Application of hyperbaric oxygen therapy in femoral head necrosis: a systematic review and meta-analysis by Yangbin Cao, Peiyuan Tang, Han Tan, Wenbo Ma, Hua Chai, Bin Lin, Ying Zhu, Wenfeng Xiao, Ting Wen, Jun Zhang, Yusheng Li, Shuguang Liu

“…Results: Ten studies were included, involving 568 participants. Pre-post meta-analyses to show the visual analog scale after HBOT (MD = −2.94, 95% CI: −4.27, −1.60, P < 0.0001), short form 12 physical component summary scale (SF12 PCS) (MD = 17.28, 95% CI: 8.26, 26.31, P = 0.0002), short form 12 mental component summary scale (SF12 MCS) (MD = 4.26, 95% CI: 2.56, 5.95, P < 0.00001), Harris hip score (HHS) (MD = 26.91, 95% CI: 0.35, 53.46, P = 0.05), modified Harris hip score (mHHS) (MD = 44.31, 95% CI: 13.75, 74.87, P = 0.004) were significantly different from those before treatment. …”
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Deep learning-based prediction model of acute kidney injury following coronary artery bypass grafting in coronary heart disease patients: a multicenter clinical study from China by Biao Hou, Biao Hou, Tingting Liu, Pengyun Yan, Yuqing Wang, Xuejian Hou, Liang Li, Haiping Yang, Lin Chen, Taoshuai Liu, Kui Zhang, Shijun Xu, Yang Li, Ran Dong

“…This study aimed to develop a robust risk prediction model for post-OPCABG AKI using machine learning (ML) techniques.MethodsWe conducted a multicenter, retrospective study involving 3,043 coronary artery disease (CAD) patients, with an overall AKI incidence of 15.28%. …”
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Assessment of Exenatide Extended‐Release for Maintenance of Diabetic Remission in Cats by Chen Gilor, Linda M. Fleeman, Sean E. Hulsebosch, Stijn J. M. Niessen, Charlotte R. Bjørnvad, Jully Pires, Katarina Hazuchova, Jocelyn Mott, Allison L. O'Kell, Ruth Gostelow, Adam J. Rudinsky, Audrey K. Cook

“…Paired t‐tests and Mann–Whitney were used to compare pre‐ versus post‐study characteristics within groups and between group outcomes, respectively. …”
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The impact of six weeks of swimming exercise on the levels of proteins associated with the myelination of hippocampal tissue in Wistar rats with multiple sclerosis by Mohammad Rami, Samaneh Rahdar, Sayed Shafa Marashi, Abdolhamid Habibi

“…The data were analyzed using one-way ANOVA and post-hoc comparisons were made by using Tukey's test at a significance level of p<0.05.Results: The findings of the shuttle box and rotarod tests revealed that the MS group had impaired memory function and balance maintenance, but these improved significantly after swimming training (p<0.001). …”
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Evaluating the impact of two next-generation long-lasting insecticidal nets on malaria incidence in Uganda: an interrupted time-series analysis using routine health facility data by Moses R Kamya, Sarah G Staedke, Grant Dorsey, Adrienne Epstein, Jane Frances Namuganga, Isaiah Nabende, Samuel Gonahasa, Martha J Nassali, Catherine Maiteki-Sebuguzi, Katherine Snyman, Joaniter I Nankabirwa, Jimmy Opigo, Martin J Donnelly

“…Interrupted time-series analyses estimated a 23% reduction in malaria incidence (incidence rate ratio [IRR]=0.77, 95% CI 0.65 to 0.91) in the first 12 months following distribution relative to what would be expected had no distribution occurred, which was not sustained in the 13–24 month post-distribution period (IRR=0.97, 95% CI 0.75 to 1.28). …”
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Evaluation of combined multi-chamber with compounded bags and multi-chamber bags only for British adults on home parenteral nutrition: A mixed methods pilot study by Karen Allsopp, Simon Lal, Anne Marie Sowerbutts, Debra Jones, Michael Taylor, Simon Harrison, Arun Abraham, Kirstine Farrer, Gavin Leahy, Antje Teubner, Sorrel Burden

“…Data were gathered at baseline and 180 days post-discharge. Patients were interviewed about their lived experiences and completed a QoL questionnaire. …”
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“Take-home” functional electrical stimulation for depression: protocol for a prototype development and proof of concept randomized controlled trial by Fatemeh Gholamali Nezhad, Vanessa K. Tassone, Ilya Demchenko, Jia Xi Mary Chen, Stephanie N. Iwasa, Josh Martin, Naaz Desai, Hani E. Naguib, Milos R. Popovic, Venkat Bhat

“…They will also attend 25 online visits including a screening visit, a baseline visit, 20 days of FES treatment (sham or active), and three post-stimulation follow-up visits. Discussion Data obtained from this trial will be used to optimize the home-based FES prototype and design a follow-up, multi-site, large-scale randomized control trial to assess the effectiveness of take-home FES. …”
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Asymptomatic sigmoid diverticulum perforation-induced subcutaneous, mediastinal, and retroperitoneal emphysema: A case report and literature review by Daichi Setoguchi, Naoki Iwanaga, Kotaro Nema, Tomoya Hagiwara, Kotaro Hayashida, Koki Yamashita, Tatsuro Hirayama, Masataka Yoshida, Kazuaki Takeda, Shotaro Ide, Masato Tashiro, Takahiro Takazono, Masachika Kitajima, Noriho Sakamoto, Koichi Izumikawa, Katsunori Yanagihara, Keiji Inoue, Hiroshi Mukae

“…The patient was then admitted to the hospital and the patient was treated conservatively. On Day 7 post-admission, the emphysema was mildly relieved. …”
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Transcriptome-based screening in TARDBP/TDP-43 knock-in motor neurons identifies the NEDD8-activating enzyme inhibitor MLN4924 by Sarah Lépine, Gilles Maussion, Alexandria Schneider, Angela Nauleau-Javaudin, María José Castellanos-Montiel, Georgina Jiménez Ambriz, Dan Spiegelman, Narges Abdian, Anna Krystina Franco-Flores, Ghazal Haghi, Lale Gursu, Michael R. Fiorini, Allison A. Dilliott, Sali M. K. Farhan, Mathilde Chaineau, Thomas M. Durcan

“…Among top-scoring compounds selected for further investigation, the NEDD8-activating enzyme inhibitor MLN4924 effectively improved cell viability and neuronal activity, highlighting a possible role for protein post-translational modification via NEDDylation in the pathobiology of TDP-43 in ALS.…”
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Effect of Biostimulants on Drought Tolerance of Greenhouse-Grown Tomato by Kalliopi I. Kadoglidou, Eleni Anthimidou, Konstantinos Krommydas, Eleni Papa, Eleftherios Karapatzak, Nektaria Tsivelika, Maria Irakli, Ifigeneia Mellidou, Aliki Xanthopoulou, Apostolos Kalivas

“…However, this trend was not reflected in the evaluated post-harvest parameters, such as fruit yield, fruit number, fruit weight, and quality indices. …”
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Immediate impact of augmented reality visual training on choroidal thickness and accommodative function: A small sample study by Guo-rui Hu, Zhi-xing Xu, Chang-feng Pan, Zheng-yang Tao, Hang Chu, Zong-yue Lv, Ze-feng Kang, Hong-wei Deng

“…The AR group underwent a single session of visual training, with post-training metrics recorded within five minutes. …”
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Predictive Role of Complete Blood Count-Derived Inflammation Indices and Optical Coherence Tomography Biomarkers for Early Response to Intravitreal Anti-VEGF in Diabetic Macular Ed... by Ece Ergin, Ana Maria Dascalu, Daniela Stana, Laura Carina Tribus, Andreea Letitia Arsene, Marina Ionela Nedea, Dragos Serban, Claudiu Eduard Nistor, Corneliu Tudor, Dan Dumitrescu, Paul Lorin Stoica, Bogdan Mihai Cristea

“…Treatment response was defined as a minimum 10% reduction in central macular thickness (CMT) at one month post-injection. <b>Results:</b> NLR, MLR, PLR, and SII were significantly higher in non-responders (<i>p</i> < 0.001), but their predictive value was fair, with an area under the ROC curve ranging between 0.704 (MLR) and 0.788 (SII). …”
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Targeting Gut Microbiome With Prebiotic in Patients With CKD: The TarGut-CKD Study by Michael B. Sohn, Bei Gao, Cynthia Kendrick, Anvesha Srivastava, Tamara Isakova, Jennifer J. Gassman, Linda F. Fried, Myles Wolf, Alfred K. Cheung, Kalani L. Raphael, Patricia Centron Vinales, John P. Middleton, Ana Pabalan, Dominic S. Raj, Cynthia Kendrick, Tamara Isakova, Jennifer J. Gassman, Linda F. Fried, Myles Wolf, Alfred K. Cheung, Kalani L. Raphael, Joe Ix, John P. Middleton, Susan Mendley, Michael F. Flessner, Dominic S. Raj

“…The stability of microbiome and metabolome was studied during the pretreatment phase (8 weeks), a p-inulin treatment phase (12 weeks), and a post treatment phase (8 weeks) of the study. Results: Study participants completed 373 of the 420 expected study visits (88.8%). …”
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Immunological cluster complexes in kidney transplantation by S. V. Zybleva, S. L. Zyblev

“…By means of cluster analysis, immunotypes of regulatory complexes were detected and characterized in various courses of the post-transplant period. To assess the immune response in allogeneic kidney transplantation, a set of immune cells with a phenotype should be determined: CD3+CD4+CD25+highCD127+low, CD3+CD4-CD8-, CD3+CD4+CD69+, CD3+CD16+CD56+, CD19+CD5+, LIN-HLA-DR+CD11c-CD123+, CD3+CD8+CD69+, CD3+CD4+CD8+, CD3+CD8+CD38+, CD19+CD86+, CD19+IgD+CD27-, CD3-CD16+CD56+, CD3+CD38+, CD14+lowCD86+, LIN-HLA-DR+CD11c+CD123-. …”
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Brazilian Academy of Neurology practice guidelines for stroke rehabilitation: part I by Cesar Minelli, Rodrigo Bazan, Marco Túlio Araújo Pedatella, Luciana de Oliveira Neves, Roberta de Oliveira Cacho, Sheila Cristina Sayuri Abe Magalhães, Gustavo José Luvizutto, Carla Heloísa Cabral Moro, Marcos Christiano Lange, Gabriel Pinheiro Modolo, Bruna Correia Lopes, Elisandra Leites Pinheiro, Juli Thomaz de Souza, Guilherme Riccioppo Rodrigues, Soraia Ramos Cabette Fabio, Gilmar Fernandes do Prado, Karla Carlos, Juliana Junqueira Marques Teixeira, Clara Monteiro Antunes Barreira, Rodrigo de Souza Castro, Thalita Dayrell Leite Quinan, Eduardo Damasceno, Kelson James Almeida, Octávio Marques Pontes-Neto, Marina Teixeira Ramalho Pereira Dalio, Millene Rodrigues Camilo, Michelle Hyczy de Siqueira Tosin, Bianca Campos Oliveira, Beatriz Guitton Renaud Baptista de Oliveira, João José Freitas de Carvalho, Sheila Cristina Ouriques Martins

“…The main objective was to guide physicians, physiotherapists, speech therapists, occupational therapists, nurses, nutritionists, and other professionals involved in post-stroke care. Recommendations and levels of evidence were adapted according to the currently available literature. …”
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Multi-omics based and AI-driven drug repositioning for epigenetic therapy in female malignancies by Annamaria Salvati, Viola Melone, Alessandro Giordano, Jessica Lamberti, Domenico Palumbo, Luigi Palo, Dilia Rea, Domenico Memoli, Vittoria Simonis, Elena Alexandrova, Francesco Silvestro, Francesca Rizzo, Alessandro Weisz, Roberta Tarallo, Giovanni Nassa

“…Abstract Histone post-translational modifications (PTMs) have long been recognized as critical regulators of chromatin dynamics and gene expression, with aberrations in these processes driving tumorigenesis, immune escape, metastasis, and therapy resistance. …”
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Pre-Exercise Ingestion of Hydrogen-Rich Cold Water Enhances Endurance Performance and Lactate Response in Heat by Mariem Khlifi, Nidhal Jebabli, Nejmeddine Ouerghi, Fatma Hilal Yagin, Ashit Kumar Dutta, Reem Alwhaibi, Anissa Bouassida

“…<i>Results:</i> Our results revealed a significant variation in dehydration, MAS, number of shuttle run repetitions, blood lactate, RPE, and FS (<i>p</i> = [0.001–0.036]); additionally, a significant group × time interaction was found for body temperature (<i>p</i> = 0.021). Post hoc tests revealed a significant change for MAS (HRCW: <i>p</i> < 0.001), number of shuttle run repetitions (HRCW: <i>p</i> < 0.001), dehydration (HRCW: <i>p</i>= 0.009; IEPC: <i>p</i> = 0.008), blood lactate (HRCW: <i>p</i> < 0.001; IEPC: <i>p</i> < 0.001), RPE (HRCW: <i>p</i> = 0.05; IEPC: <i>p</i> = 0.004), and FS (HRCW: <i>p</i> = 0.05; IEPC: <i>p</i> = 0.004), as well as a significant decrease in body temperature (IEPC: <i>p</i> < 0.001; HRCW: <i>p</i> = 0.028) compared to the control condition after the test. …”
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Significance of heterogenity in endothel-dependent vasodilatation occurrence in healthy individuals with or without coronary risk factors by Polovina Marija, Potpara Tatjana, Giga Vojislav, Ostojić Miodrag

“…True maximal FMD value was calculated as a percent change of the true maximal diameter from the baseline, and compared with FMD value calculated assuming that every participant reached maximal dilation at 60 seconds post cuff deflation (FMD60). Correlation of different RF with brachial artery temporal response was assessed. …”
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A rare complication of DRESS syndrome in the treatment of cardiac device-related lead thrombus and infective endocarditis by James Tomlinson, Anil Gurung, Oliver Watkinson

“…He deteriorated further with evolving multi-organ failure.Post-mortem (PM) examination confirmed non-infective thrombus associated with the pacing lead, measuring 5 mm in thickness and 4 cm in length. …”
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Methyl Indole-3-Acetate (MEIAA) mediated stem curvature and apical meristem necrosis in Ageratina adenophora: impacts on cell wall components, vascular system integrity, and key me... by Yanan Ruan, Xi Gao, Mehboob Hussain, Xiaoping Qin, Jingyi Ning, Dewei Yang, Tao Zhu, Deqiang Qin, Min Ye, Guoxing Wu

“…Results At 20 mM (optimized concentration), MEIAA induced dose-dependent stem curvature (1d post-treatment) and apical meristem necrosis (3d). …”
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