Inhaled ciclesonide in adults hospitalised with COVID-19: a randomised controlled open-label trial (HALT COVID-19) by Peter Ueda, Johan Hansson, Johan Ljungberg, Anders Krifors, Björn Johansson, Martin Larsson, Per Tornhammar, Daniel Peter Andersson, Daniel Brodin, Eli Westerlund, Simon Athlin, Sandra Wojt, Olof Elvstam, Anca Neumann, Arsim Elshani, Julia Giesecke, Jens Edvardsson-Källkvist, Sayam Bunpuckdee, Christian Unge, Jonas Lindell, Ola Blennow

“…Median (IQR) duration of oxygen therapy was 5.5 (3–9) days in the ciclesonide group and 4 (2–7) days in the standard care group (HR for termination of oxygen therapy 0.73 (95% CI 0.47 to 1.11), with the upper 95% CI being compatible with a 10% relative reduction in oxygen therapy duration, corresponding to a <1 day absolute reduction in a post-hoc calculation). Three participants in each group died/received invasive mechanical ventilation (HR 0.90 (95% CI 0.15 to 5.32)). …”
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Navigating the shadows: the impact of mindfulness, cognitive fusion, and coping strategies on psychological distress among mental health workers in Timor Leste by Gaspar Quintao, Noviyanti Carla Tilman Leite, Nicholas Tze Ping Pang, Eugene Boon Yau Koh, Jhia Mae Woo, Marina Abdul Rahman Sabri, Kah Mun Wan, Noor Melissa Noor Hadi, Ming Gui Tan, Assis Kamu, Chong Mun Ho

“…Abstract Background Mental health workers in post-conflict settings such as Timor Leste face distinct stressors stemming from limited human resources, underdeveloped systems, and ongoing socio-political instability, all of which increase the risk of psychological distress among these professionals. …”
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Assessment of pit viper associated subclinical myocardial injury by speckle tracking imaging by Jing Chen, Yang Feng, Jiaqi Chen, Chunmei Yin, Jiaming Xia, Li Fan, Liqun Sun, Chunjiang Yang

“…Abstract In post-snakebite patient care, cardiac function is chiefly monitored through Left Ventricular Ejection Fraction (LVEF) via traditional echocardiography. …”
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Retrospective assessment of the frequency of cancer in the population of kidney transplant recipients - the experience of two transplant centers by Karolina Komorowska-Jagielska, Alicja Dębska-Ślizień, Aureliusz Kolonko, Zbigniew Heleniak, Jakub Ruszkowski, Kamila Czarnacka, Beata Imko-Walczuk, Bogdan Biedunkiewicz, Barbara Bułło-Piontecka, Beata Bzoma, Andrzej Chamienia, Justyna Gołębiewska, Joanna Konopa, Ewa Król, Monika Lichodziejewska-Niemierko, Przemysław Rutkowski, Agnieszka Tarasewicz, Andrzej Więcek, Sławomir Lizakowski

“…The most common cancers in women were breast cancers (17.8%), colon cancers (14.5%), lung cancers and post-transplant lymphoproliferative disorder (PTLD) (8.9% each). …”
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Abstract 013: Infarct density: a novel imaging biomarker of long‐term functional outcome after endovascular thrombectomy by Christopher G. Favilla, Heta Patel, Mohammad Hossein Abassi, Jesse Thon, Michael T. Mullen, Scott E. Kasner, Jae W. Song, Stephanie Cummings, Steven R. Messe

“…Here we aimed to quantify the relationship between functional outcome and a range of ADC thresholds on post‐EVT MRI. Methods A single‐center cohort of consecutive acute stroke patients with anterior circulation large vessel occlusion, successful recanalization via EVT (mTICI ≥ 2b), and MRI of the brain between 12 hours and 7 days after EVT was evaluated. …”
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PARP9-PARP13-PARP14 axis tunes colorectal cancer response to radiotherapy by Rimvile Prokarenkaite, Karolina Kuodyte, Greta Gudoityte, Elzbieta Budginaite, Daniel Naumovas, Egle Strainiene, Kristijonas Velickevicius, Audrius Dulskas, Ernestas Sileika, Jonas Venius, Virginijus Tunaitis, Augustas Pivoriunas, Vytaute Starkuviene, Vaidotas Stankevicius, Kestutis Suziedelis

“…Elevated pre-treatment PARP9 expression levels and a blunted post-treatment increase in PARP9 and PARP14 expression predicted poor overall survival in rectal cancer patients, while PARP13 emerged as the most significant discriminator between tumor and healthy tissue. …”
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Six‐Minute Walk Test Is Superior to Grip Strength as a Marker of Functional Recovery During Cancer Cachexia Rehabilitation by Addison Barber, Amber Willbanks, Kathryn Abplanalp, Christopher W. Lewis, Ben Binder‐Markey, Prakash Jayabalan, Richard L. Lieber, Ishan Roy

“…In a multivariate logistic regression model, discharge from IRF to home with independence was predicted by change in 6MWT (p = 0.0007) but not hGS (p = 0.8075). Six‐month survival post‐rehabilitation was predicted by change in 6MWT (p = 0.0345) but not hGS (p = 0.9025) in a multivariate Cox proportional hazards model. …”
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Human‐wildlife conflict at high altitude: A case from Gaurishankar conservation area, Nepal by Abhinaya Pathak, Saneer Lamichhane, Maheshwar Dhakal, Ajay Karki, Bed Kumar Dhakal, Madhu Chetri, Jeffrey Mintz, Prakash Pun, Pramila Neupane, Tulasi Prasad Dahal, Trishna Rayamajhi, Prashamsa Paudel, Ashim Thapa, Pramod Raj Regmi, Shankar Thami, Ganesh Thapa, Suraj Khanal, Supriya Lama, Jenisha Karki, Sujan Khanal, Arockia E J Ferdin

“…While bear attacks showed no significant change post‐rule alteration, leopard attack reports surged from 1 to 60 annually, indicating improved compensation may have resulted in increased leopard‐attack reporting rates. …”
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Development and internal validation of a depressive symptoms prediction model among the patients with cardiovascular disease who have recovered from SARS-CoV-2 infection in Wuhan,... by Zhenwei Dai, Xin Liu, Shu Jing, Hao Wang, Yiman Huang, Jiaqi Fu, Yijin Wu, Ling Zhang, Bicheng Han, Xiaoyou Su

“…The prediction model included age, stethalgia after recovery, insomnia after recovery, post-traumatic stress disorder (PTSD), anxiety, fatigue, and perceived social support as predictors. …”
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AVATAR Virtual Reality Social therapy (AVATAR_VRSocial) for distressing voices and their interference in social everyday life in early psychosis: protocol of a single-blind paralle... by Tom K J Craig, Silvia Schneider, Philippa Garety, Thomas Ward, Mar Rus-Calafell, Melina Luker, Maren Marzinzik, Phuong-Mi Nguyen, Tobias Teismann, Nils Ehrbar, Ekincan Tas, Xiao Chi Zhang, Clementine Edwards, Mark Huckvale

“…Assessor-blinded assessments will be conducted at baseline, 3 months (post-intervention) and 6 months (follow­-up). Key therapeutic targets of AVATAR_VRSocial will be those established by the previous evidence of this approach (ie, power and control, self-esteem and future focus), while introducing exposure and management of distressing voices during social interactions. …”
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Systemic Immune-Inflammation Index (SII) vs. Neutrophil-to-Lymphocyte Ratio (NLR): evaluating the predictive power of SII and NLR in severity of acute ischaemic stroke based on NIH... by Arbaz Hassan, Anfal Hamza, Kiran Khan, Aiza Shafique, Faiza Naz, Rameen Riaz, Fazeel Shabbir, Muhammad Zafar Majeed Babar, Muhammad Saleem, Hafiz Haseeb Ahsan, Ghulam Mustafa, Hafiz Muhammad Usama Amjad

“…Introduction: Stroke ranks third in terms of its combined impact on mortality and disability.1 Ischaemic strokes account for ∼87% of all strokes and occur because of blood vessel blockage, caused by either cerebral thrombosis or cerebral embolism.2 Previous studies have found higher neutrophil-to-lymphocyte ratios (NLRs) to be associated with post-stroke cognitive impairment, parenchymal haemorrhage, symptomatic intracranial haemorrhage and death.3–5 The Systemic Immune–Inflammation Index (SII) is a well-established prognostic indicator in several malignancies. …”
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Low-dose Esketamine combined with Propofol in microscopic pediatric strabismus surgery: a randomized controlled study by Yaping Shen, Bo Shi, Yu Mo, Junhe Wu, Zhentao Sun

“…HR and MAP were recorded in the two groups at 5 min before induction, after induction, at the start of the procedure, and at the end of the procedure. operative time, extubation time and post-anesthesia care unit (PACU) stay were recorded. …”
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Random vibration study of cold rolling mill excited by different hardness of strip steel by Weiquan Sun, Xiaoqiang Yan, Shen Wang, Lu Zhang, Weijing Yun, Yuchen Chen

“…Finite element simulations were conducted to resolve the probability density distributions of mill vibration responses under varying strip hardness conditions. Post-processing in MATLAB enabled a quantitative analysis of power spectral density (PSD) responses, establishing correlations between strip surface hardness parameters and dynamic vibration characteristics. …”
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Global burden of vaccine-associated Guillain-Barré syndrome over 170 countries from 1967 to 2023 by Yi Deun Jeong, Seoyoung Park, Sooji Lee, Woojin Jang, Jaeyu Park, Kyeongmin Lee, Jinseok Lee, Jiseung Kang, Raphael Udeh, Masoud Rahmati, Seung Geun Yeo, Lee Smith, Hayeon Lee, Dong Keon Yon

“…Vigilance for at least one-week post-vaccination is crucial, particularly for older adults. …”
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Transcriptomic and histological characteristics of innate immune activation in brain parenchyma in a rat model of neonatal intraventricular hemorrhage by Miriam Zamorano, Sanjna Udtha, Aidan M. Collier, Erica Underwood, Razan El Sayed, Ankit Agarwal, Devin S. Hatchell, Chunfeng Tan, Paul J. Nietert, Scott D. Olson, Brandon A. Miller

“…There is no effective treatment for IVH other than supportive care and surgery for post-hemorrhagic hydrocephalus. We previously reported that the innate neuroimmune response in an animal model of IVH was dependent on developmental stage, only occurring in older animals. …”
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Reversal of Rocuronium Induced Muscle Relaxation with Sugammadex versus Neostigmine in Patients Undergoing General Anaesthesia: A Randomised Controlled Trial by Ankur Garg, Kirti Gupta, Richa Chandra, Jyoti Pathania, Malti Agrawal

“…Significant changes in Heart Rate (HR), Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP) and Mean Arterial Pressure (MAP) were observed post-extubation at 0, 5, and 10 minutes (p<0.05). group 1 had a lower incidence of postoperative nausea compared to group 2 (p<0.05). …”
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Epitope Variation in Hemagglutinin and Antibody Responses to Successive A/Victoria A(H1N1) Strains in Young and Older Adults Following Seasonal Influenza Vaccination: A Pilot Study by Mónica Espinar-García, Isabel María Vallejo-Bermúdez, María Ángeles Onieva-García, Irene Reina-Alfonso, Luis Llapa-Chino, Pablo Álvarez-Heredia, Inmaculada Salcedo, Rafael Solana, Alejandra Pera, Alexander Batista-Duharte

“…Antibody responses were measured pre- and 28 days post-Vaxigrip Tetra vaccination in young (18–35) and older (>65) adults, stratified by cytomegalovirus (CMV) serostatus. …”
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External validation of a prediction model for disability and pain after lumbar disc herniation surgery: a prospective international registry-based cohort study by Allan Abbott, Casper Friis Pedersen, Henrik Hedevik, Catharina Parai, Martin A Gorosito, Mikkel Andersen, Tor Ingebrigtsen, Tore K Solberg, Margreth Grotle, Bjørnar Berg

“…Conclusion: Predictive performance of machine learning models for treatment success/non-success in disability and pain at 12 months post-surgery for lumbar disc herniation showed acceptable discrimination ability, calibration, overall fit, and net benefit reproducible in similar international contexts. …”
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Exploring Ocular Fundus Changes and Biochemical Correlations in Pregnancy-Induced Hypertension: Two Year Observational Study in Tertiary Care Center, India by A. M. Raja, G Seema

“…Recurrence of retinal changes highlights the necessity of detailed patient history and regular follow-ups, as any persistent retinal abnormalities post-pregnancy may suggest chronic hypertension or renal disease, conditions that require continued management. …”
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Colistin Sulfate-Based Combination Therapy for Infections Caused by Carbapenem-Resistant Organisms in Intensive Care Units: A Multicenter, Prospective, Observational Clinical Trial by Fan Zhang, Danyang Peng, Faming He, Ying Liu, Binbin Zang, Yanqiu Gao, Chao Qin, Suping Guo, Yawei Qi, Xisheng Zheng, Lin Guo, Tingting Zhao, Yue Jin, Rongqi Su, Juan Du, Jiazhan Pan, Bingyu Qin, Huanzhang Shao

“…Nephrotoxicity was reported in 13.1% of patients not receiving continuous renal replacement therapy (CRRT), with no significant duration-dependent increase. Post-treatment serum creatinine (Scr) levels remained stable or improved across all renal function subgroups. …”
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