Polymorphisms in the GNAS Gene as Predictors of Ventricular Tachyarrhythmias and Sudden Cardiac Death: Results From the DISCOVERY Trial and Oregon Sudden Unexpected Death Study by Heinrich Wieneke, Jesper Hastrup Svendsen, Jeffrey Lande, Sebastian Spencker, Juan Gabriel Martinez, Bernhard Strohmer, Lauri Toivonen, Hervé Le Marec, F. Javier Garcia‐Fernandez, Domenico Corrado, Adriana Huertas‐Vazquez, Audrey Uy‐Evanado, Carmen Rusinaru, Kyndaron Reinier, Csaba Foldesi, Wieslaw Hulak, Sumeet S. Chugh, Winfried Siffert

“…In the DISCOVERY trial, genotypes of 2 SNPs in the GNAS gene were nominally significant in the prospective screening and significantly associated with VT when viewed as recessive traits in post hoc analyses (TT vs CC/CT in c.393C>T: HR 1.42 [CI 1.11‐1.80], P=0.005; TT vs CC/CT in c.2273C>T: HR 1.57 [CI 1.18‐2.09], P=0.002). …”
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Long‐Term Clinical Outcomes of Treatments for In‐Stent Chronic Total Occlusions: A Real‐World Study Based on Different Strategies of Revascularization by Zhuoran Yang, Jiasheng Yin, Yiqing Hu, Li Zhu, You Zhou, Yaqi Zhang, Nirupama Krishnamurthi, Jieyu Jiang, Wenxian Zhou, Nitin Barman, Hao Lu, Junbo Ge

“…In this single‐center retrospective cohort study of 198 patients with IS‐CTO post‐DES, 3‐year outcomes of DCB, DES, and plain old balloon angioplasty (POBA) were compared, focusing on target vessel failure (TVF). …”
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Theory-screened Prussian blue analogues-based nanozymes for promoting diabetic wound healing via ferroptosis inhibition by Qingrong Dong, Xiaomei Shen, Ge Fang, Jia Shi, Xiafeng Zhu, Jiangfeng Du, Hui Zhang, Cuicui Ge

“…Through computational and experimental methods, the optimized Prussian blue analogues (MPBs) with highest iron chelating efficiency and efficacy (CuPBs) are screened out and both the CuPBs and the post-chelated products have been demonstrated to exhibit reactive oxygen species (ROS)-scavenging activities. …”
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Diagnostic value of microRNA-27 and -339 in heart transplant recipients with myocardial fibrosis by O. P. Shevchenko, D. A. Velikiy, S. O. Sharapchenko, O. E. Gichkun, A. V. Marchenko, A. A. Ulybysheva, V. S. Pavlov, N. P. Моzheikо, N. N. Кoloskovа, A. O. Shevchenko

“…The combination of molecular-genetic and proteomic biomarkers in one test improves the diagnostic characteristics of these expressions with respect to post-transplant complications in heart recipients.…”
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Regulation of retinoic acid inducible gene I signal transduction by bluetongue virus through the ubiquitin-proteasome system by Danfeng LU, Zhenxing ZHANG, Zhanhong LI, Pei ZHU, Zhuoran LI

“…Treatment with the proteasome inhibitor MG-132 significantly suppressed RIG-I degradation induced by BTV infection; The nuclear translocation ratio of IRF3 in MG-132 treated SPAE cells increased by 9.67 and 8.66 percentage points compared with their untreated counterparts at 24 hours post-infection (24 hpi) and 48 hpi; The expression level of IFN-α increased by 2.18-fold comparing with that of the corresponding untreated group at 48 hpi; The genomic copy numbers of BTV decreased to 74% and 85% of those of the untreated counterparts at 24 and 48 hpi, respectively. …”
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Biochemical investigation of association of arsenic exposed polymorphic variants and disease susceptibility by Syed Muhammad Shoaib, Samina Afzal, Muhammad Sajid Hamid Akash, Kanwal Rehman, Amjad Hussain, Ahmed Nadeem, Asif Shahzad, Sabry M. Attia

“…The groundwater exhibited significantly elevated arsenic concentrations (68.18 ± 21.28 μg/L) in comparison to both water and sanitation agency Faisalabad (WASA)-supplied water (9.81 ± 1.2 μg/L) and locally filtered water (8.12 ± 1.42 μg/L), as determined by one-way ANOVA followed by Bonferroni's post-test at P < 0.05. An association was established between arsenic concentration and the incidence of disease, such as diabetes mellitus. …”
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Development and Validation of a Machine Learning Model for Predicting Long-Term Depression Risk in ACS Patients After PCI: A Retrospective Cohort Study by Lv H, Sun F, Zhang Y, Zhou X

“…Decision curve analysis demonstrated the clinical benefit of both models across a range of thresholds.Conclusion: The models demonstrated potential for early risk stratification of post-PCI depression and may inform targeted clinical interventions.Plain Language Summary: Depression is a common but often overlooked problem in people recovering from heart procedures. …”
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The role of ubiquitination and deubiquitination in urological tumours by Lifeng Gan, Lifeng Gan, Lifeng Gan, Peiyue Luo, Peiyue Luo, Peiyue Luo, Junrong Zou, Junrong Zou, Wei Li, Wei Li, Wei Li, Qi Chen, Qi Chen, Qi Chen, Le Cheng, Le Cheng, Le Cheng, Fangtao Zhang, Fangtao Zhang, Fangtao Zhang, Haidong Zhong, Haidong Zhong, Haidong Zhong, Liying Zheng, Biao Qian, Biao Qian

“…Ubiquitination, a form of post-translational modification, occurs in eukaryotic cells and involves several key components, such as Ub-activating enzymes, Ub-binding enzymes, and Ub-protein ligases. …”
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The ASSIST Trial: Acute Effects of Manipulating Strength Exercise Volume on Insulin Sensitivity in Adults Living With Obesity: A Randomized Controlled, Crossover, Clinical Trial by Luis Filipe Rocha Silva, Paulo H. Evangelista Silva, Jordan Ottoni do Carmo, Bruna Caroline Chaves Garcia, Elizabethe Adriana Esteves, Zachary Aaron Mang, Fabiano Trigueiro Amorim, Marco Fabrício Dias‐Peixoto, Fernando Gripp, Valmor Tricoli, Flavio de Castro Magalhaes

“…Results One‐way repeated measure analysis of variance followed by Tukey as post hoc showed that indexes of insulin sensitivity improved after the high‐volume session (p < 0.05) but not after the low‐volume session (p > 0.05) (effect size [EF] for high and low volume, respectively): insulin area under the curve (AUC) [−0.53 and −0.05], C‐peptide AUC [0.58 and 0.18], Cederholm index [0.59 and 0.11], skeletal muscle index [0.89 and 0.60], Gutt index [0.78 and 0.20], Stumvoll index [0.81 and 0.18], and the simple index [0.52 and 0.16]). β‐cell function showed a strong tendency to improve (p < 0.06) after the high‐volume session (EF for high and low volume, respectively): C‐peptidogenic index [0.58 and −0.20], C‐peptide oral disposition index [0.72, −0.33]. …”
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Newborn Screening for Gaucher Disease: The New Jersey Experience by Caitlin Menello, Shaney Pressley, Madeline Steffensen, Sarah Schmidt, Helio Pedro, Reena Jethva, Karen Valdez-Gonzalez, Darius J. Adams, Punita Gupta, Lorien Tambini King, Milen Velinov, Sharon Anderson, Peyman Bizargity, Beth Pletcher, Allysa Tuite, Christina Kresge, Debra Lynn Day-Salvatore, Ryan Kuehl, Can Ficicioglu

“…Three type I GD patients started enzyme replacement therapy, with the youngest starting at 28 months of age. Post-treatment data are available for these individuals. …”
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Effects of histone acetyltransferase and deacetylase inhibitors on the expression of S100A genes after TLR4 and TLR2 stimulation in human dental pulp cells by Holger Jungbluth, Dominik Kraus, Diana Lalaouni, Sarah Hossam Fahmy, Jochen Winter, Søren Jepsen

“…Analysis of variance (ANOVA) followed by tukey post-hoc-test was calculated. Results: HDAC and HAT inhibitors significantly altered the expression of S100A genes in hDPCs both in presence and absence of LPS and Pam3CSK4, respectively. …”
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A Retrospective Longitudinal Study on Venous Thromboembolisms: The Impact of Active Monitoring on the Venous Thromboembolism Management Practices of Healthcare Providers to Improve... by Rateb Abd Alrazak Daowd, Ateeq Mohamad Algarni, Majed Abdulhadi Almograbi, Sara Majed Saab, Naif Mansour Alrashed, Maryam Mohammad Harthi, Amira Fatmah Paguyo Quilapio, Ibrahim Numan Alnajjar, Shahzad Ahmad Mumtaz, Raed Fahad Albusayyis, Dalya Ali Aljumaiah, Yazeed Alsalamah, Huda Ibrahim Almulhim

“…Lastly, we recommend addressing the risk factors associated with the occurrence of hospital-acquired VTE and performing post-discharge follow-ups of patients.…”
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10-year experience in orthotopic heart transplantation in Kuzbass by L. S. Barbarash, O. L. Barbarash, E. V. Grigoriev, D. L. Shukevich, T. B. Pecherina, M. G. Zinets, A. V. Sotnikov, I. K. Khalivopulo, T. S. Golovina, E. M. Kurguzova, A. V. Ivanova, Yu. S. Ignatova, A. V. Yurkina, D. P. Golubovskaya, P. G. Parfenov, J. I. Gusel’nikova, E. V. Dren’

“…At the same time, there is lower perioperative mortality and higher survival in the post-OHT long-period.Objective: to analyze OHT outcomes in Kuzbass over a 10-year period.Material and methods. …”
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Senescence-associated alterations in histone H3 modifications, HP1 alpha levels and distribution, and in the transcriptome of vascular smooth muscle cells in different types of sen... by Agnieszka Gadecka, Marta Koblowska, Helena Kossowska, Roksana Iwanicka-Nowicka, Dorota Janiszewska, Grażyna Mosieniak, Krzysztof Bojakowski, Krzysztof Goryca, Anna Bielak-Zmijewska

“…Methods We investigated the level and distribution of HP1α and H3 modifications that are markers of hetero- and euchromatin (H3K9me3, H3K27me3, H3K4me3, H3K9Ac - WB and IF), alterations in the transcriptomic profile (DNA microarray, qPCR), H3K4me3, H3K9me3 and HP1α protein distribution in the genome (ChIP-seq), and expression of enzymes involved in histone post-translational modifications (DNA microarray, qPCR, WB, IF). …”
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Listening effort and stress in tinnitus: a multidimensional approach by Giovanna Giliberto, Maria Itati Palacio, Giulia Cartocci, Emiliano Fernandez-Villalba, Dario Rossi, Nieves Minguez, Maria Botia, Maria Botia, Jose Domingo Cubillana, Jose Joaquin Ceron, Jose Joaquin Ceron, Fabio Babiloni, Maria Trinidad Herrero

“…Salivary amylase increased post-task (p = 0.016), electrodermal activity differed between the initial and final quiet phases (p &lt; 0.001), and heart rate varied according to noise levels (p = 0.008). …”
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Measurement of Intratumor Heterogeneity and Its Changing Pattern to Predict Response and Recurrence Risk After Neoadjuvant Chemotherapy in Breast Cancer by Mingxi Zhu, Qiong Wu, Xiaochuan Geng, Huaying Xie, Yan Wang, Ziping Wu, Yanping Lin, Liheng Zhou, Shuguang Xu, Yumei Ye, Wenjin Yin, Jia Hua, Jingsong Lu, Yaohui Wang

“…Patients with increased heterogeneity exhibited a higher risk of recurrence approaching two years post-surgery, particularly within the non-pCR population. …”
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Determination of the optimal ejaculate concentration of a buffalo bull for successful semen cryopreservation by Krishna Bansal, Krishna Bansal, Dinesh Jhamb, Usha Yadav, Usha Yadav, Mamta Meel, Mamta Meel, Akanksha Gupta, Akanksha Gupta, Renu Bala, Meenakshi Virmani, Meeti Punetha, Dharmendra Kumar, Pradeep Kumar

“…The second objective was to evaluate the post-thaw sperm quality of ejaculates that initially met the criteria for cryopreservation. …”
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Inhibition of Mitochondrial Dynamics by Mitochondrial Division Inhibitor-1 Suppresses Cell Migration and Metastatic Markers in Colorectal Cancer HCT116 Cells by Mehmood T, Nasir Q, Younis I, Muanprasat C

“…Moreover, Mdivi.1 decreased dynamin-related protein-1 (Drp1) and phosphorylated-Drp1 expression and increased mitofusin-2 (Mfn2) expression in a concentration-dependent manner at 48 and 72 h post-treatment. Notably, Mdivi.1 induced inhibition of translocation of Drp1 from the cytosol to the outer mitochondrial membrane. …”
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MicroRNA-15a-5p mediates abdominal aortic aneurysm progression and serves as a potential diagnostic and prognostic circulating biomarker by Greg Winski, Ekaterina Chernogubova, Albert Busch, Suzanne M. Eken, Hong Jin, Moritz Lindquist Liljeqvist, Tooba Khan, Alexandra Bäcklund, Valentina Paloschi, Joy Roy, Rebecka Hultgren, Christine Brostjan, Gert J. de Borst, Joost P. G. Sluijter, Nadja Sachs, Hans-Henning Eckstein, Reinier A. Boon, Joshua M. Spin, Philip S. Tsao, Folkert W. Asselbergs, Lars Maegdefessel

“…Abstract Background MicroRNAs are post transcriptional modulators of gene expression. …”
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Supplementation of live yeast (Saccharomyces cerevisiae) as natural feed additives on growth performance, meat quality and physiological status of broiler chickens by Maruf Hossain, Amio Kante Das, Kanan Talukder, Md Momotaj Hossen, Kanon Das, Chondhon Bormon, Mansur Ahmed, Mohammad Al Mamun, Mohammad Abujar Shuva, Mahmoud Azzam, Shad Mahfuz

“…At 42 days of age, the broilers fed diets containing live yeast had a lower 7-day drip loss, a lower cooking loss, and a higher breast muscle pH at 45 min post-mortem (P < 0.05) than the control group. Supplementing with live yeast also decreased serum triglycerides, total cholesterol, and heterophil/lymphocyte ratio (P < 0.05). …”
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