Assessment of effectiveness and safety of thrombolytic therapy to pulmonary emboli by endobronchial ultrasound-guided transbronchial needle injectionCentral MessagePerspective by Yuki Sata, MD, PhD, Masato Aragaki, MD, PhD, Terunaga Inage, MD, PhD, Nicholas Bernards, PhD, Alexander Gregor, MD, PhD, Shinsuke Kitazawa, MD, PhD, Fumi Yokote, MD, PhD, Takamasa Koga, MD, PhD, Hiroyuki Ogawa, MD, PhD, Yoshihisa Hiraishi, MD, PhD, Tsukasa Ishiwata, MD, PhD, Andrew Effat, MS, Kate Kazlovich, MS, Harley Chan, PhD, Ichiro Yoshino, MD, PhD, Kazuhiro Yasufuku, MD, PhD, FRCSC

“…Considering the elapsed time, the average decrease of clot volume per hour at pre-t-PA to post t-PA was significantly greater in the TBNI group than in the systemic group (mm3/hour: systemic 68.1 ± 68.1 vs TBNI 256.8 ± 148.1, P < .05). …”
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Challenges and prospects in mentoring medical scientists in Latin America: a narrative review and recommendations by Rodrigo C. Menezes, Rodrigo C. Menezes, Rodrigo C. Menezes, Caian L. Vinhaes, Caian L. Vinhaes, Caian L. Vinhaes, Caian L. Vinhaes, Felipe Ridolfi, Felipe Ridolfi, Isabella B. B. Ferreira, Isabella B. B. Ferreira, Isabella B. B. Ferreira, Isabella B. B. Ferreira, Moises A. Huaman, Cesar Ugarte-Gil, Bruno B. Andrade, Bruno B. Andrade, Bruno B. Andrade, Bruno B. Andrade

“…ObjectiveTo identify the challenges for the development and mentorship of physician-scientists in Latin America, outline the key barriers to integrating research training into medical education and post-graduate pathways, and propose recommendations to foster structured mentorship, improve institutional support, and strengthen the research ecosystem for future physician-scientists.Study designNarrative review.MethodsA narrative review of relevant literature, institutional reports, and existing educational models was undertaken. …”
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Fecal Metabolome and Bacterial Composition in Severe Obesity: Impact of Diet and Bariatric Surgery by Nuria Salazar, Manuel Ponce-Alonso, María Garriga, Sergio Sanchez-Carrillo, Ana María Hernández-Barranco, Begoña Redruello, María Fernández, José Ignacio Botella-Carretero, Belén Vega-Piñero, Javier Galeano, Javier Zamora, Manuel Ferrer, Clara G de Los Reyes-Gavilán, Rosa Del Campo

“…Each participant contributed 4 fecal samples (baseline, post-diet, 1 month after surgery and 3 months after surgery). …”
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In-vitro and bioinformatic studies of bioactive compounds from Oceanimonas sp. JM-AZM31 and Lysinibacillus fusiformis JM-AZM37 of sponge-associated marine bacteria from a mangrove... by Jendri Mamangkey, Corrina Lailatul Fadjri, Sunarto, Apon Zaenal Mustopa, Dwi Suryanto, Nabila Swarna Puspa Hermana, Nur Arfa Yanti, Kusmiati Kusmiati, Herman Irawan, Adrian Hartanto, La Ode Adi Parman Rudia, Rizna Akmaliyah, Lucas William Mendes, Ferdin

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Sex-related differences in postoperative patient-reported outcomes among lung cancer patients: a multicenter cohort study by Jia Liao, Xiaoqun Hu, Xing Wei, Wei Dai, Hongfan Yu, Xin Tian, Yaqin Wang, Qin Qin, Na Xu, Yuanyuan Li, Qiang Li, Qiuling Shi, Xiaoqin Liu

“…Abstract Background Studies on sex-related differences in post-lung cancer surgery symptoms are limited. Understanding these differences may provide insights into patient recovery. …”
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Neuropsychiatric symptoms cluster as primary drivers of Long COVID complexity: a South Texas retrospective cohort study by Anne Marie Wells, Anne Marie Wells, Summer Rolin, Summer Rolin, Barbara Robles-Ramamurthy, Gabriela Gibson-Lopez, Gabriela Gibson-Lopez, Martin Goros, Jonathan A. Gelfond, Stephen Gelfond, Philip Balfanz, Melissa Deuter, Donald McGeary, Donald McGeary, Monica Verduzco-Gutierrez, Monica Verduzco-Gutierrez

“…Long COVID, previously known as Post-Acute Sequelae of SARS-CoV-2 (PASC), refers to prolonged symptoms or diagnosable conditions following COVID-19 infection. …”
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The Effect of Cerebellar Vermal rTMS with TBS Paradigm on Negative Symptoms, Cognitive Function and Serum Inflammatory Factors in Elderly Patients with Chronic Schizophrenia: a Ran... by DONG Xiaomei, ZHAO Hongyan, GENG Zhongli, XU Tianchao, WANG Qi

“…Compared with the control group, the observation group had higher post-treatment information processing speed scores [ (39.78±2.45) scores vs (37.24±1.10) scores], attention alertness scores [ (47.07±4.27) scores vs (40.01±2.17) scores], working memory scores [ (45.12±3.20) scores vs (41.89±4.11) scores], and social cognitive scores [ (46.40±4.29) scores vs (41.42±7.45) scores] (P&lt;0.05) . …”
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Pre-exposure prophylaxis of COVID-19 with tixagevimab/cilgavimab (Evusheld) in 63 rituximab-treated patients with ANCA-associated systemic vasculitis: two-year follow-up results by T. V. Beketova, N. O. Levina, Yu. A. Uskova, I. V. Rozanova, M. V. Dubinskaia, S. A. Evdokimova, V. V. Babak, M. F. Beketova, A. V. Devyatkin

“…At the same time, in immunocompromised patients, in particular those receiving anti-B cell therapy with rituximab (RTX), the post-vaccination effect may be insufficient. Since 2022 the long-acting virus-neutralizing monoclonal antibodies (MAB) tixagevimab and cilgavimab (Evushheld, AZD7442) have been used as pre-exposure prophylaxis for COVID-19.The aim of the study is to evaluate the effectiveness of tixagevimab and cilgavimab (TC) for pre-exposure prophylaxis of COVID-19 and its safety in RTX treated patients with AAV.Materials and methods. …”
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What are the broader impacts and value from a randomised controlled trial conducted in six public hospital antenatal clinics in Australia? An impact assessment using the Framework... by Peter G Gibson, Kirsten McCaffery, John Attia, Joerg Mattes, Megan E Jensen, Andrew Searles, Paul B Colditz, Shanthi Ann Ramanathan, Vanessa E Murphy, Michael Hensley, Michael Peek, Andrew Bisits, Leonie Kaye Callaway, Helen Barrett, Sean Seeho, Melanie Rao, Elissa Elvidge, Karen McLaughlin, Annelies Robijn, Warwick Giles, Alistair Abbott

“…Of the 1200 mothers who were part of BLT, 508 now have written asthma plans, 268 had a clinically significant improvement in their asthma control score and the proportion who improved their asthma plan knowledge increased by 58 percentage points from 12 to 70%.Conclusion This case example in the developing field of impact assessment illustrates how researchers can use evidence to demonstrate and report more broadly on the impact of and returns on research investment in a clinical trial.Trial registration number ACTRN12613000202763; Post results.…”
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Genetic diversity, heritability, and estimated breeding values for growth of domesticated Asian seabass Lates calcarifer from Thailand by Sirikan Prasertlux, Atra Chaimongkol, Jutaporn Chaimongkol, Sirithorn Janpoom, Sureerat Tang, Puttawan Rongmung, Wanwipa Ittarat, Parichart Ninwichian, Putth Songsangjinda, Takashi Sakamoto, Bavornlak Khamnamtong, Panya Sae-Lim, Sirawut Klinbunga

“…Heritability and estimated breeding values (EBVs) for growth in G0 families were evaluated at 519 day post hatch (dph, mean body weight = 616.64 ± 266.80 g, N = 1655). …”
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Experience with Tixagevimab and Cilgavimab (Evusheld) in 86 rheumatic patients undergoing anti-B cell therapy with rituximab by T. V. Beketova, N. О. Levina, M. V. Dubinskaia, Yu. A. Uskova, I. V. Rozanova, V. V. Babak, M. F. Beketova, T. N. Krasnova

“…The presence of IRD is associated with a high risk of disease and severe course of COVID-19 during immunosuppressive treatment, primarily anti-B cell therapy with rituximab (RTX), and a low level of post-vaccination response in such patients. A new strategy for the prevention and treatment of COVID-19 are virus-neutralizing monoclonal antibodies to coronavirus; currently, combined long-acting monoclonal antibodies tixagevimab and cilgavimab (Evusheld) are registered for prevention in the world and the Russian Federation. . …”
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Engineering a 3D platform for testis bioengineering: generation and proteomic profiling of decellularized fish testicular scaffolds by Ivana Felipe Rosa, Ivana Felipe Rosa, Ivana Felipe Rosa, Beatriz Marques Souza, Lucas Benites Doretto, Lucas Benites Doretto, Maira da Silva Rodrigues, Caroline Nascimento Barquilha, Matheus Naia Fioretto, Luiz Marcos Frediani Portela, José Carlos Souza Vieira, Luis Antonio Justulin, Pedro de Magalhães Padilha, Changwei Shao, Changwei Shao, Rafael Henrique Nóbrega

“…Notably, critical ultrastructural features—such as the basal lamina, seminiferous tubules, and the D-periodic banding pattern of collagen fibrils—were retained post-decellularization. Proteomic analyses revealed enrichment of proteins associated with ECM organization, cell adhesion, and collagen biosynthesis, while proteins involved in glycolysis and metabolic pathways were downregulated. …”
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Clinical Evidence of Acupoint Stimulation for Primary Dysmenorrhea: A Systematic Review and Updated Meta-Analysis by Wang Y, Liu L, Wu X, Wu Y, Qin R, Wang M, Zhou B, Sun J, Song Y, Zhang M, Li M, Yu L

“…Compared with non-steroidal anti-inflammatory drugs (NSAIDs), acupoint stimulation showed both immediate effects (post-first-treatment SMD − 2.85, 95% CI − 4.06 to − 1.64) and sustained benefits (3 cycles SMD − 1.58, 95% CI − 2.43 to − 0.73; following 3 cycles SMD − 3.74, 95% CI − 5.57 to − 1.90), particularly with invasive techniques. …”
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Cardiovascular risks associated with adjuvant endocrine therapy in women with breast cancer: a population-based cohort study by Iokfai Cheang, Ying Gue, Mei-Zhen Wu, Jia-Yi Huang, Qing-Wen Ren, Ziqi Chen, Yi-Kei Tse, Hang-Long Li, Yap-Hang Chan, Hung-Fat Tse, Xinli Li, Gregory Y. H. Lip, Kai-Hang Yiu

“…Conclusion The study indicates that AIs are linked to a higher risk of cardiovascular events in post-menopausal patients compared to TMX. In younger patients, TMX’s protective effect on cardiovascular outcomes may be less pronounced. …”
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Peculiarity of Clinical Course of Childhood Hepatitis C Depending on the Viral Genotype by E. A. Leybman, L. I. Nikolaeva, E. I. Samokhvalov, K. K. Kyuregayn, O. V. Isaeva, G. V. Sapronov, T. V. Cherednechenko, A. G. Pisarev, A. E. Grishechkin, M. I. Michailov, V. F. Uchaikin

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Sex differences in discontinuations due to side effects of second-generation integrase strand transfer inhibitors: a systematic review and meta-analysisResearch in context by Zhou Fang, Tetiana Povshedna, Rowan Patterson, Erin Ready, Helene C.F. Cote, Melanie C.M. Murray, Elizabeth M. King

“…Studies in pregnancy, post-partum, pediatrics, co-infections (e.g., TB), and monotherapy were excluded. …”
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Un broche de cinturón tardoantiguo de la cueva de Lazaldai (Zuia, Álava/Araba) by José Ángel Hierro Gárate, Enrique Gutiérrez Cuenca, Leticia Tobalina Pulido, Diego Garate Maidagan, Iñaki Intxaurbe Alberdi, Antonio Torres Riesgo, Sergio Salazar Cañarte

“…This f ind contributes to our understanding of regional identity construction and the circulation of objects and ideas in post-Roman western Europe.…”
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Breaking prolonged sitting with high-intensity interval training to improve cognitive and brain health in middle-aged and older adults: a protocol for the pilot feasibility HIIT2SI... by Charles Hillman, Talha Syed, Dominika M Pindus, Tomasz S Ligeza, Jin Kuang, Scott Paluska, Joseph So, Miroslaw Wyczesany, Jesus Sarol, Flor B Quiroz, Ramiya Shanmugam, Maciej Kos, Naiman Khan, Art Kramer

“…The primary outcomes include the feasibility (recruitment and retention rates, percentage of valid electroencephalogram data), acceptability of time commitment, HIIT bouts and neurocognitive assessments, fidelity (the intensity of HIIT breaks, percentage of time spent sitting) and the amplitude and the latency of the P3b component of event-related brain potentials measured during the modified Eriksen flanker task at pretests, after the first and the third PA bout and at post-test. General linear mixed-effects models will be used to test the effects of the intervention on the P3b component.Ethics and dissemination The Institutional Review Board at the University of Illinois Urbana-Champaign provided the ethical approval for the study. …”
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Glucose metabolism in heterozygous familial hypercholesterolemia with a founder effect and a high diabetes prevalence: a cross-sectional study by Ana María González-Lleó, Yeray Brito-Casillas, Virginia Martín-Santana, Yaiza Gil-Quintana, Antonio Tugores, Roberto Scicali, Marta Riaño, Luisa Hernández-Baraza, Roberto Jiménez-Monzón, Josefa Girona, Francesco Di Giacomo Barbagallo, Luis Masana, Mauro Boronat, Ana M. Wägner, Rosa M. Sánchez-Hernández

“…Compared with HeFH-It patients, HeFH-GC individuals had higher fasting glucose levels (99 vs. 92.5 mg/dL; p = 0.004) and lower 120-min post-OGTT glucose levels (115 vs. 136.5 mg/dL; p = 0.001). …”
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Histone deacetylases facilitate Th17-cell differentiation and pathogenicity in autoimmune uveitis via CDK6/ID2 axis by Chun Zhang, Xiuxing Liu, Chenyang Gu, Yuhan Su, Jianjie Lv, Yidan Liu, Yuehan Gao, Hui Chen, Nanwei Xu, Jing Xiao, Zhuping Xu, Wenru Su

“…Our further studies showed that targeted inhibition of HDACs effectively alleviated EAU, restored its Th17/Treg balance, and reduced inflammatory gene expression, especially in CD4+ T cells. Post-HDACs inhibition, Treg proportions increased with enhanced immunomodulatory effects. …”
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