Accelerated iTBS-Induced changes in resting-state functional connectivity correspond with cognitive improvement in amnestic MCI by Stephanie Aghamoosa, Sara A. Nolin, Andrew A. Chen, Kevin A. Caulfield, James Lopez, Katrina Rbeiz, Holly H. Fleischmann, Olivia Horn, Katrina Madden, Michael Antonucci, Gonzalo Revuelta, Lisa M. McTeague, Andreana Benitez

“…Methods: Eighteen patients with MCI received 3-day a-iTBS (8 sessions/day) to the left dorsolateral prefrontal cortex at Beam F3 (14,400 total pulses) and completed MRI and cognitive testing at pre- and post-treatment. Based on electric field models, we selected 3 stimulated target regions of interest (ROIs) which belonged to the frontoparietal (FPN), default mode (DMN), and ventral attention (VAT) networks (3 target networks). …”
Get full text

2025 Korean Thyroid Association Management Guidelines for Radioactive Iodine Therapy in Patients with Hyperthyroidism by Kyeong Jin Kim, Eyun Song, Mijin Kim, Hyemi Kwon, Eu Jeong Ku, Hyun Woo Kwon, Jee Hee Yoon, Eun Kyung Lee, Won Woo Lee, Young Joo Park, Dong-Jun Lim, Sun Wook Kim, Ho-Cheol Kang, Jae Hoon Chung, Tae Yong Kim, Sin Gon Kim, Dong Gyu Na, Jee Soo Kim

“…Thyroid function should be monitored at 4–6 weeks post-treatment, every 2–3 months until stabilized, and then every 6–12 months. …”
Get full text

Induction of lung mucosal immunity by a next-generation inhaled aerosol COVID-19 vaccine: an open-label, multi-arm phase 1 clinical trial by Mangalakumari Jeyanathan, Sam Afkhami, Michael R. D’Agostino, Imran Satia, Dominik K. Fritz, Kate Miyasaki, Jann C. Ang, Anna Zganiacz, Karen J. Howie, Marilyn Swinton, Emilio Aguirre, Michael B. Zheng, Natallia Kazhdan, Anna Dvorkin-Gheva, Lawrence Mbuagbaw, Maria Fe C. Medina, Nermin Diab, Danica L. Brister, Gail M. Gauvreau, Brian D. Lichty, Matthew S. Miller, Fiona Smaill, Zhou Xing

“…Ag-specific immune responses (secondary outcome) are assessed in peripheral blood and in respiratory tract via bronchoscopy at baseline and at timepoint(s) post-vaccination. Eighteen-65-year-old, healthy participants who have received at least 3 doses of mRNA COVID-19 vaccine are enrolled with those vaccinated with any Ad-vectored COVID-19 vaccine excluded. …”
Get full text

Age‐Dependent Associations Between Pulse Pressure and Long‐Term Outcomes After Myocardial Infarction by Congliang Miao, Dandan Zhao, Shuohua Chen, Lina Xu, Yusong Huang, Huimin Li, Huibiao Deng, Lili Wu, Yuchen Wang, Yu Fu, Guoyan Wu, Shouling Wu, Jiang Hong, Wen‐Yi Yang

“…Elevated PP is an independent predictor of recurrent cardiovascular outcomes in post‐MI patients, with particularly stronger associations observed in younger and middle‐aged adults. …”
Get full text

Differences between valve types in anatomic changes of the aortic root after surgical aortic valve replacementCentral MessagePerspective by Ai Kawamura, MD, PhD, Kazuo Shimamura, MD, PhD, Daisuke Yoshioka, MD, PhD, Yusuke Misumi, MD, PhD, Kizuku Yamashita, MD, PhD, Koichi Maeda, MD, PhD, Takuji Kawamura, MD, PhD, Masashi Kawamura, MD, PhD, Yutaka Matsuhiro, MD, Shumpei Kosugi, MD, Daisuke Nakamura, MD, Isamu Mizote, MD, PhD, Yasushi Sakata, MD, PhD, Shigeru Miyagawa, MD, PhD

“…We investigated the changes in the aortic root and evaluated the differences in changes between valve types. Methods: Pre- and post-SAVR computed tomography scans of 124 patients with aortic stenosis who underwent SAVR with various bioprosthetic valves were analyzed retrospectively. …”
Get full text

Validating the pathogenic mechanism of chronic obstructive pulmonary disease induced by negative emotions via Mendelian randomization and traditional Chinese medicine theory of emo... by Zhiying Wang, Yun Li, Zhixian Zhong, Ling Xu, Yi Zhong, Jian Chen

“…Multivariable MR demonstrated that anxiety remained independently associated with COPD after adjusting for smoking (P = 0.002), while associations with other negative emotions were attenuated post-adjustment. The mediation analysis revealed that CRP mediated 3.93% of the total effect of anxiety on COPD. …”
Get full text

Case Report: Decentralized trial of tolerability-adapted exercise therapy after severe Covid-19 by Jessica M. Scott, Jessica M. Scott, Zhuyu Qiu, Zhuyu Qiu, Jahan Rahman, Chaya S. Moskowitz, Meghan G. Michalski, Sarah Lehman, Catherine P. Lee, Jenna Harrison, Anthony F. Yu, Anthony F. Yu, Amira Marouf, Amira Marouf, Santosha Vardhana, Santosha Vardhana, Paul C. Boutros, Paul C. Boutros, Paul C. Boutros, Paul C. Boutros, Lee W. Jones, Lee W. Jones

“…Correlative proteomic and single-cell immune sequencing of peripheral blood samples revealed marked alterations in protein and immune phenotypes implicated in post COVID-19 condition. (ClinicalTrials.gov number, NCT04824443).…”
Get full text

Modulatory effects of synbiotic blend on selected human fecal bacteria and TNFα + LPS-induced inflammation in human intestinal epithelial cells by Anita Rawat, Arka Bhattacharya, Rupa Tharu, Ruchika Maurya, Sanjay Kumar Bhadada, Mahendra Bishnoi, Kanthi Kiran Kondepudi

Get full text

Cloning and expression profile of an ubiquitin-conjugating enzyme-like gene OsCROC-1A in rice (Oryza sativa L.) by WANG Ya, LIU Jianping, XU Mengyun, JI Weijie, TU Jumin, ZHANG Xiaobo

“…Protein ubiquitination is a fundamental post-translational modification event that serves as a signaling function in diverse biological processes. …”
Get full text

Contributory factors to partial implementation of prevention of mother to child transmission policy in South Africa by Hermina Manjekana Dyeshana, Sibusiso Memory Zuma

“…This study ascertained identified gaps as follows: Of 163 accounted for pregnant women participants, 82(53.0%) booked before 20 weeks of gestational dates for their first ANC booking as advocated for by the PMTCT policy,81 were late bookers who had potential for not having their viral load suppressed, with high risk of MTCT.15 were missing and unaccounted for. 91 of 101 (89.11%) pregnant HIV positive women commenced ART on the day of their diagnosis, during their first ANC attendance. 67 were known HIV positive pregnant women already on ART who came for their first booking The remaining 10 pregnant HIV positive women did not begin ART early in their pregnancy and have the potential of not being virally suppressed Viral load was poorly monitored—25.0% had no viral load testing done at their first ANC booking,47% were tested at delivery and 49.0% tested at 6-months after delivery.150 of 164 HIV positive women who were eligible for a routine six-to-twelve-week post-partum were missed opportunities.100 of 178 (56.2%) HIV exposed babies were given NVP and AZT prophylaxis Baby Polymerase Chain Reaction(PCR) testing:Of 178 HIV exposed babies, 122 (69%) were tested at birth, 113 of 178(63%) were tested at 10 weeks There was 6 (3.5%) of babies who seroconverted after 103 of 178 (58%) were tested. at 6-months. …”
Get full text

TaPUB57 confers drought tolerance, governs grain size and salt sensitivity by ubiquitinating TaEXPB3 in rice by Chunmei Yu, Min Wang, Long Li, Yuying Li, Yanfei Zhang, Jie Zhang, Xin Chen, Lili Yang, Chaonan Li, Jingyi Wang, Guangchao Liu, Matthew P Reynolds, Qi Xie, Ruilian Jing, Xinguo Mao

“…Ubiquitination is a major type of post-translational modification in eukaryotes. The plant U-Box (PUB) protein is the smallest family in the E3 ligase superfamily, and involved in the responses to various environmental stimuli. …”
Get full text

Second Edition of the Scientists of Tomorrow/Cientistas do Amanhã Project: advancing scientific thinking, methodology, and equitable education by Érika Bevilaqua Rangel, Victoria Tomaz, André Luiz Teles e Silva, Érica Kássia de Sousa Vidal, Isabella de Sousa Nóbrega, Alexandre Giannecchini Romagnolo, Olívia Furiama Metropolo Dias, Marcella Liciani Franco, Guilherme Ferreira de Britto Evangelista, Pedro Cancello, Thiago Pinheiro Arrais Aloia, Guilherme Martelossi Cebinelli, Lorrayne Belotti, Letícia Yamawaka de Almeida, Ilana Eshriqui Oliveira, Daiana Bonfim, Raymundo Machado de Azevedo Neto, Ronaldo Hueb Baroni, Marcella Zuliani Lopes Soares, Priscilla Cerullo Hashimoto, Thomaz Bittencourt Couto, João Carlos Barbosa, Luciana Cintra, Camila Hernandes, Elisa Harumi Kozasa, Eliseth Ribeiro Leão, Lionel Fernel Gamarra, Luciano Cesar Pontes de Azevedo, Luiz Vicente Rizzo

“…Diverse teaching strategies enhanced learning, as evidenced by theory-practical classes, pre- and post-tests (p<0.05), Kahoot! quizzes, design thinking, and real-time feedback. …”
Get full text

The Effect of Postoperative Tranexamic Acid and Dexamethasone on Quality of Recovery After Arthroscopic Rotator Cuff Repair: a Double-Blinded, Randomized Controlled Trial by Jiang X, Xu C, Yuan C, Gao W, Liu W, Wang Y, Wang H, Yu W, He Y

“…The primary outcome was the Quality of Recovery-15 (QoR-15) score at 24 hours post-surgery. Secondary outcomes included mean visual analog scale (VAS) scores every four hours within 24 hours, postoperative blood test results the day after surgery, and American Shoulder and Elbow Surgeons (ASES) score at 3 months postoperatively.Results: No significant differences in QoR-15 scores at 24 hours were observed among the groups [control, 127.0 (112.8, 138.0); TXA, 125.0 (116.5, 136.8); TXA+DEX, 132.0 (120.3, 140.8), p = 0.176]. …”
Get full text

Vécu émotionnel de patients victimes de lésion cérébrale acquise après apprentissage de régulation émotionnelle : une étude qualitative. by Perrine Roulin, Lola Marmisse, Marie Kuppelin, Charone Attias, Salomé Klein, Marie-Eve Isner-Horobeti, Hélène D'Apote Vassiliadou, Agata Krasny-Pacini

“…Conclusion : Il est donc primordial d'intégrer le vécu émotionnel des participants et leurs objectifs dans une perspective de croissance post-traumatique et de reconstruction identitaire, en accordant une attention particulière à cette dimension en rééducation orthophonique. …”
Get full text

Interhemispheric effects of iTBS on the fronto-parietal network: Evidence from dual-site stimulation by Isabell Int-Veen, Beatrix Barth, Ramona Täglich, Betti Schopp, Hans-Christoph Nuerk, Christian Plewnia, Stefanie De Smet, Marie-Anne Vanderhasselt, Andreas J. Fallgatter, Ann-Christine Ehlis, David Rosenbaum

“…Trait rumination emerged as a modulator of TBS effects: In study 1, significant interactions for FC between the right VLPFC and Somatosensory Association Cortex (SAC) when stimulating the left DLPFC emerged, while study 2 revealed similar interactions for FC between the left DLPFC and SAC and intra-SAC FC when stimulating the right VLPFC. Correlations between post-stress state rumination and FC changes further support these findings. …”
Get full text

A phase 3 randomized, open-label study evaluating the immunogenicity and safety of concomitant and staggered administration of a live, pentavalent rotavirus vaccine and an inactiva... by Shaomin Chen, Zhifang Ying, Yan Liu, Yuan Li, Yebin Yu, Meilian Huang, Zhuhang Huang, Zhiqiang Ou, Yuyi Liao, Yong Zhang, Guixiu Liu, Weiwei Zhao, Rong Fu, Qiong Shou, Minghuan Zheng, Xueyan Liao, Yingmei Tu, Jon Stek, Jonathan Hartzel, Changgui Li, Jikai Zhang

“…Antibody responses were measured at baseline and 1-month post-dose 3 (PD3). Parents/legal guardians recorded adverse events for 30 or 15 d after study vaccinations in the concomitant-use or staggered-use groups, respectively. …”
Get full text

Lymphodepletion, tumor-infiltrating lymphocytes, and high versus low dose IL-2 followed by pembrolizumab in patients with metastatic melanoma by Merve Hasanov, Simin Kiany, Marie-Andrée Forget, Roland Bassett, Michael A. Davies, Adi Diab, Jeffrey E. Gershenwald, Isabella C. Glitza, Jeffrey E. Lee, Anthony Lucci, Jennifer L. McQuade, Sapna P. Patel, Merrick I. Ross, Hussein A. Tawbi, Jennifer A. Wargo, Michael K. Wong, Chantale Bernatchez, Patrick Hwu, Cara Haymaker, Rodabe N. Amaria

“…Patients received pembrolizumab 200 mg IV starting 21 days post-TIL infusion, and every 3 weeks for up to 2 years. …”
Get full text

Biomass and nutrient release dynamics of decomposing rolling down legume cover crops in a steep-sloped Mediterranean vineyard by Cátia Brito, Cátia Brito, Sandra Martins, Sandra Martins, Francisco Saraiva, João Roque, Margarida Arrobas, Margarida Arrobas, Manuel Rodrigues, Manuel Rodrigues, Carlos Correia, Carlos Correia

“…The observed nutrient release from cover crop residues, particularly during the first 45 days post-termination, suggested a potential to support grapevine nutrient requirements, although direct uptake by grapevines was not assessed in this study. …”
Get full text

Modelling the liver’s regenerative capacity across different clinical conditions by Anh Thu Nguyen-Lefebvre, Soumita Ghosh, Cristina Baciu, Bima J. Hasjim, Sara Naimimohasses, Graziano Oldani, Elisa Pasini, Michael Brudno, Nazia Selzner, Jeffrey Wrana, Mamatha Bhat

“…Interestingly, fibrotic livers exhibited reduced collagen deposition and partial regression to stage 1 fibrosis post-hepatectomy. Transcriptomic and proteomic analyses revealed consistent downregulation of cell cycle genes in impaired regeneration. …”
Get full text

Transcriptome analysis provides new insights into the berry size in ‘Summer Black’ grape under a two-crop-a-year cultivation system by Peiyi Ni, Shengdi Yang, Yunzhang Yuan, Chunyang Zhang, Hengliang Zhu, Jing Ma, Shuangjiang Li, Guoshun Yang, Miao Bai

“…Phenotypic and histological analyses revealed fewer cell number occurring between 7 and 14 days post anthesis (DPA) in the second season fruits, which ultimately resulted in a smaller fruit size compared with the first season fruits. …”
Get full text