Ten-Year Evaluation of Ventilator-Associated Pneumonia (VAP) According to Initial Empiric Treatment: A Retrospective Analysis Using Real-World Data by Alejandro Rodríguez, Julen Berrueta, Carolina Páez, Ronny Huertas, Marco Marotta, Laura Claverias, Josep Gómez, Sandra Trefler, Frederic F. Gómez Bertomeu, María Dolores Guerrero-Torres, Sergio Pardo-Granell, Ester Picó-Plana, Alicia Selles-Sánchez, Francisco Javier Candel, Ignacio Martín-Loeches, María Bodí

“…The population was divided into three periods: (P1) from 2014 to 2018 (pre-COVID-19); (P2) from 2019 to 2021 (COVID-19); and (P3) from 2022 to 2024 (post-COVID-19). Binary logistic regression was used to identify which variables were independently associated with ICU mortality. …”
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Genetic variants in immune mediators as potential molecular biomarkers for oral cancer evaluation: Insights from a systematic revaluation by computational analyses and Bayesian app... by Juliana Campos Botelho, Samuel Arcebispo Brasileiro, André Victor Oliveira Monteiro, Alessandro Luiz Araújo Bentes Leal, Naum Neves da Costa dos Santos, Gabrielly Ribeiro Alves, Reyce Santos Koga, Haline Alves da Silva, José Rogério Souza Monteiro, Denis Vieira Gomes Ferreira, Adenilson Leão Pereira, Ana Carolina Alves de Oliveira, Márcia Socorro Silva Lima Duarte, Felipe Rodolfo Pereira da Silva

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Creatine monohydrate versus creatine hydrochloride on strength and body composition in elite team-sport athletes: A placebo-controlled randomized clinical trial comparing low dosag... by Daniel Londoño-Velásquez, Yuliana Zuluaga-Narváez, Luis Rojas-Posada, Maximiliano Kammerer-López, Óscar M. Cardona-Arenas, Olga L. Quiroz-Bastidas, Mario A. Quintero-Velásquez, Andrés Rojas-Jaramillo, Richard B. Kreider, Diego A. Bonilla

“…All groups followed an 8-week supplementation protocol with standardized body composition and performance tests assessed pre- and post-intervention. The isokinetic strengths and peak torque of the external and internal rotation muscle strengths of the bilateral shoulders were measured using a Humac Norm isokinetic dynamometer (Computer Sports Medicine Inc., Stoughton, MA, USA). …”
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Robot-assisted augmented reality navigation for osteotomy and personalized guide-plate in mandibular reconstruction: a preclinical study by Xing Li, Qing Sun, Long Shao, Zhihui Zhu, Ruiqi Zhao, Fanhao Meng, Zehua Zhao, Kedi Jihu, Xiting Xiang, Tianyu Fu, Danni Ai, Minghao Huo, Xiaojun Wang, Jian Yang, Tao Zhang

“…Abstract Background Oral and maxillofacial tumors, particularly those requiring mandibular reconstruction, present significant clinical challenges due to the complexities involved in achieving precise surgical outcomes and ensuring post-operative stability. Traditional methods for mandibular reconstruction, such as freehand bending of titanium plates, often result in errors in osteotomy and reconstruction, compromising both the precision and stability of the procedure. …”
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Assessment of regional variation in the management of heart failure with a preserved ejection fraction between the Russian Federation and the European Union: the results of the int... by Nathan Mewton, Clara Saldarriaga, Irina Dyachuk, Han Naung Tun, Ilya Giverts, Anastasia Shchendrygina, Natalia Cherkasova, Aleksandr Suvorov, Irina Komarova, Nadezhda Mukhina, Violetta Sitnikova, Elena Kuzheleva, Soloveva Anzhela, Nikolay Novitsky, Andrey Baglikov, Alina Bibarsova, Anastasia Rogova, Viktoria Lezhneva, Ekaterina Stepanenko, Sydney Goldfeder de Gracia, Vergun Marija, Yu V Mareev, Galib Imanov

“…We aimed to assess a physician-reported HFpEF management in the Russian Federation (RF) and a variation in the diagnosis and treatment of HFpEF between the RF and the European Union (EU).Design/settings It is a post hoc analysis of an academic web-based international HFpEF designed as a cross-sectional survey and conducted between May 2023 and July 2023.Participants Medical doctors who work in the fields of cardiology and general medicine.Results Among 1460 medical doctors who completed the study were 166 Russian and 646 European specialists. …”
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An Evaluation of the Safety, Immunogenicity, and Protective Efficacy of a Combined Diphtheria–Tetanus–Acellular Pertussis, <i>Haemophilus influenzae</i> Type b, and ACYW135 Meningo... by Xiuwen Sui, Zhujun Shao, Yuanyuan Ji, Hairui Wang, Qingfu Xu, Bochao Wei, Zhuojun Duan, Chang Wang, Ying Yang, Jiayu Zhao, Tao Zhu

“…Orbital blood was collected 14 days post-immunization to measure IgG titers against pertussis, diphtheria, tetanus, Hib, and meningococcal antigens. …”
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Timing of mechanical ventilation and its association with in-hospital outcomes in patients with cardiogenic shock following ST-elevation myocardial infarction: a multicentre observ... by Waleed AlHarbi, Mohammed Qutub, Prashanth Panduranga, Jassim Al Suwaidi, Wael Al Mahmeed, Hassan Khan, Sultan Alobaikan, Abdullah Alenezi, Mohammed AlShehri, Abdulrahman Arabi, Amin Daoulah, Awad Abdulrazaq AlQahtani, Zubair Shahid, Ahmed Jamjoom, Ahmed Elmahrouk, Abeer Said Mohamed Al Rawahi, Gladsy Selva Livingston, Ala’a Al-deen Tayseer Mousa, Hatem Aloui, Mubarak Aldossari, Nooraldaem Yousif, Husam Noor, Rajesh Rajan, Amr A Arafat, Omar Kanbr, Alsayed Almarghany, Mokhtar Kahin, Abdulwali Abohasan, Faisal Al Nasser, Badr Alzahrani, Alaa Aldossari, Taher Hassan, Mohammed Ali Balghith, Khalid Alshali, Amir Lotfi

“…Increased delay in MV was associated with a higher mortality risk during the first 60 min post-diagnosis, beyond which the risk plateaued. …”
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Placental epigenetic clocks derived from crowdsourcing: Implications for the study of accelerated aging in obstetrics by Gaurav Bhatti, Herdiantri Sufriyana, Roberto Romero, Tushar Patel, Fasil Tekola-Ayele, Ibrahim Alsaggaf, Nardhy Gomez-Lopez, Emily C.Y. Su, Bogdan Done, Steve Hoffmann, Alena van Bömmel, Cen Wan, Jake Albrecht, Charles Novak, Tinnakorn Chaiworapongsa, Marina Sirota, Nima Aghaeepour, Gustavo Stolovitzky, David R. Bryant, Adi L. Tarca

“…Models developed during and post-challenge compared favorably to existing models in terms of accuracy, yet they were better calibrated throughout gestation and indicated that reports of accelerated epigenetic aging in preterm preeclampsia were likely due to modeling artifacts. …”
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Intranasal Administration of Cold-Adapted Live-Attenuated Eurasian Avian-like H1N1 Vaccine Candidate Confers Protection Against Different-Lineage H1N1 Viruses in Mice by Qiu Zhong, Zuchen Song, Fei Meng, Yanwen Wang, Yijie Zhang, Zijian Feng, Yali Zhang, Yujia Zhai, Yan Chen, Chuanling Qiao, Hualan Chen, Huanliang Yang

“…In mice, it was attenuated, with viral titers in the nasal turbinates and lungs reduced 1000–10,000-fold compared to the wild-type strain, and it cleared by day 5 post infection. Intranasal immunization elicited strong cross-reactive immune responses. …”
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Suicídio decomposto by Vera Couto, Tatiana Gomes, Rui Almeida, Eduarda Duarte

“…Nos casos em que os cadáveres se apresentam em avançado estado de decomposição, esta classificação poderá ser mais difícil de estabelecer, tendo em conta que eventuais lesões traumáticas poderão estar dissimuladas por fenómenos post mortem. Apresentação do caso: Um cadáver em avançado estado de decomposição apareceu no areal de uma praia. …”
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Multi-omics and AI-driven advances in miRNA-mediated hair follicle regulation in cashmere goats by Zhang Chunhua, Zhang Chunhua, Zhang Chunhua, Fu Le, Fu Le, Fu Le, Li Shengli, Li Shengli, Li Shengli, Wu Sachula, Wu Sachula, Wu Sachula, Hua Bao, Hua Bao, Hua Bao, Mu Lan, Mu Lan, Mu Lan, Marco Antonini, Sun Haizhou, Sun Haizhou, Sun Haizhou

“…Hair follicle development and cycling are governed by intricate genetic and molecular networks, with microRNAs (miRNAs) playing essential roles as post-transcriptional regulators. In cashmere goats, valued for their fine fiber, miRNAs have emerged as key modulators influencing hair follicle morphogenesis, regeneration, and fiber traits such as fineness and pigmentation. …”
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Neutralization sites of human papillomavirus-6 relate to virus attachment and entry phase in viral infection by Xinlin Liu, Jie Chen, Zhiping Wang, Daning Wang, Maozhou He, Ciying Qian, Shuo Song, Xin Chi, Zhibo Kong, Qingbing Zheng, Yingbin Wang, Hai Yu, Qinjian Zhao, Jun Zhang, Shaowei Li, Ying Gu, Ningshao Xia

“…HighlightsMajor neutralization sites of HPV6 were mapped on the pseudovirus cryo-EM structuremAb 15F7 binds HPV6 capsid with a novel top-rim binding modality and confers a post-attachment neutralizationmAb 17D5 binds capsid in top-centre manner but unexpectedly prevents virus from attachment to cell surface…”
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Leucine-rich pentatricopeptide repeat-containing protein (LRPPRC)-stabilized lncRNA small nucleolar RNA host gene 15 (Snhg15) modulates hematopoietic injury induced by γ-ray irradi... by Shuqin Zhang, Yajia Cheng, Yujia Gao, Feifei Xu, Yuna Wang, Junling Zhang, Yue Shang, Deguan Li, Saijun Fan

“…N6-methyladenosine (m6A), the most pervasive representative of post-transcriptional modifications, plays critical roles in diverse biological events. …”
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Role of heavy sweating for ST-segment elevation myocardial infarction: analysis of the China Acute Myocardial Infarction registry by Chao Wu, Zilong Zhang, Shuhong Su, Haiyan Xu, Lei Song, Yongjian Wu, Shubin Qiao, Yang Wang, Wei Li, Yida Tang, Xiaojin Gao, Jingang Yang, Yuejin Yang, on behalf of the China Acute Myocardial Infarction Registry Study Group

“…Heavy sweating group was more likely to achieve primary PCI (44.7% vs 32.9%) but shown similar rates of post-PCI TIMI 3 flow (95.5% vs 94.1%) and STR ≥ 50% (79.8% vs 78.2%). …”
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High-throughput phenotyping discovers new stable loci controlling senescence rate in bread wheat by Lei Li, Jindong Liu, Muhammad Adeel Hassan, Duoxia Wang, Keyi Wang, Shuaipeng Fei, Jianqi Zeng, Awais Rasheed, Xianchun Xia, Zhonghu He, Yong He, Yong Zhang, Yonggui Xiao

“…A total of 262 recombinant inbred lines derived from the cross of Zhongmai 578/ Jimai 22 were evaluated for senescence-related traits across three environments, spanning from heading to 35 d post-anthesis. The manual senescence rate (MSR) was quantified using the FLC and the active accumulated temperature, and UAV derived vegetation index were utilized to assess the stay-green rate (USG) facilitating the identification of senescent and stay-green lines. …”
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Involvement of a variant secretory protein in virulence of emerging Cryptosporidium parvum subtypes by Falei Li, Jiayu Li, Yongping Tang, Wei He, Yingying Fan, Ni Huang, Zhuowei Wan, Martin Kváč, Yaqiong Guo, Na Li, Lihua Xiao, Yaoyu Feng

“…One of the mice infected with IIpA11 died on day 33 post infection. The genomes of IIaA17G2R1, IIoA15G1, and IIpA11 had 203, 46839, and 47,122 single nucleotide polymorphisms, respectively, compared to C. parvum IOWA II. …”
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Ruxolitinib and decitabine plus a busulfan–cyclophosphamide conditioning regimen for relapse prophylaxis in patients with high-risk acute myeloid leukemia or myelodysplastic syndro... by Yujun Wei, Yujun Wei, Songhua Luan, Lu Wang, Lili Wang, Fei Li, Xiangshu Jin, Ruoling Yang, Ruoling Yang, Kun Qian, Kun Qian, Bo Peng, Jingwen Tang, Haoyang Zhang, Liping Dou, Liping Dou, Daihong Liu, Daihong Liu, Daihong Liu

“…The most common grade ≥3 adverse event was oropharyngeal mucositis (8.6%, n=5). Within 6 months post-transplantation, the cumulative incidence of cytomegalovirus (CMV) reactivation was 34.5%, and that of Epstein–Barr virus (EBV) reactivation was 62.1%.ConclusionsThis investigational study revealed that the Rux-Dec-mBu/Cy conditioning was tolerable and reduced relapse in high-risk AML/MDS patients.…”
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Protective Measures Taken in Residential Care Homes in England During the COVID-19 Pandemic. An Assessment of the Change in Mortality Rates Before and During the COVID-19 Pandemic... by Michael Stedman, Samuel Kitching, Martin B. Whyte, Adrian Heald

“…The Care Quality Commission publish annually a register of residential care homes (RCH) which includes the post code location, which can be linked to an LSOA, and the number of beds split according to nursing care (CH) or purely residential homes (RH). …”
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Host-specific adaptation in Fusarium oxysporum correlates with distinct accessory chromosome content in human and plant pathogenic strains by Dilay Hazal Ayhan, Serena Abbondante, Domingo Martínez-Soto, Siyuan Wu, Ricardo Rodriguez-Vargas, Shira Milo, Katherine Rickelton, Vista Sohrab, Shunsuke Kotera, Tsutomu Arie, Michaela Ellen Marshall, Marina Campos Rocha, Sajeet Haridas, Igor V. Grigoriev, Neta Shlezinger, Eric Pearlman, Li-Jun Ma

“…Interestingly, ACs from both genomes also encode proteins with shared functions, such as chromatin remodeling and post-translational protein modifications. Our phenotypic assays and comparative genomics analyses lay the foundation for future studies correlating genotypes with phenotype and for developing targeted antifungals for agricultural and clinical uses.IMPORTANCEFusarium oxysporum is a cross-kingdom fungal pathogen that infects both plants and animals. …”
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Arachidonic Acid Metabolism Down-Regulation-Mediated Tumor Necrosis Factor Signaling Contributes to Cutaneous Fibrosis and Skull Hyperplasia in Goldfish Hoods by Liang-Liang Li, Qi-Lin Xu, Wen-Jing Yi, Di-Di Ma, Hui Jin, De-Zheng Fu, Xiao-Li Yang, Yang Wang, Zhi Li, Zhong-Wei Wang, Xi-Yin Li, Meng Lu, Xiao-Juan Zhang, Li Zhou, Jian-Fang Gui, Peng Yu

“…Furthermore, we found that the down-regulation of arachidonic acid metabolism triggers an inflammatory response, culminating in the dysregulation of the tumor necrosis factor (TNF) pathway, which in turn enhances collagen deposition and epithelial cell proliferation—central to hood morphogenesis. During post-formation process, the aberrant TNF pathway expression and collagen accumulation inhibit osteoclast differentiation, promoting the irregular proliferation of the skull and the formation of bony protrusions that support hood attachment. …”
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