PO51 | Thrombocythemia associated with a non-canonical JAK2 mutation: a case report

“…In MF, for instance, CBL mutations may be linked to poorer survival post-transplant. The CBL 1227+4C>T variant (rs201747825) is intronic and reported as “benign” in ClinVar (8 submissions). …”
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Effect of the Protein Composition of Whole Nutrition Food for Special Medical Purposes on in Vitro Digestion Properties and Cell Calcium Transport Promotion by Weirong GUAN, Gengjie CUI, Shulin ZHENG, Na DONG, Yiming DING, Shengkai FANG, Hongyan LI, Jing WANG

“…Furthermore, a Caco-2 monolayer cell model was established to explore the effects of three whole nutrient foods for special medical purposes on calcium transport both pre- and post-digestion. The results showed that when the digestion time was 240 min, the degrees of hydrolysis for non-hydrolyzed whey protein B1 and moderately hydrolyzed whey protein B2 were 50% and 45.5%, respectively, which were greater than that of non-hydrolyzed protein B0 (the degrees of hydrolysis was 36.5%), and the average peptide chain lengths for B1 and B2 were 5.06 and 4.52, respectively, both shorter than that of B0 (average peptide chain length of 5.45), suggesting that B1 and B2 exhibited greater in vitro digestibility. …”
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SMALL INTESTINAL BACTERIAL OVERGROWTH IN PEOPLE WITH CYSTIC FIBROSIS: SYSTEMATIC REVIEW by Maria Lidiane Lavor LANDIM, José Dirceu RIBEIRO, Daniela de Souza Paiva BORGLI, Danielle Rossana Queiroz Martins BONILHA, Elizete Aparecida LOMAZI, Maria de Fátima Correa Pimenta SERVIDONI

“…ABSTRACT Background: In patients with cystic fibrosis (pwCF) acid suppression therapy, gastrointestinal dysmotility, and post-operative bowel status, may predispose to the development of small intestinal bacterial overgrowth (SIBO). …”
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Conglomerated Imiquimod and Metronidazole Incorporated Biodegradable Nanofibrous Mats for Potential Therapy of Cervical Cancer by Chen YP, Chiu CF, Wang CN, Lin CC, Shen CR, Yao YC, Kuo YH, Liu SJ

“…Group B received treatment with pure PLGA nanofibers (no drugs loaded), whereas Group C received treatment with nanofibers loaded with imiquimod and metronidazole. Post implantation, the variations in tumor sizes of rats receiving the implantation of drug-eluting nanofibers were monitored.Results: The experimental data show that drug-eluting nanofibers could discharge in vitro high concentrations of imiquimod and metronidazole for exceeding 30 days. …”
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An Inducible CYP19A1 Excision Model for Sexual Differentiation in Chicken (<i>Gallus gallus</i>) via the CRISPR/Cas9 System by Guangzheng Liu, Yixiu Peng, Zeyu Li, Xilin Zhu, Hongyan Sun, Guohong Chen, Qisheng Zuo, Yingjie Niu, Jiuzhou Song, Wei Han, Wanhong Wei, Bichun Li, Kai Jin

“…Western blotting showed decreased protein expression of CYP19A1 and FOXL2, and increased SOX9 expression in female embryos post-DOX induction. Elisa detection further confirmed lower estradiol levels in the gonads of induced female embryos compared to normal and non-induced females. …”
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Feasibility and Pathologic Outcomes of Peripheral Lung Vascular Targeted Photodynamic Therapy in a Normal Porcine Lung ModelTake-home Points by Jason Beattie, Mario Ghosn, Kwanghee Kim, Raymond Parrish, Jie Chen, Stephen B. Solomon, Sebastien Monette, Christopher Cheleuitte-Nieves, Reza Bergemann, Mohit Chawla, Bryan C. Husta, Or Kalchiem-Dekel, Yaniv Cohen, Dina Preise, Zachary Sacks, Avigdor Scherz, Lonny Yarmus, Jonathan A. Coleman, Robert P. Lee

“…Posttreatment radiology and pathology support measurable ablation fields and expected post-VTP changes. Interpretation: Our preclinical evidence provides early rationale for the study of safety and feasibility of bronchoscopic VTP ablation of peripheral lung cancers in humans.…”
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Closed-loop versus open-loop “remind-to-move” treatment using wearables for hemiparetic upper extremity in patients after stroke: A proof-of-concept study by Kenneth N. K. Fong, Jasmine P. Y. Pak, Alissa H. L. Koo, Maggie M. K. Szeto, Natalie M. T. Wong, Keily K. Y. Yau, Sharon F. M. Toh, Vivian W. Lou, Hector W. H. Tsang, Gary K. K. Lau

“…Evaluations were conducted at pre-/post-intervention and follow-up after 4 weeks using upper extremity motor performance behavioral measures, actual arm use questionnaire, and the kinematic data obtained from the device. …”
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A Cost-Effectiveness Analysis of Mosunetuzumab vs Tisagenlecleucel for Treatment of Third- or Higher-Line (3L+) Relapsed or Refractory (R/R) Follicular Lymphoma (FL) in Italy by Luminari S, Pinto A, Puccini B, D’Arpino A, Omodeo Salè E, Bellone M, Pradelli L, Sabinot A

“…The PSM model tracks patient outcomes based on time-to-event data, including progression-free survival (PFS) and post-progression survival (PPS). A matching-adjusted indirect treatment comparison (MAIC) approach was used to account for differences in trial population characteristics on the relative efficacy of mosunetuzumab to tisagenlecleucel. …”
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Synthesis and physico-chemical properties of high-quality expanded graphite by Yu. V. Hrebelna, E. M. Demianenko, M. I. Terets, V. V. Lobanov, S. V. Zhuravskyi, O. M. Ignatenko, K. O. Ivanenko, Yu. I. Gornikov, M. T. Kartel, Yu. I. Sementsov

“…The magnitude of the mass loss of oxidized graphite according to various variants of chemical post-cleaning and the temperature range of such loss remain practically unchanged. …”
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Walking gait biomechanics in individuals with quadriceps tendon autograft anterior cruciate ligament reconstruction by Kate Pfile, Bennett Prosser, Harris Slone, Michelle McLeod, Chris Gregory, Jennifer Hunnicutt

“…We hypothesized hip and knee joint biomechanics will differ between the QT-ACLR and nonsurgical limbs during the stance phase of gait.MethodsWe recruited a convenience sample of 14 patients with unilateral QT-ACLR ∼11 months post-surgery from an orthopedic surgery clinic. Three-dimensional hip and knee kinematics and kinetics and vertical ground reaction force were assessed while participants walked at self-selected speeds. …”
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Multi-omics integration reveals the impact of mediterranean diet on hepatic metabolism and gut microbiota in mice with metabolic dysfunction-associated steatotic liver disease by Zixuan Wang, Zixuan Wang, Ge Chen, Xutong Sun, Jia Xiao, Lingling Kong, Shunshun Jiang, Tingting Xu, Meijiao Wang, Meijiao Wang, Hong Zhao

“…ObjectiveTo investigate the effects of the Mediterranean diet (MD) on hepatic metabolism and gut microbiota in mice with metabolic dysfunction-associated steatotic liver disease (MASLD).MethodsC57BL/6 mice were fed a high-fat diet for 12 weeks to induce MASLD, with normal chow (NC)-fed mice as controls. Post-modeling, MASLD mice were randomized into three groups: HF (continued high-fat diet), HF-NC (switched to normal chow), and HF-MD (switched to MD). …”
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Regulating effect of empagliflozin plus liraglutide on glucose/lipid metabolism and serum levels of SFRP5， Irisin and tAPN in obese type 2 diabetics by Gao Rui-chao, Li Min, Jin Peng-ran, Liu Xuan, Feng Xue, Tan Zeng-huan

“…At pre-treatment and 3 months post-treatment， two groups were compared regarding the parameters of weight loss ［weight， waist circumference （WC）， body mass index （BMI）］， glucose metabolism ［glycated hemoglobin （HbA1c）， fasting blood glucose （FPG）， 2 h postprandial blood glucose （2 hPG）］， lipid metabolism ［low-density lipoprotein cholesterol （LDL-C）， high-density lipoprotein cholesterol （HDL-C）， triglycerides （TG）， total cholesterol （TC）］， insulin sensitivity ［homeostasis model islet β cell function index （HOMA-β）， homeostasis model insulin resistance index （HOMA-IR）］， serum levels of SFRP5， Irisin and tAPN and occurrences of adverse reactions.ResultsAfter 3-month treatment， body weight ［（74.93±2.68） <italic>vs</italic> （78.21±3.47） kg］， WC ［（90.40±2.17） <italic>vs</italic> （93.28±2.53） cm］ ，BMI ［（26.57±0.94） <italic>vs</italic> （27.94±1.06） kg/m²］ ，HbA1c ［（6.03±0.59）% <italic>vs</italic> （6.76±0.68）%］， FPG ［（6.24±0.73） <italic>vs</italic> （6.97±0.95） mmol/L］， 2 hPG ［（8.06±1.25） <italic>vs</italic> （8.83±1.50） mmol/L］， LDL-C ［（2.27±0.21） <italic>vs</italic> （2.58±0.27） mmol/L］， TG ［（1.83±0.34） <italic>vs</italic> （2.20±0.48） mmol/L］， TC ［（5.36±0.42） <italic>vs</italic> （5.92±0.53） mmol/L］ and HOMA-IR （2.35±0.24 <italic>vs</italic> 2.69±0.31） were lower in observation group than those in control group（<italic>P</italic>&lt;0.05）. …”
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Comparison of middle molecule removal with expanded hemodialysis versus haemodiafiltration among Chinese hemodialysis patients by Liangying Gan, Leyi Gu, Yongchun Ge, Hongli Lin, Yiwen Li, Fengling Chen, Wenge Li, Bihu Gao, Feng Ding, Xinzhou Zhang, Zhenwei Shi, Jiayao Ji, Qiang Yao, Brad Keller, Surupa Sarkar, Li Zuo

“…Background This study aimed to compare uremic toxin removal with expanded hemodialysis against post-dilution online haemodiafiltration therapy in Chinese patients with chronic kidney failure in a single treatment.Methods This randomized, controlled, open-label, parallel, multicenter trial enrolled prevalent patients on hemodialysis. …”
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Effectiveness of an online mindfulness based stress reduction intervention on psychological distress among patients with COVID19 after hospital discharge by Maryam Mozaffari, Manijeh Naderi, Hosein Zahednezhad, Fataneh Ghadirian

“…Cohen’s d was used to determine effect sizes. The post-test score of stress after the online MBSR training program for 4 weeks significantly decreased in the MBSR group to 12.59 ± 6.77 compared with the control group which had a score of 22.60 ± 10.82(p < 0.001). …”
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Design and testing of add-on prototypes for transport containers to improve the loading process for end-of-lay hens and catchers by Femke Delanglez, Anneleen Watteyn, Bart Ampe, Gunther Antonissen, Jan Detand, Wout Verroens, Frank Tuyttens

“…Parameters (filling duration, number of escapes, number of body part entrapments, restlessness, and loading inefficiency in container) were scored during the catch, supplemented by a post-loading catcher survey, and at the slaughterhouse (loading damage prevalence, number of dead-on-arrivals). …”
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Predictive demographic and clinical features for the development of dysthyroid optic neuropathy in a multi-ethnic TED population: a retrospective cohort study by Malik Moledina, Vickie Lee, Ahmed Alnahrawy, Ourania Fydanaki, Nicole George, Nour Hubby, Daisy Metcalf, Natalie Man, Gabriella Guevara, Claire Feeney, Rashmi Akshikar, Rajni Jain, Ahmad Aziz, Vassiliki Bravis, Karim Meeran

“…Consecutive patients aged over 18 years old with a minimum of 6 months follow-up post-diagnosis of TED were included. We compared those patients with DON and those without (no-DON) to determine which factors were more prevalent in patients with DON. …”
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The Association of Lipoprotein(a) and Stroke Recurrence: A Systematic Review and Meta-Analysis by Lina Palaiodimou, Konstantinos Melanis, Maria-Ioanna Stefanou, Aikaterini Theodorou, Sotirios Giannopoulos, Vaia Lambadiari, Diana Aguiar de Sousa, Simona Sacco, Mira Katan, Gerasimos Siasos, Georgios Tsivgoulis

“…Results A total of 12 studies, including one RCT post hoc analysis and 11 observational studies, comprising 17,903 patients (mean age 63 years, 38% female), were included. …”
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Burden and Outcomes of Severe Lower Respiratory Tract Infections with Unknown Etiology: A Retrospective Observational Study on Epidemiological Trends Over an 8-Year Period (2016–20... by Giovanni Scaglione, Marta Canuti, Martina Offer, Valentina Breschi, Antonio Piralla, Fausto Baldanti, Gabriele Del Castillo, Francesco Scovenna, Sabrina Buoro, Federica Morani, Danilo Cereda, Alessandra Bandera, Andrea Gori, Marta Colaneri

“…Hospitalizations with unknown etiology were more common in minors (42,190 episodes, 57.6% of total in < 18 years) and elderly (358,534 episodes, 56.2% of total in > 75 years), especially during warm seasons. Post-pandemic years saw increased bacterial and viral hospitalizations alongside a reduced proportion of those without an unknown etiology. …”
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A Novel Analysis via Micro-CT Imaging Indicates That Chemically Modified Tetracycline-3 (CMT-3) Inhibits Tooth Relapse after Orthodontic Movement: A Pilot Experimental Study by Giovanni Modesto Vieira, Denise Pinheiro Falcao, Sormani Bento Fernandes de Queiroz, Valthierre Nunes de Lima, Ricardo Bentes de Azevedo, Valdenize Tiziane, Heitor Moreno, Rivadavio Amorim

“…The difference was statistically significant between the groups as to recurrence (p=0.048), and the post hoc test identified the value of p=0.007 between the control group and the CMT-3 group. …”
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Sediment exposure decreases diversity in the surface mucus layer microbiome of Porites lobata at Honoliʻi, Hawaiʻi by Joseph W. P. Nakoa, Joseph W. P. Nakoa, John H. R. Burns, John H. R. Burns, Makoa Pascoe, Makoa Pascoe, Manuela Cortes, Manuela Cortes, Sofia B. Ferreira, Sofia B. Ferreira, Kailey H. Pascoe, Kailey H. Pascoe, Haunani H. Kane, Haunani H. Kane, Clifford A. Kapono, Clifford A. Kapono

“…Microbial community structure was characterized using 16S rRNA gene sequencing, at three time points, before, during, and after the sedimentation event, to identify changes in microbial composition and diversity.ResultsSedimentation caused a significant decline in microbial diversity and shifted community composition, with the most pronounced changes observed post-sedimentation. Indicator species analyses identified 206 bacterial taxa associated with specific sedimentation periods, including enrichment of Flavobacteriaceae during sedimentation and dominance of Endozoicimonaceae after sedimentation.DiscussionThese findings demonstrate that sedimentation induces both immediate and delayed shifts in the SML microbiome, with potential implications for coral resilience. …”
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