed using GraphPad Prism 10, and statistical difference between groups was determined using one-way ANOVA followed by Tukey’s post hoc test (p &lt; 0.05).Result and discussion: There was significant reduction in superoxide dismutase (SOD), catalase (CAT) and significant increase malondialdehyde (MDA) in the cadmium-only group; however, this effect was mitigated in Groups C–F that received zingerone treatment. …”
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Variability of bulb morpho-geometrical properties in onion (Allium cepa L.) germplasm collections, using digital imaging tools by Seong-Hoon Kim, Kanivalan Iwar, JiWon Han, Inchan Choi, Jaesu Lee, Kingsley Ochar

“…Onion bulb morphology, and geometrical properties, which are the physical and spatial dimensions and shape characteristics influence consumer and market demand, as well as suitability for processing and mechanizing post-harvest handling. Many previous studies employed manual tools such as Vernier calipers for measurement of onion bulb parameters, which is time-consuming. …”
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A multivariate cell-based liquid biopsy for lung nodule risk stratification: Analytical validation and early clinical evaluation by Jason D. Berndt, Fergal J. Duffy, Mark D. D'Ascenzo, Leslie R. Miller, Yijun Qi, G. Adam Whitney, Samuel A. Danziger, Anil Vachani, Pierre P. Massion, Stephen A. Deppen, Robert J. Lipshutz, John D. Aitchison, Jennifer J. Smith

“…Two models demonstrated discriminative ability in blind validation, one with AUC = 0.64 (95 % CI: 0.51–0.76). Post hoc integration with CT imaging features yielded a combined model with 90 % sensitivity, 64 % specificity, and 95 % negative predictive value at 25 % prevalence, suggesting clinical utility and surpassing performance of existing rule-out tests. …”
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Perbandingan Arsitektur Convolutional Neural Network Pada Klasifikasi Pneumonia, COVID-19, Lung Opacity, dan Normal Menggunakan Citra Sinar-X Thoraks by Agung Wahyu Setiawan

“…Therefore, it is necessary to classify Covid-19 and pneumonia not only during a pandemic but also post-pandemic. One of the methods is using chest X-ray images. …”
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Comparative child mental health and academic outcomes after primary school teachers deliver task-shifted mental health care in India by Priscilla Giri, Molly M. Lamb, Venessa C. Fuentes, Arpana Thapa, Surekha Bhattarai, Choden Dukpa, Catherine C. Shrestha, Setareh Ekhteraei, Juliana L. Vanderburg, Breanna Windsor, Abhishek K. Rauniyar, Karen Hampanda, Bradley N. Gaynes, Rinzi Lama, Michael Matergia, Christina M. Cruz

“…We conducted a pragmatic, mixed methods, post hoc analysis using data from 2019 of an open trial of Tealeaf running in parallel with the all-EUC first step of a stepped wedge cluster randomized controlled trial (SW-CRCT). …”
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Bone morphogenetic protein (BMP) signaling determines neuroblastoma cell fate and sensitivity to retinoic acid by Min Pan, Yinwen Zhang, William C. Wright, Xueying Liu, Barbara Passaia, Duane Currier, Jonathan Low, Richard H. Chapple, Jacob A. Steele, Jon P. Connelly, Bensheng Ju, Emily Plyler, Meifen Lu, Allister J. Loughran, Lei Yang, Brian J. Abraham, Shondra M. Pruett-Miller, Burgess Freeman, George E. Campbell, Michael A. Dyer, Taosheng Chen, Elizabeth Stewart, Selene Koo, Heather Sheppard, John Easton, Paul Geeleher

“…Curiously, RA has little effect on primary human tumors during upfront treatment but can eliminate neuroblastoma cells from the bone marrow during post-chemo maintenance therapy—a discrepancy that has never been explained. …”
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Association between 45T/G Polymorphism of Adiponectin Gene and Coronary Artery Disease in an Iranian Population by Somaye Sabouri, Majid Ghayour Mobarhan, Mohsen Moohebati, Mitra Hassani, Jamal Kassaeian, Farnoosh Tatari, Fatemeh Mahmoodi-kordi, Habib A. Esmaeili, Shima Tavallaie, Roghayeh Paydar, Amirhossein Sahebkar, Shahireh Omidvar Tehrani, Gordon Ferns, Javad Behravan

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VF arrest secondary to immune checkpoint inhibitor (ICI)-associated myocarditis; improving patient outcomes by maintaining a high clinical suspicion for ICI toxicity by Victoria Floyd-Ellis

“…In view of a 600% troponin rise (baseline 29 ng/L to 170 ng/L), fatigue and ventricular arrhythmia, a fulminant ICI myocarditis was favoured, in accordance with the European Society of Cardio-Oncology (ESCO) definition.3Treatment included admission to the intensive care unit (ICU), starting immunosuppression (corticosteroids and mycophenolate) and a dual chamber ICD implant 12 days post-arrest. The patient made a good recovery and returned to all pre-admission activities. …”
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Risk of Serious Infections in Patients Treated With Biologic or Targeted‐synthetic Disease Modifying Antirheumatic Drugs in Qatar by Sreethish Sasi, Hamad Abdel Hadi, Masautso Chaponda, Reem El Ajez, Mohamed Ataelmanan, Sief Khasawneh, Hind Saqallah, Maisa Ali, Nabeel Abdulla, Javed Iqbal, Ali S. Omrani, Muna Al Maslamani, Abdullatif Al‐Khal

“…Mean duration of onset was 10.8 months post‐initiation of therapy. Younger age groups (18–52 years) were predominantly affected. …”
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Promoting ferroptosis of keloid fibroblasts: a key mechanism underlying the efficacy of 5-aminolevulinic acid photodynamic therapy for keloids by Jiaying Zhang, Yahui Feng, Ning Zhang, Xiaoqing Wang, Dongmei Li, Dongmei Shi

“…ALA-PDT disrupted keloid fibroblasts ultrastructure, evidenced by mitochondrial swelling, autophagosome formation, and membrane blebbing, with a 3.2-fold increase in morphological changes post-treatment. The inhibitory effect of ALA-PDT on KFs mitochondrial dehydrogenase activity was ALA dose-dependent. …”
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Clinical manifestations and pathogenicity of Clade IIb monkeypox virus in rabbits by Chao Shang, Shaowen Shi, Qiwei Jiang, Xiaohan Wang, Xiaohong Yao, Wanzi Li, Gaojie Song, Yiquan Li, Yongyang Sun, Jinglei Hu, Cuiling Zhang, Yilong Zhu, Zirui Liu, Chaode Gu, Yan Liu, Wanyu Shi, Zongzheng Zhao, Xiao Li

“…Following intravenous MPXV injection, adult rabbits exhibited characteristic clinical manifestations, including widespread rash and fever, with viral replication in the skin, lungs, and testes, resulting in severe pathological damage by 6 days post-infection (dpi). Intradermal injection of MPXV into the dorsal skin of adult rabbits produced red lesions with central necrosis and hemorrhage accompanied by dense inflammatory infiltrates. …”
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Development and application of a curcumin-cinnamon essential oil nanoemulsion agent against mycobacteria by Zhihui Lei, Zhihui Lei, Zhihui Lei, Yixuan Ren, Jinyao Wang, Haisu Shi, Hu Lin, Hong Chen, Lijun Bi, Lijun Bi, Yutang Wang, Hongtai Zhang, Hongtai Zhang, Hongtai Zhang

“…Furthermore, the aerosol form of the nanoemulsion effectively inhibited both surface and airborne mycobacteria, with no significant changes in structural properties post-atomization. Lung deposition studies indicated that 75.6% of aerosol particles of the nanoemulsion reached the alveolar region, suggesting its potential as an inhalation agent. …”
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