Estradiol Downregulates MicroRNA-193a to Mediate Its Angiogenic Actions by Lisa Rigassi, Mirel Adrian Popa, Ruth Stiller, Brigitte Leeners, Marinella Rosselli, Raghvendra Krishna Dubey

“…Moreover, these actions occur post-transcriptionally, as the expression of pri-miR-193a-3p was not affected. …”
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Unveiling Bifurcated Blue Straggler Sequences in NGC 2173: Insights from Binary Evolution by Li Wang, Dengkai Jiang, Chengyuan Li, Licai Deng, Antonino P. Milone, Long Wang

“…In contrast, the blue sequence BS binaries are formed through nonconservative post-MT processes, all involving white dwarf (WD) companions. …”
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Pain localization and response to botulinum toxin in cervical dystonia by Alexander S. Wang, Alexander S. Wang, Hanieh Agharazi, Hanieh Agharazi, Aetan Parmar, Camilla W. Kilbane, Camilla W. Kilbane, Lauren Cameron, Lauren Cameron, Aasef G. Shaikh, Aasef G. Shaikh, Aasef G. Shaikh, Steven A. Gunzler, Steven A. Gunzler

“…The locations of pain remained relatively stable in the post-treatment state.ConclusionWe confirmed that botulinum toxin is effective for treatment of pain related to CD. …”
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Outcome Following Chest Tube Removal with Respect to Phase of Respiration in Chest Trauma Patients: A Randomised Controlled Trial by Ritesh Kumar, Sandeep Chauhan, Mahavir Singh, Mohammed Faiz, Deepak, Gaurav Sharma, Manish Kumar Yadav, Sanjay Marwah

“…Materials and Methods: The present study was a randomised controlled trial conducted at the Department of Surgery, Pt. BD Sharma Post Graduate Institute of Medical Sciences, Rohtak, India, between 1st August 2020 and 31st July 2022. …”
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Changes in rapid HIV treatment initiation after national "treat all" policy adoption in 6 sub-Saharan African countries: Regression discontinuity analysis. by Olga Tymejczyk, Ellen Brazier, Constantin T Yiannoutsos, Michael Vinikoor, Monique van Lettow, Fred Nalugoda, Mark Urassa, Jean d'Amour Sinayobye, Peter F Rebeiro, Kara Wools-Kaloustian, Mary-Ann Davies, Elizabeth Zaniewski, Nanina Anderegg, Grace Liu, Nathan Ford, Denis Nash, IeDEA consortium

“…The rate of rapid ART initiation accelerated sharply following treat all policy adoption in Malawi, Uganda, and Zambia; slowed in Kenya; and did not change in Rwanda and Burundi. In post hoc analyses restricted to patients enrolling under treat all, young adults (16-24 years) and men were at increased risk of not rapidly initiating ART (compared to older patients and women, respectively). …”
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Altered brain structure age gap estimation in major depressive disorder patients with and without anhedonia: a machine learning-based study by Qingli Mu, Kejing Zhang, Yue Chen, Yuwei Xu, Shaohua Hu, Manli Huang, Peng Zhang, Dong Cui, Shaojia Lu

“…ANCOVAs revealed significant BSAGE differences among three groups in the bilateral putamen (PU), left cerebellar white matter (CB), left cuneus (CUN), left fusiform gyrus (FuG), left subcallosal area (SCA), left superior occipital gyrus (SOG), left triangular inferior frontal gyrus (IFG-Tri), right lateral ventricle (L-V), right superior frontal gyrus medial segment (SFG-SM), right opercular inferior frontal gyrus (IFG-Oper), right precuneus (pre-CUN), right posterior insula (INS-Post), and right superior temporal gyrus (STG). Compared to HCs, the MDD-WA group showed significant BSAGE increase in all of the aforementioned brain regions, while the MDD-WoA group showed limited BSAGE increase in the CB, FuG, and SCA of left hemisphere only. …”
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Development of BK polyomavirus-associated nephropathy risk prediction in kidney transplant recipients by Junji Yamauchi, Katalin Fornadi, Divya Raghavan, Duha Jweehan, Suayp Oygen, Silviana Marineci, Michelle Buff, Michael Fenlon, Motaz Selim, Michael Zimmerman, Miklos Z. Molnar

“…Background With the development of potential prevention therapies for BK polyomavirus (BKPyV)-associated nephropathy (BKPyVAN), risk prediction models are needed to identify kidney transplant recipients at high risk for BKPyVAN.Methods This single-center retrospective study aimed to develop a risk prediction model and an integer-based risk score for BKPyVAN development, defined as plasma BKPyV-DNA >10,000 copies/mL and/or biopsy-proven BKPyVAN, within 1-year post-transplant, using donor and recipient characteristics at the time of transplantation. …”
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Effects of electron beam irradiation on microbial loads, physicochemical properties, stability of active ingredients, and antioxidant activity in Angelica sinensis Radix by Yunxia Hu, Haijun Wang, Zhijun Xin, Wensheng Gou, Zhuanzi Wang, Xiao Liu, Xihong Lu, Aimei Yang, Xuehu Li, Libin Zhou

“…Antioxidant activity remained elevated post-irradiation, correlating with the enrichment trends of volatile oil and phenolic acids. …”
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The differential expression of MAGI2 in glomerulopathies and its application as a molecular discriminator of podocytopathies by Florian Siegerist, Eleonora Hay, Elke Hammer, Anna Iervolino, Claudia Weber, Juan Saydou Dikou, Eleni Stamellou, Linus Butt, Thomas Benzing, Thorsten Wiech, Paul T. Brinkötter, Uwe Zimmerman, Giovambattista Capasso, Christos Chatziantoniou, Christos E. Chadjichristos, Tobias B. Huber, Uwe Völker, Maximilian Schindler, Nicole Endlich

“…This downregulation was also conserved in a zebrafish model of focal and segmental glomerulosclerosis (FSGS), and the podocyte-specific MAGI2 ortholog Magi2a was reduced post podocyte injury. CRISPR/Cas9-generated zebrafish mutants for magi2a exhibited marked glomerular filtration barrier defects and downregulation of nephrin, underscoring MAGI2's critical role in podocyte function. …”
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Evaluating treatment options for symptomatic uterine fibroids: a systematic review and meta-analysis of effectiveness, recovery, and long-term outcomes (MARIE WP1) by Elena Bedggood, Sun Jie, Snehal Ghosh, Vindya Pathiraja, Tharanga Mudalige, Nirmala Rathnayake, Heitor Cavalini, Om Kurmi, George Uchenna Eleje, Peter Phiri, Peter Phiri, Paula Briggs, Jian Qing Shi, Jian Qing Shi, Gayathri Delanerolle, Gayathri Delanerolle, Gayathri Delanerolle, Sohier Elneil

“…Three studies (n = 520) assessed HRQoL via UFS-QoL pre- and post-uterine artery embolisation and myomectomy. …”
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Uso do retalho miogorduroso segmentar do músculo latíssimo do dorso em decúbito único para reconstrução da mama pós-quadrantectomia externa Use of latissimus dorsi muscle segment w... by João Batista Fortaleza de Araújo, Luiz Gonzaga Porto Pinheiro, Sérgio Saboya Pinheiro de Sousa, João Ivo Xavier Rocha, Patrícia Lopes Gaspar, Leila Yasmim Maria Cidrão Fortaleza

“…In the case of external quadrant tumors, there is no option of rotation of the entire latissimus dorsi muscle, which usually exceeds the actions necessary for repairing lost volume. A new option for post-quadrantectomy reconstruction in external quadrants is proposed in this study. …”
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Sequential 90Y Selective Internal Radiation Therapy (SIRT) and Stereotactic Body Radiation Therapy (SBRT) using 90Y PET-based Absorbed Dose Maps: Interim Analysis of a Phase 1 Stud... by Daniel F. Polan, PhD, Justin K. Mikell, PhD, Kellen Fitzpatrick, MS, Joseph J. Gemmete, MD, Jared A. Christensen, MD, Hassan Anbari, MD, Molly Roseland, MD, Joseph R. Evans, MD, PhD, Daniel T. Chang, MD, Mamadou Sanogo, MD, Baljendra S. Kapoor, MD, Matthew J. Schipper, PhD, Yue Cao, PhD, Madhava P. Aryal, Theodore S. Lawrence, MD, PhD, Kyle C. Cuneo, MD, Yuni K. Dewaraja, PhD

“…Methods and Materials: In this ongoing, single-center prospective trial, patients received standard-of-care 90Y SIRT with glass microspheres for the treatment of unresectable primary or secondary liver cancer. Post-SIRT dosimetry was performed using 90Y positron emission tomography/computed tomography to calculate mean lesion absorbed doses. …”
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Analysis of the results of treatment of patients with malignant tumors of the salivary glands by V. T. Vayradyan, A. M. Mudunov, V. D. Ermilova, R. I. Azizyan, I. A. Zaderenko, S. B. Aliyeva, E. L. Dronova

“…In case of other MSGN localizations, prophylactic lymphadenectomy does not improve long-term outcomes. Radiotherapy in the post-op period significantly improves long-term results of treatment in comparison with a group of preoperative radiotherapy (local recurrence rates are 29.5 and 9.7 %, respectively, p = 0.0002). …”
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Supported implementation of tailored multicomponent fall prevention interventions in hospital: a feasibility study by Bethan Richards, Vasi Naganathan, Catherine Sherrington, Leanne Hassett, Matthew Jennings, Andrew Hallahan, Abby Haynes, Charlotte McLennan, Wendy Tilden, Tamsin McVeigh, Veethika Nayak

“…Reach: 28/38 (74%) survey respondents were aware of the multicomponent fall prevention interventions on their ward, with 24 (86%) reporting a positive impact on clinical practice post implementation. Adoption: delivery of multicomponent hospital fall prevention interventions increased 1.1/10 points between preimplementation (n=61) postimplementation (n=38) surveys. …”
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A universal testing and treatment intervention to improve HIV control: One-year results from intervention communities in Zambia in the HPTN 071 (PopART) cluster-randomised trial. by Richard Hayes, Sian Floyd, Ab Schaap, Kwame Shanaube, Peter Bock, Kalpana Sabapathy, Sam Griffith, Deborah Donnell, Estelle Piwowar-Manning, Wafaa El-Sadr, Nulda Beyers, Helen Ayles, Sarah Fidler, HPTN 071 (PopART) Study Team

“…Data from four communities in Zambia receiving the full intervention (including immediate ART for all individuals with HIV) were used to determine proportions of participants who knew their HIV status after the CHiP visit; proportions linking to care and initiating ART following referral; and overall proportions of HIV-infected individuals who knew their status (first 90 target) and the proportion of these on ART (second 90 target), pre- and post-intervention. We are not able to assess progress towards the third 90 target at this stage of the study. …”
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Application of the Fitness and Nutrition Program for Seniors (FANS) to improve Physical Activity and Kinanthropometric Measures among Community-Dwelling Older Adults living with Fr... by Pei-Shan Li, Chia-Jung Hsieh, Nae-Fang Miao, Chuan-Hsiu Tsai, Chieh-Yu Liu, Hung-Ru Lin, Shu-Fang Vivienne Wu, Jordan Koh

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Optimizing High-Power Performance of [001]-Oriented Pb(Mg_1/3Nb_2/3)-PbTiO₃ Through Combined DC and AC Polarization Above Curie Temperature by Yuliang Zhu, Xiaobo Wang, Wenchao Xue, Xinran Wen, Chengtao Luo

“…Pb(Mg_1/3Nb_2/3)O₃-PbTiO₃ single crystals (PMN-PT SCs) are widely utilized in high-performance piezoelectric devices due to their exceptional piezoelectric properties. Among the various post-processing techniques for domain engineering in PMN-PT SCs, alternating current polarization (ACP) has become a widely adopted method for enhancing piezoelectric performance. …”
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Safety and effectiveness of multimodal opioid-free anaesthesia for pain and recovery after laparoscopic surgery: a systematic review and meta-analysis by Jiang Liu, Li Jing, Lin Cheng, Sifan Qin, Xinyan Geng, Shirong Fang

“…The secondary outcomes included the incidence of postoperative nausea and vomiting (PONV), antiemetic use, extubation time (measured in minutes), post-anaesthesia care unit discharge time (measured in minutes), shivering, bradycardia, hypotension and pruritus.Data extraction and synthesis Meta-analyses were performed using Stata16 software, using the DerSimonian and Laird’s method and inverse variance to summarise effect sizes for each outcome under a random effects model for all outcomes. …”
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Stationary Cycling Exercise With Virtual Reality to Reduce Depressive Symptoms Among People With Mild to Moderate Depression: Randomized Controlled Trial by Na Zhang, Chenlu Hong, Yuejia Wang, Haiqin Chen, Yueli Zhu, Miao Da, Zhongxia Shen, Xudong Zhao, Jiali Xu, Jiaxiu Sheng, Yanan Luo, Meiying Xu

“…Response rate, remission rate, satisfaction, compliance, and adverse events were assessed post intervention. Outcomes were analyzed using an ITT approach. …”
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Enhanced T-cell immunity and lower humoral responses following 5-dose SARS-CoV-2 vaccination in patients with inborn errors of immunity compared with healthy controls by Vitor Gabriel Lopes da Silva, Gabriela Justamante Händel Schmitz, Kathleen E. Sullivan, Júlia Barbate, Maria Izabel de Haro Azinar, Carolina Sanchez Aranda, Maria Isabel de Moraes-Pinto

“…T-cell responses to Spike were stronger in patients with IEI post-booster (405 vs. 149 spot-forming cells/million PBMC; p = 0.002). …”
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