The Influence of Fracture Defect Size on Treatment Outcomes in Distal Femur Fractures: A Comparative Study Between Lateral Locking Plate and Double Plate Fixation by Meng Li, Taoguang Wu, Zicheng Zhang, Xiaomeng Ren, Mengmeng Hu, Dong Zhang, Wei Zhang

“…Information such as demographic data, fracture classification, operation details, metaphyseal bone defect size, pre‐nd post‐operative imaging data, and other medical records were compiled. …”
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Early Gestational Hepatic Lipidomic Profiles Are Modulated by One-Carbon Metabolite Supplementation and Nutrient Restriction in Beef Heifers and Fetuses by Kazi Sarjana Safain, Matthew S. Crouse, Jessica G. Syring, Yssi L. Entzie, Layla E. King, Alison K. Ward, Lawrence P. Reynolds, Pawel P. Borowicz, Carl R. Dahlen, Kendall C. Swanson, Joel S. Caton

“…The four resulting groups (CON − OCM, CON + OCM, RES − OCM, RES + OCM) were maintained for 63 days post-breeding. Maternal and fetal liver samples were collected, and lipidomic profiling was performed using ultra-performance liquid chromatography–tandem mass-spectrometry. …”
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Dynamic changes in chromatin accessibility within one month of mouse intracerebral hemorrhage by Rong Xiang, Kang OuYang, Junmin Wang, Zhan Chen, Jin Tao, Xinru Zhang, Houlian Zhang, Zhiyun Li, Luyao Wang, Ruoqi Ding, Chuanyu Liu, Jun Xie, Yong Hou, Jian Wang, Longqi Liu, Mingyue Wang

“…We also observed a significant upregulation of genes involved in hypoxia response and lipid metabolism within the remyelination pathways post-ICH. This study provides crucial insights into the epigenetic changes that occur following ICH, laying a solid foundation for future research and potential therapeutic interventions.…”
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Association Between High Jugular Bulb and Sudden Sensorineural Hearing Loss: A Computed Tomography Based Study by Wanting Y, Rafiq M, Wu J, Jin L, Liu G, Cheng C

“…Pre-treatment THI scores in the HJB group were significantly higher than in the non-HJB group (P< 0.01). Post-treatment THI scores improved in both groups (P< 0.05), with the non-HJB group showing significantly better outcomes (P< 0.01). …”
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The impact of breaking up prolonged sitting with physical activity during simulated dayshifts and nightshifts on sleep architecture: a randomised controlled trial by Charlotte C. Gupta, Imesha Vitanege, Sally A. Ferguson, Corneel Vandelanotte, Mitch J. Duncan, Dayna F. Easton, Georgia Tuckwell, Courtney Ah Shay, Philip Tucker, Michele Lastella, Maria Zerella, Grace E. Vincent

“…In the analysis of day shifts, mixed model ANOVAs demonstrated a significant physical activity *sleep opportunity interaction for total sleep time (p < 0.001), sleep onset latency (p < 0.001), time spent in N2 (p < 0.001) and N3 (p = 0.03). Post-hoc analyses revealed that participants in the 9 h sleep opportunity conditions had longer total sleep time, shorter sleep onset latency, and more slow-wave sleep (N3) during sleep opportunities 1–4 but not sleep opportunity 5. …”
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Comparison of perioperative outcomes of open (CUSA) versus laparoscopic (LOTUS) major hepatectomy – revisited. First evaluation of efficacy and safety of AEON™ stapler by Affan Iqbal, Minas Baltatzis, Minas Baltatzis, Panagiotis Stathakis, Jenifer Barrie, Ajith Kumar Siriwardena, Ajith Kumar Siriwardena, Saurabh Jamdar, Aali Jan Sheen, Aali Jan Sheen

“…Propensity score matching was performed to identify matched open and laparoscopic cases, which were compared for intra- and post-operative short-term outcomes. The LOTUS™ ultrasonic energy device was used for transection in laparoscopic cases, whereas CUSA was used in open procedures. …”
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Gender-Specific Differences in Diastolic Dysfunction and HFpEF: Pathophysiology, Diagnosis, and Therapeutic Strategies by Francesca Coppi, Gianluca Pagnoni, Francesca Grossule, Ashraf Nassar, Arianna Maini, Giuseppe Masaracchia, Francesco Sbarra, Elisa Battigaglia, Enrico Maggio, Daniela Aschieri, Federica Moscucci, Marcello Pinti, Anna Vittoria Mattioli, Francesco Fedele, Susanna Sciomer

“…Significant gender-specific differences are observed, with women, particularly post-menopausal, experiencing higher prevalence and distinct clinical profiles compared to men. …”
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Prognostic factors and clinical outcomes of stenting on malignant central airway obstruction by Jia Chao Qi, Li Jia Zhi, Zhi Wu, Tie Zhu Wang, Hao Li, Li Lin, Yu Ming Ye

“…The length of survival was measured in months from the date of the first bronchoscopy procedure to the date of death, or until six months post-procedure or loss to follow-up. Dyspnea was assessed using the Borg score, modified Medical Research Council (mMRC), and 6-minute walk distance (6MWD), while quality of life (QoL) was evaluated using the Short Form 6-Dimension (SF-6D) and Karnofsky Performance Status (KPS) score. …”
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Analysis of microstructural evolution and mechanical properties of FGH101 powder superalloy and IN718 deformed superalloy via inertia friction welding by Jun Zhou, Jun Zhou, Yongqiang Zhang, Yongqiang Zhang, Yongqiang Zhang, Feng Qin, Feng Qin, Xuelong Zhang, Xuelong Zhang, Hao Wang, Hao Wang, Ze Liu, Ze Liu, Wenhan Zhang, Wenhan Zhang, Caiyan Huang, Caiyan Huang, Chunbo Zhang, Chunbo Zhang

“…Microhardness analysis revealed higher hardness at the weld interface, followed by a sharp decline near the Heat Affected Zone (HAZ) on the IN718 side due to phase re-dissolution, while FGH101 showed quicker recovery. Post-weld aging treatments enhanced hardness and strength through γ′ and δ phase precipitation in FGH101 and γ″ phases in IN718. …”
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Effect of Repetitive Peripheral Magnetic Stimulation Combined with Task-Oriented Training on Motor Function and Motor Evoked Potential of Upper Limbs in Stroke Patients by YUAN Fei, YUAN Aihong, TANG Youbin, LIU Youxiang, TONG Hongmei

“…The Modified Ashworth Scale (MAS) was used to evaluate the muscle tone of elbow flexor and wrist flexor muscles before and after treatment; the short-form Fugl-Meyer Assessment for Upper Extremity (FMA-UE) scale was used to evaluate the upper limb motor function of patients; the Modified Barthel Index (MBI) was used to assess the patients' activities of daily living; and the MEP amplitude and latency of the abductor pollicis brevis muscle on the affected side were measured to evaluate the excitability of the cerebral cortex on the affected hemisphere.Results(1) Comparison of muscle tone of the elbow flexor and wrist flexor muscles: Compared with pre-treatment, MAS scores of the upper limb elbow flexor and wrist flexor muscles decreased after treatment in both groups (<italic>P</italic>&lt;0.05); compared with the control group, MAS scores of the elbow flexor and wrist flexor muscles in the experimental group decreased more significantly after treatment (<italic>P</italic>&lt;0.05). (2) Comparison of upper limb motor function: Compared with pre-treatment, FMA-UE scores increased after treatment in the two groups (<italic>P</italic>&lt;0.05); compared with the control group, FMA-UE score increased more significantly in the experimental group after treatment (<italic>P</italic>&lt;0.05). (3) Comparison of activities of daily living: Compared with pre-treatment, MBI scores of the two groups increased after treatment (<italic>P</italic>&lt;0.05); compared with the control group, MBI score of the experimental group increased more significantly after treatment (<italic>P</italic>&lt;0.05). (4) Comparison of excitability in the cerebral cortex of patients: Compared with pre-treatment, MEP amplitude of abductor pollicis brevis muscle on the affected side increased (<italic>P</italic>&lt;0.05) and the latency period shortened (<italic>P</italic>&lt;0.05) in both groups after treatment; compared with the control group, the experimental group had a significantly larger MEP amplitude and shorter latency of abductor pollicis brevis muscle on the affected side after treatment (<italic>P</italic>&lt;0.05).ConclusionrPMS combined with task-oriented training can enhance cortical excitability of the affected hemisphere, reduce upper limb muscle tone, improve upper limb motor function, and improve activities of daily living in post-stroke patients.…”
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Disturbances of energy metabolism in the internal organs in traumatic cranial injury on the background of diabetes by V. M. Meretskyі

“…Succinate dehydrogenase activity decreased 22,6% after 3 h, by 38,8% after 24 h, by 34,7% after 5 days, and by 22,2% after 14 days post-traumatically in diabetic rats. The most pronounced decrease in cytochrome oxidase activity in the liver was 26,3 and 40 % after 5 and 14 days after TBI, respectively. …”
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Predictors of Clinical Stability and Mortality in COPD: A Longitudinal Study by Loo WTW, Chew SY, Tan JHY, Soh RY, Koh MS, Lapperre TS, Tiew PY

“…Predictors of 2-year clinical stability included higher body mass index (BMI) (p&lt; 0.001), higher post-bronchodilator FEV1/FVC ratio (p=0.0132), fewer baseline exacerbations (p=0.007), absence of bronchiectasis (p=0.045), preserved hemoglobin levels (p=0.019), and successful smoking cessation (p=0.039). …”
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Epidermal growth factor enhances spinal fusion: Posterolateral lumbar fusion model on rats by Engin Çetin, İsmail Daldal, Ali Eren, Saadet Özen Akarca Dizakar, Suna Ömeroğlu, Bora Uzuner, Hakan Hamdi Çelik, Hasan Hüseyin Saygılı, Benat Koçkar, Alpaslan Şenköylü

“…Rats were euthanized at 8 weeks post-surgery. 6 rats from each group were selected for manual palpation examination, micro-computed tomography analysis and histologic analysis; and the rest was used for biomechanical analysis. …”
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Toward a Smartphone-Based and Conversational Agent–Delivered Just-in-Time Adaptive Holistic Lifestyle Intervention for Older Adults Affected by Cognitive Decline: Two-Week Proof-of... by Esther Brill, Rasita Vinay, Marcia Nißen, Priyam Joshi, Stefan Klöppel, Tobias Kowatsch

“…Participants received notifications to engage in 7 health-related activities, and adherence to the activities was self-reported. Post intervention, participants rated their experience with the app and assessed their working alliance with the CA through the 6-item session alliance inventory. …”
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Assessment of structural and functional changes in recipient's transplanted heart in the long-term postoperative period by M. Sh. Khubutiya, Kh. G. Alidzhanova, A. V. Dyatlov, A. A. Ivannikov, S. Yu. Shemakin, D. A. Kosolapov

“…Considering the normal values of left ventricular myocardial strains, we can assume that after 6 years post-orthotopic heart transplantation, the recipients have restored the heart adaptive functions, and a favorable outcome has been achieved. …”
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Prognostic value of circulating HPV cell-free DNA in cervical cancer using liquid biopsy by Ashna Gupta, Gunjan Dagar, Sumit Kr. Das, Ravi Chauhan, Abhishek Shankar, Daya Nand Sharma, Vaishali Suri, Maroof Ahmad Khan, Muzafar A. Macha, Ikhlak Ahmed, Ammira S. Al-Shabeeb Akil, Ajaz A. Bhat, Mayank Singh

“…Blood samples were collected from 60 cervical cancer patients (Stages I–IV) at AIIMS, New Delhi, at baseline and three months post-treatment. Samples from 10 healthy controls were also included. …”
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Comparison of Gait Parameters Collected Across Two Commercially Available Gait Systems in Older Adults by Alexandria Hoang, Jeannette Mahoney, Ying Jin, Sofiya Milman, Nir Barzilai, Joe Verghese, Emmeline Ayers

“…However, such parameters can vary across these widely used software applications due to differences in algorithms and post-processing techniques, making it potentially unsuitable to pool parameters acquired from different applications. …”
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Immune enhancement and disease resistance against Aeromonas hydrophila infection by dietary Lactobacillus plantarum-fermented Moringa oleifera leaves in Oreochromis niloticus by Ghada S. Abdelkader, El-Sayed Y. El-Naenaeey, Hossam M. Abdallah, Ehsan H. Abu-Zeid, Ibrahim F. Rehan, Ibrahim F. Rehan, Ibrahim F. Rehan, František Zigo, Gamal A. Elmowalid

“…In contrast, the expression of the IL-10 gene was markedly upregulated in the spleen and head kidney (anterior) post A. hydrophila challenge in the MOLF-groups than the MOLP-groups. …”
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Classification and identification of yeast strain A82-2 and its inhibitory effect on Rhizopus stolonifer by ZHOU Xiaohong, YAN Dong, LU Zhaoxin, LU Fengxia, SHEN Chang, BIE Xiaomei

“…Based on the above results, we concluded that P. anomala A82-2 significantly inhibited R. stolonifer, therefore it has an important application potential in biological control and post harvest preservation of fruit and vegetable.…”
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Civilian death and injury from airstrikes: evidence from the war in Tigray, Ethiopia by Mulugeta Gebregziabher, Akeza Awealom Asgedom, Hiluf Ebuy Abraha, Hale Teka, Abenezer Etsedingl, Tsegay Berihu, Gebru Hailu Redae, Nahom M. Gebreselassie, Araya Abrha Medhanyie, Hagos Godefay, Demoz Gebre-Egziabher, Hannah Wild

“…Enhanced collaboration between health and protection stakeholders can improve support to victims from immediate post-injury care as well as rehabilitation so that they can live as healthy, dignified, and productive citizens.…”
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