Isobavachalcone ameliorates Alzheimer disease pathology by autophagy-mediated clearance of amyloid beta and inhibition of NLRP3 inflammasome in primary astrocytes and 5x-FAD mice by Dilpreet Kour, Dilpreet Kour, Parul Khajuria, Parul Khajuria, Kuhu Sharma, Kuhu Sharma, Alpa Sharma, Alpa Sharma, Ankita Sharma, Ankita Sharma, Syed Mudassir Ali, Priya Wazir, P. Ramajayan, P. Ramajayan, Sanghapal D. Sawant, Sanghapal D. Sawant, Sanghapal D. Sawant, Utpal Nandi, Utpal Nandi, Zabeer Ahmed, Zabeer Ahmed, Ajay Kumar, Ajay Kumar

“…Data from all in vitro and in vivo experiments were analyzed by using one-way ANOVA and post-hoc Bonferroni tests.ResultsIn-vitro analyses in astrocytes demonstrated that IBC at 5 and 10 μM concentrations induce AMPK phosphorylation through CAMKK2, promoting autophagy and inhibiting the NLRP3 inflammasome in primary astrocytes. …”
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LRRK2-mutant microglia and neuromelanin synergize to drive dopaminergic neurodegeneration in an iPSC-based Parkinson’s disease model by Lucas Blasco-Agell, Meritxell Pons-Espinal, Veronica Testa, Gerard Roch, Jara Montero-Muñoz, Irene Fernandez-Carasa, Valentina Baruffi, Marta Gonzalez-Sepulveda, Yvonne Richaud-Patin, Senda Jimenez, Thais Cuadros, Joana M. Cladera-Sastre, Joan Compte, Zoe Manglano-Artuñedo, Salvador Ventura, Manel Juan, Eduardo Tolosa, Angel Raya, Miquel Vila, Antonella Consiglio

“…When exposed to NM-containing particles, but not α-synuclein fibrils, LRRK2 hMG trigger DAn degeneration, in a process that is prevented by pre-treatment with the immunomodulatory drug ivermectin. Finally, post-mortem analysis of midbrain tissue of LRRK2-PD patients show increased microglia activation around NM-containing neurons, confirming our in vitro findings. …”
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Scapular dyskinesis-based exercise therapy versus multimodal physical therapy for subacromial impingement syndrome in young overhead athletes with scapular dyskinesis: a randomized... by Meilin Wen, Xuanming Hu, Guiying Bao

“…Although registration occurred post-enrolment, the study protocol was finalized and ethically approved prior to participant recruitment. …”
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Telomere biology disorders in lung transplantation: Clinical challenges and management strategies by Farah Mesli, Quentin Philippot, Kinan El Husseini, Vincent Bunel, Caroline Kannengiesser, Marie Pierre Debray, Alice Guyard, Bruno Crestani, Ibrahima Ba, Raphaël Borie

“…Shortened telomeres—whether due to inherited telomeropathies or acquired attrition—have emerged as a risk factor for various pulmonary diseases, particularly pulmonary fibrosis, which is a leading indication for lung transplantation.This review provides a comprehensive overview of current knowledge on the impact of short telomeres in lung transplant recipients, encompassing pre-transplant assessment and post-transplant outcomes. Patients with telomere-biology disorder present unique clinical challenges. …”
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Cause-specific mortality in individuals with and without mental disorders according to socioeconomic position: a population-based cohort studyResearch in context by Danni Chen, Linda Ejlskov, Julie Werenberg Dreier, Natalie C. Momen, Lisbeth Mølgaard Laustsen, Henrik Toft Sørensen, Jayati Das-Munshi, Oleguer Plana-Ripoll

“…All subgroup, sensitivity, and post-hoc analyses indicated similar patterns. Interpretation: We provide detailed descriptions of cause-specific mortality associated with specific mental disorders by SEP and reveal potentially differential roles of SEP across causes of death. …”
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Proof of principle for a light dark matter search with low-energy positron beams at NA64 by The NA64 collaboration, Yu. M. Andreev, A. Antonov, M. A. Ayala Torres, D. Banerjee, B. Banto Oberhauser, V. Bautin, J. Bernhard, P. Bisio, M. Bondì, A. Celentano, N. Charitonidis, P. Crivelli, A. V. Dermenev, S. V. Donskov, R. R. Dusaev, T. Enik, V. N. Frolov, S. V. Gertsenberger, S. Girod, S. N. Gninenko, M. Hösgen, Y. Kambar, A. E. Karneyeu, G. Kekelidze, B. Ketzer, D. V. Kirpichnikov, M. M. Kirsanov, V. A. Kramarenko, L. V. Kravchuk, N. V. Krasnikov, S. V. Kuleshov, V. E. Lyubovitskij, V. Lysan, A. Marini, L. Marsicano, V. A. Matveev, R. Mena Fredes, R. Mena Yanssen, L. Molina Bueno, M. Mongillo, D. V. Peshekhonov, V. A. Polyakov, B. Radics, K. Salamatin, V. D. Samoylenko, H. Sieber, D. Shchukin, O. Soto, V. O. Tikhomirov, I. Tlisova, A. N. Toropin, M. Tuzi, P. V. Volkov, I. V. Voronchikhin, J. Zamora-Saá, A. S. Zhevlakov

“…This data set was analyzed with the primary aim of evaluating the performance of the NA64e detector with a lower energy positron beam, towards the realization of the post-LS3 program. The analysis results, other than additionally probing unexplored regions in the LDM parameter space, provide valuable information towards the future NA64e positron campaign.…”
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Quantitative insights into stroke recovery utilizing delayed vessel ratio from color-coded multiphase computed tomography angiography by Yu Lin, Yu Lin, Yu Lin, Xiaoxiao Zhang, Zhen Xing, Xiefeng Yang, Qingwen Tong, Shaomao Lv, Jinan Wang, Jinan Wang, Dairong Cao, Dairong Cao, Dairong Cao, Dairong Cao

“…DVR from cmCTA may enhance pre-treatment collateral assessment and post-treatment outcome prediction in AIS, facilitating informed treatment decisions.…”
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MSAB limits osteoarthritis development and progression through inhibition of β-catenin-DDR2 signaling by Ke Lu, Zhidong Liao, Jingwen Li, Yuhan Wang, Yuting Zhang, Lintao Cai, William W. Lu, Fan Yang, Hong Pan, Di Chen

“…Despite its potential as a therapeutic target, clinical translation is impeded by the lack of a targeting delivery system and effective drug candidate that can modulate steady-state protein levels of β-catenin at post-translational level. Our study addresses these challenges by offering a new approach for OA treatment. …”
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Combination of Cv-aCO2/Ca-vO2 and Pv-aCO2 as markers of resuscitation or microcirculation in patients with septic shock: a pilot study by Luping Cheng, Wenxin Wang, Xia Hu, Chuanliang Pan

“…We classified patients into four groups based on their Cv-aCO2/Ca-vO2 and Pv-aCO2 levels at 6 h post-ICU admission (T6), monitored sublingual microcirculation, and followed them for 28 days. …”
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Pathologic and Oncologic Outcomes of Patients Undergoing Orchiectomy After Chemotherapy for Advanced Testicular Germ Cell Tumors by Viranda H. Jayalath, Fady Baky, Samuel A. Gold, Nicole Liso, Brandon Williams, Samuel A. Funt, Darren R. Feldman, Victor E. Reuter, Joel Sheinfeld, Richard S. Matulewicz

“…There is poor histologic concordance with pcRPLND pathology. Post-treatment ultrasound findings may be suggestive of the presence of RVD. …”
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Value of synthetic MRI in predicting treatment response to neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer by WANG Kangning, ZHU Lan, FENG Weiming, XIA Yihan, SHI Bowen, ZHANG Huan

“…After the synthetic MRI sequence scanning was completed, synthetic images of T1 mapping, T2 mapping, and proton density (PD) mapping were generated using Synthetic MR post-processing software. Histogram-based quantitative parameters at baseline were extracted using python software, including quantitative parame-ters of the primary tumor and peritumoral fat region: T1 relaxation time (T1RT), T2 relaxation time (T2RT), and proton density (PD). …”
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Analysis of physicochemical properties, electronic sensory, and HS-GC-IMS to explore the effects of density-related stress on the texture, nutritional profile, and flavor of Larimi... by Songpeng Jia, Mengqi Lu, Tianyi Lan, Zhenyu Gao, Ran Meng, Xuelei Wang, Xiongfei Wu, Lin Huang, Xujie Li, Zhongming Zheng, Weiliang Shen

“…The results indicate that the MSD group showed superior water-holding capacity, higher muscle fiber density, and greater post-heating hardness. All groups had high protein content and essential amino acid profiles meeting FAO/WHO recommendations. …”
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Prognostic effect of body mass index in patients with acute leukemia undergoing allogeneic hematopoietic stem cell transplantation: A retrospective cohort study by Jing Yu, Zhuoyue Shi, Hengwei Wu, Yi Luo, Jian Yu, Yamin Tan, Xiaoyu Lai, Lizhen Liu, Huarui Fu, Yishan Ye, Luxin Yang, Congxiao Zhang, He Huang, Jimin Shi, Yanmin Zhao

“…To elucidate the influence of pretransplant BMI on post-allo-HSCT outcomes including graft-versus-host disease (GVHD), overall survival (OS), relapse-free survival (RFS), and nonrelapse mortality (NRM), we conducted a retrospective study using registry data which comprised 1092 adult patients who underwent allo-HSCT between 2015 and 2023. …”
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CT derived ECV in severe aortic stenosis: prognosticator and screening test for co-existent transthyretin cardiac amyloidosis by Joshua N. McShane, Anahita Tavoosi, Huda El Mais, Keren Mbondo Kasuku, Anthony Poulin, Mehmet Onur Omaygenc, Ian G. Burwash, David Messika-Zeitoun, Benjamin J.W. Chow, Gary R. Small

“…A delayed cardiac acquisition was acquired 5 min post TAVR-CT. Pre-contrast and delayed -images were used to determine ECV. …”
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Kitlo hematopoietic stem cells exhibit distinct lymphoid-primed chromatin landscapes that enhance thymic reconstitution by Harold K. Elias, Sneha Mitra, Marina B. da Silva, Adhithi Rajagopalan, Brianna Gipson, Nicole Lee, Anastasia I. Kousa, Mohamed A. E. Ali, Simon Grassmann, Rhoshini Raghuraman, Xiaoqun C. Zhang, Susan DeWolf, Melody Smith, Hana Andrlova, Kimon V. Argyropoulos, Roshan Sharma, Teng Fei, Joseph C. Sun, Cynthia E. Dunbar, Christopher Y. Park, Christina S. Leslie, Avinash Bhandoola, Michael G. Kharas, Marcel R. M. van den Brink

“…Using a preclinical allo-HCT mouse model, we demonstrate that Kitlo HSCs provide superior thymic recovery and T cell reconstitution, resulting in improved immune responses to post-transplant infection. Kitlo HSCs with augmented bone marrow (BM) lymphopoiesis mitigate age-associated thymic alterations and enhance T cell recovery in middle-aged mice. …”
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Impact of Warmed Irrigation Fluid During Shoulder Arthroscopy on Patient Temperature, Recovery, and Cognitive Function: A Prospective Analysis of Influencing Factors by Jingfeng Liu, Xiaohong Huang, Xiaowei Xu, Yanyan Song, Jie Chen, Pei Yu, Tingjun Ye, Yin Zhang, Dahang Zhao, Gen Li, Lei Wang, Ying Wang, Zhenjin Ju, Chengyu Zhuang

“…Analysis of MMSE and MOCA scores revealed that the areas of cognitive decline post‐surgery mainly involved cumulative memory and attention, while orientation was not affected. …”
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Tilt-induced changes in f-wave characteristics during atrial fibrillation: an experimental and computational investigation by Mostafa Abdollahpur, Chiara Celotto, Chiara Celotto, Carlos Sánchez, Carlos Sánchez, Felix Plappert, Sten Östenson, Pyotr G. Platonov, Pablo Laguna, Pablo Laguna, Esther Pueyo, Esther Pueyo, Frida Sandberg

“…Transient phase is defined as the initial 2-minute interval following each postural change, reflecting immediate autonomic adaptation, whereas steady phase refers to the subsequent interval (from 3 minutes post-change until phase end) representing a stable autonomic state.MethodsOur primary aim is to investigate how the two branches of the autonomic nervous system (ANS) influence the f-wave frequency time series (f(m)). …”
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Two-drug versus three-drug regimens for treating Mycobacterium avium complex infection: A systematic review and meta-analysis by Van-Dong Nguyen, Hai Duong, Ming-Chia Lee, Jin-Hua Chen, Wei-Chang Huang, Hsiao-En Chen, Jung-Chun Lin, Jann-Yuan Wang, Chih-Hsin Lee

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Constructing the optimal experimental autoimmune thyroiditis mouse model using porcine thyroglobulin by Ke Liu, Pei Zhang, Zi-Shan Jin, Xiang-Kun Meng, Jin-Li Luo, Jin-Li Luo, Jin-Li Luo, Lin Han, Xiao-Tong Yu

“…Thyroid histopathology (HE staining, infiltration scoring), serum TPO-Ab/TG-Ab (ELISA), cytokines (multiplex assay), Th17/Treg cells (multiplex immunofluorescence), and thyroid IL-17A/NLRP3/Caspase-1 (immunohistochemistry) were analyzed 2 weeks post-last immunization.ResultsHigh-dose antigen (200 μg pTg) with high-frequency immunization (three times) via SC or IV routes induced severe thyroid lymphocyte infiltration (scores: SC 3.4±0.55, IV 3.2±0.45; p<0.01 vs. controls), follicular destruction, and elevated serum antibodies (TPO-Ab: IV 438.8±13.15 > SC 406.2±7.46; TG-Ab: IV 158.4±5.32 > SC 141.9±2.36). …”
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Feeding amylolytic and fibrolytic exogenous enzymes in feedlot diets: effects on ruminal parameters, nitrogen balance and microbial diversity of Nellore cattle by Igor Machado Ferreira, Hilario Cuquetto Mantovani, Fiorella Viquez-Umana, Yury Tatiana Granja-Salcedo, Luiz Fernando Costa e Silva, Anne Koontz, Vaughn Holder, James Eugene Pettigrew, Arlan Araújo Rodrigues, Aline Naime Rodrigues, Mateus José Inácio de Abreu, Saulo Teixeira Rodrigues de Almeida, Pedro Marcus Pereira Vidigal, Gustavo Rezende Siqueira, Flávio Dutra de Resende

“…The experimental period lasted 19 d and included total urine and feces collection (d 15 to 18) and rumen fluid sampling (d 19) at 0, 4, 8, 12, and 16 h post-feeding for ammonia, volatile fatty acids (VFA), pH and microbiome analysis. …”
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