Discovery of natural CdnP inhibitors through structure-based virtual screening and molecular dynamics simulations by Xiaoxia Gu, Chaohu Xiong, Xinyu Wang, Hucheng Zhu, Weiguang Sun, Yan He, Jinwen Zhang

“…ABSTRACT Tuberculosis, caused by Mycobacterium tuberculosis, remains one of the most lethal infectious diseases both historically and in the post-coronavirus disease 2019 era. CdnP (Rv2837c) functions as a bifunctional oligoribonuclease and 3′(2′)-phosphoadenosine 5′-phosphate-phosphatase that impedes host immune responses by recognizing bacterial cyclic dinucleotides such as c-di-AMP, which serve as pathogen-associated molecular patterns. …”
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Using a Social Application to Manage Women with Gestational Diabetes Mellitus: A Prospective Study by Hong Liu, Hongying Peng, Chunxia Cheng, Meng Wang, Chunmei Mi, Guo Feng, Jinru Wu, Hao Nie, Jiaoyang Wu, Yufang Luo, Min Liu

“…Among the 375 participants, 277 (73.9%) had completed post-partum 75 g OGTT, 202 (72.9%) had normal glucose levels, and 75 (27.1%) had impaired glucose regulation (IGR). …”
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Alcohol consumption, high-sensitivity C-reactive protein, and estimated glomerular filtration rate: tripartite predictors of 10-year cardiovascular risk progression in patients wit... by Yizhe Wang, Yizhe Wang, Yu Duan, Yongcheng Zhang, Yongcheng Zhang, Na Li, Ying Hu, Liping Gu, Yanfang Hou, Yuhang Ma

“…Finally, the predictive performance of various factor combinations for 10-year CVD risk progression during the post-acute COVID-19 phase in type 2 diabetes mellitus cohorts was measured by area under roc curve (AUC).ResultsAfter infection with COVID-19, 12.2% (n=46) experienced progression in their 10-year CVD risk category. …”
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Effects and neural mechanisms of a brain–computer interface-controlled soft robotic glove on upper limb function in patients with subacute stroke: a randomized controlled fNIRS stu... by Xiang Ji, Xia Lu, Yi Xu, Wenbin Zhang, Han Yang, Chenghui Yin, Hewei Wang, Caili Ren, Yingying Ji, Yongqiang Li, Guilan Huang, Ying Shen

“…Moreover, changes in prefrontal activation (post–pre) were positively correlated with improvements in ARAT scores, with significant correlations observed in the left dorsal lateral prefrontal cortex (LDLPFC) (Ch9, r = 0.592, P = 0.012; Ch25, r = 0.488, P = 0.047) and right dorsal lateral prefrontal cortex (RDLPFC) (Ch19, r = 0.671, P = 0.003). …”
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Association of β1- and β2-adrenergic receptor gene polymorphisms with the risk of heart failure in patients with type 2 diabetes mellitus by N.M. Kulaiets

“…Two hundred and one patients with HF on the background of post-infarction cardiosclerosis were included. Control group consisted of 43 healthy persons of comparable age and sex. …”
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Pain Management Strategies and Adverse Effects of Opioids in Patients with Neurotrauma with Acute and Chronic Pain by Marie-Ève McGennis, Marc-Aurèle Gagnon, Jérôme Paquet, Alexis F. Turgeon, Tassia Macedo, Caroline Côté, Mwanack Kakule Matina, Michael Verret, Lynne Moore, Andréane Richard-Denis, Line Guénette, Léonie Archambault, Cécile Duval, Mélanie Bérubé

“…We collected data at hospital discharge (T1) and at 3 months post-injury (T2). A total of 70 patients, including 49 with TBI and 21 with SCI, with a mean age of 56 years (±21.1, ±17.9) were included. …”
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The association between hepatic steatosis, vitamin D status, and insulin resistance in adolescents with obesity by Emir Tas, Amanda Flint, Ingrid Libman, Radhika Muzumdar, Xiawei Ou, David K. Williams, Elisabet Børsheim, Eva C. Diaz

“…This study examined the relationship between changes in vitamin D status and markers of IR in adolescents, with a focus on the modifying effect of liver fat. Methods: A post-hoc analysis was performed using data from 44 adolescents participating in a 6-month observational study evaluating biomarkers of hepatosteatosis. …”
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Enhanced efficacy of Helicoverpa armigera nucleopolyhedrovirus against Spodoptera litura larvae using zeolite and chitosan nanoparticle formulations by Mia Miranti, Iqbal Nur Iskandar, Melanie Melanie, Desak Made Malini, Camelia Panatarani, I Made Joni, Dedat Prismantoro, Febri Doni, Ravindra Chandra Joshi, Wawan Hermawan

“…Notably, even the lowest concentration tested (0.125 %) of both chitosan and zeolite nanoparticles achieved 66.67 % larval mortality within seven days post-infection. However, no significant differences in lethal time were observed among treatments, regardless of nanoparticle type or concentration. …”
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A protocol for estimating health burden posed by early life exposure to ambient fine particulate matter and its heavy metal composition: a mother–child birth (ELitE) cohort from Ce... by Tanwi Trushna, Vikas Yadav, Vikas Yadav, Uday Kumar Mandal, Vishal Diwan, Vishal Diwan, Rajnarayan R. Tiwari, Rajnarayan R. Tiwari, Rajesh Ahirwar, Rajesh Ahirwar, Dharma Raj, Sindhuprava Rana, Sindhuprava Rana, Suchitra Vishwambhar Surve, Sagnik Dey, Sagnik Dey, Yogesh Damodar Sabde, Yogesh Damodar Sabde

“…We will also estimate the incidence of Acute Respiratory Infections (ARI) during infancy.DiscussionThis manuscript describes the protocol for an Indian mother–child air pollution birth cohort study that aims to generate comprehensive evidence regarding the adverse effects of early-life (i.e., both pre- and post-natal) exposure to air PM and its constituent heavy metals among Indian children. …”
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Risk factors and adverse outcomes of extubation failure in preterm infants ≤32 weeks with neonatal respiratory distress syndrome by Chen Zhu, Chen Zhu, Zhengli Wang, Zhengli Wang, Kaizhen Liu, Kaizhen Liu, Jiacheng Li, Wenyan Tang, Wenyan Tang, Yuan Shi, Qingxiong Zhu, Qingxiong Zhu

“…Patients were stratified into a success group (n = 228) and a failure (n = 62) group based on whether reintubation was required within 72 h post-extubation. Multivariable logistic regression and nomogram modeling were employed to analyze independent risk factors.ResultsA total of 290 cases were included, comprising 228 in the successful extubation group and 62 in the failed extubation group, yielding an extubation failure rate of 21.4%. …”
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Preparation of photo-crosslinked hyaluronic acid/silk fibroin hydrogel for promoting wound healing by Shujing Li, Wensheng Pan, Maohu Chen, Ruyue Wang, Feng Chen

“…The appropriate incorporation of SF was shown to enhance cellular proliferation. On day 3 post-wounding, the HASF hydrogel group demonstrated a wound closure rate of 41.7%, outperforming commercial products under identical conditions. …”
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The TgAMPK-TgPFKII axis essentially regulates protein lactylation in the zoonotic parasite Toxoplasma gondii by Chenghuan Li, Yang Zhao, Qilong Li, Ran Chen, Ying Feng, Xiaoyu Sang, Xiangrui Li, Bang Shen, Ning Jiang, Qijun Chen

“…Lysine lactylation, as a novel post-translational modification, is essential for epigenetic regulation and cellular processes, and proteomic analyses have shown that lactylated proteins are involved in a wide range of biological processes including energy metabolism, gene regulation, and protein biosynthesis. …”
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An antisense oligonucleotide-based strategy to ameliorate cognitive dysfunction in the 22q11.2 Deletion Syndrome by Pratibha Thakur, Martin Lackinger, Anastasia Diamantopoulou, Sneha Rao, Yijing Chen, Khakima Khalizova, Annie Ferng, Curt Mazur, Holly Kordasiewicz, Robert J Shprintzen, Sander Markx, Bin Xu, Joseph A Gogos

“…Furthermore, antisense oligonucleotide administration and normalization of Emc10 in the adult mouse brain not only alleviates cognitive deficits in social and spatial memory but remarkably sustains these improvements for over 2 months post-injection, indicating its therapeutic potential. …”
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Effect of Faricimab versus Aflibercept on Hyperreflective Foci in Patients with Diabetic Macular Edema from the YOSEMITE/RHINE Trials by Usha Chakravarthy, FRCOphth, PhD, Varun Chaudhary, MD, FRCS(C), Srinivas R. Sadda, MD, Colin S. Tan, FRCOphth, FRCSEd (Ophth), Stela Vujosevic, MD, PhD, Sascha Fauser, MD, Kara Gibson, PhD, Carl Glittenberg, MD, Nancy Holekamp, MD, FASRS, Ben Lanza, PhD, Andreas Maunz, PhD, Jeffrey R. Willis, MD, PhD, Rishi P. Singh, MD

“…Purpose: To compare the effect of faricimab, a dual angiopoietin-2 (Ang-2) and VEGF-A inhibitor, with aflibercept on resolution of hyperreflective foci (HRF) in patients with diabetic macular edema (DME). Design: A post hoc analysis of the randomized, double-masked, noninferiority YOSEMITE/RHINE (NCT03622580/NCT03622593) phase III trials. …”
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Individual responses to encapsulated caffeine and caffeine chewing gum on strength and power in strength-trained males by Hamed Teimouri-Korani, Mohammad Hemmatinafar, Mark ET Willems, Rasoul Rezaei, Babak Imanian

“…Data were analyzed using one-way repeated measures ANOVA and Bonferroni post hoc tests, with significance set at p ≤ 0.05. …”
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Effect of different blood transfusion threshold on the prognosis of elderly patients with anemia in intensive care unit by HU Feihuan, YANG Heng, ZHANG Pushan, LI Jun, YE Hanshen

“…Blood transfusion details of these patients in the ICU were collected and documented, including pre-transfusion Hb levels, volume and number of red blood cell transfusion, and post- transfusion Hb levels. Propensity score matching (PSM) was used to match the baseline data of the two groups of patients, and the clinical outcomes were compared and analyzed after matching. …”
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Media Art—XXI Century: Genesis, Art Programs, Education Problems International Scientific Conference / Международная научно-практическая конференция «Медиаискусство XXI век. Генези... by SAZIKOV ALEXEY V. / САЗИКОВ А.В., EVALLYO VIOLETTA D. / ЭВАЛЛЬЁ В.Д.

“…It is how contemporary media, digital and post-digital technologies influence the state and development of contemporary art and art history practice, architecture, design, and decorative arts, that became the key research task of Media Art—XXI Century Conference. …”
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Real-world treatment patterns and outcomes among patients with HER2-positive unresectable or metastatic breast cancer in China by Jiajia Huang, Limin Chen, Lihua Song, Zhongsheng Tong, Tao Sun, Xiaojia Wang, Yi Liu, Shusen Wang

“…De novo mBC at initial diagnosis, recurrence post 6 months of (neo)adjuvant treatment, absence of brain metastasis, and younger age, were associated with the choice of dual anti-HER2 mAB regimen in 1L treatment. …”
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The genetic history of Portugal over the past 5,000 years by Xavier Roca-Rada, Roberta Davidson, Matthew P. Williams, Vanessa Villalba-Mouco, António Faustino Carvalho, Shyamsundar Ravishankar, Evelyn Collen, Christian Haarkötter, Leonard Taufik, Daniel R. Cuesta-Aguirre, Catarina Tente, Álvaro M. Monge Calleja, Rebecca Anne MacRoberts, Linda Melo, Gludhug A. Purnomo, Yassine Souilmi, Raymond Tobler, Eugénia Cunha, Sofia Tereso, Vítor M. J. Matos, Teresa Matos Fernandes, Anne-France Maurer, Ana Maria Silva, Pedro C. Carvalho, Bastien Llamas, João C. Teixeira

“…The latter remains stable during the post-Islamic period, suggesting enduring African influences. …”
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A Randomized Controlled Pilot Study Evaluating the Safety and Efficacy of Nifuroxazide in Patients with Ulcerative Colitis by AlRasheed HA, Abdallah MS, El-Khateeb E, Kamal M, Alrubia S, Alsegiani AS, Ahmed TI, Bahaa MM

“…Secondary outcomes: change in IBDQ-32 and in the level of measured biomarkers.Results: Baseline measurements were comparable between groups (p > 0.05). Post-treatment values showed significant improvements within both groups compared to baseline. …”
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