Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning. by Patrick Y Sips, Xu Shi, Gabriel Musso, Anjali K Nath, Yanbin Zhao, Jason Nielson, Jordan Morningstar, Amy E Kelly, Brittney Mikell, Eva Buys, Vikhyat Bebarta, Jared Rutter, V Jo Davisson, Sari Mahon, Matthew Brenner, Gerry R Boss, Randall T Peterson, Robert E Gerszten, Calum A MacRae

“…We found that zebrafish embryos in the first 3 days post fertilization (dpf) are highly resistant to cyanide, becoming progressively more sensitive thereafter. …”
Get full text

Dynamic Monitoring of CD200 Mediated by Ascites-Derived Exosomes as a Predictor of Survival and Response to Front-Line Chemotherapeutics in Advanced High-Grade Serous Ovarian Cance... by Ying Ji, Shanshan Liu, Genju Wang, Xin Chen, Yujuan Li, Xiaogai Zhi, Hongxiu Jiang, Juan Tang, Yi Ding, Shuli Zhao, Hongmei Zhou, Aiwei Xiong

“…Methods: We performed dynamic measurements of exosome-mediated or serum CD200 levels at primary diagnosis, post-operation, and three cycles after chemotherapy. …”
Get full text

Correlation Between the Online Visiting Time and Frequency Increase in Telemedicine Services Offered by Health Care Providers Before, During, and After the COVID-19 Pandemic in Chi... by Weiyi Wang, Yuntian Chu, Fangfang Cui, Xiaobing Shi, Xu Zhang, Dongxu Sun, Jinming Shi, Jie Zhao

“…However, what role telemedicine will play post–COVID-19 is still uncertain. ObjectiveWe aimed to determine the frequency change in health care providers offering telemedicine services before, during, and after COVID-19, as well as the correlation between the frequency change and telemedicine visit time. …”
Get full text

Fever in travelers returning from tropical and subtropical areas: a hospital-based study of factors affecting investigations and diagnoses in children and adults by Klara Sondén, Donya Satarvandi, Helena Hildenwall, Sara Falck-Jones, Victor Yman, Niclas Johansson, Katja Wyss, Elin Folkesson, Hilmir Asgeirsson, Irene Nordling, Anna Löwhagen Welander, Anna Färnert

“…Background: As global travel surges in the post-pandemic era, healthcare systems must prepare for proper management of diseases encountered by returning travelers. …”
Get full text

Utilizing Sargassum polycystum as Co-Feedstock to Enhance Methane Yield from Pig Dung in Anaerobic Digestion by Earl Francis A Busilaoco, Wendyl M Aligato, Jan Nico R Gaslang, Hyrn G Almoroto, Kristine Yhuri A Libreta, Mervy Aretha Deon L Loon, Camella A Redulla, Darius Miguel Pederes, Angela Glaiza B Pingcas, Rovie Joice M Durante, Ricksterlie C Verzosa

“…The pretreated group exhibited the highest methane concentration (>9,999.00 ppm), followed by the untreated group (8,931.75 ppm), while the control group produced the lowest yield (3,644.25 ppm). Post hoc analysis confirmed a significant difference in methane yield in the pretreated group compared to the control (p = 0.010). …”
Get full text

Renal function in liver recipients: in-depth analysis of data from the Local Scientific Transplant Registry of the Burnasyan Federal Medical Biophysical Center by A. I. Sushkov, V. S. Rudakov, M. V. Popov, A. E. Kalachyan, E. V. Naydenov, A. I. Artemiev, S. E. Voskanyan

“…Particular attention should be paid to elderly patients, with arterial hypertension, reduced baseline eGFR, post-LT AKI RIFLE > I (especially in combination with EAD). …”
Get full text

Spleen Infarction in Plasmodium Infection by Vitorino Modesto dos Santos, Andressa Plaça Tedeschi, Julia Campos Modesto

“…The patient evolved with stable hemodynamic status and did not need emergency surgery; malarial trophozoites were not observed on the peripheral blood smear post-treatment [3]. A 30-year-old man with the diagnosis of P. falciparum infection underwent artemether-lumefantrine, and presented with upper left abdominal pain; the abdominal images revealed splenomegaly with a hypoechoic lesion confirmed as a splenic infarction [4]. …”
Get full text

Pneumonitis after normofractionated radioimmunotherapy: a method for dosimetric evaluation by Kim Melanie Kraus, Caroline Bauer, Lisa Steinhelfer, Benedikt Feuerecker, Juliana Cristina Martins, Julius Clemens Fischer, Kai Joachim Borm, Jan Caspar Peeken, Denise Bernhardt, Stephanie Elisabeth Combs

“…Abstract Background Post-Therapy-Pneumonitis (PTP) is a critical side effect of both, thoracic radio(chemo)therapy (R(C)T) and immune checkpoint inhibition (ICI). …”
Get full text

MRI-based texture analysis for the evaluation of the response to neoadjuvant chemoimmunotherapy in locally advanced head and neck squamous cell carcinoma by Haoran Wei, Kai Wang, Fan Yang, Xiaolu Li, Xiaoduo Yu, Yanfeng Zhao, Lin Li, Lizhi Xie, Xiaolei Wang, Meng Lin

“…Results A total of 24 (49.0%) patients achieved pCR, and 25 (51.0%) did not. The Pre_model, Post_model, and Delta_model demonstrated AUCs of 0.678, 0.795, and 0.805, respectively. …”
Get full text

Multilevel risk analysis of postoperative pulmonary complications following mandibular fractures: a retrospective cohort study based on patient characteristics and healthcare syste... by Shuwei Liao, Guanxiong Zhu, Liting Zeng, Yang Yu, Zeyu Zhang, Hongru Zhang, Jingyuan Wang, Lina Yu

“…Abstract Background Pulmonary complications (PPCs) following mandibular fractures are serious post—surgery problems. This study analyzed risk factors of PPCs following mandibular fractures using the National Inpatient Sample (NIS) database, aiming to help clinicians specify surgical protocols and postoperative care for patients. …”
Get full text

H3K14 lactylation exacerbates neuronal ferroptosis by inhibiting calcium efflux following intracerebral hemorrhagic stroke by Tingting Sun, Jian-Nan Zhang, Ting Lan, Lei Shi, Liye Hu, Liyan Yan, Chao Wei, Lisha Hei, Weihua Wu, Zhaoli Luo, Meng Liu, Xingmei Ren, Yamei Wang, Yabin Lu, Peipei Wang, Chenguang Zhang, Liheng Bian, Xingquan Zhao, Fei Yang, Qian Li

“…We discovered elevated lactate and histone lactylation post-ICH in mice, with a significant increase in H3K14la during the early stages of ferroptosis in hemin-challenged primary cortical neurons. …”
Get full text

Intrinsic tectal low grade astrocytomas: is surgical removal an alternative treatment? Long-term outcome of eight cases Astrocitomas tectais de baixo grau: o tratamento cirúrgico é... by Ricardo Ramina, Mauricio Coelho Neto, Yvens Barbosa Fernandes, Guilherme Borges, Donizeti Cesar Honorato, Walter Oleschko Arruda

“…No recurrence occurred after total removal. Post-surgical follow-up time ranged from 2 1/2 to 22 1/2 years (mean 9.9 ± 5.9 years). …”
Get full text

Cognitive behavioural therapy in comparison to treatment as usual in young adults at high risk of developing bipolar disorder (Bipolar At Risk): a randomised controlled trial to in... by Sophie Parker, Lydia Pearson, Rebekah Carney, Richard P. Bentall, Matthew R. Broome, Emma Cernis, Timothy Clarke, Steven Jones, Katherine Moran, Jonathan Wilson, Isabel Coleman, Catherine Hewitt, Wendy Jones, Heather Law, Sarah Peters, Gemma Shields, David Shiers, Luke Strachan, Anton Strong, Judith Watson, Chris J. Sutton

“…Outcome and mediational variables will be collected at baseline, 17-weeks (in treatment), 27-weeks (post-CBTBAR /TAU), and 52-weeks. Qualitative work will examine the perceived mechanisms of change and implementation of CBTBAR in the NHS. …”
Get full text

The comparative effects of ventilation shutdown with heat (VSDH), relative humidity (VSDHRh), or CO2 (VSDCO2) on broiler electroencephalogram (EEG), blood chemistry and gene expres... by Kari L. Harding, Emmillie Boot, Jackson O. Evans, Sanjay B. Shah, Ramon D. Malheiros, Kenneth E. Anderson

“…However, both VSDH and VSDHRh broilers had significantly greater (P<0.0001) post core body temperatures indicating hyperthermia being the mode of action rather than hypoxia which is the mode of action in VSDCO2. …”
Get full text

Screening of cytokines in blood serum and lacrimal liquid in wet and atrophic forms of age-related macular degeneration by V. V. Neroev, N. V. Balatskaya, N. V. Neroeva, A. G. Karmokova, M. V. Ryabina, I. G. Kulikova

“…Therapy-induced effects of post-treatment cytokine concentrations also need to be studied, both at long and short observation terms. …”
Get full text

Impact of Long-Acting Somatostatin Analogues on Glucose Metabolism in Acromegaly: A Hospital-Based Study by Ming Shen, Meng Wang, Wenqiang He, Min He, Nidan Qiao, Zengyi Ma, Zhao Ye, Qilin Zhang, Yichao Zhang, Yeping Yang, Yanjiao Cai, Yakupujiang ABuDuoReYiMu, Yun Lu, Bin Lu, Xuefei Shou, Yongfei Wang, Hongying Ye, Yiming Li, Shiqi Li, Yao Zhao, Xiaoyun Cao, Zhaoyun Zhang

“…Deterioration was associated with lower baseline BG120 (plasma glucose 120 min post-OGTT), less reduction of growth hormone (GH), and greater reduction of insulin secretion after SSA therapy. …”
Get full text

Changes in C-reactive protein， neutrophil-to-lymphocyte ratio， and hemoglobin levels in maintenance hemodialysis patients with tunnel catheter and arteriovenous fistula vascular ac... by Wang Zi-jing, Zhong Jie, Gong Xue-feng, Ru Xue

“…Renal function indicators （serum creatinine ［Scr］， blood urea nitrogen ［BUN］）， dialysis adequacy （single ventricular urea clearance index ［spKt/V］， urea reduction ratio［URR］， post-equilibrium urea clearance index［eKt/V］）， CRP， NLR， Hb and incidence of infection were compared between the two groups at baseline and at 6-month follow-up. …”
Get full text

Tunable electrical properties of lignin: morphology-dependent ionic conduction in Kraft and organosolv-derived materials by Rosarita D’Orsi, Sebastiano De Stefano, Ofelia Durante, Marianna Ambrico, Domenico Aceto, Paolo Francesco Ambrico, Nadia Martucciello, Filippo Giubileo, Sandra Rivas, Alessandra Operamolla, Antonio Di Bartolomeo

“…This study investigates the composition, morphology, and DC electrical behavior of three distinct lignins: two derived from the Kraft extraction process and differing in their post-treatment ( L 1, L 2) and one ( L 3) extracted from Cynara cardunculus using an ethanolic organosolv process catalyzed by aqueous ammonia. …”
Get full text

Traditional Chinese Medicine Borneol‐Based Polymeric Micelles Intracerebral Drug Delivery System for Precisely Pathogenesis‐Adaptive Treatment of Ischemic Stroke by Yanan Wang, Xutao Ma, Xinyuan Wang, Liru Liu, Xue Zhang, Qiuyue Wang, Yingfei Zhu, Huanhua Xu, Liangmin Yu, Zhiyu He

“…In MCAO mice, the nanoformulation (polymer: 3.2 mg·kg−1, BAPTA‐AM: 400 µg·kg−1) reversibly opened the BBB and achieved high brain biodistribution up to 12.7%ID/g of the total administered dose after 3 h post single injection, effectively restoring intracellular Ca2+ and redox homeostasis, improving cerebral histopathology, and inhibiting mitochondrial PI3K/Akt/Bcl‐2/Bax/Cyto‐C/Caspase‐3,9 apoptosis pathway for rescuing dying neurons (reduced apoptosis cell from 59.5% to 7.9%). …”
Get full text

Impact of COVID-19 vaccination on symptoms and immune phenotypes in vaccine-naïve individuals with Long COVID by Connor B. Grady, Bornali Bhattacharjee, Julio Silva, Jillian Jaycox, Lik Wee Lee, Valter Silva Monteiro, Mitsuaki Sawano, Daisy Massey, César Caraballo, Jeff R. Gehlhausen, Alexandra Tabachnikova, Tianyang Mao, Carolina Lucas, Mario A. Peña-Hernandez, Lan Xu, Tiffany J. Tzeng, Takehiro Takahashi, Jeph Herrin, Diana Berrent Güthe, Athena Akrami, Gina Assaf, Hannah Davis, Karen Harris, Lisa McCorkell, Wade L. Schulz, Daniel Griffin, Hannah Wei, Aaron M. Ring, Leying Guan, Charles Dela Cruz, Harlan M. Krumholz, Akiko Iwasaki

“…Simultaneously, SARS-CoV-2-reactive TCR enrichment, SARS-CoV-2-specific antibody responses, antibody responses to other viral and self-antigens, and circulating cytokines were quantified before vaccination and at 6 and 12 weeks after vaccination. Results At 12 weeks post-vaccination, self-reported improved health is seen in 10 out of 16 participants, 3 have no change, and 3 have worse health although 2 report transient improvement after vaccination. …”
Get full text