Safety and pharmacokinetics of dolutegravir in pregnant mothers with HIV infection and their neonates: A randomised trial (DolPHIN-1 study). by Catriona Waitt, Catherine Orrell, Stephen Walimbwa, Yashna Singh, Kenneth Kintu, Bryony Simmons, Julian Kaboggoza, Mary Sihlangu, Julie-Anne Coombs, Thoko Malaba, Josaphat Byamugisha, Alieu Amara, Joshua Gini, Laura Else, Christie Heiburg, Eva Maria Hodel, Helen Reynolds, Ushma Mehta, Pauline Byakika-Kibwika, Andrew Hill, Landon Myer, Mohammed Lamorde, Saye Khoo

“…<h4>Methods and findings</h4>In DolPHIN-1, HIV-infected treatment-naïve pregnant women (28-36 weeks of gestation, age 26 (19-42), weight 67kg (45-119), all Black African) in Uganda and South Africa were randomised 1:1 to dolutegravir (DTG) or efavirenz (EFV)-containing ART until 2 weeks post-partum (2wPP), between 9th March 2017 and 16th January 2018, with follow-up until six months postpartum. …”
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Comparative efficacy and safety of nitinol vs. novel fully biodegradable occluders for transcatheter patent foramen ovale closure in migraine treatment: a retrospective cohort stud... by Rui-lin Li, Jing-juan Huang, Jie Ming, Ying Hao, Wei Wen, Yun-li Shen, Li Lin, Lin-xiang Lu

“…Secondary outcomes included the incidence of safety-related events and the rate of residual right-to-left shunt.ResultsBoth the nitinol group and biodegradable groups showed significant reductions in MIDAS scores post-procedure with no significant difference in migraine relief between groups (P = 0.644, Kaplan-Meier analysis). …”
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Construction and multidimensional effect evaluation of a mindfulness-based second victim intervention support programme for intensive care unit nurses: a case–control study by Xiaolei Chen, Aiyan Du, Mei Yu, Cen Zhang, Xuefen Zhu, Yan Cao, Linghong Hua, Xiaodong Cao

“…Specifically, the PSQI score in the experimental group decreased from 12.94 ± 2.03 at baseline to 9.32 ± 2.13 post-intervention, whereas the control group’s score only decreased from 12.76 ± 2.21 to 10.72 ± 1.99. …”
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Self-injurious behavior in Greek adolescents: the role of mental health problems and COVID-19 trauma by Georgios Giannakopoulos, Foivos Zaravinos-Tsakos, Efrosyni Pilafa, Andre Sourander, Gerasimos Kolaitis

“…Participants completed the Strengths and Difficulties Questionnaire (SDQ) to assess emotional symptoms, conduct problems, hyperactivity, and peer difficulties, and the Children’s Revised Impact of Event Scale-8 (CRIES-8) to evaluate post-traumatic stress symptoms. SIB was assessed via self-report, and specific COVID-19–related experiences (e.g., quarantine, hospitalization) were recorded alongside measures of suicidal ideation and suicide attempts. …”
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U–Pb dating on calcite paleosol nodules: first absolute age constraints on the Miocene continental succession of the Paris Basin by V. Monchal, R. Rateau, K. Drost, C. Gagnaison, B. Mennecart, R. Toullec, K. Torremans, D. Chew

“…Recent progress in carbonate U–Pb dating can improve correlations between continental successions by providing absolute age constraints on carbonate deposition and/or on syn- to post-depositional processes such as pedogenesis.</p> <p>In this study, we analysed pedogenic calcite nodules within a continental Miocene succession in the southwestern Paris Basin (the important paleontological site at Mauvières quarry, France). …”
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Transient gray matter decline during antarctic isolation: Roles of sleep, exercise, and cognition by David Roalf, Mathias Basner, Joanne C. Beer, Russell T. Shinohara, Kosha Ruparel, Tyler M. Moore, David F. Dinges, Alexander C. Stahn, Jad Nasrini, Emanuel Hermosillo, Adrian J. Ecker, Karthik Prabhakaran, Mustafa M. Almuqbel, Michael G. Smith, Christopher W. Jones, Bernd Johannes, Darius A. Gerlach, Beth Healey, Floris P. van den Berg, Hanns-Christian Gunga, Tracy R. Melzer, Bruce V. Taylor, Ruben C. Gur

“…This study assessed brain structure changes in 25 crewmembers who spent 12 months at Concordia, with MRI scans conducted before, immediately after, and five months post-mission. The study included 25 controls scanned over a similar interval and 4 “flying phantom” individuals who were scanned at all sites. …”
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Cross-lineage 5-methylcytosine methylome profiling reveals methylated divergence among Toxoplasma gondii tachyzoites of the three major clonal lineages by Xiao-Nan Zheng, Hong-Yu Song, Hany M. Elsheikha, Chen-Ran Tian, Xing Tian, Qing Liu, Wen-Bin Zheng, Xing-Quan Zhu

“…Among the emerging layers of gene regulation, 5-methylcytosine (m5C) has emerged as a pivotal post-transcriptional modification in eukaryotes. …”
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OCTA changes of retinal microvessels and thickness in moyamoya disease by Xian-Zhe Qian, Cheng Chen, Hong-Liang Li, Lei Zhong, Hong Wei, Qian-Min Ge, Jin-Yu Hu, Qi Hong, Xiao-Yu Wang, Yan-Mei Zeng, Xu Chen, Yi-Xin Wang, Chong-Gang Pei, Yi Shao

“…Analyses of variance (ANOVA) and Bonferroni post hoc analysis were used to calculate statistical differences between the three groups. …”
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More Evidence that Surgical Intervention for Unstable Distal Radius Fracture in Elderly Does not Offer a Superior Patient Perceived Functional Advantage over Time Honored Conservat... by Raghavendra S Kulkarni, Sriram R Kulkarni

“…Introduction: In this study, elderly distal radius fracture treatment by both conservatively and surgical intervention was examined at 1 and 2 years post-injury and then reevaluated after a median of 10 (range 10–13) years. …”
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Consumers’ healthy lifestyle as a determinant of the influence of microcelebrities and microinfluencers by Mariola Palazón, María del Carmen Alarcón-del-Amo, Borja Martínez, Manuela López

“…Design/methodology/approach – An empirical study with a real healthy food brand was developed in which three real influencers from Instagram collaborated and posted a story showing the company’s products. A total of 148 individuals participated in the study. …”
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Carotid revascularization for ocular ischemic syndrome – a systematic review by Leonor Baldaia, Miguel Silva, Eduardo Silva, Celso Nunes, Luís Orelhas, Maria Carmona, Luís F. Antunes, Manuel Fonseca

“…We aim to study the potential improvement of visual symptoms post-carotid endarterectomy (CEA) in patients with carotid stenosis and hypoperfusion-related ocular issues. …”
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Fibrocartilage repair involves chronic cellular senescence in a rat model of bone marrow stimulation by Luke Childress, Landon B. Gatrell, Hong Wu, Elisabeth Ferreira, Intawat Nookaew, Ryan M. Porter

“…Objective: Cellular senescence has been implicated in the progression of post-traumatic osteoarthritis, but any role in pre-osteoarthritic cartilage repair is unknown. …”
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PO13 | Monitoring of anti-factor XA activity levels in patients treated with direct oral anticoagulants and concomitant tyrosine kinase inhibitors agents: a monocentric experience

“…No major B-AEs or T-AEs were reported during a median post-assay follow-up of 5 months (range 1.1–20.4). …”
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Resting-State Activity Changes Induced by tDCS in MS Patients and Healthy Controls: A Simultaneous tDCS rs-fMRI Study by Marco Muccio, Giuseppina Pilloni, Lillian Walton Masters, Peidong He, Lauren Krupp, Abhishek Datta, Marom Bikson, Leigh Charvet, Yulin Ge

“…In HCs, fALFF increased in the right pre- and post-central gyrus whilst it decreased in subcortical regions. …”
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Machine learning-based prognostic prediction for acute ischemic stroke using whole-brain and infarct multi-PLD ASL radiomics by Zhenyu Wang, Chaojun Jiang, Xianxian Zhang, Tianchi Mu, Qingqing Li, Shu Wang, Congsong Dong, Yuan Shen, Zhenyu Dai, Fei Chen

“…This study aimed to assess the predictive value of radiomics features from whole-brain and infarct cerebral blood flow (CBF) images using multiple post-labeling delay arterial spin labeling (multi-PLD ASL), and to develop a prediction model incorporating clinical risk factors. …”
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Written Exposure Therapy for PTSD Integrated with Cognitive Behavioral Coping Skills for Cannabis Use Disorder After Recent Sexual Assault: A Case Series by Christine K. Hahn, Selime R. Salim, Emily L. Tilstra-Ferrell, Kathleen T. Brady, Brian P. Marx, Barbara O. Rothbaum, Michael E. Saladin, Constance Guille, Amanda K. Gilmore, Sudie E. Back

“…<b>Results</b>: This case series describes the novel intervention and examines clinical outcomes post-treatment and at the 1-month follow-up. Past-week PTSD symptoms (based on a clinical interview) and past-month cannabis use decreased among all participations after receiving STEPS. …”
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DRUG TREATMENT OF PATIENTS WITH THE HISTORY OF ACUTE STROKE: DATA OF THE PILOT PHASE OF THE OUTPATIENT REGISTRY «REGION» by S. A. Boytsov, M. M. Loukianov, S. S. Yakushin, S. Yu. Martsevich, L. V. Stakhovskaya, A. N. Vorobyev, A. V. Zagrebelnyy, A. N. Kozminsky, K. A. Moseichuk, K. G. Pereverzeva, E. A. Pravkina, E. N. Belova, V. G. Klyashtorny, E. V. Kudryashov, E. Yu. Okshina, A. D. Deev

“…Drugs with a proven beneficial effect on the prognosis in the post-stroke period were prescribed significantly (p and after 2 years – in the AS-FA registry, the frequency of the therapy was not significantly different from the frequency of prescribing at the stage of inclusion in the registers, with the exception of statins (they were taken 1.7 and 1.5 times less frequently). …”
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In vitro evaluation of hydro-ethanolic seed extract of Zanthoxyllum armatum DC to establish its mechanism of action for paralysis of Paramphistomum cervi in continuation with in vi... by Hazarika S., Barua C. C., Mohan P., Das A., Hazorika M., Tamuly S., Pathak P., Borah B., Phangchupi D., Chakraborty A., George S.

“…An in vivo experiment of HESEZA @ 150 and 250 mg/kg body weight in naturally infected goats were accomplished with complete reduction of EPG count on 28th day of post-treatment of the extract @ 250 mg/kg b. wt. …”
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Comparison of biodegradable and metal occluders in patients with PFO and migraine: study design and rationale of BioMetal Trial by Ziping Li, Jie Dong, Jing Dong, Yiming Yan, Manchen Gao, Fang Fang, Fengwen Zhang, Wenbin Ouyang, Shouzheng Wang, Chuangshi Wang, Xiangbin Pan, BioMetal investigators

“…A total of 400 participants will be enrolled, randomized 1:1 to receive either the biodegradable or metal devices, and followed up for 24 months post-randomization. The primary endpoint is the change in monthly migraine days at 12 months compared to baseline. …”
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AAV-mediated transduction of songbird retina by Pranav Kumar Seth, Pranav Kumar Seth, Dominik Heyers, Dominik Heyers, Baladev Satish, Ezequiel Mendoza, Katrin Haase, Lisa Borowsky, Isabelle Musielak, Karl-Wilhelm Koch, Karl-Wilhelm Koch, Regina Feederle, Constance Scharff, Karin Dedek, Karin Dedek, Henrik Mouritsen, Henrik Mouritsen

“…Subsequent immunohistochemical analyses revealed that the AAV2/9-EGFP serotype almost exclusively targeted photoreceptors: rods, various single cones (UV, blue, green, and red cones), and both (accessory and principal) members of double cones.DiscussionThe consistently high and photoreceptor-specific transduction efficiency makes the AAV2/9 serotype a powerful tool for carrying out genetic manipulations in avian retinal photoreceptors, thus opening a wealth of opportunities to investigate physiological aspects underlying retinal processing in birds, such as physiological recordings and/or post-transductional behavioural readouts for future vision-related research.…”
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