Validation of the COAPT risk score in Polish patients undergoing transcatheter edge-to-edge repair of severe, functional mitral regurgitation: a multicenter, observational study by Karolina Jasińska-Gniadzik, Michał Łomiak, Jerzy Pręgowski, Zbigniew Chmielak, Piotr Kasprzyk, Jan Kasprzyk, Rafał Gałąska, Michał Chmielecki, Miłosz J. Jaguszewski, Marcin Fijałkowski, Aleksandra Topolska, Michał Sekuła, Marcin Grabowski, Janusz Kochman, Adam Rdzanek, Piotr Scislo, Agnieszka Kapłon-Cieślicka, Renata Główczyńska, Monika Budnik, Radosław Piątkowski, Łukasz Kołtowski, Arkadiusz Pietrasik, Aleksandra Gąsecka

“…CONCLUSIONS: In Polish patients fulfilling COAPT criteria, the COAPT risk score has moderate predictive value for post-procedural outcomes. In COAPT non-eligible patients, novel tools are required to predict outcomes.…”
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Final Survival Outcomes With Ramucirumab Plus Erlotinib Versus Placebo Plus Erlotinib in Patients With Untreated EGFR-Mutated Metastatic NSCLC: RELAY Japanese Subset by Makoto Nishio, MD, PhD, Takashi Seto, MD, PhD, Martin Reck, PhD, Edward B. Garon, MD, Kazuto Nishio, MD, PhD, Kazuo Kasahara, MD, PhD, Kazumi Nishino, MD, PhD, Miyako Satouchi, MD, PhD, Kiyotaka Yoh, MD, Hidetoshi Hayashi, MD, PhD, Kazuko Sakai, PhD, Sotaro Enatsu, MD, PhD, Bente Frimodt-Møller, MSc, Tomoko Matsui, Sunoj Chacko Varughese, MSc, Michelle Carlsen, MS, Carla Visseren-Grul, MD, Kazuhiko Nakagawa, MD, PhD

“…In L858R (n = 110) and ex19del (n = 100) subgroups, the mOS was 54.3 versus 43.2 months (HR = 0.63, 95% CI: 0.40–0.99) and 53.9 versus 62.1 months (HR = 1.40, 95% CI: 0.86–2.28), respectively. T790M rates post-progression were 52.0% versus 51.1%, respectively. …”
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Identification and Characterization of Antiviral Activity of Synthetic Compounds Against Mayaro Virus by Ana Paula Andreolla, Andrea Cristine Koishi, Alessandra Abel Borges, Larissa Albuquerque de Oliveira, Viviane Guedes de Oliveira, Nerilson Marques Lima, Eloah Pereira Ávila, Pedro Pôssa de Castro, Giovanni Wilson Amarante, Mauro Vieira de Almeida, Juliano Bordignon, Claudia Nunes Duarte dos Santos

“…<b>Results:</b> Seven compounds showed anti-MAYV activity and were non-toxic for the following cell lines: Naringenin, LLA9A, chrysin, and its ester C6. Post-infection treatments with these selected compounds significantly decreased the percentage of infected cells and the release of infectious viral particles in the supernatant. …”
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COMMENTARY: LEARNER-BASED LISTENING AND TECHNOLOGICAL AUTHENTICITY by Richard Robin

“…Effective users of raw electronic resources, such as easily repeatable video clips, captions, and even translation bots will bring a wider variety of input at the proper level for a broader range of learning styles than could possibly be made available in any pre-packaged closed-track program.In listening comprehension, attention over the last twenty-five years has turned from adapted scripts to authentic audio and video in which we scaffold "real media" with remediated tasks (pre- and post-script activities) instead of changing the media itself. …”
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A pragmatic randomized trial to compare strategies for implementing primary HPV testing for routine cervical cancer screening in a large healthcare system by Chun R. Chao, Nancy Cannizzaro, Erin E. Hahn, Ernest Shen, Chunyi Hsu, Quyen Ngo-Metzger, Michael K. Gould, Corrine E. Munoz-Plaza, Michael H. Kanter, Patricia Wride, Lena H. Ajamian, Melissa Hodeib, Benjamin I. Broder, Ivette T. Curiel, Alicia Castaneda, Stephanie K. Ong, Krishnansu Tewari, Ramez N. Eskander, Devansu Tewari, Brian S. Mittman

“…., use of primary HPV screening) during the post-intervention period was high, with no observed difference between study arms: 98.4% (95% confidence interval [CI] 96.3%-100%) for the locally-tailored arm and 99.1% (95% CI: 97.8%-100%) for the centrally-administered arm (p = 0.34). …”
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Bismuth ferrite reinforced porous bioactive glass scaffolds: In vitro and antibacterial properties by S. Amitha Banu, Sk Hasanur Rahaman, Khan Sharun, Merlin Mamachan, Swapan Kumar Maiti, Amarpal, Subhadip Bodhak, Vamsi Krishna Balla, Abhijit M. Pawde

“…The BAG and BAG-BF porous scaffolds exhibited porosities of ∼74 % (BAG), ∼65 % (0.5 BAG-BF), and ∼64 % (1.5 BAG-BF), with post-sintering weight losses of 5 %, 2.5 %, and 5 %, respectively. …”
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S-nitros(yl)ation of CaMKIIα and its precision redox regulation by SNOTAC plays a critical role in learning and memory by Boyu Chu, Xinhua Qiao, Hui Ye, Xiaoli Cui, Shuli Zhang, Wenting Su, Yuying Zhang, Chuanxin Sun, Xuanhao Wu, Tiepeng Wang, Hua Li, Jianbing Wu, Zhangjian Huang, Chang Chen

“…To address this question, our study surprisingly observed that during learning and memory tasks, S-nitrosation of CaMKIIα, a key redox-based post-translational modification, significantly increased in mouse hippocampus. …”
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Integrated omics identifies molecular networks of brain-body interactions of brain injury by Yuan-Hong Deng, Hong Wang, Jia-Hang Zhang, Yu-Fei Wang, Meng-Yao Wang, Xin-Ru Pan, Yao-Dan Zhang, Yuan-Hui Gan, Yi He, Fang Xie, Xiao-Shuang Feng, Jia-Xin Xie, Bai-Tong Liu, Jiang-Tao Wang, Xin-Xiao Zhang, Peng-Fei Wang, Jie Li, Shu-Guang Yu, Qing-Wu Yang, Ming-Ze Bai, Yong Tang, Xiao-Yi Xiong

“…Ten DEPs were shared among three organs post-stroke, with eight in heart, six in spleen, and five in intestine. …”
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Effects of aerobic or resistance exercise during neoadjuvant chemotherapy on tumor response and therapy completion in women with breast cancer: The randomized controlled BENEFIT tr... by Martina E. Schmidt, Siri Goldschmidt, Charlotte Kreutz, Jana Müller, Andreas Schneeweiss, Anne M. May, Friederike Rosenberger, Joachim Wiskemann, Karen Steindorf

“…Results: Overall, there was no significant difference in post-intervention tumor size between RT or AT and WCG. …”
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Antimicrobial efficacy of methylene blue-functionalized graphene oxide-mediated photodynamic therapy against Enterococcus faecalis in root canal disinfection by Rizwan Jouhar, FCPS, Mohamad S. Halim, M.Res.Dent, Sayed A. Quadri, MD, Muhammad A. Ahmed, PhD, Faheem Shah, PhD

“…Sonic activation (groups 2, 4, and 6) was performed at 6000 cpm for 2 min, whereas laser activation (groups 3–6) was performed with a 650 nm, 200 mW laser for 2 min. Post-treatment CFU/mL counts and bacterial load decreases were recorded. …”
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Feasibility and Usability of a Web-Based Peer Support Network for Care Partners of People With Serious Illness (ConnectShareCare): Observational Study by Aricca D Van Citters, Megan M Holthoff, Colleen Young, Sarah M Eck, Amelia M Cullinan, Stephanie Carney, Elizabeth A O'Donnell, Joel R King, Malavika Govindan, David Gustafson, Stephanie C Tomlin, Anne B Holmes, Ann D Bradley, Brant J Oliver, Matthew M Wilson, Eugene C Nelson, Amber E Barnato, Kathryn B Kirkland

“…Two-thirds of the 250 members did not post, 20% (n=50) posted 1‐10 times, 6% (n=14) posted 11‐25 times, 6% (n=15) posted 26-100 times, and 3% (n=7) posted more than 100 times. …”
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The role of deubiquitinases in cardiovascular diseases: mechanisms and therapeutic implications by Xiangyu Fei, Xiangyu Fei, Xiangyu Fei, Xiangyu Fei, Xiangyu Fei, Chao Song, Chao Song, Chao Song, Chao Song, Jian Cui, Jian Cui, Jian Cui, Jian Cui, Yuqing Li, Yuqing Li, Yuqing Li, Yuqing Li, Yuqing Li, Xiaoyong Lei, Huifang Tang, Huifang Tang, Huifang Tang, Huifang Tang, Huifang Tang

“…The ubiquitination system is a vast and complex. It is an important post-translational modification that plays a crucial role in various cellular processes. …”
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On the problem of research schools in the library science by A. N. Vaneev, V. S. Kreydenko, V. A. Borodina, M. N. Kolesnikova, V. V. Orlov

“…It’s doubtful the desire to correlate a research school with the number of dissertations defended under the guidance of a supervisor, as the number of graduate students is not always dependent on the scientific head, but of the plan of admission to post-graduate school. As for RS it’s more important not the number of students, but what new things they introduce in the studied problem. …”
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Applications of Human‐Centered Design to Food Is Medicine Interventions: The THRIVE Pilot Trial by Khadijat Adeleye, Kennedy McDaniel, Irma Iribe, Adeline Assani‐Uva, Janice Dugbartey, Aminata Sinyan, Bijaya Bhattarai, Samantha DeMarco, Tosin Tomiwa, Mojisola Olusola‐Bello, Chelsea Akubo, Faith E. Metlock, D’Janee Kyeremeh, Adrián McMahon, Maya Kramer‐Johansen, India Washington, Peiyu Chen, Christy Rodriguez, Mia Johnson, William Xiao, Samuel Gledhill, Samuel Yeboah‐Manson, Natania Kurien, Lydia Vassiliadi, Jennifer Freeman, Anna Maria Izquierdo‐Porrera, Lessly Palencia, Valerie K. Sullivan, Yvonne Commodore‐Mensah, Oluwabunmi Ogungbe

“…Data collection included detailed session notes, post‐session surveys, prototypes, and documentation of visual outputs. …”
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Impacto de los cuidados domiciliarios en la calidad de vida. Análisis de la experiencia piloto “A Gusto en Mi Casa” by Javier García García, Álvaro Elices Acero, Juan María Prieto Lobato, Pablo De la Rosa Gimeno

“…Se recogieron datos a través de entrevistas semiestructuradas con las personas usuarias (Escala GENCAT pre-post), cuestionarios telefónicos de satisfacción y valoración de las atenciones y entrevistas con las profesionales orientadas a recoger su valoración experta sobre la implementación y los resultados del proyecto. …”
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Engineering injectable bone/bioadhesive grafts delivery system with self-healing properties for bone regeneration by Qingzu Liu, Bin Zhu, Huikai Yang, Chongyang Liu, Yurong Chen, Xiaoyu Wu, Wangling Duan, Luyao Feng, Binhui Wang, Liang Shao, Jianpeng Gao, Yazhong Bu, Hongjian Liu, Keya Mao, Jianheng Liu

“…Additionally, bone defects are frequently associated with substantial bleeding, and bone graft system often fail to effectively seal and prevent leakage, increasing the post-operative complications. In this study, based on PEG active ester (Bi-PEG-SG) and gelatin, we developed a micro-scale calf bone granules/PEG-Gelatin bioadhesive grafts delivery system with self-healing properties, which not only possesses antioxidant properties but also demonstrates injectability, shape adaptability, adhesive capabilities and high bursting pressure. …”
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International society of liquid biopsy (ISLB) perspective on minimal requirements for ctDNA testing in solid tumors by Nicola Fusco, Konstantinos Venetis, Francesco Pepe, Omshree Shetty, Silvia Calabuig Farinas, Simon Heeke, Julia V. Burnier, Simon J. Patton, Ellen Heitzer, Giovanni Nigita, Paul Hofman, Maria Jose Serrano, Massimo Cristofanilli, Eloisa Jantus-Lewintre, David R. Gandara, Christian Rolfo, Umberto Malapelle

“…Ensuring reliable and reproducible ctDNA testing necessitates standardization across the pre-analytical, analytical, and post-analytical phases. Key considerations include appropriate blood collection, efficient cfDNA isolation and purification, thorough assay validation, and precise data interpretation. …”
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Factors Influencing Nerinetide Effect on Clinical Outcome in Patients Without Alteplase Treatment in the ESCAPE-NA1 Trial by Mayank Goyal, Bijoy K. Menon, Johanna Ospel, Mohammed Almekhlafi, Charlotte Zerna, Raul Nogueira, Ryan McTaggart, Andrew M. Demchuk, Alexandre Y. Poppe, Brian Buck, Kathy Heard, Manish Joshi, Diogo Haussen, Shawna Cutting, Shelagh B. Coutts, Daniel Roy, Jeremy L. Rempel, Thalia S. Field, Dar Dowlatshahi, Brian van Adel, Richard Swartz, Ruchir Shah, Eric Sauvageau, Volker Puetz, Frank L. Silver, Bruce Campbell, René Chapot, Michael Tymianski, Michael D. Hill, on Behalf of the ESCAPE-NA1 Investigators

“…We constructed two multivariable models using variables known prior to randomization and variables known immediately post-EVT procedure to provide adjusted estimates of effect. …”
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Risk of neuropsychiatric and related conditions associated with SARS-CoV-2 infection: a difference-in-differences analysis by Yiwen Lu, Jiayi Tong, Dazheng Zhang, Jiajie Chen, Lu Li, Yuqing Lei, Ting Zhou, Leyna V. Aragon, Michael J. Becich, Saul Blecker, Nathan J. Blum, Dimitri A. Christakis, Mady Hornig, Maxwell M. Hornig-Rohan, Ravi Jhaveri, W. Schuyler Jones, Amber Brown Keebler, Kelly Kelleher, Susan Kim, Abu Saleh Mohammad Mosa, Kathleen Pajer, Jonathan Platt, Hayden T. Schwenk, Bradley W. Taylor, Levon H. Utidjian, David A. Williams, Raghuram Prasad, Josephine Elia, Christopher B. Forrest, Yong Chen

“…Neuropsychiatric outcomes are examined 28 to 179 days post-infection or negative test between March 2020 and December 2022. …”
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Complicaciones de la administración intraósea de vancomicina en artroplastia total de cadera by W.F. Martínez, L. Camacho Terceros, F. Garbini, E.J. Bochatey, F.A. Lopreite

“…Detailed records and documentation of complications during hospitalization and the first three months post-surgery were maintained. As a secondary outcome measure, the incidence of PJI was explored. …”
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