The XEC Variant: Genomic Evolution, Immune Evasion, and Public Health Implications by Alaa A. A. Aljabali, Kenneth Lundstrom, Altijana Hromić-Jahjefendić, Nawal Abd El-Baky, Debaleena Nawn, Sk. Sarif Hassan, Alberto Rubio-Casillas, Elrashdy M. Redwan, Vladimir N. Uversky

“…New research priorities include genomic surveillance in undersampled regions, updated vaccine formulations against novel spike epitopes, and long-term longitudinal studies to monitor post-acute sequelae. These efforts can be augmented by computational modeling and the One Health approach, which combines human and veterinary sciences. …”
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Evaluating the Effectiveness of New Criteria for Early Detection of the Start and Intensity of Influenza Epidemics in Russian Federation by L. S. Karpova, M. Yu. Pelikh, K. M. Volik, N. M. Popovtseva, T. P. Stolyarova, D. A. Lioznov

“…In the 2022-23 season application of new criteria for the start of epidemics (prev.- and post-epidemic baseline influenza incidence) and their intensity revealed: early onset of the influenza epidemic (07–13.11 2022); simultaneous onset in all children's age groups; geographical spread of the epidemic in federal districts; intensity of the epidemic in the general population and age groups. …”
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The Influence of Deep Margin Elevation and Immediate Dentin Sealing on the Fracture Strength of Premolars Restored With Indirect Inlays: An In Vitro Study by Lulwa E. Al‐Turki, Osamah A. Alsulimani, Khadijah M. Baik, Haytham Othmani, Naif M. Alqarni, Abdullah A. Alqarni, Raghad A. Al‐Dabbagh

“…Failure loads and locations were recorded and analyzed using one‐ and two‐way ANOVA with Tukey's post‐hoc testing (α = 0.05). Failure modes were analyzed using descriptive statistics. …”
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PROGNOSTIC IMPLICATIONS OF HIGH-RISK GENETIC MUTATIONS IN MULTIPLE MYELOMA PATIENTS UNDERGOING SECOND AUTOLOGOUS STEM CELL TRANSPLANT by Taner Tan, Ahmet Umur Topcu, Ümit Barbaros Üre, Emre Osmanbasoglu, Sinem Civriz Bozdağ, Olga Meltem Akay

“…Results: The analyzed cohort included 10 males (52.6%) and 9 females (47.4%), with a mean age of 56.79-years (SD = 10.39, range 34–69). Median follow-up post-second transplantation was 31-months (IQR 18–54). …”
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Patterns of mental health problems and resilience among immigrant and refugee adolescents: a latent profile analysis by Sanni Aalto, Raija-Leena Punamäki, Mervi Vänskä, Reeta Kankaanpää, Tiina Turunen, Oskari Lahtinen, Ilse Derluyn, Caroline Spaas, Lucia De Haene, Signe Smith Jervelund, Morten Skovdal, Arnfinn J. Andersen, Marianne Opaas, Fatumo Osman, Anna Sarkadi, Natalie Durbeej, Emma Soye, Kirsi Peltonen

“…Background: Immigrant and refugee adolescents often face traumatic experiences and are vulnerable to mental health problems, such as post-traumatic stress disorder (PTSD), anxiety and depression. …”
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The Practical, Robust Implementation and Sustainability (PRISM)-capabilities model for use of Artificial Intelligence in community-engaged implementation science research by Nabila El-Bassel, James David, Trena I. Mukherjee, Maneesha Aggarwal, Elwin Wu, Louisa Gilbert, Scott Walters, Redonna Chandler, Tim Hunt, Victoria Frye, Aimee Campbell, Dawn A. Goddard-Eckrich, Katherine Keyes, Shoshana N. Benjamin, Raymond Balise, Smaranda Muresan, Eric Aragundi, Marc Chen, Parixit Davé, David Lounsbury, Nasim Sabounchi, Dan Feaster, Terry Huang, Tian Zheng

“…Although AI was not initially used during the HCS, we highlight how AI will be leveraged to complete post-hoc analyses of each of the six components and validate the PRISM-Capabilities model. …”
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Psychological interventions mitigated occupational stress in high-risk workers in Shenzhen, China by Naixing Zhang, Wei Zhou, Aipin Xiao, Shaofan Weng, Liuzhuo Zhang, Dexiang Zhu, Jinlin Wang, Ling Nian, Dafeng Lin, Dafeng Lin

“…Baseline occupational stress detection rates and high social support rates were analyzed, along with their post-intervention changes, to comprehensively evaluate the intervention effectiveness.ResultsThe cohort comprised 3,237 participants, with a median age of 31 years, 92.18% were male, and 96.14% were Han Chinese. …”
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Which explanations do clinicians prefer? A comparative evaluation of XAI understandability and actionability in predicting the need for hospitalization by Laura Bergomi, Giovanna Nicora, Marta Anna Orlowska, Chiara Podrecca, Riccardo Bellazzi, Caterina Fregosi, Francesco Salinaro, Marco Bonzano, Giuseppe Crescenzi, Francesco Speciale, Santi Di Pietro, Valentina Zuccaro, Erika Asperges, Paolo Sacchi, Pietro Valsecchi, Elisabetta Pagani, Michele Catalano, Chandra Bortolotto, Lorenzo Preda, Enea Parimbelli

“…The focus is on two cognitive dimensions: understandability and actionability of the explanations provided by explainable-by-design and post-hoc methods. Methods A questionnaire-based experiment was conducted with 10 clinicians from the IRCCS Policlinico San Matteo Foundation in Pavia, Italy. …”
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Multi-target combination of antibiotics as salvage therapy for severe infection caused by pan-resistant Burkholderia cenocepacia following lung transplantation by Nadim Cassir, Benjamin Coiffard, Linda Hadjadj, Julien Bermudez, Liliane Okdah, Lucile Ailhaud, Sophie Alexandra Baron, Martine Reynaud-Gaubert, Xavier Benoit D'Journo, Sami Hraiech, Jean-Marc Rolain

“…We describe here the successful treatment of a patient with cystic fibrosis who developed post-transplant lung abscesses and sternal osteitis caused by pan-resistant Burkholderia cenocepacia. …”
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On the Possibility of Using the Topical form of the Recombinant Interferon alpha-2b Drug in the Prevention of Acute Respiratory Viral Infections in Organized Groups by M. P. Kostinov, E. V. Markelova, S. V. Knysh, Yu. A. Lee, A. A. Khasanova, I. L. Solovеva, E. S. Korovkina, A. V. Linok, M. N. Lоktionova, I. A. Khrapunova, G G. Kharseeva

“…The presented advantages of the recombinant interferon α-2b drug make it possible to draw attention to the clinical feasibility of its use for preventive purposes in organized groups, including military ones, from the position of high epidemiological effectiveness, both pre-exposure and post-exposure prevention of acute respiratory viral infections.…”
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Investigation de l’effet de la Semantic Feature Analysis sur le manque du mot au stade débutant de la maladie d’Alzheimer : études de cas by Melike Semiz, Aurélie Miceli, Sandrine Basaglia-Pappas, Isabelle Simoes Loureiro

“…Les performances en dénomination ont été évaluées lors des phases pré-intervention, post-intervention et maintien à l’aide d’une tâche de dénomination conçue pour cette étude. …”
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Neoantigen enriched biomimetic nanovaccine for personalized cancer immunotherapy by Yuwei Li, Maoxin Fang, Haotian Yu, Xianglei Wang, Shiyao Xue, Zeze Jiang, Zixuan Huang, Shaoqin Rong, Xiaoli Wei, Zhigang Lu, Min Luo

“…AECM@PC7A exhibits remarkable anti-tumor efficacy when compared to vaccines with diverse formulations, and demonstrates therapeutic potential in post-surgical and humanized xenograft tumor models. …”
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Targeting USP1 Potentiates Radiation‐Induced Type I IFN‐Dependent Antitumor Immunity by Enhancing Oligo‐Ubiquitinated SAR1A‐Mediated STING Trafficking and Activation by Weilin Zhou, Yuxuan Zhao, Wenjing Qin, Weijian Wu, Chenyang Liao, Yiqiu Zhang, Xingli Yang, Xue Chen, Youqiao Wang, Yushan Kang, Jiaxin Wu, Jiaojiao Zhao, Junmin Quan, Xuecen Wang, Xianzhang Bu, Xin Yue

“…Through chemical screening targeting deubiquitinating enzymes, we identified USP1 (Ubiquitin Specific Peptidase 1) inhibitor as an enhancer of post‐radiotherapy dsDNA responses. Mechanistically, within the context of immune‐stimulatory cells in TME, USP1 serves as a suppressor in the stress‐mediated stages of the cGAS (Cyclic GMP‐AMP synthase) ‐STING (Stimulator of interferon genes protein) signaling pathway, specifically affecting the trafficking of STING from endoplasmic reticulum to Golgi apparatus. …”
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Extracellular Vesicles Present in Bone Marrow Mesenchymal Stromal/Stem Cell Conditioned Media Restore Spermatogenesis in Azoospermic Mice by Rano Zhankina, Afshin Zare, Alireza Afshar, Arezoo Khoradmehr, Mohammad Reza Dorvash, Farhad Rahmanifar, Nader Tanideh, Omid Koohi Hosseinabadi, Ali Arabi Monfared, Shahrokh Zare, Nadiar Mussin, Asset Askerovich Kaliyev, Ulanbek Zhanbyrbekuly, Amin Tamadon

“…Testes were removed from all mice, and histomorphometry and flow cytometry analyses were performed 60 days post-treatment. Additionally, protein structure extraction, protein-protein docking analysis, and data visualization were conducted.Results: Histomorphometry and flow cytometry showed that most seminiferous tubules in the therapy groups exhibit­ed normal morphology and restored spermatogenesis, unlike the azoospermia group. …”
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Derivation and internal–external validation of clinical prediction model for postoperative clinically important hypotension in patients undergoing noncardiac surgery: an internatio... by Stephen Su Yang, German Malaga, Maria Lazo-Porras, Patricia Busta-Flores, Aida del Carmen Rotta-Rotta, Pavel S. Roshanov, Daniel I. Sessler, Amal Bessissow, Thomas Schricker, Vicky Tagalakis, Diane Heels-Ansdell, Shirley Pettit, P.J. Devereaux

“…The postoperative period was defined from the Post-Anesthesia Care Unit to hospital discharge. …”
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Treadmill Training Increases SIRT-1 and PGC-1α Protein Levels and AMPK Phosphorylation in Quadriceps of Middle-Aged Rats in an Intensity-Dependent Manner by Nara R. C. Oliveira, Scherolin O. Marques, Thais F. Luciano, José R. Pauli, Leandro P. Moura, Erico Caperuto, Bruno L. S. Pieri, Julia Engelmann, Gisele Scaini, Emilio L. Streck, Fabio S. Lira, Ricardo A. Pinho, Eduardo R. Ropelle, Adelino S. R. Silva, Cláudio T. De Souza

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Clinical and Ultrasound Evaluation of Hemiplegic Shoulder Pain in Stroke Patients: A Longitudinal Observational Study Starting in the First Hours After Stroke by Filippo Cotellessa, William Campanella, Luca Puce, Maria Cesarina May, Marta Ponzano, Riccardo Picasso, Matteo Mordeglia, Davide Subbrero, Ester Cecchella, Laura Mori, Davide Sassos, Massimo Del Sette, Matteo Formica, Carlo Trompetto

“…This longitudinal study aimed to investigate the clinical and ultrasound characteristics of HSP emerging within the first 72 h (T0) post-stroke, with follow-ups at one month (T1) and three months (T2). …”
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Neural Plasticity and Hearing‐Speech Development in Children with Auditory Brainstem Implants for Congenital Hearing Loss Due to Severe Inner Ear Malformation by Yu Zhang, Yongchuan Chai, Yiwen Zhang, Huan Jia, Zhaoyan Wang, Zhihua Zhang, Zhili Wang, Jie Chen, Xue Wang, Yun Li, Ying Chen, Hao Wu

“…The average percentage of elicited electrodes (eABR%) during the operation is 72.73±17.99%. Post‐activation, hearing and speech outcomes improved steadily. …”
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Analysis of failure mechanisms and behavior of LiCoO2-graphite batteries at 0 ℃ by Ke Li, Jia Niu, Yifan Hao, Jiaxin Yao, Pushpendra Kumar, Zhenhao Luo, Songtong Zhang, Jing Wang, Xiayu Zhu, Wenjie Meng, Jingyi Qiu, Guiling Wang, Hai Ming

“…Through the analysis of differential voltage and incremental capacity curves, along with post-mortem analysis after cycling, it is revealed that the desolvation energy of lithium largely determines whether lithium integrates into the active materials or plates on the electrode surface. …”
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Exploring Aneurysmal Bone Cysts of the Skull: Insights from a Review of the Literature and a Case Report by Flavio Panico, Leonardo Bradaschia, Pasquale Cardellicchio, Fabio Cofano, Enrico Lo Bue, Stefano Colonna, Alberto Morello, Andrea Bianconi, Diego Garbossa, Gianluca Piatelli, Marco Pavanello

“…Secondary lesions showed a higher frequency of complications within the first months post-surgery (<i>p</i> = 0.041). <b>Conclusions</b>: No significant correlation was found between ABCs and fibrous dysplasia (FD) or head trauma. …”
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