Donor – recipient selection using epitope mismatches in kidney transplantation by A. V. Vatazin, A. B. Vatazin, V. A. Stepanov

“…With the number of EpMM in the range from 10 to 24 and from 25 to 43  the difference in survival rates was statistically significant, but only at the late stages of the post-transplant  period: log-rank test p = 0.0067, Breslow test p = 0.0982. …”
Get full text

Reconstitution of T cell‐mediated immunity by umbilical cord‐derived mesenchymal stem cells in ulcerative colitis by Xiaoying Luo, Jieping Deng, Xiaoke Jiang, Jun Mi, Yangqiu Bai, Huimin Zhang, Yalong Li, Min Liu, Conghui Cai, Pengju Li, Huanrong Huang, Yueping Xu, Yiwen Qin, Yang Mi, Hui Ding, Zhiyu Yang, Yue Wu, Zhenjuan Li, Ling Lan, Lida Zhang, Li Wang, Guobing Chen, Han Yue, Oscar Junhong Luo, Bingyong Zhang

“…The 26 enrolled patients were administered two UMSC doses intravenously. Pre‐ and post‐therapy colon biopsy specimens were analysed by single‐cell RNA sequencing (scRNA‐seq). …”
Get full text

Characterization of <i>SPL</i> Family Genes in Banana Reveals the Critical Role of <i>MaSPL1</i> in Regulating Fruit Ripening by Bo Wang, Tongxin Dou, Ou Sheng, Weidi He, Guiming Deng, Fangcheng Bi, Chunyu Li, Tao Dong, Qiaosong Yang, Chunhua Hu, Huijun Gao, Siwen Liu, Cancan Liu, Jihong Liu, Ganjun Yi, Yaoyao Li

“…In conclusion, this study provides comprehensive information for further investigation of the specific roles of <i>SPL</i> genes in banana developmental processes, particularly during fruit development and post-harvest stages, and may implement molecular strategies to regulate maturation and enhance fruit quality in bananas.…”
Get full text

Effects of nutritional counseling on dietary patterns in patients with mild cognitive impairment: insights from the BrainFit-Nutrition study by Etienne Hanslian, Etienne Hanslian, Melanie Dell’Oro, Julia K. Schiele, Julia K. Schiele, Farid I. Kandil, Farid I. Kandil, Dzenita Hasanbasic, Dzenita Hasanbasic, Cirus Henn, Elmar Graessel, Julia-Sophia Scheuermann, Petra Scheerbaum, Andreas Michalsen, Andreas Michalsen, Michael Jeitler, Michael Jeitler, Michael Jeitler, Michael Jeitler, Christian S. Kessler, Christian S. Kessler, Christian S. Kessler

“…Dietary behaviors in 261 participants (52.2% female), aged between 60 and 86 years, were monitored using food frequency questionnaires at baseline (t0), post-intervention (t6), and at a 12-months follow-up (t12). …”
Get full text

Decitabine combined with reduced-intensity conditioning for older patients with acute myeloid leukemia in composite complete remission undergoing allogeneic hematopoietic stem cell... by Qifa Liu, Zhongli Hu, Na Xu, Yirong Jiang, Zhiping Fan, Fen Huang, Ren Lin, Hua Jin, Yunxin Zeng, Hai He, Ping Zhu, Guopan Yu, Pengcheng Shi, Ruijuan Sun, Xiaojun Xu, Zhangkun Li, Yu Zhang, Jing Sun, Yu Wang, Li Xuan

“…The 2-year OS rate was 67% (95% CI 56–80), which met the primary objective. Within 100 days post-transplantation, the most common grade 3–4 non-hematological treatment-emergent adverse events (TEAEs) were infections (22 [37%]), acute graft-versus-host disease (21 [35%]), and gastrointestinal disorders (16 [27%]). …”
Get full text

Cognitive training gain transfer in cognitively healthy aging: per protocol results of the German AgeGain study by Florian U. Fischer, Florian U. Fischer, Bianca Kollmann, Bianca Kollmann, Dominik Wolf, Alexandra Sebastian, Alexandra Sebastian, Kristel Knaepen, David Riedel, Andreas Mierau, Andreas Mierau, Nicolas Ruffini, Nicolas Ruffini, Kristina Endres, Kristina Endres, Jennifer Winter, Heiko K. Strüder, Gerard N. Bischof, Gerard N. Bischof, Sofia Faraza, Sofia Faraza, Bernhard Baier, Harald Binder, Alexander Drzezga, Alexander Drzezga, Alexander Drzezga, Stefan Teipel, Stefan Teipel, Andreas Fellgiebel, Andreas Fellgiebel, Oliver Tüscher, Oliver Tüscher, Oliver Tüscher, Oliver Tüscher, Oliver Tüscher

“…Therefore, the present multicentric study used a cognitive training intervention to demonstrate training transfer and identify neurobiological modulators of successful transfer.MethodsIn total 235 subjects were enrolled in AgeGain; 180 underwent a broad 4-week cognitive training intervention at three study sites. Pre- and post-training neuropsychological testing was conducted and successful transferers were identified according to preregistered definitions. …”
Get full text

Tocilizumab-Based Treatment of Microvascular Inflammation in Kidney Transplant Recipients: A Retrospective Study by Johan Noble, Johan Noble, Johan Noble, Giorgia Comai, Giorgia Comai, Valeria Corredetti, Reda Laamech, Celine Dard, Thomas Jouve, Thomas Jouve, Diane Giovannini, Audrey Le Gouellec, Shivani Wadnerkar, Paolo Cravedi, Della Apuzzo, Della Apuzzo, Daniele Vetrano, Daniele Vetrano, Marco Busutti, Chiara Abenavoli, Chiara Abenavoli, Paolo Malvezzi, Lionel PE Rostaing, Lionel PE Rostaing, Gaetano Lamanna, Gaetano Lamanna

“…The eGFR trajectory significantly decreased after TCZ treatment (−1.2 ± 0.2 vs. 0.03 ± 0.2 mL/min/1.73 m2/month pre- vs. post-TCZ, respectively; p = 0.001). The percentage of patients with DSA decreased from 63.9% to 38.9% (p &lt; 0.001), and the average MFI decreased from 9,537 to 7,250 (p = 0.001). …”
Get full text

Loomeprotsessi semiootilisest uurimisest helilooja käsikirjade näitel. Arvo Pärdi „Sieben Magnificat-Antiphonen“ lähivaates / Composer Manuscripts and the Semiotic Study of the Cre... by Kristina Kõrver

“…From a textological standpoint, the article considers the full lifespan of a work, from the earliest notation of an idea to the final manuscript, including post-publication revisions and arrangements for new ensembles. …”
Get full text

“WHEN THE HORN THAWED, THE TUNE POURED OUT”: PAVEL LUNGIN ON THE MAKING OF TAXI BLUES / «КОГДА РОЖОК ОТТАЯЛ, ПОЛИЛИСЬ ЗВУКИ МУЗЫКИ…»: ПАВЕЛ ЛУНГИН О СОЗДАНИИ ФИЛЬМА «ТАКСИ-БЛЮЗ»... by Lungin Pavel S. / Лунгин П.С., Trusevich Elizaveta S. / Трусевич Е.С., Klemeshev Pyotr A. / Клемешев П.А.

“…Russian film director Pavel Lungin explores the topic of independent cinema during perestroika, using the example of his debut film Taxi Blues, which received one of the first international awards in post-Soviet Russia—the Best Director Prize and the Special Mention of the Ecumenical Jury at the 1990 Cannes Film Festival. …”
Get full text

Mir-218-5p from Extracellular Vesicles of Endometrium in Patients with Recurrent Implantation Failure Impairs Pre-Implantation Embryo Development by Cai L, Lv M, Wei J, Liu C, Li Y, Liao Z, Li T, Zhang H, Xi L, Sui C

“…RNA-sequencing was used to analyze transcriptional changes in embryos post miR-218-5p agomir treatment. The abnormal segregation genes of trophectoderm (TE) and inner cell mass (ICM) were visualized via qRT-PCR and immunofluorescence staining. …”
Get full text

Genomic characterization of invasive Neisseria meningitidis in Spain (2011/12–2022/23): expansion of clonal complex 213 and the potential threat to 4CMenB vaccine strain coverage by Josep Roca-Grande, Alba Mir-Cros, Carmen Muñoz-Almagro, Mayli Lung, Alba Bellés-Bellés, Jordi Càmara, Emilia Cercenado, M. Ángeles Galán-Ladero, Andrea Martín-Nalda, Albert Moreno-Mingorance, Daniel Navarro de la Cruz, M. Ángeles Orellana, Begoña Palop, Amaresh Pérez-Argüello, Guillem Puigsech-Boixeda, M. Dolores Quesada, Alba Rivera, Ana Rodriguez-Fernandez, Enrique Ruiz de Gopegui, Carolina Sarvisé, Aleix Soler-Garcia, Belén Viñado, Nieves Larrosa, Juan José González-López

“…MenB predominated throughout most seasons, except during the 2019/20 season when serogroup W peaked. Post-COVID-19 pandemic, MenB remained the most frequent (70.2%). …”
Get full text

Industry sponsorship bias in randomized controlled trials of digital cognitive behavioral therapy for insomnia: a meta-research study based on the 2023 Brazilian guidelines on the... by Viviane Akemi Kakazu, Marcia Assis, Andrea Bacelar, Andréia Gomes Bezerra, Giovanna Lira Rosa Ciutti, Silvia Gonçalves Conway, Silvia Gonçalves Conway, Silvia Gonçalves Conway, José Carlos Fernandes Galduróz, Luciano F. Drager, Mariana Pery Khoury, Mariana Pery Khoury, Ingrid Porto Araújo Leite, Ingrid Porto Araújo Leite, Ygor de Matos Luciano, Dalva Poyares, Dalva Poyares, Sergio Tufik, Sergio Tufik, Gabriel Natan Pires, Gabriel Natan Pires, Gabriel Natan Pires

“…For each included study, sponsorship bias was analyzed in a 5-points scale, considering the role of the sponsor (from “no funding received” to “all author authors are affiliated to the company developing the dCBT-I”). Immediate post-treatment ISI data was extracted for both intervention and control groups in each included study, and the between-groups Cohen’s d effect size was calculated for each included study. …”
Get full text

Studying the Requirement of Water Police to Control Groundwater Resources in the Villages Iij, Jovin and Soufiabad of Sorkheh - Semnan by Peyman Akbarzadeh, Mohammadreza Yazdani, Shima Nikoo

“…The highest level of education among the selected sample was below basic education or diploma with 50.62% and the post-graduated level was PhD with 1.2%. The pattern of water consumption is currently undergoing drastic changes (10 years ago). …”
Get full text

Genetic Interplay Between Attention-Deficit/Hyperactivity Disorder and Pain Suggests Neurodevelopmental Pathways and Comorbidity Risk by Nicolas P. Ciochetti, Victor F. de Oliveira, Iago Junger-Santos, Cibele E. Bandeira, Maria E. Tavares, Eduardo S. Vitola, Luis A. Rohde, Gustavo Melo de Andrade, Bruna S. da Silva, Eugenio H. Grevet, Claiton H. Dotto Bau, Diego L. Rovaris

“…Methods: We utilized various post–genome-wide association study analyses on summary data from samples ranging between 225,534 and 766,345 individuals. …”
Get full text

Expanded analysis of vertebral endplate disruption and its impact on vertebral compression fracture risk by Khaled Dibs, Prasath Mageswaran, Raju Raval, Evan Thomas, Emile Gogineni, Jeff Pan, Brett Klamer, Ahmet Ayan, Eric Bourekas, Daniel Boulter, Nicholas Fetko, Eric Cochran, Vikram Chakravarthy, John McGregor, Esmerina Tili, Joshua Palmer, Natalie Peters, Russell Lonser, Ahmed Elguindy, Eugene Yap, Soheil Soghrati, William Marras, John Grecula, Arnab Chakravarti, James Elder, Dukagjin Blakaj

“…The 1-year cumulative incidence of VCF was evaluated by follow-up MRI and CT scans at 3-month intervals post-treatment. Based on multivariate analysis, a nomogram was created using four independent predictors: EP disruption, steroid use, SINS ≥ 7, and adverse histology. …”
Get full text

A proteogenomic analysis of cervical cancer reveals therapeutic and biological insights by Jing Yu, Xiuqi Gui, Yunhao Zou, Qian Liu, Zhicheng Yang, Jusheng An, Xuan Guo, Kaihua Wang, Jiaming Guo, Manni Huang, Shuhan Zhou, Jing Zuo, Yimin Chen, Lu Deng, Guangwen Yuan, Ning Li, Yan Song, Jia Jia, Jia Zeng, Yuxi Zhao, Xianming Liu, Xiaoxian Du, Yansheng Liu, Pei Wang, Bing Zhang, Li Ding, Ana I. Robles, Henry Rodriguez, Hu Zhou, Zhen Shao, Lingying Wu, Daming Gao

“…Proteomic stratification identifies three patient subgroups with distinct features in prognosis, genetic alterations, immune infiltration, and post-translational modification regulations. PRKCB is further identified as a potential radioresponse-related biomarker of CC patients. …”
Get full text

Machine learning-based prediction model for lung ischemia-reperfusion injury: insights from disulfidptosis-related genes by Yanpeng Zhang, Yanpeng Zhang, Yanpeng Zhang, Jingyang Sun, Jingyang Sun, Jingyang Sun, Yihan Lin, Yihan Lin, Yihan Lin, Rongxuan Jiang, Rongxuan Jiang, Rongxuan Jiang, Niuniu Dong, Niuniu Dong, Niuniu Dong, Huanhuan Dong, Huanhuan Dong, Huanhuan Dong, Peng Li, Peng Li, Peng Li, Jinteng Feng, Jinteng Feng, Jinteng Feng, Zijiang Zhu, Guangjian Zhang, Guangjian Zhang, Guangjian Zhang

“…The CIBERSORT method was used to assess the infiltration levels of immune cells in lung tissue samples post-transplant. Finally, cell line and animal experiments were carried out to validate the effectiveness and applicability of the model.ResultsA total of 14,592 hub differential-expressed genes were identified, showing significant changes in cold ischemia and reperfusion samples. …”
Get full text

Basic therapeutic approaches to the management of hematology/oncology patients with new coronavirus infection (COVID-19) by E. N. Misyurina, E. A. Baryakh, N. F. Frolova, O. N. Kotenko, Z. Yu. Mutovina, S. S. Andreev, T. N. Tolstykh, K. V. Yatskov, E. A. Karimova, A. B. Makeshova, O. A. Rukavitsyn, A. V. Misyurin, Yu. Yu. Polyakov, M. A. Mingalimov, T. S. Chudnova, D. E. Gagloeva, D. D. Ivanova, A. I. Koneva, O. L. Kochneva, E. N. Zotina, E. Yu. Grishina, L. T. Shimanovskaya, V. N. Yakimets, E. I. Zhelnova

“…Recently, antiviral drugs and monoclonal antibodies have become available for pre- or post-exposure prophylaxis, as well as for early treatment of COVID-19. …”
Get full text

Triamcinolone-loaded nanocarriers: a novel strategy to mitigate cognitive and emotional sequelae induced by traumatic brain injury via modulation of oxidative stress by Aída Marcotti, Aída Marcotti, Sofía De la Fuente, Sofía De la Fuente, María Lina Formica, María Lina Formica, Agustín Jorge Montivero, Agustín Jorge Montivero, Martina Ramires, Martina Ramires, Verónica Leonor Romero, Verónica Leonor Romero, María Florencia Constantin, María Florencia Constantin, María Jazmín Silvero, María Jazmín Silvero, María Cecilia Becerra, María Cecilia Becerra, Gastón Diego Calfa, Gastón Diego Calfa, Miriam Beatriz Virgolini, Miriam Beatriz Virgolini, Santiago Daniel Palma, Santiago Daniel Palma, Mariela Fernanda Pérez, Mariela Fernanda Pérez

“…Animals received NT, conventional triamcinolone, or empty LNCs, 15 minutes and 24 hours post-injury. They were sacrificed 24 hours, 1 or 7 days later for biochemical analysis of AOPP, MDA, and antioxidant enzymes (catalase and superoxide dismutase) activity in the hippocampus, prefrontal, and motor cortices. …”
Get full text

Specialty choices among UK medical students: certainty, confidence and key influences—a national survey (FAST Study) by Jessica Lo, Anna Collins, Sophie West, Daniel MaGee, Sara Ali, Tomas Ferreira, Anson Wong, Kavyesh Vivek, Freya F Semple, Benjamin French, Riya Patel, Guilherme Movio, Andreas Stavrinou, Tushar Rakhecha, Alexander M Collins, Oliver Feng, Maeve K Mulchrone, Heather A Lewis, Sara Kidher, Erin Fitzsimons-West, Meghna Sreekumar, Olivia King, Malvi Shah, Samantha Burley, Basma R Khan, Vaishvi Dalal, Safa Razzaq, Hugo Bernie, Luke Dcaccia, Olivia Rowe, Ananya Jain, Arthur Handscomb, Sudhanvita Arun, Alfaiya Hashmi, Hannah Layton-Joyce, Matilda Gardener, Emily R Finbow, Sakshi Roy, Bilal Qureshi, Khyatee Shah, Mia Mäntylä, Momina Iqbal, Katie Appleton, Yasmin Owadally, Amelia Dickson, Jack M Read, Chiamaka Anthony-Okeke, Rida Khan, Shama Maliha, Catherine L Otoibhi, Sophie Kidd, Muhammed Asif, Tawfique Rizwan, Aleksandra Dunin-Borkowska, James Brawn, Ayeza Akhtar, Medha Pillaai, Sakshi Garg, Ria Bhatt Ben Sweeney, Cameron Thurlow, Alyssa Weissman, Chloe Milton, Samuel Foxcroft, James A Cairn, Leah Njenje, Daniel C Chalk, Jessica Sinyor, Ryan White, Krishnika Vetrivel, Muhammad Hamza Shah, Emily Bolton, Amelia Fortescue, Ella Plumb, Megan Fallows, Ioan Valnarov-Boulter, Hsuan-Tung Kuo, Aryan A Sagdeo, Bethany McDermott, Michael Y Luo, Sharon Yuen Shan Ho, Lubana Hemayet, Dora Pascoe, Leya Luhar, Rakeem Khalid Basith, Mayisha Samiha, Molly Doyle, Flora E MacInnes, Yasmin Al-Rawi, Manuel Giardino, Maisha Hayat, Anjali Cyril, Rivya Mathews, Ashleigh Stirling, Adam Mohamed Capdevila, Zulaikha Bibi, Mackenzie F Garlick, Lily Chadwick, Fariha Hasan, Zoe Mary Constantinou, Beray Berkay, Joseph Nicholson, Louis R Dowland, Tan Jit Yih, Dev Ranka, Kajoke M S Avolonto, Elliot Skittrall, Madison Gill, Humaira Khanom, Jonathan Craven, Harini Elankhumaren, Hannah Glover-Adams, Ishagit Kaur, Maia C Letts, Hesham Zalghana, Urja Ashish Mhatre, Nikita Sanctis, Sundaramoorthy Balasubramanian, Saimathusan Sivakandarajah, Sourab Chand Surana, Rosemary M Davis, Daria Maria Bageac, Ibrahem Al-Obaidi, Subham Roy, Mohammed Suhaib Amin, Tessa Yau, Pakhi Goel, Abderrahmane El Guernaoui, David Gringras, Soo Sun Chong, Aaliyah J Bax, Rachelle Thevathas, Ajwa Fayaz, Pranjil Pokharel Vera Onongaya, Phoebe Hatrick, Rhiannon Tanner, India R Barrons, Louis Naraine, Artemis Prevot, Muaawiyah Shaheen, Farah Ahmed, Mathumetha Rubaratnam, Harsh Sai Modalavalasa, Sushmhitah Sandanatavan, Anhukrisha Karthikeyan, Saarah Saanan Khan, Gregory A Rowland, Alexa McCloskey, Nidhi Sachidananda, Lydia Melaku, Vyom Patel, Iliyah Shahbeik, Jui Kanetkar, Hannah Bolton, Timo L Kuerten, Emily Carver, Mairi C Docherty, Nabilah Ali, Shereen Ahmad, Shiksha Guru, Anushka Pujari, Khadijah Khan, Sewa A Badejo, Ellena K Briggs, Raghad A F Sallama, Emma Marsh, Brandon S H Low, Laura A E Munn, Ahamed Hafeezul Nashith Ahamed Rizwaan, Carys M. Francis, Ali Hamed Mahmood Al-Nakeeb, Michael E. Bryan, Sydney LA Barnes, Tommy Wai Kei LI

“…Only 23.1% of students felt confident about securing a specialty training post, with confidence higher among males (OR 1.36, 95% CI 1.21 to 1.52, p&lt;0.0001) and privately educated students (OR 1.18, CI 1.03 to 1.35, p=0.02). …”
Get full text