Study protocol for assessing the effectiveness, implementation fidelity and uptake of attachment & child health (ATTACH™) Online: helping children vulnerable to early adversity by Nicole Letourneau, Lubna Anis, Cui Cui, Ian D. Graham, Kharah Ross, Kendra Nixon, Jan Reimer, Miranda Pilipchuk, Emily Wang, Simone Lalonde, Suzanna Varro, Maria Jose Santana, Ashley Stewart-Tufescu, Angela Soulsby, Barbara Tiedemann, Leslie Hill, Tiffany Beks, Martha Hart

“…Effectiveness outcomes examine children’s development and mental health, parent–child relationships, and RF, measured before, after, and 3 months post-intervention. Implementation outcomes include fidelity and uptake of ATTACH™ Online, assessed via tailored tools and qualitative interviews using NPT, with parents, health care professionals, and administrators from agencies. …”
Get full text

Diagnostic Effectiveness of Transforming Growth Factor Beta 1 in Assessing the Risk of Developing Graft Dysfunction in Liver Recipient Children by R. M. Kurabekova, O. M. Tsiroulnikova, I. E. Pashkova, A. G. Olefirenko, O. E. Gichkun, L. V. Makarova, R. A. Monakhov, P. O. Shevchenko

“…The TGF-β1 concentration in plasma was determined using ELISA on average 3 ± 2 days prior to liver transplantation and in the early post-transplant period.Results. The level of TGF-β1 in the blood of children with liver cirrhosis was lower than in healthy children (p = 0.001). …”
Get full text

The donor management algorithm in transplantation of a composite facial tissue allograft.. First experience in Russia by V. V. Uyba, K. K. Gubarev, S. E. Voskanyan, M. A. Volokh, V. L. Vinogradov, N. V. Kalakutskiy, G. G. Khubulava, A. I. Zakhlevnyy, I. Yu. Murashov, A. F. Lesnyakov, E. S. Romanova, V. A. Shcherbakov, V. V. Aleksandrov, A. S. Samoylov, M. V. Zabelin

“…Establishing of facial VCA transplantation Program is a complicated process for transplant centers and can hardly be implemented without a properly organized post-mortem organ donation system at a national level. …”
Get full text

Outcomes of Different Lifestyle Approaches in a Multicentre, Open-Label, Parallel-Group, Randomised Controlled Trial of the Effectiveness of Integrating a Pragmatic Pathway for Pre... by Werd Al-Najim, Babak Dehestani, Ahmed W. Al-Humadi, Danielle H. Bodicoat, Dimitris Papamargaritis, Michael Lean, Barbara McGowan, David R. Webb, John PH Wilding, Melanie J. Davies, Carel W. le Roux

“…<b>Background/Objectives:</b> The STRIVE study was a multicentre, open-label, real-world clinical trial evaluating the effectiveness of a targeted prescribing pathway for liraglutide 3.0 mg as an adjunct to standard care versus standard care alone in people with obesity attending Specialist Weight Management Services (SWMS) in the UK and Ireland. This post hoc analysis focuses on the standard care arm to explore differences in outcomes between sites, particularly the potential impact of offering meal replacements as part of usual care. …”
Get full text

Unraveling Genomic and Pathogenic Features of <i>Aeromonas ichthyocola</i> sp. nov., <i>Aeromonas mytilicola</i> sp. nov., and <i>Aeromonas mytilicola</i> subsp. <i>aquatica</i> su... by Nihed Ajmi, Muhammed Duman, Batuhan Coskun, Ceren Esen, Oner Sonmez, Gorkem Tasci, Orkide Coskuner-Weber, Hilal Ay, Digdem Yoyen-Ermis, Artun Yibar, Andrew P. Desbois, Izzet Burcin Saticioglu

“…Further genomic analyses identified biosynthetic gene clusters for nonribosomal peptides (NRPs) and ribosomally synthesized and post-translationally modified peptides (RiPPs), which often have roles in secondary metabolite production. …”
Get full text

Phase I first-in-human dose escalation study of the oral casein kinase 1α and cyclin dependent kinase 7/9 inhibitor BTX A51 in advanced MDS and AML by Brian J. Ball, Wenbin Xiao, Gautam Borthakur, Le Xuan Truong Nguyen, Melissa Valerio, Avanthika Venkatachalam, Guido Marcucci, Anthony S. Stein, Dung Luong Thai, David N. Cook, Kyle Chan, Sonali Persaud, Ross L. Levine, Omar Abdel-Wahab, Yinon Ben-Neriah, Eytan M. Stein

“…BTX A51 increased the expression of p53 and reduced the expression of MCL1 and RNA polymerase II phosphorylation in pre- and post-treatment immunocytochemistry studies. Overall, 3 patients (10%) experienced complete remission with incomplete count recovery (CRi). …”
Get full text

Longitudinal study on quality of life following cervical cancer treatment in Botswana by Natalie Taylor, Doreen Ramogola-Masire, Karen Canfell, Katharine A Rendle, Lesego Gabaitiri, Surbhi Grover, Nicola Zetola, Memory Bvochora-Nsingo, Sebathu Chiyapo, Dawn Balang, Lilie L Lin, Mark N Polizzotto, Erle Robertson, Salman Khan, Rohini K Bhatia, Shalini Vinod, Paseka Tladi

“…The European Organisation for Research and Treatment of Cancer Core Quality-of-Life (QLQ-C30) and cervical cancer-specific (QLQ-Cx24) questionnaires, translated into Setswana, were used to assess the QoL of patients prior to treatment (baseline), at the end of treatment (EOT) and in 3 month intervals post-treatment for 2 years, and statistical analyses were performed.Results A total of 294 women (median age: 46 years) were enrolled and followed up for an average of 16.4 months. …”
Get full text

Prediction of long-term major adverse cardiac events after myocardial infarction: value of combination of inflammatory biomarkers and GRACE score by Dan Tian, Nianxi Yu, Tianxiao Mao, Yanli Li, Ruiyan Liu, Ye Xu, Dong Huang, Qianzhou Lv, Kunming Pan, Kunming Pan

“…The primary endpoint was the post-MI occurrence of a composite of major adverse cardiovascular events (MACE), including cardiovascular death, non-fatal MI, and non-fatal ischemic stroke. …”
Get full text

Comparative Effectiveness of Different Frequencies of Spinal Cord Stimulation for the Treatment of Patients with Failed Back Surgery Syndrome: Systematic Review and Network Meta-An... by Qin YY, Zhang CP, Tang SS, Wu JP, Zhu LX, Li YH, Xu F

“…Yuan Yuan Qin,1,2,&amp;ast; Chun Pan Zhang,1,2,&amp;ast; Shun Song Tang,1,2 Jiang Ping Wu,1,2 Li Xuan Zhu,1,2 Yan Hua Li,1,2 Fei Xu1,2 1Department of Pain Management, The First People’s Hospital of Yunnan Province, Kunming, Yunnan, People’s Republic of China; 2The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Fei Xu, Department of Pain Management, The First People’s Hospital of Yunnan Province, 157 Jinbi Road, Kunming, 650032, People’s Republic of China, Email 494428530@qq.comPurpose: Failed back surgery syndrome (FBSS) is a common and challenging complication after lumbar spine surgery, with around 30% of patients experiencing this condition post-surgery. Spinal cord stimulation (SCS) is a prevalent treatment for FBSS, yet there is a lack of systematic comparisons among different SCS frequencies. …”
Get full text

SURGICAL TACTICS REGARDING CEREBRAL METASTASES WITH HEMORRHAGES by E. V. Prozorenko, V. B. Karakhan, A. Kh. Bekyashev, V. A. Alyoshin, D. M. Belov, D. R. Naskhletashvili, N. V. Sevyan, A. A. Mitrofanov

“…The patients were distributed in accordance with the RPA (recursive partitioning analysis) classes: I class (n = 7), II class (n = 39), III class (n = 23); in accordance with the hemorrhage type: intratumoral type (26 metastases), perifocal type (20), mixed type (32); in accordance with the histological principle: melanoma (n = 25), lung cancer (n = 13), kidney cancer (n = 17), breast cancer (n = 4), colorectal cancer (n = 1), soft tissue sarcoma (n = 4), non-seminomatous germ cell tumor (n = 5).Results. Early post-surgical lethality comprised 6 % (n = 4). Development of local relapses comprised 16 % (n = 11). …”
Get full text

Changes in Blood Eosinophil Counts Predict the Death of Patients With Myocardial Infarction After Hospital Discharge by Kaiyang Lin, Manqing Luo, Xia Gu, Jun‐Yan Xu, Jinwei Tian, Peter Libby, Guo‐Ping Shi, Junli Guo

“…Dynamic changes of blood eosinophil counts offer a more accurate prediction of post‐myocardial infarction deaths than a single time point data analysis.…”
Get full text

Non-inferiority comparison of medical glue and hook-wire for preoperative localization of multiple pulmonary nodules by Zexin Xie, Zexin Xie, Ran Ma, Ran Ma, Tao Gao, Tao Gao, Jingsong Liu, Jingsong Liu, Kewei Zhang, Kewei Zhang, Jun Li, Jun Li, Xiaotong Zhou, Xiaotong Zhou, Hao Zhang, Hao Zhang

“…Furthermore, compared to hook-wire, medical glue was associated with a lower incidence of pneumothorax and pulmonary hemorrhage, as well as reduced pain scores at 2 h post-localization.Clinical Trial Registrationhttps://www.chictr.org.cn, identifier (ChiCTR2400080040).…”
Get full text

Subversion of mRNA degradation pathways by EWSR1::FLI1 represents a therapeutic vulnerability in Ewing sarcoma by Bartimée Galvan, Loïc Ongena, Jonathan Bruyr, Gregory Fettweis, Eva Lucarelli, Arnaud Lavergne, Emeline Mariavelle, Tina M. O’Grady, Zahrat El Oula Hassoun, Margaux Claes, Laurence Dubois, Kevin A. W. Lee, Véronique Kruys, Cyril Gueydan, Jules Durand, Eric Hervouet, Florian H. Geyer, Ana Banito, Roland Imle, Lianghao Mao, Ashok K. Jayavelu, Thomas G. P. Grünewald, Florencia Cidre-Aranaz, Jean-Claude Twizere, Franck Dequiedt

“…Our findings uncover a post-transcriptional function of EWSR1::FLI1 and suggest that targeting mRNA stability mechanisms may offer therapeutic opportunities for EwS.…”
Get full text

Results of a study of the effectiveness of direct coronary oxygen persufflation as a donor heart conditioning method by M. O. Zhulkov, D. A. Sirota, I. S. Zykov, A. K. Sabetov, K. A. Agaeva, А. G. Makaev, D. M. Osintsev, A. P. Nadeev, V. Е. Kliver, E. E. Kliver, A. M. Volkov, A. R. Tarkova, А. V. Fomichev, A. M. Chernyavsky

“…After 3 hours of donor heart preservation, orthotopic heart transplantation (OHTx) was performed. In the post-transplant period, we studied central hemodynamic parameters, myocardial oxygen consumption, level of myocardial ischemia markers (troponin I, TnI; creatine phosphokinase-MB, CPKMB; lactate dehydrogenase, LDH), and histological signs of structural cellular injury. …”
Get full text

Finite element model-based evaluation of the effectiveness of the incisional skinbridge procedure for posterior horseshoe perianal abscess by Shi Rong, Wang Jing, Ke Minhui, Chen Zuqing, Huang Juan, Chen Riqi, Wang Zhaochu

“…Six pivotal nodes were selected for model validation, followed by comparisons of displacement disparities between the two models and an evaluation of anal pressure three months post-surgery. [Results] Displacements measured surgically at 174 nodes in the standard skin-bridge group and 173 nodes in the wide skin-bridge group significantly deviated from the model prediction (P<0.05), whereas other nodes displacements measured surgically aligned with the model (P>0.05). …”
Get full text

Long Term Outcomes of Anti-COVID-19 Vaccines in Patients with Systemic Lupus Erythematosus: A Multicentre Study by Giovanni Benanti, Giuseppe A. Ramirez, Tommaso Schioppo, Lorenza Maria Argolini, Gabriella Moroni, Grazia Bonelli, Renato Alberto Sinico, Federico Alberici, Federica Mescia, Luca Moroni, Gabriele D. Gallina, Biancamaria Venerandi, Francesco Tamborini, Chiara Bellocchi, Lorenzo Beretta, Roberto Caporali, Enrica Bozzolo, Lorenzo Dagna, Maria Gerosa

“…Limited data exist on the long-term impact of vaccination in patients with SLE. <b>Methods</b>: A post-vaccine group (PVG, <i>n</i> = 284) from a multicentric cohort of vaccinated patients with SLE from six tertiary referral centres in Northen Italy was compared with a control group (CG, <i>n</i> = 223) of similar demographics observed in the 2015–2019 period to investigate survival, hospitalisation, pregnancy, disease flare, disease progression, infection, and chronic complication accrual rates. …”
Get full text

Composted PBST Biodegradable Mulch Film Residues Enhance Crop Development: Insights into Microbial Community Assembly, Network Interactions, and Soil Metabolism by Liuliu Li, Liyuan Liu, Guoyuan Zou, Xuexia Wang, Li Xu, Yong Yang, Jinfeng Liu, Huabo Liu, Dongsheng Liu

“…These findings suggest that, although composting post-use BDM may reduce their negative ecological effects, possibly via accelerating the early breakdown of residues, the feasibility and scalability of this approach require further validation under real-world field conditions.…”
Get full text

Establishment of an Intestinal Fibrosis Model Associated with Inflammatory Bowel Disease in VDR-/- Mice Induced by Helicobacter hepaticus Infection and Mechanism Exploration by WU Zhihao, CAO Shuyang, ZHOU Zhengyu

“…Seven days after the final administration, the infection status of the mice was assessed, and their body weight was recorded weekly. At the 16th week post-infection, the mice were dissected, and the length of the colon tissue was measured, with fecal moisture content analyzed. …”
Get full text

Ecological drivers of malaria vector habitat and transmission over 1 year of long-lasting insecticidal net intervention in Côte d’Ivoire by Benoit Talbot, Ludovic P. Ahoua Alou, Alphonsine A. Koffi, Colette Sih, Edouard Dangbenon, Marius G. Zoh, Soromane Camara, Serge B. Assi, Raphael N’Guessan, Louisa A. Messenger, Natacha Protopopoff, Jackie Cook, Manisha A. Kulkarni

“…., and for P. falciparum-infected vectors, at baseline and 1-year post-LLIN intervention. We compared the projected habitat and habitat determinants for each species, and assessed the respective contributions of each intervention arm and environmental factors on the probability of species occurrence. …”
Get full text

Family protection motivation and economic vulnerability: a network analysis of public influenza risk perception, education and mitigation strategies in China by Cheng Yang, Cheng Yang, Jiawei Li, Jiawei Li, Xianqiong Feng, Xianqiong Feng, Shaoyu Su, Shaoyu Su, Qin Zeng, Qin Zeng

“…BackgroundIn the post-pandemic era, influenza and COVID-19 jointly exacerbate global public health burdens, yet persistent biases in risk perception drive declining vaccination rates and health disparities. …”
Get full text