Comprehensive Analysis of the Effects of Sacubitril/Valsartan According to Sex Among Patients With Heart Failure and Reduced Ejection Fraction in PARADIGM‐HF by Misato Chimura, Jawad H. Butt, Shingo Matsumoto, Eoghan G. M. McMurray, Alasdair D. Henderson, Atefeh Talebi, Akshay S. Desai, Martin P. Lefkowitz, Adel R. Rizkala, Jean L. Rouleau, Scott D. Solomon, Karl Swedberg, Michael R. Zile, Milton Packer, Pardeep S. Jhund, John J. V. McMurray

“…Methods and Results This post hoc analysis of PARADIGM‐HF examined sex‐based outcomes in patients with HF and reduced ejection fraction randomized to sacubitril/valsartan or enalapril. …”
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Impact on physical function of the +AGIL Barcelona program in community-dwelling older adults with cognitive impairment: an interventional cohort study by Cristina Arnal, L Monica Pérez, Luís Soto, Álvaro Casas Herrero, Joan Ars, Sonia Baró, Francisco Díaz, Araceli Abilla, M Belén Enfedaque, Matteo Cesari, Marco Inzitari

“…Physical performance was measured at baseline, three and six months follow-up. The pre-post impact on physical function was assessed by paired sample t-test for repeated samples. …”
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Estandarización de zimosán opsonizado como estímulo en la técnica de la 1,2,3-dihidrorrodamina para evaluar el estallido respiratorio del neutrófilo by Uriel Pérez-Blanco, Jenniffer Yissel Girón, Guillermo Juárez -Vega, María Jiménez, Carlos Sánchez, Ricardo Rioja, Sara Espinosa-Padilla, Lizbeth Blancas-Galicia

“…Se utilizaron las pruebas de Kolmogorov-Smirnov, ANOVA y el análisis post-hoc de Tukey. Se consideró un valor de p ≤ 0,05 como estadísticamente significativo. …”
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Chikungunya intra-vector dynamics in Aedes albopictus from Lyon (France) upon exposure to a human viremia-like dose range reveals vector barrier’s permissiveness and supports local... by Viginier, Barbara, Cappuccio, Lucie, Garnier, Céline, Martin, Edwige, Maisse, Carine, Valiente Moro, Claire, Minard, Guillaume, Fontaine, Albin, Lequime, Sébastian, Ratinier, Maxime, Arnaud, Frédérick, Raquin, Vincent

“…Transmission rate data revealed a time-dependent, but overall weak, transmission barrier, with individuals transmitting as soon as 2 days post-exposure (dpe) and >50% infectious mosquitoes at 6 dpe for the highest dose. …”
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Shifts in bla genes and Class 1 integron prevalence in beta-lactamase-producing bacteria before and after the COVID-19 pandemic in Mendoza, Argentina by F. Márquez-Friedrichs, M. B. Nolly, A. Ferreyra, L. Zuloaga, S. Dominguez, A. Secotaro, V. S. Rathour, M. T. Damiani, L. Contreras, D. G. Sánchez

“…Our findings reveal a significant increase in bacteria with the ESBL phenotype, particularly among ambulatory populations post-pandemic, suggesting a concerning spread of multidrug-resistant bacteria outside hospital environments. …”
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Can Biomarkers Predict Kidney Function Recovery and Mortality in Patients with Critical COVID-19 and Acute Kidney Injury? by Noemí Del Toro-Cisneros, José C. Páez-Franco, Miguel A. Martínez-Rojas, Isaac González-Soria, Juan Antonio Ortega-Trejo, Hilda Sánchez-Vidal, Norma A. Bobadilla, Alfredo Ulloa-Aguirre, Olynka Vega-Vega

“…Blood and urine samples were obtained when KRT was initiated (day zero), and thereafter on days 1, 3, 7, and 14 post-replacement. uSerpinA3, kidney injury molecule-1 (uKIM-1), and neutrophil gelatinase-associated lipocalin (uNGAL) were measured in urine, and interleukin-6 (IL-6), interleukin-10 (IL-10), and tumor necrosis factor alpha (TNF-α) in peripheral blood. …”
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Preoperative partial breast reirradiation and repeat breast-conserving surgery in patients with recurrent breast cancer: the prospective single-arm REPEAT trial – a study protocol... by Ellis Barbé, Joost Verhoeff, Nina Bijker, Philip Meijnen, Yasmin Civil, Lisca Wurfbain, Lysanne Jonker, Maurice van der Sangen, Arlene Oei, Katya Duvivier, Zdenko van Kesteren, Miguel Palacios, Willemien Menke-van der Houven van Oordt, Gwen Diepenhorst, Victor Thijssen, Berend Slotman, Robert-Jan Schipper, Desirée van den Bongard

“…BCS will be performed 3 (±one) weeks post PBI. The primary endpoint is the incidence of grade 2 or higher treatment-associated acute toxicity within 90 days. …”
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TSLP pretreatment inhibits M1 macrophage polarization and attenuates LPS-induced iNKT cell-dependent acute lung injury by Ting Zhou, Ziyao Zhang, Yawen Zhan, Meiying Wang, Meiying Wang, Meiying Wang, Mi Wu, Xiufang Weng, Xiufang Weng, Xiufang Weng, Xiufang Weng, Younian Xu, Younian Xu, Younian Xu

“…Thymic stromal lymphopoietin (TSLP) is known to promote Th2 responses in allergic disease, however, its role in sepsis associated ARDS remains limited.MethodsTo investigate the role of TSLP in sepsis associated lung injury, we administered exogenous recombinant TSLP to wild-type mice, followed by lipopolysaccharide (LPS) challenge. At 24 hours post-treatment, bronchoalveolar lavage fluid (BALF) and lung tissues were collected for analysis. …”
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Plasminogen deficiency reduces disease severity and immune responses in enterovirus A71-infected mice by Zheng-Xun Li, Ya-Fang Wang, Li-Ting Chiang, Li-Jin Hsu, Shih-Min Wang, Jen-Ren Wang, Hua-Lin Wu, Shun-Hua Chen, Chuan-Fa Chang

“…The viral loads in the spinal cord of PLG knockout mice were lower than those in WT mice 6 days post-infection. EV-A71-associated cytokines such as IL-1β, IL-6, MCP-1, IL-10, and IFN-γ were investigated. …”
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Recurrence and influencing factors of moderate-to-severe atopic dermatitis after dupilumab withdrawal: a retrospective cohort analysis by Maohua Chen, Xinyu Wen, Jie Liu, Ge Yang, Qingqing Li, Zhiyuan Jiang, Xinjie Zhang, Zhen Cai, Lixia Zhang

“…These findings confirm the disease characteristic of AD’s susceptibility to relapse and emphasize the need for individualized treatment, post-discontinuation monitoring, and long-term standardized management of AD patients with different risk factors for relapse.…”
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Impact of vein-to-vein time in patients with R/R LBCL treated with axicabtagene ciloleucel by Frederick L. Locke, Tanya Siddiqi, Caron A. Jacobson, Sarah Nikiforow, Sairah Ahmed, David B. Miklos, Yi Lin, Matthew A. Lunning, Brian T. Hill, Armin Ghobadi, Zhen-Huan Hu, Michael T. Hemmer, Michael J. Zoratti, Suresh Vunnum, Jonathan Tsang, Clare Spooner, Harry Smith, Christine Fu, Anik Patel, Harry Miao, Shilpa A. Shahani, Debbie L. Mirjah, Hairong Xu, Marcelo C. Pasquini

“…The impact of V2Vt (<28 days vs ≥28 to <40 days vs ≥40 days) on effectiveness and safety outcomes was evaluated in patients treated with axi-cel enrolled in a post-authorization safety study using the Center for International Blood and Marrow Transplant Research data. …”
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Agronomic potential of water hyacinth (Eichhornia crassipes) based organic-phosphate liquid fertilizer on strawberry growth, yield and fruit quality in contrasting soil types by Joyce Nababi, Bruno Kokouvi Kokou, John Finias Kamanula, Fednand Paul Wanjala, Milliam Nakawoombe, Issa Balde, Georges Lufungula Alunga, Elijah Malinga Menard Wanda

“…Vegetative growth, yield and quality-related parameters were analysed using analysis of variance (ANOVA), complemented by Tukey’s HSD post hoc tests (p < 0.05). Our results showed that B treatments significantly enhanced vegetative traits, with the highest plant height 11.80 ± 1.04 cm and leaf area 70.31 ± 3.55 cm² in sandy loam soil (B1:25 %). …”
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Seroconversion Is Misleading as a Test for HSV-2 Infection in Prophylactic Genital Herpes Vaccine Trials: Results of Vaccine Studies in Guinea Pigs by Valerie Bromberg, Lauren M. Hook, John M. Lubinski, Zauraiz Syeda, Kevin P. Egan, Gary H. Cohen, Sita Awasthi, Harvey M. Friedman

“…In the second analysis, we considered animals to be infected if they had positive virus cultures from vaginal swabs obtained on day two or four post HSV-2 inoculation. In the third analysis, we considered animals to be infected if they had any condition included in the first two analyses. …”
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Dietary supplementation with L-carnitine elevates intracellular carnitine levels and affects gene expression of SLC25A20 and COX4I1, as well as non-mitochondrial respiration of bov... by Leonie Seemann, Susanne Kersten, Susanne Bühler, Fabian Billenkamp, Ulrich Meyer, Christian Visscher, Korinna Huber, Erika Most, Klaus Eder, Sven Dänicke, Jana Frahm

“…Blood samples were collected on day 143 ante injectionem (ai), day 11 ai, 24 hours post injectionem (pi), and day 14 pi and PBMC were isolated. …”
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A Single-Chain Mpox mRNA Vaccine Elicits Protective Immune Response in Mice by Qian Xu, Rong-Rong Zhang, Mei Wu, Jie Zhang, Zu-Xin Wang, Hang Chi, Chao Zhou, Xiao-Chuan Xiong, Hai-Tao Liu, Cheng-Feng Qin, Qing Ye

“…Importantly, MPXV^eM1-eA35 demonstrated protective efficacy in a VACV challenge mouse model and showed superior capacity in preventing weight loss post-challenge compared to MPXV^eM1+eA35. …”
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Effect of involuntary and voluntary exercise in an enrichment environment on astrogliosis reaction of hippocampus white matter in type 3 diabetic rat models by Masoud Jamshidi, Mohammadreza Kordi, Fatemeh Shabkhiz

“…One-way ANOVA and Tukey post-hoc test with a significance level of 5% was used to analyze the data. …”
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An Inclusive Civil Society Dialogue for Successful Implementation of the EU HTA Regulation: Call to Action to Ensure Appropriate Involvement of Stakeholders and Collaborators by Thomas Desmet, Elaine Julian, Walter Van Dyck, Isabelle Huys, Steven Simoens, Rosa Giuliani, Mondher Toumi, Christian Dierks, Juliana Dierks, Antonella Cardone, Francois Houÿez, Mira Pavlovic, Michael Berntgen, Peter Mol, Anja Schiel, Wim Goettsch, Fabrizio Gianfrate, Stefano Capri, James Ryan, Pierre Ducournau, Oriol Solà-Morales, Jörg Ruof

“…The most important actions for regulators are to develop joint regulatory-HTA guidance documents, align processes and interfaces under the regulation, and share discussions on post-licensing evidence generation. HTDs prioritized scientific advice capacity and the review of the scoping process, and further development of the scope of the assessment report fact checks. …”
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Comparison of pilot tone-triggered and electrocardiogram-triggered cardiac magnetic resonance imaging: a prospective clinical feasibility study by Xianling Qian, Yali Wu, Peter Speier, Caixia Fu, Yunzhu Wu, Lude Cheng, Yinyin Chen, Shiyu Wang, Caizhong Chen, Kai Liu, Ling Chen, Hang Jin, Mengsu Zeng

“…Imaging included T2-weighted imaging (T2WI), T1-mapping, T2-mapping, cine, late gadolinium enhancement (LGE), and post-contrast T1-mapping sequences. Image quality and quantitative measurements were evaluated, including T2WI signal intensity, native T1-mapping, T2-mapping, and extracellular volume fraction (ECV) values, and comparative signal-to-noise ratio (compSNR) and comparative contrast-to-noise ratio (compCNR) of cine and LGE images, left/right ventricular function. …”
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Protective effects of Cordyceps militaris against hepatocyte apoptosis and liver fibrosis induced by high palmitic acid diet by Wan-Ting Tsai, Wan-Ting Tsai, Jiro Hasegawa Situmorang, Wei-Wen Kuo, Wei-Wen Kuo, Wei-Wen Kuo, Chia-Hua Kuo, Shinn-Zong Lin, Shinn-Zong Lin, Chih-Yang Huang, Chih-Yang Huang, Chih-Yang Huang, Chih-Yang Huang, Chih-Yang Huang, Tsung-Jung Ho, Tsung-Jung Ho, Tsung-Jung Ho, Tsung-Jung Ho

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Surgical management of axis' traumatic spondylolisthesis (Hangman's frature) Tratamento cirúrgico para a espondilolistese traumática do áxis (fratura do enforcado) by José Luiz Romeo Boullosa, Benedicto Oscar Colli, Carlos Gilberto Carlotti Jr, Koji Tanaka, Marcius Benigno Marques dos Santos

“…RESULTS: Nine patients had a good post surgery evolution with satisfactory consolidation of the fractures and disappearance of the symptoms. …”
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