Effect of Subthreshold Nanosecond Laser on Loss of OCT Outer Retinal Bands in Age-Related Macular Degeneration: A LEAD Study Report by Robyn H. Guymer, MBBS, PhD, Joseph P.M. Blair, PhD, Sandro De Zanet, PhD, Stefanos Apostolopoulos, PhD, Carlos Ciller, PhD, Zhichao Wu, BAppSc(Optom), PhD, S. Al-Qureshi, L. Busija, I. Constable, D. Louis, C. Harper, S. Wickremasinghe, P. Van Wijngaarden, L. Lim, S. Durkin, J. Runciman, J. Gihotra, J. Muecke, K. Haywood, C. Brko, J. Paley, M. Smith, C. Luscombe, R. Vincent, D. Lee, R.H. Guymer, C. Luu, Z. Wu, L.A.B. Hodgson, K. Brassington, E. Caruso, M. McGuinness, N. Tindill, K.Z. Aung, E. Baglin, P. Sharangan, C.A. Harper, S. Wickremasinghe, L. Lim, P. Van Wijngaarden, S. Sandhu, T. Nguyen, A. Cohn, D. Qatarneh, L. Robman, G. Makeyeva, R. Tan, S. Taori, K. Creese, M. Chen, D. Ong, S. No, R. Kandasamy, S.W. Lim, M. Okada, D. Cugley, R. O'Day, P. Keller, K. Lee, E. Alessandrello, J. Alessi-Calandro, M. Kolic, T. Wu, S. Griffin, J.J. Lek, W. Heriot, X. Fagan, R. McIntosh, C. Lowe, J. Boyle, O. Shanahan, F. Chen, I. McAllister, T. Isaacs, A. Shaw, C. Balarantnasingam, Y. Chen, W. Cunningham, R. Viljoen, K. Kennelly, R. Blum, S. Arunachalam, H. Razavi, M. Adams, H. Brown, J. Bryant, R. Cowles, S. Radtke, C. Barry, E. Wong, F. Shilton, A. Soloshenko, A. Jason, A. Lin, A. McSweeney, A. King, B. Shalan, D. Xie, H. Vu, I. Tang, K. Mather, M. Cuypers, M. Cheng, R. McKeone, T. Busby, R. Matthews, G. Lingham, J. Arnold, A. Luckie, D. Chan, J. Chang, T. Tan, L. Koh, H. Cass, R. Fitzsimons, T. Forsyth, A. Nguyen, V. Ghebrial, H. Ayson, A. Graham, M. Firibaldi, U. Chakravarthy, L. Kelly, K. Gillvray, M. Williams, G. Casalino, G. Mangoris, R. Das, T. Peto, L. Toth, M. Quinn, R. Denham, N.J. Lavery, G. Sterrett, V. Silvestri, G. Young, K. Graham, J. Keenan, L. Doyle, T. Douglas, D. Burns, P. Wright, L. Scullion

“…Purpose: To evaluate the effect of subthreshold nanosecond laser (SNL) treatment on the rate of loss of the OCT outer retinal bands in intermediate age-related macular degeneration (AMD). Design: Post hoc analysis of the Laser Intervention in the Early Stages of AMD (LEAD) study. …”
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Clinical trial and real-world evidence of circulating tumor DNA monitoring to predict recurrence in patients with resected colorectal cancer by H.T. Nguyen, V.-A. Nguyen Hoang, T.V. Nguyen, N.A.L. Trinh, T.H. Pham, D.N. Le, H.H. Ho, T.D. Nguyen, H.D. Nguyen, T.S.L. Thi, N. Nguyen, D.H. Tran, M.T. Le, T.C. Dinh, T.S. Nguyen, K.C.N. The, H. Mai, M.T. Chu, D.H. Pham, N.H.T. Phuc, D.N. Vinh, D.-N. Nguyen, X.-V. Nguyen, D.S. Nguyen, T.T.D. Thi, H. Giang, H.-N. Nguyen, L.N. Tu

“…In the real-world data analysis, post-operative ctDNA remained the only significant prognostic biomarker for DFS (HR = 44.2, 95% CI 9.2-212.0, P < 0.0001). …”
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Evaluation of the feasibility and effectiveness of trauma-focused cognitive behavioural therapy for children and youth in Ukraine during the war by Elisa Pfeiffer, Maike Garbade, Renée Beer, Anette Birgersson, Natalie Cabrera, Judith A. Cohen, Esther Deblinger, Rafaela Gjini, Veronica Kirsch, Zlatina Kostova, Michael Larsson, Anthony Mannarino, Gavin Moffitt, Marja Onsjö, Tale Ostensjo, Anna Vikgren, Hanna Weyler, Vitalii Klymchuk, Cedric Sachser

“…The patients (age 3–21, 37% male) reported significant improvement in symptoms of PTSD at the end of treatment with large pre-post effect sizes for DSM-5 PTSD (d selfreport = 2.36; d caregiverreport = 2.27), ICD-11 PTSD (d selfreport = 1.97; d caregiverreport = 1.77), ICD-11 CPTSD (d selfreport = 2.04; d caregiverreport = 1.99), and DSM-5 pre-school PTSD (dcaregiverreport = 3.14). …”
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Understanding Onset, Dynamic Transitions, and Associated Inequality Risk Factors for Adverse Posttraumatic Neuropsychiatric Sequelae After Trauma Exposure by Chiyoung Lee, Stacey L. House, Francesca L. Beaudoin, Thomas C. Neylan, Gari D. Clifford, Sarah D. Linnstaedt, Laura T. Germine, Scott L. Rauch, John P. Haran, Alan B. Storrow, Christopher Lewandowski, Paul I. Musey Jr, Phyllis L. Hendry, Sophia Sheikh, Brittany E. Punches, Robert A. Swor, Lauren A. Hudak, Jose L. Pascual, Mark J. Seamon, Erica Harris, Claire Pearson, David A. Peak, Robert M. Domeier, Niels K. Rathlev, Brian J. O'Neil, Paulina Sergot, Leon D. Sanchez, Steven E. Bruce, John F. Sheridan, Steven E. Harte, Karestan C. Koenen, Ronald C. Kessler, Samuel A. McLean, Qing Yang, Xinming An

“…Objective Several gaps remain in the understanding of the onset, dynamic transitions, and associated risk factors of adverse posttraumatic neuropsychiatric sequelae (APNS) in the acute post‐trauma window. Based on serial assessments of symptoms from a large cohort study, we identified homogeneous statuses across multiple APNS symptom domains and investigated the dynamic transitions among these statuses during the first 2 months after trauma exposure. …”
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Clinical application value of intracavitary PRP infusion combined with IVF-FET in patients with chronic endometritis by ZHANG Xiaotong, HAO Xiaoyuan, FANG Rui, HU Shuyao, MA Linkun, ZHAO Yaqi, HAN Wei

“…[Conclusion] Intrauterine autologous PRP perfusion in CE patients enhances pregnancy and live birth rates, improves pregnancy outcomes post-FET, and demonstrates superior efficacy in endometrial repair and receptivity with two PRP perfusions compared to a single perfusion. …”
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Unhealthy family functioning is strongly associated with warfighter brain health following traumatic brain injury in United States service members and veterans by Tracey A. Brickell, Tracey A. Brickell, Tracey A. Brickell, Tracey A. Brickell, Louis M. French, Louis M. French, Louis M. French, Brian J. Ivins, Brian J. Ivins, Sara M. Lippa, Sara M. Lippa, Megan M. Wright, Megan M. Wright, Megan M. Wright, Samantha M. Baschenis, Samantha M. Baschenis, Samantha M. Baschenis, Jamie K. Sullivan, Jamie K. Sullivan, Jamie K. Sullivan, Lars D. Hungerford, Lars D. Hungerford, Rael T. Lange, Rael T. Lange, Rael T. Lange, Rael T. Lange

“…Participants completed 10 HRQOL measures from the TBI-QOL and Neuro-QOL, and the Family Assessment Device-General Functioning subscale (FAD-GF) 2-or-more years post-injury. Using the FAD-GF, the NIC, MTBI, and STBI participants were divided into six subgroups: Group 1 = NIC Healthy Family Functioning (HFF) (n = 34); Group 2 = NIC Unhealthy Family Functioning (UnHFF) (n = 28); Group 3 = MTBI HFF (n = 88); Group 4 = MTBI UnHFF (n = 101); Group 5 = STBI HFF (n = 58); and Group 6 = STBI UnHFF (n = 50).ResultsParticipants with UnHFF had a significant and meaningfully higher number of clinically elevated HRQOL scores compared to those with HFF in the MTBI (p &lt; 0.001, ηp2=0.07) and STBI (p = 0.001, ηp2=0.10) groups, but not in the NIC group (p = 0.107, ηp2=0.04). …”
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Circulating immunoregulatory B cell and autoreactive antibody profiles predict lack of toxicity to anti-PD-1 checkpoint inhibitor treatment in advanced melanoma by Akshay Patel, Yin Wu, Sophie Papa, Sean Whittaker, Ashley Di Meo, Ioannis Prassas, Katie E Lacy, Eleftherios P Diamandis, Sophia N Karagiannis, Thomas J Tull, Sophia Tsoka, Dhruva Biswas, Jitesh Chauhan, Katie Stoker, Zena N Willsmore, Lucy Booth, Amanda Fitzpartick, Matthaios Kapiris, Esperanza Perucha, Gary W Middleton

“…In paired blood samples pretreatment and post-treatment, these humoral immune response profiles were monitored and correlated with the onset of toxicity.Results We found increased circulating IL-10+ (Interleukin-10+) plasmablasts and double-negative (DN) B cell frequencies, higher PD-L1 (programmed death ligand 1), TGFβ (Transforming Growth Factorβ) and CD95 expression by B cells, alongside higher IgG4 and IgE serum levels in patients with stage III/IV melanoma. …”
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Seismic Performance Analysis of Energy Dissipation Building with Non-preload Variable Friction Inerter Under Extremely Rare Earthquake by ZHAO Guifeng, LIU Wei, MA Yuhong, KONG Sihua, CHEN Jiachuan, CHEN Zhaosheng

“…A Bouc‒Wen elastoplastic model was employed in the SDOF system with a yield strength of 24 kN and post-elastic stiffness of 200 kN/m. The SDOF system with and without the proposed NVFI was considered and denoted as SDOF‒NVFI and SDOF, respectively. …”
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Understanding patient pathways to Mother and Baby Units: a longitudinal retrospective service evaluation in the UK by Nikolina Jovanović, Žan Lep, Giles Berrisford, Aysegul Dirik, Julia Barber, Bukola Kelani, Olivia Protti

“…Most patients were in the post partum period, admitted for the first time through emergency, informal and complex pathways. …”
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CRYOGENESIS AND GEODYNAMICS OF ICING VALLEYS by V. R. Alekseyev

“…Five stages of cryogenic channelling are distinguished: I – pre-glacial development, II – transgression, III – stabilization, IV – regression, and V – post-glacial development. Each stage is characterised by a specific glaciohydrological regime of runoff channels and their specific shapes, sizes and spatial patterns.The channel network is subject to the maximum transformation in aufeis development stages III and IV, when the transit flow channel is split into several shallow-water branches, producing a complicated plan pattern of the terrain. …”
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Long noncoding RNA LINC00339 promotes osteoporosis development via modulating of regulator CDC42 by binding PARP1 by Dong-Li Zhu, Yan Zhang, Xiao-Yu Zhang, Zi-Han Qiu, Ke Li, Xiao-Rong Zhou, Zhen-Zhen He, Xiao-Feng Chen, Shan-Shan Dong, Wen Tian, Ya-Kang Wang, Tie-Lin Yang, Bo Yang, Yan Guo

“…Notably, integrated transcriptomic and rescue experiments revealed that LINC00339 and PARP1 coregulate CDC42 expression through post-transcriptional regulatory mechanisms. Conclusions: The identification of the LINC00339-PARP1-CDC42 regulatory axis elucidates a novel molecular mechanism contributing to osteoporosis pathogenesis. …”
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Development and validation of a prediction model for early recurrence in upper tract urothelial carcinoma treated with radical nephroureterectomy by Yi-Ju Chou, Hao-Lun Luo, Hung-Jen Wang, Steven K. Huang, Yu-Che Hsieh, Wen-Jeng Wu, Ching-Chia Li, Han-Yu Weng, Ta-Yao Tai, Chao-Hsiang Chang, Hsi-Chin Wu, Po-Hung Lin, Jacob See-Tong Pang, Chung-Hsin Chen, Jian-Hua Hong, Jen-Shu Tseng, Marcelo Chen, I-Hsuan Alan Chen, Chia-Cheng Yu, Pi-Che Chen, Ian-Seng Cheong, Chung-You Tsai, Pai-Yu Cheng, Yuan-Hong Jiang, Yu-Khun Lee, Shian-Shiang Wang, Chuan-Shu Chen, Thomas Y. Hsueh, Wei-Chieh Chen, Chia-Chang Wu, Yung-Tai Chen, Wei-Yu Lin, Richard Chen-Yu Wu, Chi-Wen Lo, Marco Moschini, Francesco Soria, Ekaterina Laukhtina, Tamás Fazekas, Marcin Chlosta, Jeremy Yuen-Chun Teoh, Shahrokh F. Shariat, Yao-Chou Tsai

“…Results Early recurrence time point in localized UTUC was determined at 9 months post-surgery, with patients experiencing early recurrence exhibiting worse overall and cancer specific survival. …”
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Safety and immunogenicity of primary vaccination with a SARS-CoV-2 mRNA vaccine (SYS6006) in Chinese participants aged 18 years or more: Two randomized, observer-blinded, placebo-c... by Gui-Ling Chen, Yuan-Zheng Qiu, Kai-Qi Wu, Ying Wu, Yuan-Hui Wang, Yu-Ying Zou, Cong-Gao Peng, Jie Zhao, Chang Su, Jun-Heng Ma, Shao-Nan Ni, Xing Wang, Ting-Han Jin, Qi Jiang, Tong Guo, Yan Xu, Chao-Chao Huang, Qing Zhang, Kai-Li Liu, Li Ji, Han-Yu Yang, Chun-Lei Li, Yu-Wen Su, Xiang Lu, Lan-Juan Li

“…Adverse events (AEs) were collected through 30 days post the second vaccination. Immunogenicity was assessed by live-virus neutralizing antibody (Nab), spike protein (S1) binding antibody (S1-IgG), and cellular immunity. …”
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Case report of non-gene editing CD7 CAR T cell therapy in CD7+ Sézary syndrome: preclinical validation and first-in-human use by Haichan Xu, Lihua Sun, Zehua Wu, Vincent M. DeStefano, Masayuki Wada, Jennifer E. Chow, Hui Yi, Hui Yi, Guoling Wang, Guoling Wang, Jing Dai, Wei Zheng, Ting Wang, Ting Wang, Wenli Zhang, Chengxing Song, Jing Luo, Yu Ma, Benjamin Waner, Mengjie Dong, Haibo Chen, Baozhen Qin, Hongyu Zhang, Jamie Hsing-Ming Chang, Yupo Ma, Yupo Ma, Jia Feng

“…The patient achieved medication and symptom free complete remission (CR) within 28 days post-CAR. The patient remained in CR at 18-month follow-up. …”
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Millinovae: A New Class of Transient Supersoft X-Ray Sources without a Classical Nova Eruption by Przemek Mróz, Krzysztof Król, Hélène Szegedi, Philip Charles, Kim L. Page, Andrzej Udalski, David A. H. Buckley, Gulab Dewangan, Pieter Meintjes, Michał K. Szymański, Igor Soszyński, Paweł Pietrukowicz, Szymon Kozłowski, Radosław Poleski, Jan Skowron, Krzysztof Ulaczyk, Mariusz Gromadzki, Krzysztof Rybicki, Patryk Iwanek, Marcin Wrona, Mateusz J. Mróz

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Integrative metagenomics and metabolomics reveal age-associated gut microbiota and metabolite alterations in a hamster model of COVID-19 by Patrícia Brito Rodrigues, Vinícius de Rezende Rodovalho, Valentin Sencio, Nicolas Benech, Marybeth Creskey, Fabiola Silva Angulo, Lou Delval, Cyril Robil, Philippe Gosset, Arnaud Machelart, Joel Haas, Amandine Descat, Jean François Goosens, Delphine Beury, Florence Maurier, David Hot, Isabelle Wolowczuk, Harry Sokol, Xu Zhang, Marco Aurélio Ramirez Vinolo, François Trottein

“…Our data also reveal age-specific changes in the composition and metabolic activity of the gut microbiota during both the acute phase (day 7 post-infection, D7) and the recovery phase (D22) of infection. …”
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A discourse analysis of six stories based on the thematic progression factor: Halliday and Matthiessen's functional grammar approach (2014) by seyed abbas navabi sohi, ferdous aghagolzade, ahmad mohseni

“…For example, Marfuaty and Wahyudi (2015), in their investigation of thematic progression patterns in the opinion section of the Jakarta Post, concluded that the most frequent pattern and theme were linear pattern and topical theme. …”
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Social Media Suicide Watch by Katherine Prothro

“…Some may argue that the posts on Twitter are public and can be viewed by anyone. …”
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Should the Food and Drug Administration Limit Placebo-Controlled Trials? by Max Goodman, Connor Pedersen

“…The World Medical Association. http://www.wma.net/policies-post/wma-declaration-of-helsinki-ethical-principles-for-medical-research-involving-human-subjects/. …”
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Mice mucosal leishmaniasis model shown high parasite load, increased cytotoxicity and impaired IL-10+ T cell response by Alisson Amaral Da-Rocha, Alisson Amaral Da-Rocha, Júlio Souza Dos-Santos, Júlio Souza Dos-Santos, Igor Santos Bittencourt, Igor Santos Bittencourt, Douglas B. De-Almeida, Douglas B. De-Almeida, Naiara Carla dos Santos Manhães, Naiara Carla dos Santos Manhães, Hozany Praxedes, Hozany Praxedes, João Victor Paiva Romano, João Victor Paiva Romano, Elias Barbosa da Silva-Junior, Antônio José da Silva-Gonçalves, Marcia Pereira Oliveira, Luciana Polaco Covre, Daniel Claudio de Oliveira Gomes, Alda Maria Da-Cruz, Alda Maria Da-Cruz, Alessandra Marcia da Fonseca-Martins, Alessandra Marcia da Fonseca-Martins, Herbert Leonel de Matos Guedes, Herbert Leonel de Matos Guedes

“…Three infection modes were performed and compared according to the injection site. Six weeks post infection, mice presented edema in the nasal and premaxillary region, with progressive growth until twelve weeks. …”
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