Comprehensive genomic and transcriptomic analyses reveal prognostic stratification for esophageal squamous cell carcinoma by Jian Gao, Qiming Wang, Fangqiu Fu, Yue Zhao, Teng Yang, Xiangze Li, Yihua Sun, Hong Hu, Longfei Ma, Longsheng Miao, Xiaoyang Luo, Ting Ye, Yiliang Zhang, Yang Zhang, Ziling Huang, Hang Li, Longlong Shao, Midie Xu, Kuaile Zhao, Shiyue Zhang, Mou Zhang, Jun Wang, Chong Dai, Xiaoxiao Shang, Tingyi An, Yawei Zhang, Jiaqing Xiang, Zhiwei Cao, Bin Li, Haiquan Chen

“…In contrast, activation of the epithelial-keratinization (EpK) pathway was strongly linked to favorable prognosis and lower post-chemotherapy recurrence rates. Independent validation supported S100A8 + S100A9 complex as a key marker of EpK pathway. …”
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Remote Ischemic Preconditioning Prevents Acute Kidney Injury Following Coronary Angiography by Oladipupo Olafiranye, MD, MS, Adam C. Straub, PhD, Yingze Zhang, PhD, Rahul Chaudhary, MD, MBA, Megan P. Miller, BS, Kathan Trivedi, MD, Lawrence Hoang, MD, Oussama Khalifa, MD, Adetola Ladejobi, MD, MPH, Floyd W. Thoma, BS, Ning Feng, MD, PhD, Aref Rahman, MD, John A. Kellum, MD

“…The product of urinary tissue inhibitor of metalloproteinase-2 and insulin-like growth factor-binding protein-7, 2 markers of AKI, significantly increased at 48 hours post-angiography compared to pre-angiography level (0.51 vs 0.89; P = 0.004) in the sham-RIPC but not in the RIPC group (0.39 vs 0.68; P = 0.091). …”
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Myostatin Levels in SMA Following Disease‐Modifying Treatments: A Multi‐Center Study by Fiorella Piemonte, Sara Petrillo, Anna Capasso, Giorgia Coratti, Adele D'Amico, Michela Catteruccia, Maria Carmela Pera, Concetta Palermo, Marika Pane, Emanuela Abiusi, Gianpaolo Cicala, Marianna Villa, Chiara Bravetti, Chiara Arpaia, Agnese Novelli, Salvatore Falqui, Stefania Fiori, Giulia Napoli, Silvia Baroni, Francesco Danilo Tiziano, Enrico Bertini, Giacomo Comi, Stefania Corti, Eugenio Mercuri

“…The longitudinal cohort included 46 treatment‐naive patients assessed at baseline and 12 months post‐treatment. Myostatin levels were measured using ELISA. …”
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Construction and Evaluation of a Rat Model of Abnormal Uterine Bleeding by LIAN Hui, JIANG Yanling, LIU Jia, ZHANG Yuli, XIE Wei, XUE Xiaoou, LI Jian

“…Uterine bleeding was recorded during the 48-hour observation period post-modeling. Serum and uterine tissue samples were collected from the model group at 0, 12, 24, 36, and 48 h after mifepristone administration, while the normal control group was sampled at 36 h. …”
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Magnolia officinalis enhanced immune responses and the resistance to Vibrio harveyi infection in pearl gentian groupers by Yilin Zhang, Yilin Zhang, Yuhao Li, Yuhao Li, Xinlan Xu, Xinlan Xu, Luxi Xu, Luxi Xu, Weifu Li, Weifu Li, Zhen Gan, Zhen Gan, Yishan Lu, Yishan Lu

“…After being challenged with V. harveyi ZJ0603 at 28 days post-injection, the survival rate (SR) of groupers were 50.0, 60.0, 73.3, and 66.7% in MO groups at different concentrations, respectively, indicating that MO administration could improve the resistance to V. harveyi infection in groupers. …”
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Transcranial direct current stimulation over the temporal-parietal junction yields no lexical-semantic effects in logopenic primary progressive aphasia: a double-blind sham-control... by Marc Teichmann, Clara Sanches, Angelina Bourbon, Dennis Q. Truong, Marom Bikson, Antoni Valero-Cabré

“…Computational modeling was used to characterize predicted cortical tDCS current distribution.Comparisons of post/pre-tDCS results did not show language improvement in any task. …”
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Adjuvant melatonin therapy during exercise prescription in breast cancer survivors on physical and anthropometric parameters, quality of life, and hormonal response. A randomized c... by Ana M. Celorrio San Miguel, Luis M. Cacharro, Gema Santamaría, Manuel Garrosa, Manuel Garrosa, Marta Celorrio San Miguel, Enrique Roche, Enrique Roche, Enrique Roche, Enrique Roche, Evelina Garrosa, Diego Fernández-Lázaro, Diego Fernández-Lázaro, Diego Fernández-Lázaro

“…Our findings suggest no clear effect of melatonin in post-treatment for BCS in the mentioned parameters. …”
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The Impact of Whole Body Vibration on Muscle Tone, and Sensory Motor Function in Children with Spastic Diplegic Cerebral Palsy by Hussein HM, Dakheel N, Alshammari HZM, Alshammari AA, Gabr AM, El-Shamy SM, SD S, A RH, Dewir IM, Mohamed AR, Ibrahim AA

“…However, there were limited studies involving the effect of WBV on the tone and function of diplegic CP; we aimed to investigate the effect of WBV on muscle tone, function, and sensorimotor function in children with CP.Patients and Methods: This is a single-blind randomized controlled clinical trial involving 54 spastic diplegic CP child recruited from local rehabilitation centers in the Ha’il region of Saudi Arabia, they were randomly divided into the WBV group (n = 28 with mean age of 9.47± 1.92), which received standard physical therapy and WBV therapy, and the control group (n = 26 with mean age of 9.73± 1.62) they received standard physical therapy three time per week for four weeks; Muscle tone, function, strength and Sensory motor integration were evaluated pre and post interventions.Results: At baseline, the two groups had no significant differences. …”
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Efficacy and safety of flupentixol-melitracen in patients with refractory chronic cough: a randomised, double-blinded, placebo-controlled clinical trialResearch in context by Qiang Chen, Mengru Zhang, Li Zhang, Alimire Aierken, Ran Dong, Xianghuai Xu, Li Yu, Kefang Lai, Zhongmin Qiu

“…The safety set (SS) was used for safety analysis and included all patients who took at least one dose of treatment and had post-dose safety records. The FAS and SS were equivalent in this study. …”
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<i>Cenostigma bracteosum</i> Hydroethanolic Extract: Chemical Profile, Antibacterial Activity, Cytotoxicity, and Gel Formulation Development by Addison R. Almeida, Francisco A. S. D. Pinheiro, Marília G. M. Fideles, Roberto B. L. Cunha, Vitor P. P. Confessor, Kátia N. Matsui, Weslley S. Paiva, Hugo A. O. Rocha, Gislene Ganade, Laila S. Espindola, Waldenice A. Morais, Leandro S. Ferreira

“…The prepared gels remained stable over the 30-day post-production analysis period. <b>Conclusions</b>: These findings provide a better understanding of the chemical diversity of the secondary metabolites of a common Caatinga biome species—<i>C. bracteosum</i>—specifically present in leaves hydroethanolic extract and gel formulation adapted for skin application with activity against <i>S. aureus.…”
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Trends in prescription opioid use in Europe: A DARWIN EU® multinational cohort study including seven European countries by Junqing Xie, Mike Du, Yuchen Guo, Cesar Barboza, James T. Brash, Antonella Delmestri, Talita Duarte-Salles, Talita Duarte-Salles, Jasmine Gratton, Romain Griffier, Raivo Kolde, Wai Yi Man, Núria Mercadé-Besora, Marek Oja, Sarah Seager, Katia Verhamme, Dina Vojinovic, Edward Burn, Daniel Prieto-Alhambra, Daniel Prieto-Alhambra, Martí Català, Annika M. Jödicke

“…More data are needed to monitor evolving opioid prescription patterns in Europe, particularly in the post-pandemic era.…”
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Effect of Platelet-rich Fibrin on Soft-tissue and Hard-tissue Healing following Surgical Extraction of Mandibular Third Molar: A Prospective Interventional Study by Sudip Chakraborty, Chayan Kundu, Samiran Ghosh, Richi Burman, Avishek De Sarkar, Gourab Mandal, Somak Saha

“…Soft-tissue healing evaluation was performed using the parameters of the healing index on the 3rd, 7th, 14th, and 28th post-extraction days by two blind observers. Hard-tissue healing was evaluated using the Cone Beam Computed Tomography (CBCT) findings on the 1st month and 3rd month postoperatively. …”
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Role of Frailty Index-Laboratory to predict COVID-19 mortality: a prospective study by Elda De Vita, Nicola Veronese, Giacomo Guido, Luisa Frallonardo, Sergio Cotugno, Giorgia Manco Cesari, Marinella Cibelli, Alessandra Vigna, Davide Capruzzi, Monica Fiorella, Carmen Rita Santoro, Gaetano Brindicci, Francesco Di Gennaro, Annalisa Saracino

“…Mortality data were collected up to 90 days post-admission. Cox regression analysis, adjusting for demographics, comorbidities, COVID-19 symptoms, and vaccination status, was employed to examine the relationship between FI-LAB scores and mortality.ResultsOne thousand, four hundred ninety-two patients were included in the study population, the mean age was 57.2 years (SD = 15.9), with 56.6% being male. …”
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Suppressing lipid biosynthesis in Mycobacterium tuberculosis through polyketide synthase 13 thioesterase inhibition: Insights from computational analysis by Maha M. Alawi, Hattan S. Gattan, Azzah S. Alharbi, Mohammed H. Alruhaili, Ibrahim A. Al-Zahrani, Saad B.AL Masaud, Vivek Dhar Dwivedi, Esam I. Azhar

“…The molecular dynamics simulation was applied to analyze the structural properties in terms of stability, compactness, and flexibility of the post-validation of the docking result. The MMGBSA method was used to calculate the binding-free energy. …”
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Predictors of response and enteral autonomy in children with short bowel syndrome treated with teduglutide: a real-life multicentre cohort studyResearch in context by Lorenzo Norsa, Arianna Ghirardi, Esther Ramos Boluda, Anat Guz-Mark, Iva Hojsak, Johannes Hilberath, Ilse Juia Broekaert, Rocío González Sacristán, Antonella Lezo, Paula Guerra, Pierre Poinsot, Cecile Lambe, Lorenzo D'Antiga

“…Information on patients’ post-surgical anatomy, amount of PN calories and volume required at baseline and at 3, 6 and 12 months after TED start, along with biochemical markers of PN tolerance and complications, were recorded. …”
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Hydration assessment and physical performance of mountain bike cyclists in competition in a hot environment by Rayane Carvalho de Moura, Crislane de Moura Costa, Cirley Pinheiro Ferreira, Valmir Oliveira Silvino, Bruna Lorena Soares Cavalcante Sousa, Esmeralda Maria Lustosa Barros, Leandra Caline dos Santos, Karoline de Macêdo Gonçalves Frota, Sandro Soares Almeida, Sérgio Luís Galan Ribeiro, Acácio Salvador Veras e Silva, Michelly da Silva Pinheiro, João Victor Neves Veras, Paulo Henrique Carvalho de Sousa, Guilherme de Azambuja Pussieldi, Glêbia Alexa Cardoso, Marcos Antonio Pereira dos Santos

“…There was a significant decrease in body mass between the pre- and post-competition moments (79.15 ± 14.65 kg; 76.15 ± 14.36 kg) (p = 0.000). …”
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THE AESTHETICS OF RUINS IN VERNACULAR PHOTOGRAPHY IN RUSSIAN SOCIAL MEDIA: STATING THE RESEARCH PROBLEM / ЭСТЕТИКА РУИН В ВЕРНАКУЛЯРНОЙ ФОТОГРАФИИ РУССКОЯЗЫЧНЫХ СОЦИАЛЬНЫХ МЕДИА: П... by CHUMAKOVA VARVARA PAVLOVNA / ЧУМАКОВА ВАРВАРА ПАВЛОВНА

“…As our research has demonstrated, the popularity of the aesthetization of ruins in the modern network culture may be associated with the crisis of identity and the reevaluation of relations with the past in the post-Soviet space. Статья посвящена феномену вернакулярной фотографии руин и связанных с ней изображений в современных русскоязычных социальных медиа. …”
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Pirfenidone Prevents Myocarditis by Restoring Metabolic Hormone Levels in a Mouse MASH Model and its Effect on H9c2 Myoblast Viability under Glucolipotoxicity by Daniel López-Cifuentes, Ana S. Sandoval-Rodríguez, Ángel O. Vázquez-Esqueda, Jonathan S. Rodríguez-Sanabria, Juan Armendáriz-Borunda, Jorge Gutiérrez-Cuevas

“…The data were analyzed using one-way ANOVA followed by Tukey's post-hoc test in Graphpad Prism v10.0. Results: HFHC mice developed MASH, myocarditis and fibrosis (P≤0.05). …”
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Characterization of Netrin-1 and Its Receptors UNC5B and Neogenin-1 in a Rat Rotator Cuff Tear Model: Associations with Inflammatory Mediators and Neurite Extension by Kosuke Inoue, Kentaro Uchida, Mitsuyoshi Matsumoto, Ryo Tazawa, Etsuro Ohta, Akito Hattori, Tomonori Kenmoku, Yuka Ito, Yui Uekusa, Gen Inoue, Masashi Takaso

“…A rat supraspinatus tear model was employed to assess, in vivo, the expression of genes encoding netrin-1 (<i>Ntn1</i>) and its receptors (<i>Unc5b</i> and <i>Neo1</i>) at 0, 7, 14, 28, and 56 days post-injury (n = 10 per time point). Primary rat tenocytes isolated from rotator cuff tissue were treated in vitro with recombinant netrin-1, and transcriptional changes in genes encoding TNF-α (<i>Tnfa</i>), IL-6 (<i>Il6</i>), MMP-1 (<i>Mmp1</i>), and MMP-3 (<i>Mmp3</i>) were quantified by qRT-PCR. …”
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C-reactive protein-to-prealbumin ratio as prognostic marker in hemodialysis patients with Omicron infection by Quanchao Zhang, Caibao Lu, Zhifen Wu, Shaofa Wu, Lili Jiang, Han Wang, Jin He, Bingshuang Tang, Bingfeng Yang, Shengli Liao, Liao Wang, Hongwei Chen, Moqi Li, Wenchang He, Yiqin Wang, Jie Li, Jinghong Zhao, Ling Nie

“…Survival rate differences between higher and lower CP ratio groups were analyzed using the Kaplan-Meier method.Results From the total, 98 patients (11.6%) succumbed, with a majority (80/98) within a month post-infection. C-reactive protein, prealbumin, and CP ratio were all associated with all-cause mortality in the crude model. …”
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