Postoperative complications following salvage neck dissection after (chemo)radiotherapy for head and neck squamous cell carcinoma: which patients are at high risk? by Arash Navran, Zeno A. R. Gouw, Willem M. Klop, Willem H. Schreuder, Maarten L. Donswijk, Emilia Owers, Jan Paul de Boer, Laura Smit, Luc Karssemakers, Michiel van den Brekel, Abrahim Al-Mamgani

“…However, the available literature could not identify potential groups at higher risk of post-operative complications because of the missing demographic information and the heterogeneity in studies and outcome data. …”
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High rate of persistent HPV detection after diagnostic cervical excision in older screen‐positive women by Line Winther Gustafson, Louise Krog, Bayan Sardini, Mette Tranberg, Lone Kjeld Petersen, Berit Andersen, Pinar Bor, Anne Hammer

“…However, little is known on treatment efficacy and post‐treatment surveillance for older women. We aimed to investigate the proportion of women testing negative for human papillomavirus (HPV) following a diagnostic cervical excision due to an abnormal screening test. …”
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Sex‐specific disparities in COVID‐19 outcomes by Zubaid Rafique, Valerie Durkalski‐Mauldin, William F. Peacock, Kabir Yadav, Joshua C. Reynolds, Clifton W. Callaway

“…Blood samples were collected on day 0 (pre‐/post‐infusion), 15, and 30 to measure Ab levels with the Broad Institute using the Plaque Reduction Neutralization Test assay. …”
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Inflammation and platelet hyperresponsiveness in coronary artery disease and the influence of Talin-1/αIIbβ3-mediated bidirectional signaling pathway by Shengnan Shi, Jiaming Gao, Yehao Zhang, Min Zhan, Zhanfei Tan, Peili Wang, Jianhua Fu, Jianxun Liu

“…Through systematic bioinformatics analysis of differential gene expression patterns and pathway activation in CHD patients, this study aims to elucidate key molecular regulators of platelet hyperactivity, establishing a theoretical framework for developing precision therapeutic strategies to mitigate post-CHD complications.MethodsThis randomized controlled study included 16 CHD patients and 16 healthy controls. …”
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The delaying effect of toripalimab on disease progression in patients with advanced hepatocellular carcinoma and changes in serum tumor markers by Zhuo Yin, Yaomin Xiao, Jiangxue Gu, Pei Hu, Jiandu Jing, Xia Wang, Yao Liu, Shirong Yan

“…Results The intervention group exhibited significantly higher ORR compared to controls (70.0% vs. 35.0%, P = 0.002), with complete response (CR) in 25.0% of patients. Post-treatment tumor markers declined markedly in the intervention group: AFP (412.3 ± 98.5 to 156.7 ± 45.2 ng/mL, P < 0.001), HSP90α (68.4 ± 12.3 to 34.2 ± 8.7 ng/mL, P < 0.001), and CEA (15.2 ± 3.1 to 6.8 ± 1.9 ng/mL, P = 0.003). …”
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HIPEC after Interval Debulking Surgery as Best Clinical Practice in Ovarian Cancer Patients: Case Series and Literature Review by Stefano Restaino, Jessica Mauro, Stefano Cianci, Alessandro Buda, Claudia Andreetta, Elena Poletto, Enrico Maria Pasqual, Alice Poli, Cosimo Vittorio Agrimi, Doriana Armenise, Alice Buzzelli, Domenico Caccamo, Lorenza Driul, Giuseppe Vizzielli

“…Conclusions: The addition of HIPEC to interval debulking surgery should be offered to all eligible patients, considering that the association of HIPEC to IDS seems to improve patients’ outcomes in terms of OS and DFS, without increasing post-operative morbidity .…”
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A time-course comparative clinical and immune response evaluation study between the human pathogenic Orientia tsutsugamushi strains: Karp and Gilliam in a rhesus macaque (Macaca mu... by Manutsanun Inthawong, Piyanate Sunyakumthorn, Sirima Wongwairot, Tippawan Anantatat, Susanna J Dunachie, Rawiwan Im-Erbsin, James W Jones, Carl J Mason, Luis A Lugo, Stuart D Blacksell, Nicholas P J Day, Piengchan Sonthayanon, Allen L Richards, Daniel H Paris

“…<h4>Methodology/principle findings</h4>We evaluated the clinical outcomes and host immune responses of the two most relevant human pathogenic strains of O. tsutsugamushi; Karp (n = 4) and Gilliam (n = 4) in a time-course study over 80 days post infection (dpi) in a standardized scrub typhus non-human primate rhesus macaque model. …”
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Screening and Risk Analysis of Atrial Fibrillation After Radiotherapy for Breast Cancer: Protocol for the Cross-Sectional Cohort Study “Watch Your Heart (WATCH)” by Laura Saint-Lary, Baptiste Pinel, Loic Panh, Gaelle Jimenez, Julien Geffrelot, Youlia Kirova, Jeremy Camilleri, David Broggio, Marie-Odile Bernier, Corinne Mandin, Christelle Levy, Serge Boveda, Juliette Thariat, Sophie Jacob

“…Cross-sectional screening for AF at the time of the scheduled 5-year post-RT visit will be conducted by recording data from a Withings ScanWatch smartwatch for 1 month, confirmed by an electrocardiogram (ECG), and validated by a physician. …”
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Succession characteristics and assembly process of soil microbiome at reclaimed farmlands in coal mining area by Jianhua Li, Jianhua Li, Zixu Li, Yanwen Sun, Jinjing Lu, Jinjing Lu, Qiang Zhang, Xinhua He, Xinhua He, Xinhua He, Minggang Xu, Minggang Xu

“…We analyzed soil microbial diversity, composition, co-occurrence network structure, and assembly processes using 16S rDNA/ITS sequencing and null models at 0 (R0), 1 (R1), 6 (R6), and 10 (R10) years of post-reclamation. Results showed that (1) Compared to R0, the R10 treatment resulted in significant increases in soil organic matter (SOM), total nitrogen (TN), available phosphorus (AP), and available potassium (AK) by 2.1-fold, 1.3-fold, 1.5-fold, and 0.4-fold, and also in activities of β-glucosidase (BG), N-acetyl-β-glucosaminidase (NAG), and leucine aminopeptidase (LAP), by 17-fold, 8.7-fold, and 1.8-fold, respectively (p &lt; 0.05). (2) Rising bacterial diversity (Shannon, Chao1) over time, contrasting with fungal diversity that declined initially before recovering. (3) As the reclamation progressed, the network complexity was increased for both bacteria and fungi, improving stability. …”
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The growth mechanism and corrosion resistance of laser-assisted plasma electrolytic oxidation (PEO) composite coating on AZ31B magnesium alloy by Guolong Wu, Lin Li, Xianghui Chen, Lebin Zhu, Ye Wang, Chen Wen, Jianhua Yao

“…The results demonstrated that laser-assisted irradiation not only induced plasma discharge on the anode surface, but also limited the plasma discharge size in the post-processing stage, which significantly increased the proportion of corrosion-resistant phase Mg2SiO4 (the proportion of Mg2SiO4 increased from 23.70% to 39.22%), thickness and density in the coating, and obviously reduced the oxygen vacancy defects and microcracks in the coating. …”
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Does constipation affect the effectiveness of washed microbiota transplantation in treating autism spectrum disorders? by Zihao Pan, Zheng Gao, Junyi Chen, Yongxi Quan, Jiating Xu, Xiaofeng Liang, Wenrui Xie, Xingxiang He, Xingxiang He, Lihao Wu, Lihao Wu

“…After one course of WMT, constipation group showed an obvious increase in microbial diversity and a significant increase in the relative abundance of Bifidobacteria compared to non-constipation group.ConclusionPost WMT, core symptoms and sleep disorders were significantly improved in both groups. …”
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Methylation of a group of microRNA genes as a marker for the diagnosis and prognosis of non-small cell lung cancer by V. I. Loginov, M. S. Gubenko, A. M. Burdennyy, I. V. Pronina, P. V. Postnikov, Yu. A. Efimova, F. V. Radus, E. S. Mochalova, T. P. Kazubskaya

“…MicroRNAs, which function as post-transcriptional regulators of the expression of protein-coding genes, including those associated with oncogenesis, are involved in the processes of cell proliferation, differentiation, and apoptosis. …”
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Gender Disparities in COVID-19 Survivors with Impaired Quality of Life, Effort Intolerance, and Cardiopulmonary Symptoms: A Prospective Cohort Study by Krista Zachariah, Dustin Wessells, Prianca Tawde, Mahniz Reza, Caitlin Chiu, Pablo Villar Calle, Alexander Volodarskiy, Evelyn M. Horn, Parag Goyal, Jonathan Weinsaft, Jiwon Kim

“…Conclusion: Whereas males have greater morbidity during acute COVID hospitalization, females are disproportionately impacted by post-COVID impaired functional status despite higher biventricular ejection fraction and smaller infarct size.…”
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Biological maturation determines the beneficial effects of high-intensity functional training on cardiorespiratory fitness in male adolescents by Jarosław Domaradzki, Cristian Alvarez, Rafał Szafraniec, Dawid Koźlenia

“…The MO role in the HIFT intervention was tested by MANCOVA and ANCOVA with post hoc detailed comparisons. Results MO contributed to the studied model more than CA (Wilk’s Λ = 0.49, ηp2 = 0.24, p < 0.001; Wilk’s Λ = 0.83, ηp2 = 0.07, p < 0.063, respectively). …”
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Prediagnosis Insights Into Amyotrophic Lateral Sclerosis: Clinical Symptoms and Medication Use by Chunyang Pang, Wen Cao, Jiali Xie, Yaojia Li, Luyi Zhu, Huan Yu, Dongsheng Fan, Binbin Deng

“…In the ALS cohort, the male‐to‐female ratio was 2.9, with a median age at onset of 64.61 years (Interquartile range (IQR): 56.80–71.31) and a median survival time post‐diagnosis of 9.08 months (IQR: 3.18–18.98), while females (log‐rank p = 0.038) and individuals with earlier (< 64.61 years) disease onset (log‐rank p < 0.001) had longer survival periods. …”
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Dexamethasone-eluting cochlear implants reduce inflammation and foreign body response in human and murine cochleae by Muhammad Taifur Rahman, Brian J Mostaert, Peter Eckard, Shakila Mahmuda Fatima, Rachel Scheperle, Ibrahim Razu, Bryce Hunger, Rafal T. Olszewski, Shoujun Gu, Cristina L. Garcia, Nashwaan Ali Khan, Douglas M Bennion, Jacob Oleson, Jonathon R. Kirk, Ya Lang Enke, Robert D. Gay, Robert J. Morell, Keiko Hirose, Michael Hoa, Alexander D. Claussen, Marlan R. Hansen

“…This study aims to investigate the long-term efficacy of dexamethasone-eluting cochlear implant and locally delivered dexamethasone, a potent anti-inflammatory glucocorticoid, on the intracochlear FBR and electrical impedance post-implantation in a murine model. Preliminary impedance data in humans are also provided as a complement to the murine data to illustrate generalizability and reinforce implications related to clinical application. …”
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Cardiac protection of wogonin in mice with pulmonary fibrosis by regulating Sirt1/ γ-H2AX pathway by Libo Wang, Libo Wang, Fei Lin, Runran Miao, Tianhao Zhao, Yuan Liu, Lin Yang, Min Zhang, Min Zhang

“…This gap in understanding complicates the management and treatment of HF in patients with PF.ObjectivesTo investigate the effects of PF on cardiac function and myocardial fibrosis using a mouse PF model and evaluate the therapeutic potential of wogonin, a flavonoid compound known for its anti-PF properties.MethodsA PF mouse model was established via intratracheal administration of bleomycin (BLM). Starting on day 8 post-BLM treatment, wogonin (50 mg/kg) was intraperitoneally administered every 2 days for 2 weeks. …”
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AAV-shDUX4 provides short-term benefits but limited long-term efficacy in a DUX4 mouse model of FSHD by S. Sohn, S. Reid, M. Bowen, C. Hudon, E. Corbex, B. Morel, C. Hourde, V. Mariot, J. Dumonceaux

“…However, by 10 months post-treatment, the therapeutic effects had substantially diminished, with most pathological markers remaining uncorrected and no sustained improvement in muscle force. …”
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In Vitro Evaluation of the Antiviral Activity of Polyphenol (-)-Epigallocatechin-3-Gallate (EGCG) Against Mayaro Virus by Pâmela Jóyce Previdelli da Conceição, Gabriela Miranda Ayusso, Tamara Carvalho, Maria Leticia Duarte Lima, Mikaela dos Santos Marinho, Fábio Rogério Moraes, Paola Elaine Galán-Jurado, José González-Santamaría, Cíntia Bittar, Bo Zhang, Ana Carolina Gomes Jardim, Paula Rahal, Marilia Freitas Calmon

“…Finally, it also showed significant inhibition in the post-entry stages of the MAYV replication cycle, acting on the replication of the genetic material and late stages, such as assembly and release. …”
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The effect of infectious bursal disease virus infection on gut microbiota of broiler chicken and the role of prebiotics and probiotics on correction of gut dysbiosis using analysis... by M. I. Mosa, H. M. Salem, M. Hassan, M. A. El-Saied, M. A. Bastamy, M. M. Amer

“…The clinical signs, postmortem lesions (PM), mortality, bursal index (BI), immune response, body weight gain (BWG), feed intake (FI), feed con-version rate (FCR), caecum villi morphometry and gut microbiome profile were studied. At 3 days post infection (dpi), significant decrease in caecum total mucosal thickness (P<0.05) were observed in CP group (204±12.6 µm) compared to CN group (266±16 µm) while it was corrected in infected pro-phylaxis groups P1 (310±10.5 µm), P2 (320±13.4 µm), P3 (267±13.9 µm) and P4 (265±10.6 µm). …”