SREBF1-mediated SND1 transcriptional activation promotes prostate cancer progression via MTDH interaction through the SESN2/AMPK/mTOR axis by Yijie Tang, Yufan Ying, Xueyou Ma, Jiahe Yi, Zixiang Liu, Yuqing Wu, Shen Lin, Xuan Shu, Zhixiang Qi, Jindan Luo, Xiangyi Zheng, Jiangfeng Li, Liping Xie, Ben Liu

“…Growing evidence indicates that Staphylococcal nuclease and Tudor domain containing 1 (SND1) is a multifunctional protein extensively involved in transcriptional regulation, RNA maturation, post-transcriptional modifications, and other processes. …”
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Scaling a parenting program to reduce child maltreatment in Tanzania: The role of facilitator fidelity in adolescent and parent outcomes by Mackenzie Martin, Jamie M. Lachman, Francisco Calderon, Qing Han, Yulia Shenderovich, Esther Nydetabura, Nyasha Manjengenja, Joyce Wamoyi, Frances Gardner

“…A total of 24 facilitator assessments could be linked with pre-post surveys from 3057 families. Findings: Analyses found mixed results, with fidelity having positive, negative, and insignificant associations with participant outcomes. …”
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The promoting effects of digital targeted cognitive training in medication treatment for children with ADHD: a randomized controlled trial by Chen Dang, Yu Zhu, Xiangsheng Luo, Lu Liu, Yuan Feng, Guisen Wu, Shaogen Zhong, Xin Wang, Jianzhao Zhang, Yike Zhu, Siqi Liu, Ziqi Liu, Li Qin, Xiaohui Ma, Yufeng Wang, Xiaoyi Wang, Jian Yang, Changming Wang, Li Sun

“…Results Main results: When compared with M treatment, the TCT + M treatment did not show significant greater improvements in ADHD core symptoms, ecological executive functions, social functions, or laboratory cognitive functions. Post-hoc exploratory analysis results: (1) In patients who received ATX treatment, TCT + ATX led to greater improvement in ADHD-RS total, inattention, and hyperactivity/impulsivity symptoms. …”
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Snake Venom Peptide Fractions from <i>Bothrops jararaca</i> and <i>Daboia siamensis</i> Exhibit Differential Neuroprotective Effects in Oxidative Stress-Induced Zebrafish Models by Felipe Assumpção da Cunha e Silva, Brenda Rufino da Silva, Leticia Ribeiro de Barros, Emidio Beraldo-Neto, Adolfo Luis Almeida Maleski, Carlos Alberto-Silva

“…In vivo, neither pf-<i>Ds</i> nor pf-<i>Bj</i> (1–20 µg mL⁻¹) induced significant developmental toxicity in zebrafish larvae up to 120 h post-fertilization (hpf). The neuroprotective effects of both pf were evaluated using two experimental models: (I) Larvae at 96 hpf were exposed to either pf-<i>Ds</i> or pf-<i>Bj</i> (10 µg mL⁻¹) for 4 h, followed by co-exposure to H₂O₂ (0.2 mmol L⁻¹) for an additional 10 h to induce oxidative stress (4–20 h model); (II) Embryos at 4 hpf were treated with pf-<i>D</i>s or pf-<i>Bj</i> (10 µg mL⁻¹) continuously until 96 hpf, after which they were exposed to H₂O₂ (0.2 mmol L⁻¹) for another 24 h (96–120 h model). …”
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Evaluation of a fermented palm kernel meal as a prebiotic for enhancing immune response in Indonesian red claw crayfish (Cherax quadricarinatus) by Diki Danar Tri Winanti, Hilma Nahwa Firdausi, Maulid Wahid Yusup, Putu Cinthia Delis, Agus Setyawan, Yeni Elisdiana, Hilma Putri Fidyandini, Muhammad Kholiqul Amiin, Ari Widodo

“…Hemolymph samples were collected at baseline (day 0) and on days 3, 5, 7, and 14 post-treatment. Non-specific immune responses evaluated included total hemocyte count (THC), differential hemocyte count (DHC), phagocytosis activity (PA), phagocytosis index (PI), phenol oxidase (PO) activity, superoxide dismutase (SOD) activity, total plasma protein (TPP), and immune gene expression (lipopolysaccharide and β-1,3-glucan-binding protein [LGBP], lectin). …”
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At-home Breast Oncology care Delivered with EHealth solutions (ABODE) study protocol: a randomised controlled trial by Wei Xu, Eitan Amir, Madeline Li, Gary Rodin, Toni Zhong, Raymond H Kim, Allan Okrainec, Michael Reedijk, David McCready, Emily Thain, Kelly Metcalfe, Siba Haykal, Jeanna Mccuaig, Robin Forbes, Jaime Escallon, Janet Papadakos, Erin Kennedy, Amanda Mac, Dalia Schaffer, Mohini Kalia, Emma Reel, Adina Isenberg, C Anne Koch, Sarah Rotstein, Tulin D Cil, Jordan Cleland, Alexandra Easson, Sheila Jarvis, Wey Leong, Daniel Santa Mina, Larissa Peck, Sharmy Sarvanantham, Fahreen Walimohamed

“…Patients will complete questionnaires at enrolment, 6 and 12 months post-diagnosis to measure patient activation (Patient Activation Measure-13 score), distress, anxiety, quality of life and experiences with their care and information received. …”
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Uncovering the link between incidental physical activity and inhibition of automatic responses in aging. An ERP study by Javier Sanchez-Lopez, Juan Silva-Pereyra, Sergio Manuel Sánchez-Moguel, Graciela Catalina Alatorre-Cruz, Graciela Catalina Alatorre-Cruz, Mauricio González-López, Mauricio González-López, Mauricio González-López, Jorge A Sigg-Alonso, Mariana Pérez-Figueroa, Thalía Fernández

“…ERP analyses revealed greater late negativity as a result of the differences between conditions (1,050–1,200 ms) during the counting-Stroop task in the high-IPA group, suggesting more effective late-stage inhibitory processing post-execution likely related to re-evaluation and resolution of the conflict, while the low-IPA group lacked this effect. …”
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COVID-19 incidence after vaccination with different types of vaccines against SARS-CoV-2 by O. M. Drapkina, S. A. Berns, M. G. Chashсhin, A. Yu. Gorshkov, O. V. Zhdanova, L. N. Ryzhakova, O. A. Litinskaya, M. S. Pokrovskaya

“…Until now, there remains a certain interest in studying the role of booster vaccination  in  the  formation  of  post-vaccination  immunity  against  the Severe  acute  respiratory  syndrome  coronavirus  2  (SARS-CoV-2).  …”
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A nationwide analysis of resource utilization and safety in patients undergoing mitral transcatheter edge-to-edge repair by Tharusan Thevathasan, Sophie Berlinghof, Daniel Elschenbroich, Julia M. Wiedenhofer, Sêhnou Degbeon, Luise Holzhauser, Fabian Barbieri, Mario Kasner, Anna Brand, Henryk Dreger, Steffen Desch, Ulf Landmesser, Markus Reinthaler, Carsten Skurk

“…Methods: Primary outcomes (healthcare resource utilization) included hospital length of stay (LOS), adverse discharge to a short-term hospital or skilled nursing facility and hospital costs. Secondary outcomes (safety) were in-hospital mortality and post-procedural complications. …”
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Self-reported health and depression among EIRA cohort: a moderated mediation model of sex and perceived social support by Raquel Sánchez-Recio, Raquel Sánchez-Recio, Bárbara Oliván-Blázquez, Bárbara Oliván-Blázquez, Bárbara Oliván-Blázquez, Fátima Méndez-López, Fátima Méndez-López, Fátima Méndez-López, Santiago Gascón-Santos, Santiago Gascón-Santos, Ruth Martí-Lluch, Ruth Martí-Lluch, Ruth Martí-Lluch, Ruth Martí-Lluch, Edurne Zabaleta-Del-Olmo, Edurne Zabaleta-Del-Olmo, Edurne Zabaleta-Del-Olmo, Olaya Tamayo-Morales, Olaya Tamayo-Morales, José A. Maderuelo-Fernández, José A. Maderuelo-Fernández, José A. Maderuelo-Fernández, Marc Casajuana, Tomas López-Jiménez, Emma Motrico, Emma Motrico, Irene Gómez-Gómez, Irene Gómez-Gómez, Álvaro Sánchez-Pérez, Álvaro Sánchez-Pérez, Álvaro Sánchez-Pérez, María Luisa Rodero-Cosano, Joan Llobera, Joan Llobera, Joan Llobera, Juan A. Bellón, Juan A. Bellón, Juan A. Bellón, Juan A. Bellón, Patricia Moreno-Peral, Patricia Moreno-Peral, Bonaventura Bolíbar, Bonaventura Bolíbar, José I. Recio-Rodríguez, José I. Recio-Rodríguez, Rafel Ramos, Rafel Ramos, Rafel Ramos, Rafel Ramos, Ana Clavería, Ana Clavería

“…Men reported experiencing more social support and self-perceived health (p &lt; 0.001) than women at the beginning of the study, but women reported higher social support at post-intervention. Moderation analyses showed that, post-intervention, those women (bsimple = −2.9867, p &lt; 0.001) and males (bsimple = −1.4337, p &lt; 0.001) who scored lower in depression reported higher social support.ConclusionIn primary care, it is necessary to encourage intervention strategies that promote social networks as a key element of positive action aimed at maintaining and improving the population’s health, especially in adults and more specifically in women.Clinical trial registrationClinicalTrials.gov, identifier NCT03136211.…”
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A Phase I Dose-Escalation Clinical Trial of Bronchoscopic Cryoimmunotherapy in Advanced-Stage NSCLC by Jun-Chieh J. Tsay, MD, MS, Antonio Velez, MD, Destiny Collazo, BS, Isaac Laniado, MD, Jamie Bessich, MD, Vivek Murthy, MD, Andrew DeMaio, MD, Samaan Rafeq, MD, Benjamin Kwok, MD, Fares Darawshy, MD, Ray Pillai, MD, Kendrew Wong, MD, Yonghua Li, MD, PhD, Rosemary Schluger, RN, Alena Lukovnikova, BS, Sofia Roldan, BS, Matt Blaisdell, BS, Fernanda Paz, Kelsey Krolikowski, BS, Katherine Gershner, MD, Yong Liu, PhD, Judy Gong, BA, Sara Borghi, PhD, Fang Zhou, MD, Aristotelis Tsirigos, PhD, Harvey Pass, MD, Leopoldo N. Segal, MD, MS, Daniel H. Sterman, MD

“…Safety was assessed by review of BCI-related complications, including grades 2 to 3 bleeding, pneumothorax requiring intervention, and National Cancer Institute Common Terminology Criteria for Adverse Events grade 3 to 5 adverse events. Pre- and post-BCI blood samples were collected to explore changes in the systemic immune profile. …”
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日本解決學力下降問題之政策分析： 以課綱修訂和全國學力測驗為主 The Policy Analysis to Solve Academic Decline in Japan– Course of Study and National Assessment of Academic Ability... by 李宜麟 Yi-Lin Lee, 楊思偉 Szu-Wei Yang

“…Japan’s education system thus faced a quality bottleneck, with a knowledge-heavy approach that struggled to meet the demands of a knowledge-based post-industrial economy. Mounting social issues, such as intense competition, school violence, absenteeism, student suicides, and juvenile crime, underscored the need for reform. …”
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應用智慧型家教系統於國小學童閱讀策略 教學之學習歷程研究 A Study on the Learning Process of Applying an Autotutoring System to Teach Reading Strategies to Elementary School Children... by 陳茹玲 Ju-Ling Chen, 曾厚強 Hou-Chiang Tseng, 連啟舜 Chi-Shun Lien, 蔡旻穎 Min-Ying Tsai, 宋曜廷 Yao-Ting Sung

“…The between-subject factor is reading ability (high vs. low), while the within-subject factor is test type (pre-test and post-test), with background knowledge as a covariate. …”
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Development mechanism and practical significance of deep coalbed methane (coal rock gas) infiltration and displacement by Lihong ZHOU, Xia YAN, Hongtao LIU, Xianyue XIONG, Feng WANG, Shuguang LI, Jiyuan ZHANG, Chuanqing LIU, Xiong HU, Pu YUAN, Qianli MA, Xueguang ZHU

“…However, the mechanistic role of hydraulic fracturing in methane production, beyond enhancing permeability, remains unclear. High costs and operational uncertainties in field trials have hindered the optimization of deep CBM technologies and efficient development. …”
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The Circular Kitchen by Bas Jansen

“…Despite higher initial costs, the most adaptable CIK variant proved cost-effective over extended periods, confirmed by the second study comparing TECH and BIO kitchens. …”
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Serotonin 5-HT2A and 5-HT2C receptors differentially modulate the acquisition and expression of voluntary alcohol drinking in male mice by Sandy C. Simões, Livia N. Amorim, Yasmim A. Serra, Camila S. Abreu, Maria Clara E. Santana, João P. C. Leite, Carla M. Kaneto, Roberta C. A. Costa, Kaio R. Ferreira, Isabelle C. S. de Oliveira, Alexandre J. Oliveira-Lima, Agnieszka Sulima, Kenner C. Rice, Eduardo A. V. Marinho, Lais F. Berro, Lais F. Berro

“…On the other hand, while post-acquisition treatment with a 5-HT2A antagonist alone decreased alcohol intake and preference during re-exposure, co-administration of a 5-HT2C antagonist blocked these effects.DiscussionOur findings suggest that 5-HT2A and 5-HT2C receptors differentially modulate the acquisition and expression of voluntary alcohol drinking in mice.…”
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When gender matters: inequalities in health services utilization and risk factors monitoring after acute myocardial infarction by Irene López-Ferreruela, Irene López-Ferreruela, Antonio Gimeno-Miguel, Antonio Gimeno-Miguel, Clara Laguna-Berna, Clara Laguna-Berna, Sara Malo, Sara Malo, Sara Malo, Sara Castel-Feced, Sara Castel-Feced, María José Rabanaque, María José Rabanaque, María José Rabanaque, Isabel Aguilar-Palacio, Isabel Aguilar-Palacio, Isabel Aguilar-Palacio

“…In addition, socioeconomic status and place of residence played a role in health services utilization differences.ConclusionsGender inequalities are still present in post-AMI care and CVRF management, with women being more likely to receive less adequate treatment and management. …”
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Caregiver feeding practices for infants and toddlers and their eating behaviors in Singapore by Phaik Ling Quah, Phaik Ling Quah, Daniel Wei Keong Chan, Daniel Wei Keong Chan, Daniel Wei Keong Chan, See Ling Loy, See Ling Loy, Chengsi Ong, Chengsi Ong, Chai-Hoon Nowel Tan, Michael Yong Hwa Chia, Terence Buan Kiong Chua, Fabian Yap, Fabian Yap, Fabian Yap, Mei Chien Chua, Mei Chien Chua, Mei Chien Chua, Kok Hian Tan, Kok Hian Tan

“…Older children (13– &lt; 36 months) also more frequently required special mealtime settings (36.6%), viewed screens during meals (29.9%), and were less likely to be offered post-midnight meals nightly (22.6% compared to infants; 70.3%; 0–&lt; 13 months; p &lt; 0.05).ConclusionThese findings underscore the need for culturally tailored educational interventions to improve suboptimal feeding practices in children under three in Singapore’s multiethnic population.…”
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The safety of combining Endostar with concurrent chemoradiotherapy for the treatment of locally advanced cervical cancer and the evaluation of its anti-angiogenic effects via trans... by Fang Wu, Fang Wu, Zhouxue Lu, Zhouxue Lu, Jinting Que, Shanshan Ma, Shanshan Ma, Li Jiang, Li Jiang, Xiaobi Tang, Xiaobi Tang, Chengshan Zheng, Chengshan Zheng, Li Zhou, Li Zhou, Qiufeng Huang, Qiufeng Huang, Yong Zhang, Yong Zhang

“…In the CRT+E group, VM rates, TTP, and MTT significantly differed at three time points (with P values of 0.003, 0.002, and P&lt;0.001, respectively), whereas the CRT group showed no significant changes (all P&gt;0.05). Post-radiotherapy, statistically significant differences emerged between the CRT+E and CRT groups for VM rates (P = 0.027), MTT (P = 0.027), and TTP (P &lt; 0.001), while PI showed no significant difference (65.67 ± 36.53 vs. 74.69 ± 61.21, P = 0.598).ConclusionThe combination of Endostar with CCRT for locally advanced cervical cancer (LACC) demonstrated favorable safety and tolerability. …”
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Characterization of full-length long noncoding RNAs and identification of virus-responsive lncRNAs in Sogatella furcifera by Yawen Ban, Yawen Ban, Ting Cui, Ting Cui, Lifei Zhao, Lifei Zhao, Xue Li, Xue Li, Qing Bai, Qing Bai, Qingfa Wu, Qingfa Wu

“…., 93 transcripts between 0 and 72 h post-oviposition) and molting (e.g., 16 in pre-ecdysis), while sex-biased expression patterns emerged after 24 h. …”
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