Long-term follow-up of modified shunt-restricted instep arterialized venous flap for reconstruction of hand defects by Wei Chen, Yang Jian, Maolin Cheng, Runxue Guan, Wenyu An, Chenglan Yang, Jian Zhou, Shujun Li, Shusen Chang, Chengliang Deng, Chengliang Deng, Kaiyu Nie, Kaiyu Nie, Zairong Wei, Zairong Wei, Zairong Wei, Zairong Wei

“…The flap color was pale in 11 cases and transitioned to a ruddy color within 2–5 h post-operatively, with an average of 3.3 h. Moreover, 12 cases developed mild swelling within 2 weeks postoperatively, whilst 4 cases presented with sporadic blisters. …”
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Delayed Viral Clearance Accompanied by Early Impaired Humoral and Virus-Specific T-Cell Response in Patients with Coronavirus Disease 2019 and Interstitial Lung Disease by Jiaying Zhong, Juan Li, Rui Wei, Bingpeng Guo, Tingting Cui, Peiyu Huang, Zhongfang Wang, Qun Luo, Qian Han

“…Similarly, a lower virus-specific T-cell (VST) immune response was observed 14 days post-symptom onset in the ILD group (CD4⁺ VSTs: 0.018 vs. 0.082, <i>p</i> = 0.005; CD8⁺ VSTs: 0.0008 vs. 0.047, <i>p</i> = 0.004). …”
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Impulsivity and aggression in suicide across age and sex: case–control study by Sergio Sanz-Gómez, Constanza Vera-Varela, Diego de-la-Vega-Sánchez, María Luisa Barrigón, Adrián Alacreu-Crespo, Julio A. Guija, Ana Sánchez, Santiago de León, Enrique Baca-García, Lucas Giner

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A custom-made mouthguard reduces head acceleration during soccer heading and prevents acute electrophysiological and cognitive changes in amateur male playersResearch in context by Claire Pitteu, Philippine Lepère, Philippe Poisson, Etienne Guillaud, Emilie Doat, Bertrand Glize, Patrick Dehail, Hélène Cassoudesalle

“…The difference in mean cSP between pre- and post-heading decreased statistically significantly with the CM-MG (−9·17 ms) compared to without (20·03 ms; p = 0·0016), with a median difference of −22·87 ms (95% CI [−45·85; −4·02]). …”
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Cryopreservable, scalable and ready-to-use cell-laden patches for diabetic ulcer treatment by Bangrui Yu, Lanlan Peng, Wenjun Dang, Ying Fu, Zhijie Li, Jinteng Feng, Heng Zhao, Tian Wang, Feng Xu, Martin L. Yarmush, Haishui Huang

“…This cell-hydrogel patch not only maintains cell viability and structure integrity during cryopreservation, but also can be directly utilized without centrifugation or incubation post cryopreservation. In addition, this tissue-adhesive hydrogel patch enables close wound contact and fast cellular response, and its scalable and flexible structure enables assembly for large or irregularly shaped ulcers. …”
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Activation of the Wnt signaling pathway and its role in epithelial-mesenchymal transition and hepatic fibrosis in alveolar echinococcosis by Binjie Wu, Binjie Wu, Yuxuan Yang, Yuxuan Yang, Shilei Cheng, Shilei Cheng, Zhixin Wang, Zhixin Wang, Haining Fan, Haining Fan

“…The mice were divided into control, Wnt pathway enhancement (Wnt3a), and Wnt pathway inhibition (DKK1) groups. Four weeks post-infection, AAV-EGFP, AAV-Wnt3a-EGFP, or AAV-DKK1-EGFP vectors were administered, followed by tissue collection four weeks later. …”
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Transcatheter aortic valve implantation for aortic stenosis in high surgical risk patients: A systematic review and meta-analysis. by Zulian Liu, Elaine Kidney, Danai Bem, George Bramley, Susan Bayliss, Mark A de Belder, Carole Cummins, Rui Duarte

“…This systematic review compares mortality and other important clinical outcomes up to 5 years post treatment following TAVI or other treatment in these risk groups.…”
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PATIENTS WITH COMBINATION OF CHRONIC HEART FAILURE, HYPERTENSION AND HISTORY OF MYOCARDIAL INFARCTION: CLINICAL AND ANAMNESTIC CHARACTERISTICS, ADMINISTRATION OF ACE INHIBITORS, AN... by M. M. Loukianov, A. N. Kozminsky, S. Yu. Martsevich, S. S. Yakushin, A. N. Vorobyev, A. V. Zagrebelnyy, R. P. Myasnikov, K. G. Pereverzeva, E. A. Pravkina, E. Yu. Andreenko, E. N. Belova, A. D. Deev, V. G. Klyashtorny, E. V. Kudryashov, S. A. Boytsov

“…Patients with a combination of CHF, HT and post-infarction cardiosclerosis (PICS) compared with patients without PICS significantly more often had CHF class 3-4 NYHA (62% vs 47.9%, respectively), HT of degree 3 (92.5% vs 84.2%, respectively), stable angina class 3-4 (84.4% vs 66.4%, respectively). …”
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Factors associated with PEP awareness among adolescent girls and young women in Eswatini by Anne Laterra, Stephanie Spaid Miedema, Michelle Li, Phumzile Mndzebele, Nozipho Nzuza‐Motsa, Sana Nasir Charania, Katherine Ong, Meagan Cain, Udhayashankar Kanagasabai, Thobile Mkhonta, Laura Chiang, Francis Boateng Annor, Michelle R. Adler

“…Despite the World Health Organization's 2014 recommendation for post‐exposure prophylaxis (PEP) to be available for all HIV exposures, it has been underutilized among youth. …”
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Dinamika Ekosistem Seni Paduan Suara Voice of Bali dalam Perspektif Pierre Bourdieu by Alfin Syahrian, I Ketut Sariada, I Wayan Mudra

“…This research aims to explain how the Voice of Bali choir community manages interactions between capital structures, habitus, arena, pre-production and post-production, and event management to become an example for other groups developing choirs in Indonesia. …”
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Complete genomic characterization of global pathogens respiratory syntical virus and human norovirus using probe based capture enrichment by Sravya V Bhamidipati, Anil Surathu, Hsu Chao, Daniel P. Agustinho, Qin Xiang, Kavya Kottapalli, Abirami Santhanam, Zeineen Momin, Kimberly Walker, Vipin K. Menon, George Weissenberger, Nathanael Emerick, Faria Mahjabeen, Qingchang Meng, Jianhong Hu, Richard Sucgang, David Henke, Fritz J. Sedlazeck, Ziad M. Khan, Ginger A. Metcalf, Vasanthi Avadhanula, Pedro A. Piedra, Sasirekha Ramani, Robert L. Atmar, Mary K. Estes, Joseph F. Petrosino, Richard A. Gibbs, Donna M. Muzny, Sara Cregeen Javornik, Harsha Doddapaneni

“…The percentage of reads mapped to viral genomes was 85.1% for RSV and 40.8% for HuNoV post-capture, compared to 0.08% and 1.15% in pre-capture libraries. …”
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ACTivity as medicine In Oncology for Head and Neck (ACTIOHN): a feasibility study investigating a patient-centred approach to exercise for head and neck cancer patients by Joanne M. Patterson, Mary G. Cherry, Andrew Levy, Simon N. Rogers, Rachel C. Brooker, Valerie M. Bryant, Steven Lane, Michael M. Nugent, Ruth Price, Andrew G. Schache, Jennifer A. Kirton, Bridget Young, Debra Fisher, Adrian W. Midgely

“…ObjectiveTo determine the feasibility and acceptability of integrating a remote, personalised, collaborative, and flexible exercise programme into the head and neck cancer (HNC) care pathway.DesignA single arm mixed-methods feasibility study across two UK NHS hospitals.ProcedureEligible HNC patients (aged ≥ 16 years old, treated with curative intent and classified as low/medium risk according to an exercise risk stratification tool) were invited to participate between diagnosis and 8 weeks post-treatment. Patients treated with palliative intent and those identified as high risk on an exercise risk stratification tool were excluded. …”
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Differential Effects of Human Immunodeficiency Virus Nef Variants on Pulmonary Vascular Endothelial Cell Dysfunction by Amanda K. Garcia, Noelia C. Lujea, Javaria Baig, Eli Heath, Minh T. Nguyen, Mario Rodriguez, Preston Campbell, Isabel Castro Piedras, Edu Suarez Martinez, Sharilyn Almodovar

“…<b>Methods:</b> We utilized well-characterized Nef molecular constructs to examine their effects on cell adhesion molecule gene expression (<i>ICAM1</i>, <i>VCAM1</i>, and <i>SELE</i>), pro-apoptotic gene expression (<i>BAX</i>, <i>BAK</i>), and vasoconstrictive endothelin-1 (<i>EDN1</i>) gene expression in endothelial nitric oxide synthase (eNOS) nitric oxide and the production and secretion of pro-inflammatory cytokines over 24, 48, and 72 h post-transfections with Nef variants. <b>Results:</b> HIV Nef variants SF2, NA7, and PH-associated Fr17 and 3236 induced a significant increase in adhesion molecule gene expression of <i>ICAM1</i>, <i>VCAM1</i>, and <i>SELE</i>. …”
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CYTOMETRIC FEATURES OF THE CELLULAR COMPARTMENT OF THE IMMUNE SYSTEM OF PARTICIPANTS IN MODERN MILITARY CONFLICTS by S. L. Pashnin, E. V. Davydova, D. Sh. Altman, V. A. Zurochka, I. Yu. Zhuravlev, Ya. T. Zhakupova

“…A significant amount of knowledge has been accumulated about the mechanisms of immune-mediated reactions in the development of neuropsychiatric pathology, in particular post-traumatic stress disorder (PTSD). Activated T-regulatory cells play an important role in the development of neuroinflammation under stress.Purpose of the study: to study the indicators of the blood system, cytometric features of the cellular compartment of the immune system in participants in modern military conflicts with the presence of adaptation disorders associated with stress.Materials and methods. …”
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Substantia nigra related gene polymorphisms associated with antipsychotic-induced acute movement disorders: a genome-wide association study and multi-ancestry validation in schizop... by Zhe Lu, Yao-Yao Sun, Zhe-Wei Kang, Guo-Rui Zhao, Yu-Yanan Zhang, Jun-Yuan Sun, Rui Yuan, Wei-Hua Yue

“…Methods GWASs on AIMDs were conducted in 3 independent cohorts: a discovery cohort of 3067 patients (2016 subjects were reserved after quality control), a validation cohort of 277 patients, and a multi-ancestry validation cohort of 766 patients. Subsequent post-GWAS analyses included gene-based analyses, transcriptome-wide association studies (TWASs), and polygenic risk score (PRS) profiling. …”
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Adaptations to comprehensive abortion care during the COVID-19 pandemic: case studies of provision in Bolivia, Mali, Nepal, and the occupied Palestinian territory by Annik Mahalia Sorhaindo, Sarah Castle, Lola Flomen, Eva Lathrop, Shirine Mohagheghpour, Rasha Dabash, Francelle Kwankam Toedtli, Rebecca Wilkins, Laurence Läser, Patricia Titulaer, Ernest Nyamato, Mary Lea Dakouo, Ammal Awadallah, Raman Shrestha, Malena Morales, Ulrika Rehnström Loi

“…In the occupied Palestinian territory, the use of a hotline and social media expanded access to quick and reliable information, counselling, referrals, and post-abortion care. Adaptations to comprehensive abortion care service delivery to mitigate disruptions to services during the COVID-19 pandemic may continue to benefit service quality of care, access to care, routine monitoring, as well as inclusivity and communication in the longer term.…”
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Kinesiophobia and associated factors among patients after cardiac surgery under cardiopulmonary bypass: a cross-sectional study by Min You, Min You, Qianqian Mou, Qianqian Mou, Xiaotao Cao, Xiaotao Cao, Meng Luo, Meng Luo, Yi Song, Yi Song, Qingqing Li, Qingqing Li, Huiyun Hu, Huiyun Hu, Jianping Song

“…Conversely, family function and exercise self-efficacy mitigated kinesiophobia (P &lt; 0.05).ConclusionsKinesiophobia is highly prevalent and multifactorial in post-cardiopulmonary bypass patients. Healthcare providers should prioritize patients with the above risk profiles, while also establishing financial/emotional support systems, improving patient-family communication, optimizing acute pain management, implementing Enhanced Recovery After Cardiac Surgery protocols, and leveraging technology to design rehabilitation programs. …”
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Ultrasound-guided renal subcapsular transplantation of mesenchymal stem cells for treatment of acute kidney injury in a minipig model: safety and efficacy evaluation by Tuo Xiao, Yuhao Chen, Bo Jiang, Mengjie Huang, Yanjun Liang, Yue Xu, Xumin Zheng, Wenjuan Wang, Xiangmei Chen, Guangyan Cai

“…Results The method of pre-hydration at 4% of body weight, followed by post-cisplatin (3.8 mg/kg) hydration at 2% of body weight, successfully established a cisplatin-induced AKI minipig model with a survival time exceeding 28 days, closely mimicking the clinical characteristics of typical AKI patients. …”
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散装土榨花生油消费者KAP调查及信息干预效果评价KAP survey and evaluation of information intervention effect for consumers of bulk pressed peanut oil by 杨朝慧1,2， 何思蕾3， 邓俊锋3， 卢晓丹3， 何志妮3 YANG Zhaohui1,2, HE Silei3, DENG Junfeng3, LU Xiaodan3, HE Zhini3

“…The results showed that consumers initially exhibited low awareness (7.3%-42.5%), positive attitude rates (3.1%-30.6%), and positive behavioral intention rates (18.7%-52.3%). Post-information intervention, these metrics significantly increased to 24.8%-67.6%, 3.4%-51.0%, and 38.6%-60.0%, respectively. …”
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Imaging of human stem cell-derived dopamine grafts correlates with behavioural recovery and reveals microstructural brain changes by Stephen J. Paisey, Lucy R. Jones, David J. Harrison, Nicola J. Drummond, Olivia Z. Edwards, Maurice A. Canham, Victoria H. Roberton, Christopher Marshall, Greg Parker, Rachel Hills, Anne E. Rosser, Emma L. Lane, Stephen B. Dunnett, Tilo Kunath, Yaniv Assaf, Mariah J. Lelos

“…Tests of motor function and PET and MR imaging were conducted up to 6 months post-transplantation. Our data demonstrate that [18F]Fluorodopa imaging identified presynaptic DA synthesis from hfVM and hESC-derived dopaminergic grafts and [18F]Fallypride imaging confirmed occupancy and normalisation of D2/D3 receptor expression in the grafted hemisphere. …”
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