Evaluating the multitargeted potency of Pixuvri against cell cycle regulation proteins in cervical cancer by Mohammed Ali Alshehri, Hadil Alahdal, Akram Ahmed Aloqbi, Afnan Mohammed Shakoori, Ghadir Sindi, Rehab M. Bagadood, Nida Alsaffar, Mohammad Ahmad Alobaidy, Noof Abdulrahman Alrabiah, Md Khursheed, Abeer Al Tuwaijri, Abeer Al Tuwaijri

“…In this study, we screened Selleckchem approved library against cervical cancer proteins that regulate the cell cycle, particularly during mitosis and cell division (PDBIDs: 2VFX, 2WVI, 3KND, 4N14) using HTVS, SP, and XP docking followed by MMGBSA post-processing. Pixuvri (Pixantrone Maleate) emerged as the top candidate with docking scores of -5.234 to -9.218 kcal/mol and MMGBSA scores of -39.22 to -53.87 kcal/mol. …”
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A phase 4, open-label, multicenter study of the safety and efficacy of agalsidase beta in Chinese patients with Fabry disease by Hong Ren, Wei Zhang, Yan Ouyang, Junhong Guo, Hong Xu, Jie Ma, Xiaoping Luo, Xiaoxia Pan, Yun Yuan, Wei Zhang, Qian Shen, Bin Li, Qiqi Feng, Shi Liu, Nan Chen

“…The endpoints of efficacy included changes in plasma globotriaosylceramide (GL-3), globotriaosylsphingosine (Lyso-GL-3), symptoms and estimated glomerular filtration rate (eGFR) from baseline to week 48. A post-hoc subgroup analysis was conducted by age group (< 30 years and ≥ 30 years) and in patients with or without COVID-19 infection. …”
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Recurrent hyponatremia due to syndrome of inappropriate antidiuresis after traumatic brain injury: two case reports by Iulia Petria, Iulia Petria, Rita Indirli, Rita Indirli, Beatrice Mantovani, Valeria Lanzi, Valeria Lanzi, Giovanna Mantovani, Giovanna Mantovani, Emanuele Ferrante

“…Consistently, olanzapine-related hyponatremia could be ruled out and post-traumatic SIAD confirmed.Case 2A 37-year-old man experienced TBI with diffuse axonal injury falling during a mountain trip. …”
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Heart transplantation in patients undergoing extracorporeal cardiopulmonary resuscitation in in‑hospital cardiac arrest by V. N. Poptsov, E. A. Spirina, A. K. Solodovnikova, A. S. Epremyan, A. A. Kuznetsova, A. S. Ignatkina, G. B. Glinkin, S. A. Budagaev

“…The cause of death (n = 4; 15.3%) in the early post-HT period was irreversible multiple organ dysfunction.Conclusion. …”
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Plasma longitudinal metabolic changes with acute maximal aerobic exercise and one-hour recovery by William A. Fountain, Stefano Donega, Nirad Banskota, Ruin Moaddel, Mona Patel, Linda Zukley, Sarah Church, Katie Bustin, Josephine M. Egan, Josephine M. Egan, Jeremy Walston, Luigi Ferrucci

“…This study examined metabolic changes during each person’s peak aerobic exercise and one-hour post-exercise recovery in 29 Baltimore Longitudinal Study of Aging (BLSA) participants.MethodsBlood samples were collected at baseline, and at 3-min intervals during both incremental exercise on a treadmill until exhaustion and during recovery. …”
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From Breathlessness to Better Living: Transforming COPD Care with Home-Based Pulmonary Rehabilitation by Abins Thozhuthinkal Kasim, Ravi Gaur, Nitesh Manohar Gonnade, Nagma Sheenam, Chinchu Kolakkanni, Sarankumar Ganesan, Adharshna Thangamalai Kannan

“…Methods A prospective, single-arm pre–post interventional study was conducted among 62 COPD patients at All India Institute of Medical Sciences, Jodhpur. …”
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Therapeutic effects of Jing Si herbal tea for chronic obstructive pulmonary disease: a comprehensive investigation from clinical to basic research by Chou-Chin Lan, Chou-Chin Lan, Po-Chun Hsieh, Kuo-Liang Huang, Kuo-Liang Huang, Mei-Chen Yang, Mei-Chen Yang, Guan-Ting Liu, Chan-Yen Kuo, I.-Shiang Tzeng, Yao-Kuang Wu, Yao-Kuang Wu

“…Cellular studies on lipopolysaccharide (LPS)-stimulated A549 cells demonstrated that JSHT effectively reduced the release of DAMPs such as HMGB1, FPR1, and extracellular ATP, and decreased the expression of inflammatory markers including pMAPK, pJNK, NF-kB, and cCaspase 3, and pro-inflammatory cytokines like IL-1, IL-6, IL-8, and TNF-α post-LPS induction.ConclusionJSHT improved the HRQL in patients with COPD, both in stable and exacerbated states. …”
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Individual Variation in Migration and Wintering Patterns of Long‐Tailed Ducks Clangula hyemalis From a Population in Decline by Thiemo Karwinkel, Ingrid L. Pollet, Sandra Vardeh, Julia Loshchagina, Petr Glazov, Alexander Kondratyev, Aleksandr Sokolov, Vasiliy Sokolov, Julius Morkūnas, Daniela J. Tritscher, Juan F. Masello, Götz Eichhorn, Helmut Kruckenberg, Petra Quillfeldt, Jochen Bellebaum

“…Females moved from freshwater breeding sites to mostly marine post‐breeding sites after wing moult. For wintering, the majority of the birds (94%) migrated to the Baltic Sea, while the rest overwintered in the White and Barents Seas. …”
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Stable water isotope analysis of plant-soil interspecific interactions in wheat-maize intercropping by Duo-Peng Shi, Ying-Bo Liu, Yun-Ling Cui, An-Yu Zhao, He-Zhe Sun, Liang Xue, Wen-Feng Cong, Muhammad Ali Raza, Li-Qin Zhang

“…Middle-row maize showed 75 % higher flowering-stage biomass than border rows, attributed to preferential water use from middle soil layer (28 %), which reduced interspecific competition. Post wheat harvest, deep soil water storage in the maize strip increased by 8 %. …”
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A randomized controlled trial of anodal transcranial direct current stimulation (A-tDCS) and olfactory training in persistent COVID-19 anosmia by Lucilla Vestito, Marta Ponzano, Laura Mori, Carlo Trompetto, Fabio Bandini, Riccardo Canta, Anna De Giovanni, Simone Strano, Andrea Pagani

“…We also evaluated the long-term effectiveness of this intervention at both one- and six-months post-treatment assessments. Methods: This RCT involved 52 patients with persistent hypo/anosmia due to COVID-19. …”
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Research progress on the interaction between glucose metabolic reprogramming and lactylation in tumors by Yi Yang, Yi Yang, Yi Wu, Yi Wu, Hui Chen, Hui Chen, Zehai Xu, Zehai Xu, Ruisi Lu, Ruisi Lu, Sijie Zhang, Sijie Zhang, Rui Zhan, Rui Zhan, Qinghua Xi, Qinghua Xi, Yunfeng Jin, Yunfeng Jin

“…Lactylation represents a newly identified post-translational modification (PTM) that occurs due to lactate accumulation and is observed in various proteins, encompassing both histone and non-histone types. …”
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Gatekeeper training for suicide prevention: a systematic review and meta-analysis of randomized controlled trials by Hui Liu, Chaohui Zheng, Yu Cao, Fanyan Zeng, Huiting Chen, Wei Gao

“…We stratified participants into subgroups by characteristics and categorized interventions by delivery mode (online vs. offline). Post-test and follow-up data were integrated into a unified model, with follow-ups classified as short-term (1–5 months) or long-term (> 5 months). …”
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Deep crustal composition and Late Paleozoic geotectonic evolution in West Junggar, China by Shenglin Xu, Weicui Ding, Feizhou Ma, Feizhou Ma, Xuanhua Chen, Zhaogang Shao, Lele Han, Penghui Huang, Penghui Huang, Jianjie Shi, Xinru Yang

“…The Late Carboniferous-Early Permian period (320–294 Ma) is the post-orogenic extension stage, during which a massive amount of juvenile mantle source was added. …”
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A comprehensive review and critical discussion on the application of job competency-based workshops in the domain of Traditional Chinese Medicine geriatric nursing education (岗位胜任力... by MA Junhua (马君华), GOU Huijun (苟会君), ZHENG Juan (郑娟)

“…Key components include curriculum design, pre-class preparation, in-class explanation, and post-class consolidation. The advantages of this model in enhancing the quality of nursing services, strengthening practical skills, fostering the holistic development of trainees, and improving team competence were analyzed. …”
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Healthcare access and utilisation trends among the elderly in India: Evidence from the LASI Wave-1 survey by Dhruvendra Lal, Amrit Virk, Ashish Goel, Sonu Goel, Kavisha Kapoor Lal, Suneela Garg, Bhavneet Bharti

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Effect of Intravenous Tirofiban Versus Placebo on Excellent Outcome in Patients With Acute Ischemic Stroke: The Multicenter, Randomized INSTANT Trial Protocol by Fan Zhang, Minghui Xiao, Cong Zhang, Guangxiong Yuan, Zhiyong Xie, Yi Yin, Ruize Zhou, Shanggui Yuan, Genxiang Xiao, Donghuan Mei, Xiaobing Zeng, Huashi Liu, Huadong Li, Hongwen Liu, Jinchang Tan, Bin Chen, Qingqing Fu, Bin Li, Jinxing Lai, Wei Sun, Shuhua Xie, Zhaohui Lai, Zhongming Qiu, Zidian Jiang, Xianghong Liu, Guoyong Zeng

“…Our primary objective is to investigate whether the early administration of tirofiban following IVT can enhance the proportion of patients exhibiting no or minimal symptoms post acute ischemic stroke. Registration URL: ChiCTR2300074368; Unique Identifier: www.chictr.org.cn.…”
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Efficacy of Functional Endoscopic Sinus Surgery and Impact of Chronic Lung Disease on its Outcome in Patients of Chronic Rhinosinusitis by Minakshmi Karmakar, V D Prasanna Kumar Vasamsetty, Bonapart Chowdhury

“…All the patients underwent pre-operative clinical, radiological and endoscopic evaluation followed by FESS. Post-operative follow up was done at 1week, 2 weeks, 4 weeks, 8 weeks, 3 months, 6 months, 9 months and 1year intervals for one year and assessment was done in respect to improvement of symptoms using grading scale where success is meant by complete resolution of symptoms or improvement of symptoms (score +1) and cases with no change of symptoms (score 0) or deterioration of symptoms (score -1) are said to be failures within 1 year of follow-up. …”
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Genetic etiology and pregnancy outcomes of fetal hyperechoic kidneys: a retrospective analysis by Meiying Cai, Na Lin, Ziheng Xiao, Ziheng Xiao, Hailong Huang, Lin Zheng, Liangpu Xu

“…Of the 78 followed-up, 25 pregnancies were terminated, and one fetus died in utero. Post-birth follow-up of 52 live births revealed an adverse outcome incidence of 3.85% (2/52), consisting of one neonatal death within 24 h and one case of intellectual disability.ConclusionsCMA is recommended when prenatal ultrasound indicates fetal hyperechoic kidneys. …”
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Evaluation of the Efficacy of a Dentifrice Tablet to Prevent Dental Caries: A Microbial Study by Bennett Tochukwu Amaechi, Kannan Kanthaiah, Rayane Farah, Kelly Yang, Amos Chiedu Obiefuna, Parveez Ahamed Abdul-Azees, Mahalakshmi Vijayaraghavan

“…<b>Results:</b> The paired <i>t</i>-test indicated a significant difference (<i>p</i> < 0.001) between pre-treatment and post-treatment SMH in all groups. The intergroup comparison based on their %Dem using ANOVA/Tukey’s test showed that Control (29.93 ± 5.58) had significantly (<i>p</i> < 0.05) higher %Dem than Placebo (22.81 ± 7.47, <i>p</i> < 0.05), nHAP (13.93 ± 11.31, <i>p</i> < 0.001) and Fluoride (14.44 ± 10.65, <i>p</i> < 0.001). …”
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Mild hypothermia attenuates hepatic ischemia-reperfusion injury by regulating FoxO1/PPARα pathway by Zhongshan Lu, Hao Chen, Anxiong Liu, Shufang Na, Wei Wang, Zibiao Zhong, Qifa Ye

“…Moreover, high PPARα level in post-IR liver specimens correlated with improved liver transplantation outcomes. …”
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