Gaawaadhi Gadudha: understanding how cultural camps impact health, well-being and resilience among Aboriginal adults in New South Wales, Australia—a collaborative study protocol by Stephanie M Topp, Anthony B Zwi, Aryati Yashadhana, Ted Fields, Jonathan Kingsley, Evelyne de Leeuw, Brooke Brady, Michelle O'Leary, Miri Raven, Nina Serova, Warren Foster, Wendy Jopson, Brett Biles

“…A survey assessing connection to culture, access to cultural resources, resilience, self-rated health and quality of life will be administered to participants pre-camp and post-camp participation, and to a comparative group of Aboriginal adults who do not attend the camp (n=105). …”
Get full text

The Impact of As-Built Surface Characteristics of Selective-Laser-Melted Ti-6Al-4V on Early Osteoblastic Response for Potential Dental Applications by Muhammad Hassan Razzaq, Olugbenga Ayeni, Selin Köklü, Kagan Berk, Muhammad Usama Zaheer, Tim Tjardts, Franz Faupel, Salih Veziroglu, Yogendra Kumar Mishra, Mehmet Fatih Aycan, O. Cenk Aktas, Tayebeh Ameri, Sinan Sen

“…This study investigates the potential of Selective Laser Melting (SLM) to tailor the surface characteristics of Ti6Al4V directly during fabrication, eliminating the need for post-processing treatments potentially for dental implants. …”
Get full text

Development and validation of a pathological model predicting the efficacy of neoadjuvant therapy for breast cancer based on RCB scoring by Huan Li, Xianli Ju, Chuanfei Zeng, Zhengzhuo Chen, LinXin Yu, Ge Ke, Ziyin Huang, Youping Wang, Jingping Yuan, Mingkai Chen

“…Conclusions PBCS can assist clinical and pathological physicians in accurately predicting patients’ post-treatment RCB grading before initiating NAT. …”
Get full text

Usage and effectiveness of strategies to sit less and move more: evaluation of the BeUpstanding™ national implementation trial by Genevieve N. Healy, Elisabeth A.H. Winkler, Samantha K. Mulcahy, Charlotte L. Brakenridge, Ana D. Goode

“…Strategy usage (0–4) and changes (-4–4) were tested in relation to post-intervention behaviours and behaviour changes using linear mixed models. …”
Get full text

Implementing an online-delivered exercise program for childhood cancer survivors: A hybrid effectiveness-implementation protocol for the MERRIER studyKey points by David Mizrahi, Alexandra Martiniuk, Laurence Hibbert, Dinisha Govender, Tora Sibbald, Richard Mitchell, Natalia Millard, Lauren Ha, Damian Ragusa, Kylie Brown, Ben Smith

“…Physical function and patient-reported outcomes will be assessed at baseline (T0), post-intervention (T1; week 12) and follow-up (T2, week 24). …”
Get full text

High-entropy argyrodite glass–ceramic electrolytes for all-solid-state batteries by Jing Lin, Mareen Schaller, Ruizhuo Zhang, Volodymyr Baran, Hao Liu, Ziming Ding, Sylvio Indris, Aleksandr Kondrakov, Torsten Brezesinski, Florian Strauss

“…Using complementary diffraction techniques, nuclear magnetic resonance spectroscopy, and charge-transport measurements, we show that upon tailoring crystallinity and defect concentration by post-annealing at temperatures up to 220 °C, a high room-temperature ionic conductivity of about 0.9 mS cm ^−1 (∼4.4 mS cm ^−1 bulk conductivity) can be achieved. …”
Get full text

CTF development, verification, and validation for VVER core thermal-hydraulics and multi-physics modeling and simulation by Yesim Kutlu, Ivan Spasov, Svetlomir Mitkov, Pascal Rouxelin, Agustin Abarca, Nikola Kolev, Maria Avramova, Kostadin Ivanov, Kostadin Ivanov

“…In recent years, there has been considerable progress in code development, including new functionalities, application-specific correlations, various multi-physics applications, built-in pre- and post-processors, improved solvers, parallelization, and extensive testing. …”
Get full text

A study on the prediction of targeted therapy efficacy in advanced lung adenocarcinoma patients with EGFR mutations using CT-based delta-radiomics model by Zekai Wu, Zekai Wu, Peiyan Hua, Xiuying Chen, Jie Lei, Laian Zhang, Peng Zhang

“…We segmented tumor regions on pre-and post-treatment CT scans using ITK-SNAP, then extracted radiomic features and applied mRMR-LASSO (Minimum Redundancy Maximum Relevance–Least Absolute Shrinkage and Selection Operator). …”
Get full text

Intervention Strategies to Overcome HPV Vaccine Hesitancy Among Hispanic Immigrants in the USA: A Video-Based Approach by Isaiah Aduse-Poku, Diego A. Ardon, Alexis B. Call, Spencer C. Davis, Preston Evans, Spencer Johanson, Ruth J. Larson, James Rencher, Isaac A. Woolley, Brian D. Poole, Jamie L. Jensen

“…Notably, females exhibited less favorable post-intervention attitudes compared to males. Additionally, perceived care from video creators was a strong predictor of normalized gains in vaccine attitudes (β = 0.270, <i>p</i> < 0.001). …”
Get full text

Tração cutânea intraoperatória para fechamento de ferida após mastectomia bilateral higiênica: relato de caso Intraoperative skin traction for closure of hygienic bilateral mastect... by Jason César Abrantes de Figueiredo, Rodrigo Gouvea Rosique, Patricia Jackeline Maciel

“…<br>INTRODUCTION: The post-mastectomy chest wall defects require reconstruction by a safe and efficient procedure. …”
Get full text

Combined sequential hypothermic oxygenated and normothermic machine perfusion for liver transplant from an expanded criteria donor: first clinical application in Russia by S. V. Gautier, N. V. Grudinin, A. R. Monakhov, M. A. Boldyrev, V. K. Bogdanov, D. M. Bondarenko, S. I. Zubenko, N. P. Mozheiko, M. G. Minina, O. M. Tsirulnikova

“…Preservation times were: SCS – 260 minutes, D-HOPE – 124 minutes, NMP – 480 minutes, with a total preservation time of 884 minutes. Post-transplant peak levels of AST, ALT, and total bilirubin in the recipient were 922.5 U/L, 613 U/L, and 63.3 μmol/L, respectively. …”
Get full text

Sex-specific effects of gastrointestinal microbiome disruptions on Helicobacter pylori-induced gastric carcinogenesis in INS-GAS mice by Chao Peng, Xin Li, Yu Li, Xinbo Xu, Yaobin Ouyang, Nianshuang Li, Nonghua Lu, Yin Zhu, Cong He

“…Notably, we found gender disparities in the alterations of gastric and intestinal microbiota in mice post H. pylori infection. While the enrichment of Bifidobacterium and Lachnospiraceae was observed in female mice, Escherichia_Shigella and Akkermansia were more abundant in males. …”
Get full text

Antisense oligonucleotides targeting the SARS-CoV-2 nucleocapsid gene decrease viral titers in hamsters by Christopher Fitzpatrick, Nicolas Meunier, Sophie Lepoder, Sophie Dhorne-Pollet, Bruno Da Costa, Bernard Klonjkowki, Jean-François Eléouët, Verónica A. Burzio, Bernard Delmas, Eric Barrey

“…ASO-N1 induced a sustained reduction in viral RNA and inflammatory cytokine expression in the nasal mucosa and efficiently decreased infectious viral titers in nasal swabs at day 3 post infection. Further optimization of the ASO-N1 sequence with a combination of RNase-H1-dependent and steric blockage chemistries synergistically increased the antiviral efficacy in vitro. …”
Get full text

From inconsistency to sustainability: ICU night huddle compliance improvement through a structured QI approach by Prasobh PV Mukundan, Alisha Karki

“…Materials and methods: This QI project followed a plan–do–study–act (PDSA) cycle over two phases: (1) initial QIP (September 2023–March 2024): a structured Night Shift Briefing Checklist was implemented to ensure standardised communication and that compliance was monitored; (2) re-audit (September 2024–December 2024): targeted interventions were implemented to address compliance gaps:• Phase 1: Checklist placed in Doctors’ Hub (22 September 2024)• Phase 2: WhatsApp group reminders to doctors (1 October 2024)• Phase 3: Message of the Week in Morning Huddle (14 October 2024)• Phase 4: Nursing In-Charge Involvement (15 November 2024)Weekly compliance rates were recorded and analysed pre- and post-interventions. Results and discussion: Compliance improved from 32.8% (initial QIP) to 70.7% (re-audit), a 37.9% increase (Fig 1).The impact of each intervention was assessed as follows: • Phase 1: Checklist in Doctors’ Hub (22 September 2024): initial compliance was low, with inconsistent adherence. • Phase 2: WhatsApp reminders (1 October 2024): compliance increased to ∼57%, but some nights were still missed due to lack of structured accountability. • Phase 3: Message of the Week in Morning Huddle (14 October 2024): reinforcement through daily reminders resulted in a boosted compliance of ∼71%. • Phase 4: Nursing In-Charge Involvement (15 November 2024): sustained compliance of ∼75% was achieved by actively engaging nursing staff, ensuring a shared responsibility rather than relying solely on doctors.Challenges: night huddle non-compliance persisted due to: • Workload pressure – If ICU was busy, staff may have skipped the huddle; • Forgetting/skipping: some days were missed even with reminder; • No direct accountability: night huddle often relied on motivated individuals; • Staff rotation issues: new staff may not have been fully aware of the expectation; • Nursing–doctor coordination issues: some shifts lacked direct interaction.What can be done to sustain and improve compliance? …”
Get full text

Intimate partner violence among lesbian, bisexual, and queer women students on campuses in South Africa: a qualitative study exploring context, drivers, and impacts by Pinky Mahlangu, Carrie Brooke-Sumner, Yandisa Sikweyiya, Kristin Dunkle, Ntlotleng Mabena, Rachel Jewkes, Sinegugu Duma, Nelisiwe Khuzwayo, Elizabeth Dartnall, Managa Pillay, Mercilene Tanyaradzwa Machisa

“…Data were analyzed inductively using a thematic analysis approach. We drew from the post-structural feminist theory to understand the relationship dynamics in same sex relationships of LBQ women. …”
Get full text

Anti-BCL2 therapy eliminates giant congenital melanocytic nevus by senolytic and immune induction by Boxuan Wei, Qingxiong Yu, Jiamin Jin, Danli Zhu, Bohan Lai, Jieyu Gu, Ran Yang, Huailiang Huang, Hongzhan Lin, Liang Zhang, Tao Zan, Feng Xie, Kang Zhang, Qingfeng Li

“…Neutrophil depletion and immunosuppression reduce treatment efficacy, highlighting the crucial role of the immune response post-BCL2i treatment. Long-term follow-up showed no recurrence, with neutrophils and T cells residing in the dermis, indicating memory immune reactions. …”
Get full text

La transformation de l’ancien centre de détention secrète de Derb Moulay Cherif en musée des « années de plomb » (Casablanca, Maroc) by Anissa Habane

“…The first concerns the establishment of former secret detention centers in the post-independent Moroccan kingdom, enabling us to grasp this painful, shameful and dark period in the country’s history. …”
Get full text

Which novel teaching strategy is most recommended in medical education? A systematic review and network meta-analysis by Shuai-Long Zhang, Si-Jing Ren, Dong-Mei Zhu, Tian-Yao Liu, Lian Wang, Jing-Hui Zhao, Xiao-Tang Fan, Hong Gong

“…Therefore, this systematic review and network meta-analysis aims to evaluate and prioritize various teaching strategies in medical education, including simulation-based learning (SBL), flipped classrooms (FC), problem-based learning (PBL), team-based learning (TBL), case-based learning (CBL), and bridge-in, objective, pre-assessment, participatory learning, post-assessment, and summary (BOPPPS). Methods We conducted a comprehensive systematic search of PubMed, Embase, Web of Science, the Cochrane Library, and some key medical education journals up to November 31, 2023. …”
Get full text

A Culturally Tailored mHealth Intervention (MobileMen App) to Promote Physical Activity in African American Men: Protocol for a Comparative Effectiveness Trial by Kayla Nuss, Amanda Brice, Callie Hebert, Phillip Nauta, April J Stull, Damon L Swift, Derek M Griffith, David B Buller, Robert L Newton Jr

“…Participants will complete assessments at baseline and at 6 months post randomization. Assessments include objective measurements of daily steps and minutes of moderate to vigorous PA, quality of life, dietary measures, self-efficacy for fruit and vegetable consumption and PA, and autonomous motivation for PA. …”
Get full text

Transcriptome sequencing–based analysis of the molecular mechanism underlying the effect of lncRNA AC003090.1 on osteoporosis by Huafeng Zhuang, Yongjun Lin, Chengye Lin, Miao Zheng, Yizhong Li, Xuedong Yao, Youjia Xu

“…The expression levels of Runx2, Opn, and Ocn in spongy and cortical bone samples, as well as in post-infection cells, were assessed through RT-qPCR. …”
Get full text