Co-creating strategies to promote uptake of HIV self-testing among young adults in Mecklenburg county, North Carolina: a protocol for a pilot implementation study by Ucheoma Nwaozuru, Lindsay Miller, Laura H. Gunn, Laura H. Gunn, Laura H. Gunn, Sebastian Marin-Cespedes, Margaret Hanff, Patrick Robinson, Michael Dulin, Meghana Muralidhar, Prashant Jha, Goodness C. Mirikwe, Donaldson F. Conserve, Chelsea Gulden, Bernard A. Davis, Kristie Foley, Joseph Tucker, Joseph Tucker, Meagan Zarwell, Meagan Zarwell

“…Then, the final pilot implementation phase, guided by CFIR and RE-AIM, will use mixed methods to evaluate the success of the co-created HIVST implementation strategies using a pre-post design. Participants in the study will complete a baseline survey and a follow-up survey immediately following intervention completion. …”
Get full text

The role of infraclavicular and supraclavicular lymph nodes in breast cancer patients receiving neoadjuvant chemotherapy: implications for regional lymph node classification by Yanyu Chen, Yuzhi Song, Zhonghua Han, Hui Han, Tianlan Tang, Silin Chen, Ruizhi Zhao, Cheng Huang, Guiqing Shi, Yuping Lin, Ying Wang, Liuqing Jiang, Jinhua Chen, Chunsen Xu, Fangmeng Fu, Chuan Wang, Yong Yang

“…We propose a refined axillary classification that combines pathological axillary staging post-NAC with ISLN involvement, revealing 3-year PFS rates of 95.3 %, 87.6 %, 73.4 %, and 64.5 % for the respective four groups defined by this refined classification combining axillary stage and ISLN status. …”
Get full text

Safety and Immunogenicity of a Modified Self-Amplifying Ribonucleic Acid (saRNA) Vaccine Encoding SARS-CoV-2 Spike Glycoprotein in SARS-CoV-2 Seronegative and Seropositive Ugandan... by Jonathan Kitonsa, Jennifer Serwanga, Hannah M. Cheeseman, Andrew Abaasa, Jane Frances Lunkuse, Eugene Ruzagira, Laban Kato, Florence Nambaziira, Gerald Kevin Oluka, Ben Gombe, Sembera Jackson, Joseph Katende Ssebwana, Leon R. McFarlane, Sarah Joseph, Benjamin F. Pierce, Robin J. Shattock, Pontiano Kaleebu

“…Reactogenicity was assessed using diary cards for seven days post-vaccination, and adverse events were monitored throughout the 24-week study. …”
Get full text

Safety, immunogenicity and effect on viral rebound of HTI vaccines combined with a TLR7 agonist in early-treated HIV-1 infection: a randomized, placebo-controlled phase 2a trial by Lucia Bailón, José Moltó, Adrian Curran, Julen Cadiñanos, Juan Carlos Lopez Bernaldo de Quirós, Ignacio de Los Santos, Juan Ambrosioni, Arkaitz Imaz, Susana Benet, Paula Suanzes, Jordi Navarro, Juan González-García, Carmen Busca, Leire Pérez-Latorre, Juan Berenguer, Lucio Jesús García-Fraile, Gina Mejía-Abril, Jose M. Miró, Sofía Scévola, Santiago Moreno, Pere Domingo, Yuan Tian, Michelle Frankot, Daina Lim, Yanhui Cai, Elena Vendrame, Susan Guo, Jeffrey J. Wallin, Romas Geleziunas, Devi SenGupta, Yovaninna Alarcón-Soto, Isabel Leal, Alvaro Aranguen, Margarida Garcia-Garcia, Ian McGowan, Christian Brander, Jose Ramón Arribas, Beatriz Mothe, On behalf of the AELIX-003 Study Group

“…All participants experienced viral rebound in ATI; 33.3% and 23.5% (P = 0.4494) of CCMM + VES and placebo recipients, respectively, remained off antiretroviral therapy for 24 weeks. Post hoc analysis confirmed a correlation between levels of HTI-specific T cells and prolonged time off antiretroviral therapy. …”
Get full text

Adjuvant chemotherapy with S-1 after curative chemoradiotherapy in patients with locoregionally advanced squamous cell carcinoma of the head and neck: Reanalysis of the ACTS-HNC st... by Akira Kubota, Eiji Nakatani, Kiyoaki Tsukahara, Yasuhisa Hasegawa, Hideki Takemura, Tomonori Terada, Takahide Taguchi, Kunihiko Nagahara, Hiroaki Nakatani, Kunitoshi Yoshino, Yuichiro Higaki, Shigemichi Iwae, Takeshi Beppu, Yutaka Hanamure, Kichinobu Tomita, Naoyuki Kohno, Kazuyoshi Kawabata, Satoshi Teramukai, Masato Fujii, ACTS-HNC Study Group

“…The endpoints were OS, disease-free survival, locoregional relapse-free survival, distant metastasis-free survival (DMFS), and post-locoregional relapse survival.<h4>Results</h4>One hundred eighty patients (S-1, n = 87; UFT, n = 93) were included in this study. …”
Get full text

A multidisciplinary analysis of over 53,000 fascioliasis patients along the 1995–2019 countrywide spread in Vietnam defines a new epidemiological baseline for One Health approaches... by Nguyen Van De, Pham Ngoc Minh, Thanh Hoa Le, Do Trung Dung, Tran Thanh Duong, Bui Van Tuan, Le Thanh Dong, Nguyen Van Vinh Chau, Pablo F. Cuervo, M. Dolores Bargues, M. Adela Valero, Albis Francesco Gabrielli, Antonio Montresor, Santiago Mas-Coma

“…Case profiles were based on serology, symptoms, eosinophilia, imaging techniques, stool egg finding, and post-specific-treatment recovery. Radio broadcasting about symptoms and costless diagnosis/treatment led patients to hospitals after symptom onset. …”
Get full text

Hybrid deep learning enables multi-institutional delineation of active bone marrow for gynecologic radiotherapy by Zhe Zhang, Xiao Lu, Sicheng He, Tao Huang, Shaobin Wang, Mingjun Lu, Xiaomin Zhang, Zhibo Tan, John Moraros, Lei Zhang, Xin Li, Zhan Li, Zihao Deng, Yimeng Zhang, Mengjie Dong, Shuihua Wang, Yajie Liu

“…The hybrid nnU-Net approach integrated nnU-Net predictions with anatomical bone structures via Boolean operations, providing a post-processing strategy. The dataset was split into 290 cases for training and 29 for independent testing. …”
Get full text

ddPCR: a more accurate tool for SARS-CoV-2 detection in low viral load specimens by Tao Suo, Xinjin Liu, Jiangpeng Feng, Ming Guo, Wenjia Hu, Dong Guo, Hafiz Ullah, Yang Yang, Qiuhan Zhang, Xin Wang, Muhanmmad Sajid, Zhixiang Huang, Liping Deng, Tielong Chen, Fang Liu, Ke Xu, Yuan Liu, Qi Zhang, Yingle Liu, Yong Xiong, Guozhong Chen, Ke Lan, Yu Chen

“…Moreover, 6/14 (42.9%) convalescents were detected as positive by ddPCR at 5–12 days post discharge. Overall, ddPCR shows superiority for clinical diagnosis of SARS-CoV-2 to reduce the false negative reports, which could be a powerful complement to the RT-PCR.…”
Get full text

Mucosal and Serum Neutralization Immune Responses Elicited by COVID-19 mRNA Vaccination in Vaccinated and Breakthrough-Infection Individuals: A Longitudinal Study from Louisville C... by Lalit Batra, Divyasha Saxena, Triparna Poddar, Maryam Zahin, Alok Amraotkar, Megan M. Bezold, Kathleen T. Kitterman, Kailyn A. Deitz, Amanda B. Lasnik, Rachel J. Keith, Aruni Bhatnagar, Maiying Kong, Jon D. Gabbard, William E. Severson, Kenneth E. Palmer

“…<b>Results</b>: Individuals who received two doses of the mRNA vaccine exhibited reduced neutralization against Beta, Delta, and Omicron BA.1 variants compared to wildtype Wuhan, with further decline observed six months post-booster vaccination. However, individuals who experienced natural COVID-19 infection (breakthrough) after receiving two vaccine doses showed enhanced neutralization and antibody responses, particularly against Omicron BA.1. …”
Get full text

The variations, with temperature, of the morphology of metastable phases in 3000 & 5000 Aluminium alloys by Khatereh Manafi, Maziyar Azadbeh

“…In this research, the effect of the temperature of "post treatment" on characteristic of metastable phase and improving the impact strength of the alloys as extruded was investigated .…”
Get full text

Lifetime estrogen exposure and domain-specific cognitive performance: results from the IGNITE study by Amber Watts, Amber Watts, Shannon Donofry, Shannon Donofry, Hayley Ripperger, Nicole M. Eklund, Lu Wan, Chaeryon Kang, George Grove, Lauren E. Oberlin, Lauren E. Oberlin, Swathi Gujral, Eric D. Vidoni, Jeffrey M. Burns, Edward McAuley, Edward McAuley, Charles H. Hillman, Arthur F. Kramer, Arthur F. Kramer, M. Ilyas Kamboh, Kirk I. Erickson, Kirk I. Erickson

“…We hypothesized that (1) oophorectomy prior to natural menopause would be associated with poorer cognitive performance, (2) timing and duration of birth control and menopausal hormone therapy would influence associations with cognitive performance, and (3) APOE4 carrier status would interact with oophorectomy and hormone therapy to influence cognitive performance.MethodsIn 461 post-menopausal females (M age = 69.6) we assessed oophorectomy and hormone therapy use to examine associations with the Montreal Cognitive Assessment (MoCA) and factor-analytically derived composite scores for episodic memory, processing speed, working memory, executive function/attentional control, and visuospatial processing.ResultsHypothesis (1) We did not observe associations between oophorectomy prior to natural menopause and poorer cognitive performance. …”
Get full text

Public and patient involvement (PPI) in the design, execution and dissemination of a trial: the BISTRO trial by David Coyle, Paula Ormandy, Nancy Fernandes da Silva, Simon Davies

“…Main outcome measures Public and patient involvement contribution prior to trial initiation, description of the participant-facing communications, adherence to trial materials, dropout and dissemination of trial findings. Post-trial evaluation by research teams, Patient Advisory Group and co-applicants. …”
Get full text

Evaluation of Irrigation Management and Plastic Mulch Effects on Water Productivity and Quantitative and Qualitative Yield of Lemon Balm (Melissa officinalis L.) by N. Najafi Iman Abadi, M.A. Gholami Sefidkouhi, S. Shiukhy-Soqanloo

“…The Duncan multiple range post hoc test was employed to compare treatment means.   …”
Get full text

Influence of agroclimatic factors on the efficiency of multi-ovulation in cattle in the Peruvian tropics by Gleni Tatiana Segura Portocarrero, Gleni Tatiana Segura Portocarrero, Gleni Tatiana Segura Portocarrero, Nilton Luis Murga Valderrama, Rainer Marco Lopez Lapa, José Américo Saucedo Uriarte, Deiner Jhonel Gongora Bardales, Hugo Frias Torres, Annie Yoselin Poclín Rojas, Benjamin Depaz Hizo, Ronald Will Vasquez Tarrillo, Lizeth Amparo Heredia Vilchez, Gustavo Ampuero Trigoso

“…Statistical tests were applied, including ANOVA and post-hoc tests (Tukey's Test), to assess the significance of differences between variables, such as the humidity index and temperature in relation to the production of viable structures and non-viable structures. …”
Get full text

Effect of Potassium–Magnesium Sulfate on Intestinal Dissociation and Absorption Rate, Immune Function, and Expression of NLRP3 Inflammasome, Aquaporins and Ion Channels in Weaned P... by Cui Zhu, Kaiyong Huang, Xiaolu Wen, Kaiguo Gao, Xuefen Yang, Zongyong Jiang, Shuting Cao, Li Wang

“…In conclusion, dietary PMS supplementation improved immune function, inhibited the activation of intestinal NLRP3, and modulated the expression of water and ion channels in weaned piglets, thereby contributing to the maintenance of intestinal water and ion homeostasis, which could potentially alleviate post-weaning diarrhea in piglets. The recommended supplemental level of PMS in the corn-soybean basal diet for weaned piglets is 0.30%.…”
Get full text

Single-cell RNA-sequencing highlights a curtailed NK cell function in convalescent COVID-19 pregnant women by Madhuri S. Salker, Nor Haslinda Abd Aziz, Natalia Carman Prodan, Zhiqi Yang, Aditya Kumar Lankapalli, Katrin Lazar, Mohamad Nasir Shafiee, Ersoy Kocak, Ersoy Kocak, Harivignesh Ganesan, Surya Sekhar Pal, Omer Khalid, Norhana Mohd Kasim, Aida Kalok, Norashikin Abdul Fuad, Alfred Lennart Bissinger, Tina Ganzenmueller, Thomas Iftner, Karl Oliver Kagan, Stephan Ossowski, Stephan Ossowski, Nicolas Casadei, Nicolas Casadei, Sara Y. Brucker, Olaf Riess, Olaf Riess, Yogesh Singh, Yogesh Singh, Yogesh Singh, Deutsche COVID-19 OMICS Initiative (DeCOI)

“…We validated our scRNA-seq of NK cells from convalescent pregnant women and confirmed that NK cells had diminished levels of cytotoxic proteins; perforin, CD122 and granzyme B.DiscussionOverall, our study uncovers that SARS-CoV-2 infection deranges the adaptive immune response in pregnant women even after recovery and may contribute to post-COVID19 sequalae of symptoms.…”
Get full text

Quadratus lumborum block at the lateral supra-arcuate ligament for postoperative analgesia: a protocol for a systematic review and meta-analysis by Zhonghua Li, Ling Zhang, Qin Zhang, Liang Yu, Yu Shen, Keyu Fan, Mingxia Liu, Dongxu Wang, Ya Cao, Yuxuan Zhang, Lu Qian, Danru Wu, He Liu, Jiewei Xu

“…The primary outcome is the total consumption of opioid morphine equivalents within 24 h post-surgery. Secondary outcomes comprised numerical rating scale (NRS) pain scores within 24 h postoperatively, Quality of Recovery-15 (QoR-15) scores, patient satisfaction scores, opioid-related side effect incidence and block-related adverse events. …”
Get full text

Efficacy and safety of doravirine/lamivudine/tenofovir disoproxil fumarate in HIV treatment: a real-world single-center study in China by Aixin Li, Letian Liu, Hongwei Zhang, Xi Wang, Zaicun Li, An Liu, Lili Dai, Jingji Zhang, Yue Gao, Jiangzhu Ye, Jianwei Li, Lijun Sun, Lijun Sun

“…Among patients with central nervous system (CNS) symptom, both the Pittsburgh Sleep Quality Index (PSQI) and the Hospital Anxiety and Depression Scale (HADS) scores, as well as the proportion of patients with scores greater than 7 points, decreased significantly post-switch (p &lt; 0.05).ConclusionWe provided an observational report on the effectiveness and safety of the short-term use of DOR/3TC/TDF in routine clinical practice.…”
Get full text

Durability and effectiveness of dual vs. triple therapy and tablet simplification in ART: findings from the Italian MOSAICO study by Daniele Mengato, Giacomo Berti, Giacomo Berti, Andrea Francavilla, Silvia Michielan, Linda Cappellazzo, Laura Agnoletto, Maria Chiara Silvani, Marco Chiumente, Dario Gregori, Maria Mazzitelli, Francesca Venturini, Anna Maria Cattelan, the SIFaCT MOSAICO Study Group, Salvatore Agosta, Marina Allegrini, Marina Assirelli, Maria Rita Badagliacca, Giuliana Battagin, Giorgia Bo, Jenny Bolcato, Cristina Bitello, Raffaella Binazzi, Arianna Cadeddu, Marila Camboni, Francesca Cammalleri, Anila Corja, Marta Cappellini, Linda Cappellazzo, Claudia Ciraldo, Nicolò de Gennaro, Maria Dell'Aera, Silvia Enisci, Giuseppina Emanuela Fassari, Sara Ferrari, Gabriele Fabbri, Michela Falciani, Roberta Fraccaroli, Anna Gagliardi, Giovanna Gandini, Veronica Gonzi, Giuseppe Greco, Clara La Bruna, Stefano Loiacono, Kety Luzi, Eleonora Magistrelli, Marina Malena, Paola Marini, Andrea Misin, Valentina Mureddu, Arianna Orcesi, Simonetta Palazzini, Clara Palmieri, Giulia Piazza, Mariantonietta Piccoli, Fabio Pieraccini, Francesco Pomarico, Giovanna Rametta, Roberta Rampazzo, Lucia Rossi, Aurora Scazzina, Chiara Scolamacchia, Martina Tegon, Sara Tordi, Dario Ventura, Salvatore Vitale, Anastasia Zoffoli

“…People were followed-up up to 48 months post-switch. Comparative analyses assessed virological suppression (HIV-RNA &lt;50 copies/mL), CD4+ T cell count, CD4/CD8 ratio, and treatment discontinuation. …”
Get full text

Persistence of SARS-CoV-2-IgG antibody durability in convalescent COVID-19 patients 6 months after the natural infection by Qiaoli Hua, Peng Zhang, Shengle Qin, Bing Feng, Bin Xiao, Guangjuan Zheng, Taoyu Ye, Danwen Zheng, Danwen Zheng, Jiayi Mo, Yuntao Liu, Yuntao Liu, Yun Cai, Xiaohua Xu, Xiaohua Xu, Ji Hu, Banghan Ding, Banghan Ding, Yingrui Li, Yingrui Li, Yingrui Li, Yingrui Li, Jianwen Guo, Jun Wang, Jun Wang, Jun Wang, Hongzhi Cao, Hongzhi Cao, Hongzhi Cao, Zhongde Zhang, Zhongde Zhang, Zhongde Zhang

“…Through a generalized linear model and mediation analysis, older age, independent of disease severity, was found to be a key independent factor associated with higher post-infection RBD-IgG titers. Hypothesis-generating analyses through a genome-wide association study revealed that rs117929853 (p = 3.6 × 10−8), a variant located upstream of the xanthine dehydrogenase gene (XDH), was significantly associated with RBD-IgG persistence, suggesting a potential mechanistic link between XDH polymorphisms and sustained humoral immunity.ConclusionThe study underscores the significant role of age and genetic factors in the pathogenesis of sustained humoral immunity, which requires further validation.…”
Get full text