HONORING WAR VETERANS AS A COMPONENT OF THE IMPLEMENTATION OF THE SOCIO-ECONOMIC FUNCTION OF THE STATE: ADMINISTRATIVE-LEGAL ASPECT by Liudmyla Sylenko, Serhii Sivkov, Denys Komarnytskyi

“…Proposed ways of improving administrative and legal regulation aim to strengthen state support for veterans and their social integration, as well as strengthening national identity in conditions of martial law and post-war reconstruction. The subject of the article is the administrative and legal mechanisms for implementing the socio-economic functions of the state in conditions of a special period. …”
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Elevated pulmonary tuberculosis biomarker miR-423-5p plays critical role in the occurrence of active TB by inhibiting autophagosome-lysosome fusion by Huihui Tu, Su Yang, Tingting Jiang, Liliang Wei, Liying Shi, Changming Liu, Chong Wang, Huai Huang, Yuting Hu, Zhongliang Chen, Jing Chen, Zhongjie Li, Jicheng Li

“…Since the inhibition of autolysosome formation plays a critical role in tuberculosis occurrence, our findings suggests that miR-423-5p could suppress autophagosome–lysosome fusion by post-transcriptional regulation of VPS33A, which might be important for the occurrence of active tuberculosis.…”
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Multiparity induces persistent myocardial structural, functional and transcriptomic remodelling in mice by Ruth R. Magaye, Bing H. Wang, Hongyi R. Liu, Shanae Bailey, Rithy Nuon, Sabrina Sutano, Michael Nyugen, Helen Kiriazis, Kyah Grigolon, Luchen Shan, William W. H. Ho, Fumihiko Takeuchi, Daniel G. Donner, David M. Kaye

“…Cardiac function was assessed by echocardiography together with transcriptomic analysis of the left ventricular myocardium. At 15 months post oestrous cycle disruption, MP mice continued to demonstrate a constellation of myocardial alterations including higher heart to tibial length ratio (P < 0.05), body weight (P < 0.01), and fat mass (P < 0.01) compared to NP mice. …”
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In Vivo Evaluation of the Anti-Skin-Ageing Bioactivity of a Recombinant Dual Humanised Collagen and Poly-L-Lactic Acid by Mingjie Tong, Xin Zhou, Jiongni Zhong, Dengjian Qu, Wei Chen, Chun Chen, Yiting Wang, Yaoping Liu, Shaochuan Li, Yuan Xiao, Ning Wang, Chaowan Guo, Qiuling Xie, Sheng Xiong

“…Early-stage intervention (30 days post-injection) markedly upregulated COL1A1 expression through the TGF-β/Smad3 pathway activation, outperforming poly-<span style="font-variant: small-caps;">l</span>-lactic acid (PLLA) in collagen deposition. …”
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In-silico analysis of deleterious non-synonymous SNPs in the human AVPR1a gene linked to autism by Md. Delowar Kobir Jibon, Md. Asadul Islam, Md. Eram Hosen, Md. Omar Faruqe, Rashed Zaman, Uzzal Kumar Acharjee, Biswanath Sikdar, Yewulsew Kebede Tiruneh, Md. Khalekuzzaman, Motasim Jawi, Magdi E. A. Zaki

“…We analyzed the consequences of high‑risk nsSNPs on active sites, post-translational modification (PTM) sites, and their functional effects on protein stability. 3D modeling, structure validation, protein-ligand binding affinity prediction, and Protein-protein docking were conducted to verify the presence of five significant substitutions (R284W, Y140S, P107L, R149C, and F207V) and explore the modifications induced due to these mutants. …”
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Lipidomic Landscapes of Cryopreserved Sperm from Alpine and Spanish–Creole Bucks by Mustafa Bodu, Mustafa Hitit, Selamawit Woldesenbet, Muhammet Raşit Uğur, Zeynep Erdoğan, Olivia Chika Greenwood, Raheem Davian Murray, Andres Pech Cervantes, Erdoğan Memili

“…This study provides a comparative analysis of the post-thaw sperm lipidomic profiles of Alpine and Spanish–Creole goat breeds to explore breed-specific differences in fatty acid composition and their implications for sperm function and reproductive efficiency. …”
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Mining-affected water resources and ecological effects in ecologically fragile mining areas of western China by Qiangling YAO, Liqiang YU, Shengyan CHEN, Yinghu LI, Xuehua LI

“…The restoration of surface ecology in the post-coal mining stage will be the most prominent environmental problem facing the region, while water resources play a fundamental role in this process, and the contradiction between "water-environment" is prominent. …”
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The expression of renin-angiotensin system components in human carotid plaque by Kolaković Ana, Bundalo Maja, Đurić Tamara, Končar Igor, Stanković Aleksandra, Živković Maja

“…A two-way ANOVA followed by a post-hoc Tukey test was performed for the statistical analysis of results. …”
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Gagates in Crimean middle jurassic sediments (Sudak): coal petrography, paleobotany, formation conditions by I. E. Stukalova, Т. А. Sadchikova, S. V. Naugolnykh, А. L. Chepalyga

“…The type of peat accumulation is paralytic, paragenetically related to the studied sediments. Post-sedimentation transformations of the rocks correspond to early catagenesis. …”
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Identification of potential prognostic biomarkers of thymoma with myasthenia gravis based on serum proteomics by Xiaoting Lin, Xiaoting Lin, Xiaoting Lin, Xiaoting Lin, Peng Liu, Peng Liu, Peng Liu, Peng Liu, Guoyan Qi, Guoyan Qi, Guoyan Qi, Guoyan Qi

“…Through proteomic analysis, we examined preoperative serum samples from patients with TMG to identify key prognostic proteins that could serve as a foundation for clinically predicting postoperative efficacy and guiding treatment selection.MethodAccording to the Clinical Research Guidelines of the Myasthenia Gravis Foundation of America (MGFA) for Post-Intervention Status (PIS), 20 patients with TMG were divided into an effective group (T1) [the PIS was minimal manifestation status (MMS) and above] and an ineffective group (T2) (the PIS did not reach MMS and above), with 10 cases each, and a healthy control group (C) with nine cases. …”
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Effect of Integrative Balance and Plyometric Training on Balance, Ankle Mobility, and Jump Performance in Youth Football Players: A Randomized Controlled Trial by Andrew Rinaldi Sinulingga, Kristaps Slaidiņš, Anastasija Salajeva, Agris Liepa, Inese Pontaga

“…No significant pre-to-post changes were observed in the CG, except for absolute and relative peak torque of DF by 10–19% (p = 0.01–0.02, d = 0.55–0.91), peak force DF in the dominant leg by 11% (p = 0.04, d = 0.71), and jump height by 5% (p = 0.008,d = 0.82). …”
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Successful implementation of a risk assessment and mitigation program to control bovine digital dermatitis at the herd-level by Jim Weber, Marina Hillen, Torsten Seuberlich, Andreas Fürmann, Corinne Gurtner, Jens Becker, Claudia Syring, Maria Welham Ruiters, Maher Alsaaod, Lina Mazurek, Gertraud Schüpbach, Adrian Steiner

“…Considering the results of the histopathological examination, of 16S metagenomic sequencing and of the Fluorescence in situ hybridization as indicators for healing, 6/7 (85.7%) selected lesions were cured 2 months post completion of treatment. The results of this study show that the described BDD control measures can markedly reduce the within-herd prevalence of BDD. …”
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Advanced quantification pipeline reveals new spatial and temporal tumor characteristics in preclinical multiple myeloma by Zhixin Sun, Jacqueline M. Godbe, Alexander Zheleznyak, Brad Manion, Junhao Hu, Julie L. Prior, Kathleen Duncan, Ulugbek S. Kamilov, Monica Shokeen

“…A marked increase in tumor uptake was observed by day 18 post-implantation, with significant SUVmean increases in the spine (p = 0.012), left/right femurs (p = 0.007/0.006), pelvis and pelvic joints (p = 0.018), and sacrum (p = 0.02). …”
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Neuro-Cells Mitigate Amyloid Plaque Formation and Behavioral Deficits in the APPswe/PS1dE9 Model of Alzheimer Disease While Also Reducing IL-6 Production in Human Monocytes by Johannes de Munter, Kirill Chaprov, Ekkehard Lang, Kseniia Sitdikova, Erik Ch. Wolters, Evgeniy Svirin, Aliya Kassenova, Andrey Tsoy, Boris W. Kramer, Sholpan Askarova, Careen A. Schroeter, Daniel C. Anthony, Tatyana Strekalova

“…Twelve-month-old APPswe/PS1dE9 mice or their wild-type littermates were injected with NC or vehicle into the cisterna magna. Five to six weeks post-injection, cognitive, locomotor, and emotional behaviors were assessed. …”
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The impact of bariatric surgery on female reproductive health by E. Kh. Chigisheva, I. I. Batyrshin, A. F. Sarvalieva, I. V. Khalitova, T. M. Zhuk, L. V. Evdokimova, M. A. Akbulatova, Ya. R. Zolotareva, L. M. Zainysheva, S. Baloyan, E. M. Dragunova, A. A. Korenkova, N. A. Bilyal, Yu. P. Sergeev

“…It is better to recommend long-acting reversible contraceptives such as intrauterine device, to post-BS patients. Women with BS history should have a continuous comprehensive nutritional assessment as well as blood macronutrients and trace elements monitoring before, during and after pregnancy. …”
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Short- and long-term increased risk of all-cause mortality in a tuberculosis cohort attributed to SARS-CoV-2 infection: a time-dependent survival analysis in ChileResearch in conte... by Vargas-García Salvador, Eduardo A. Undurraga, Nadia Escobar, Christian García, Natalia Vergara, María Elvira Balcells

“…These findings highlight the need for continued post-treatment follow-up and prioritization of SARS-CoV-2 vaccination among individuals with TB. …”
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T cell receptor-like antibody specifically targets and eliminates cells infected with cytomegalovirus by Dabing Chen, Caidong Hu, Yunda Hong, Jingjing Xu, Jiaqi Sun, Jinhua Ren, Yangtao Wu, Ningshao Xia, Quan Yuan, Jianda Hu, Ting Yang

“…These findings highlight the potential of TCR-like antibodies in treating CMV infections, supporting a promising novel therapeutic strategy for managing post-transplant CMV complications.…”
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Early statin use might reduce the hemorrhagic transformation among acute ischemic stroke patients with recanalization therapy: a retrospective cohort study by Boyan Pan, Jiaying Lan, Xiaojun Li, Haoxuan Chen, Luankun Weng, Haoyou Xu, Yuanqi Zhao, Min Zhao

“…Secondary outcomes included in-hospital mortality, favorable clinical outcomes (mRS 0–2) at discharge, and neurological improvement 7 ± 2 days post-stroke (defined as a reduction of ≥4 points in NIHSS from baseline).ResultsA total of 266 AIS patients were analyzed, with 164 (61.7%) receiving statins within 24 h (24 h-statins group). …”
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IL-33/ST2 Pathway and Classical Cytokines in End-Stage Heart Failure Patients Submitted to Left Ventricular Assist Device Support: A Paradoxic Role for Inflammatory Mediators? by C. Caselli, A. D'Amico, R. Ragusa, R. Caruso, T. Prescimone, M. Cabiati, S. Nonini, P. Marraccini, S. Del Ry, M. G. Trivella, O. Parodi, D. Giannessi

“…IL-33, ST2, and conventional cytokines (IL-6, IL-8, and TNF-α) were determined in cardiac biopsies and plasma of 22 patients submitted to LVAD implantation (pre-LVAD) and compared with (1) control stable chronic HF patients on medical therapy at the moment of heart transplantation without prior circulatory support (HT); (2) patients supported by LVAD at the moment of LVAD weaning (post-LVAD). Results. Cardiac expression of ST2/IL-33 and cytokines was lower in the pre-LVAD than in the HT group. …”
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An analytical, mathematical annuloplasty ring curvature model for planning of valve-in-ring transcatheter mitral valve replacementCentral MessagePerspective by Matthew H. Park, MS, Mateo Marin-Cuartas, MD, Mark Sellke, PhD, Pearly K. Pandya, MS, Yuanjia Zhu, MD, PhD, Robert J. Wilkerson, BS, David M. Holzhey, MD, PhD, Michael A. Borger, MD, PhD, Y. Joseph Woo, MD

“…Evaluated semi-rigid and rigid rings showed little to no difference between pre- and post-dilation states. Annuloflex rings (flexible band) showed a postdilation variance reduction of 32.83% (P < .001) followed by an increase after 10 minutes of relaxation that was still reduced by 19.62% relative to the initial state (P < .001). …”
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