PODO447: a novel antibody to a tumor-restricted epitope on the cancer antigen podocalyxin by Blake Gilks, Martin Köbel, Diana Canals Hernaez, Michael R Hughes, Pamela Dean, Peter Bergqvist, Ismael Samudio, Ola Blixt, Katharina Wiedemeyer, Yicong Li, Chris Bond, Eric Cruz, Calvin D Roskelley, Kelly M McNagny

“…Since pathways regulating post-translational modifications are frequently perturbed in cancer cells, we sought to produce novel anti-Podxl antibodies (Abs) that selectively recognize tumor-restricted glycoepitopes on the extracellular mucin domain of Podxl.Methods Splenic B cells were isolated from rabbits immunized with a Podxl-expressing human tumor cell line. …”
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A potent protective bispecific nanobody targeting Herpes simplex virus gD reveals vulnerable epitope for neutralizing by Jing Hu, Haoyuan Tan, Meihua Wang, Shasha Deng, Mengyao Liu, Peiyi Zheng, Anmin Wang, Meng Guo, Jin Wang, Jiayin Li, Huanwen Qiu, Chengbing Yao, Zhongliang Zhu, Chaolu Hasi, Dongli Pan, Hongliang He, Chenghao Huang, Yuhua Shang, Shu Zhu, Tengchuan Jin

“…Mechanistically, Nb14-32-Fc neutralizes HSVs at both the pre-and post-attachment stages and prevents cell-to-cell spread in vitro. …”
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Plasma Versus Whole Blood Tacrolimus Concentrations and Health-Related Quality of Life in Kidney Transplant Recipients by Svea Nolte, J. Casper Swarte, Tim J. Knobbe, Ilja M. Nolte, Tanja R. Zijp, Harmen R. Moes, Marco van Londen, Niels L. Riemersma, Johannes R. Björk, Rinse K. Weersma, Gea Drost, Stefan P. Berger, Daan J. Touw, Stephan J. L. Bakker

“…<b>Methods</b>: In this cross-sectional study, 898 kidney transplant recipients (KTRs) who were at least 12 months post-transplantation were included. Plasma and whole blood tacrolimus concentrations were compared using Passing–Bablok regression analyses and Bland–Altman plots. …”
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Microwave ablation combined with immune checkpoint inhibitor enhanced the antitumor immune activation and memory in rechallenged tumor mouse model by Fengkuo Xu, Jing Sang, Nan Wang, Meixiang Wang, Yahan Huang, Ji Ma, Huanan Chen, Qi Xie, Zhigang Wei, Xin Ye

“…In preclinical models, we established a tumor rechallenged model to address post-MWA recurrence and to delve into the underlying mechanisms of the combined therapy. …”
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Relationship between DTI-MRI derived metrics and radiotherapy dose range in the contralateral cerebrum in lower grade glioma by Justyna Kłos, Justyna Kłos, Hildebrand Dijkstra, Hiska L. van der Weide, Jan H. Potze, Peter F. Sinnige, Kelvin Ng Wei Siang, Kelvin Ng Wei Siang, Kelvin Ng Wei Siang, Rudi A. J. O. Dierckx, Rudi A. J. O. Dierckx, Ronald J. H. Borra, Ronald J. H. Borra, Miranda C. A. Kramer, Anouk van der Hoorn

“…WM and GM were segmented using automated software (cNeuro) and the mean FA and ADC were extracted per RT dose bin (0-10, 10-20, 20-30, 30-40, 40-50, &gt;50 Gy) of WM and GM. One way ANOVA with post-hoc Bonferroni’s test were used to analyse differences in FA and ADC between dose bins. …”
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Isolated small airways obstruction predicts future chronic airflow obstruction: a multinational longitudinal study by Andre F S Amaral, Thorarinn Gislason, Frits Franssen, Cosetta Minelli, James Potts, Christer Janson, Rune Nielsen, Andrei Malinovschi, Padukudru Anand Mahesh, Jaymini Patel, Meriam Denguezli, Parvaiz Koul, Asaad Ahmed Nafees, Peter GJ Burney, Rana Ahmed, Sonia Buist, Ben Knox-Brown, Dhiraj Agarwal, Valentina Quintero Santofimio, Najlaa Mohammed Abass, Jayaraj BS, Sanjay K Juvekar, Stefanni Nonna M Paraguas

“…We defined chronic airflow obstruction as post-bronchodilator FEV1/FVC&lt;LLN. We performed mixed effects regression analyses to model the association between baseline isolated small airways obstruction and chronic airflow obstruction at follow-up. …”
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Efficacy of subanaesthetic esketamine on the prevention of postoperative delirium in older adult patients after cardiovascular surgery: protocol for a single-centre, randomised, do... by Wei Zhang, Liang Zhao, Ju-Min Yan, Qing-Ren Liu, Jian-Jun Yang, Hong-Qi Lin, Zhao-Yu Wen, Hao-Ran Zhang, Yi-Xin Mei, Rui-Di Wang

“…Public disclosure is guaranteed post-trial, and the results will be published in a peer-reviewed scientific journal.Trial registration number ChiCTR2300074395.…”
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Perirenal fat as a potential marker and therapeutic target for metabolic syndrome: insights from a multicenter randomized controlled trial by Yang Hua, Meng-Huan Li, Meng-Huan Li, Yu-Xuan Lou, Ke-Rui Zhang, Jia-Ming Yang, Yan-Hui Sheng, Yu-Qing Zhang, Chuan-li Cheng, Chao Zou, Ting-ting Wu, Xiang-Qing Kong, Xiang-Qing Kong, Wei Sun, Wei Sun

“…This study aims to investigate the association between perirenal fat volume (PrFV) and MetS in Chinese adults.MethodsWe conducted a post-hoc cross-sectional analysis within a multicenter, randomized clinical trial. …”
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My Back Exercise app: an automated exercise intervention supported by educational notifications, a sleep programme and diet advice to improve function in people with chronic non-sp... by Manuela L Ferreira, Kim L Bennell, Christopher J Gordon, Josielli Comachio, Paulo Ferreira, Rachel K Nelligan, Serigne N Lo, Paula Beckenkamp, Anelise Moreti Cabral Silveira, Carlos Mesa-Castrillon, Katharine Roberts, Emma K Ho, Rowena J Field

“…The primary outcome will be self-reported physical function measured by the Patient-Specific Functional Scale at 6 weeks post-randomisation. Data will be analysed using the Student’s t-test or the non-parametric Mann-Whitney U test.Ethics and dissemination This trial was approved by the Human Research Ethics Committee (HREC) of The University of Sydney (HREC Approval No. 2023/HE000772). …”
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Clinical and Behavioral Correlates of Blood Acylcarnitine Profiles in Children with Autism Spectrum Disorder: A Cross-Sectional Analysis by Adriana Prato, Martina Randazzo, Maria Anna Messina, Giovanni Puglisi, Laura Rosy Aleo, Fiorella Ciantia, Lara Cirnigliaro, Renata Rizzo, Rita Barone

“…There was a significant difference in the severity of autism symptoms (ADOS CSS) related to the repetitive and restricted behaviors domain (CSS RRB) among the different groups (χ²(2) = 6.26; <i>p</i> = 0.044). The post hoc Dunn’s test with Bonferroni correction showed that ADOS-CSS RRB was significantly higher in ASD group A compared to ASD group B (<i>p</i> = 0.013). …”
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Gender-specific assessment of lipid profiles correlation with serum uric acid in non-dialysis chronic kidney disease patients: Prospective observational cross-sectional study by Yousuf Abdulkarim Waheed, Yousuf Abdulkarim Waheed, Huanhuan Yin, Jie Liu, Shifaa Almayahe, Maryam Bishdary, Karthick Kumaran Munisamy Selvam, Syed Muhammad Farrukh, Shulin Li, Shulin Li, Yanping Wang, Yanping Wang, Disheng Wang, Disheng Wang, Disheng Wang, Xinglei Zhou, Dong Sun, Dong Sun, Dong Sun

“…The age-stratified analysis indicated that LDL-c was higher in individuals aged ≥70 compared to younger groups (P&lt;0.002), while HDL-c was higher in the 20–29 age group; with (P&lt;0.031). Post-hoc univariate tests revealed significant between quartile differences for all lipid variables (all P ≤ 0.05).ConclusionIn CKD population, SUA levels were positively associated with LDL-c, TC, and TG, while inversely associated with HDL-c. …”
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Persistence and decay of neutralizing antibody responses elicited by SARS-CoV-2 infection and hybrid immunity in a Canadian cohort by Amy Nouanesengsy, Anthony Semesi, Kim Quach, Danton Ivanochko, Walter Byrne, Matthew Hwang, Maria-Rosa La Neve, Matilde Leon-Ponte, Alice Litosh, Nicole Wisener, Khosrow Adeli, Aaron Campigotto, Eyal Grunebaum, Allison McGeer, Theo J. Moraes, Lusia Sepiashvili, Julia Upton, Jean-Philippe Julien, Upton Allen

“…Additionally, we found an association between robust antibody responses and individuals with severe COVID-19 clinical symptoms during the first-month post-symptom onset. For individuals who achieved hybrid immunity, a robust increase in anti-S1 IgGs and neutralizing antibodies followed the first vaccination dose; however, there was a minimal increase in the anti-S1 IgGs and neutralizing antibody titers after administration of the second dose of the vaccine. …”
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Characteristics and Outcome of Partial Liver Transplant among Pediatrics in a Referral Transplant Center in Iran from 2010 to 2020 by Pooya Vatankhah, Mohammad Bagher Khosravi, Mohammad Hossein Eghbal, Naeimehossadat Asmarian, Mohammad Ali Sahmeddini, Fatemeh Khalili, Samaneh Ghazanfar Tehran, Hamed Nikoupour, Alireza Shamsaeefar, Kourosh Kazemi, Sahar Sohrabi Nazari, Saman Nikeghbalian, Seyed Ali Malekhosseini

“…The primary diagnoses included cholestatic diseases (44.4%) and metabolic diseases (34.1%). Post-transplant rejection and mortality rates were 21.1% (119 patients) and 36.1% (203 patients), respectively. …”
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GLP-1 and GIP may play a role in long-term weight trajectories after gastric bypass by Sara Andrade, Sara Andrade, Carolina B. Lobato, Carolina B. Lobato, Carolina B. Lobato, Carolina B. Lobato, Mariana Machado, Mariana Machado, Bolette Hartmann, Jens J. Holst, Jens J. Holst, Rui F. Almeida, Mário Nora, Mariana P. Monteiro, Mariana P. Monteiro, Marta Guimarães, Marta Guimarães, Marta Guimarães, Sofia S. Pereira, Sofia S. Pereira

“…So, our aim was to evaluate the hormone profiles of patients with long-term optimal and suboptimal response after gastric bypass (RYGB).MethodsThis cross-sectional study included 43 individuals who underwent RYGB surgery over 10 years ago, divided into two groups: 23 participants with no T2D history but different WR trajectories (cohort 1), and 20 with prior T2D diagnosis and optimal WL (cohort 2), with post-RYGB T2D remission (n=10) or relapse (n=10). …”
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Infarct core growth rate and 90-day outcomes in ischemic stroke: subgroup analysis based on onset-to-recanalization time by Sha Chen, Sha Chen, Guofang Chen, Changzhi Zhao, Enle Wang, Yewen Zhou, Manhua Ding, Yang Zhang, Yang Zhang

“…Clinical outcomes were evaluated using the modified Rankin Scale (mRS) at 90 days post-procedure. The least absolute shrinkage and selection operator (LASSO) regression was employed for data screening. …”
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Comparative Evaluation of Apical Fit of Various Corresponding Gutta-percha Cones in Prepared S-shaped Canals of Simulated Mandibular Premolars: An In-vitro Study by Parul Bansal, Garima Singh, Mohit Kumar, Nikita Sharma, Smrity Sinha, Darshana Baruah

“…The obtained results were tabulated (One-way ANOVA and Post-hoc Tukey tests, p-value ≤0.0001, (highly significant) and subjected to statistical analysis using Statistical Package for Social Sciences (SPSS) Software. …”
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Effectiveness of clopidogrel vs. ticagrelor based on the ABCD-GENE score in acute coronary syndrome patients following percutaneous coronary intervention by Xiaotong Xu, Xiaotong Xu, Kun Na, Miaohan Qiu, Xueqing Yang, Xueqing Yang, Zizhao Qi, Zizhao Qi, Jing Li, Kai Xu, Xiaozeng Wang, Yi Li, Yaling Han

“…AimThis study employs the ABCD-GENE score (age, body mass index, chronic kidney disease, diabetes, and CYP2C19 variants) to compare the effectiveness and safety of clopidogrel versus ticagrelor-based DAPT in ACS patients post-PCI.MethodsA total of consecutive 21,705 ACS patients who underwent PCI between March 2016 and March 2023 and survived at discharge were included. …”
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Effect of IL4-589C>T, FCGR2A-166His>Arg, DEFB1-20G>A, DEFB1-52G>A gene polymorphisms on TNFα, IL-1β, IL-4, and IL-10 contents in the patients with primary hip osteoarthrosis by A. M. Miromanov, T. V. Zabello, N. A. Miromanova

“…The exclusion criteria were as follows: close relationship; other types of osteoarthritis (post-traumatic, rheumatoid, metabolic, etc.); dysplastic syndromes and phenotypes; acute and chronic inflammatory diseases at the exacerbation stage; diabetes mellitus; osteoporosis; vascular diseases; obesity; malignant neoplasia; alcohol abuse. …”
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Role of Amide Proton Transfer Weighted MRI in Predicting MGMTp Methylation Status, p53-Status, Ki-67 Index, IDH-Status, and ATRX Expression in WHO Grade 4 High Grade Glioma by Faris Durmo, Jimmy Lätt, Anna Rydelius, Elisabet Englund, Tim Salomonsson, Patrick Liebig, Johan Bengzon, Peter C. M. van Zijl, Linda Knutsson, Pia C. Sundgren

“…All patients were examined using conventional MRI, including the following: T1w-MPRAGE pre- and post-contrast administration, conventional T2w and 3D FLAIR, and APTw imaging with a 3T MR scanner. …”
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Identification of CaVβ1 Isoforms Required for Neuromuscular Junction Formation and Maintenance by Amélie Vergnol, Aly Bourguiba, Stephanie Bauché, Massiré Traoré, Maxime Gelin, Christel Gentil, Sonia Pezet, Lucile Saillard, Pierre Meunier, Mégane Lemaitre, Julianne Perronnet, Frederic Tores, Candice Gautier, Zoheir Guesmia, Eric Allemand, Eric Batsché, France Pietri-Rouxel, Sestina Falcone

“…Additionally, their expression during early post-natal development is essential for NMJ maturation and long-term maintenance. …”
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