Recurrence Prediction by Multi-Omics in the Patient with Colorectal Peritoneal Metastases After Cytoreductive Surgery: A Prospective Biomarker Study by Chen C, Gong Z, Zhang Z, Gu H, Zhu A, Peng D, Li B, Wang J, Hu Y, Wang D, Sun L

“…., Ltd, Guangzhou, Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Da Wang, Department of Colorectal Surgery and Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, People’s Republic of China, Tel +86-571-87784720, Email wangda0618@zju.edu.cn Lifeng Sun, The Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, Zhejiang, 310009, People’s Republic of China, Tel +86-571-87783586, Email sunlifeng@zju.edu.cnBackground: Colorectal cancer with peritoneal metastases (CRCPM) exhibits high recurrence post-cytoreductive surgery (CRS). This study evaluated tumor tissue biomarkers and combined circulating tumor DNA (ctDNA) and methylation analysis via ultra-deep next-generation sequencing (NGS) for recurrence prediction.Methods: CRCPM patients undergoing surgery were enrolled (n=21). …”
Get full text

Effects of intermittent cycles of ischemia with resistance and endurance training on Murf-1 and Atrogin-1 gene expression and fiber diameter of gastrocnemius muscle in diabetic rat... by Majid Zatparvar, Amin Farzaneh Hesari, Parvin Farzanegi

“…Data were analyzed by using two-way analysis of variance and Bonferroni’s post-hoc tests.Results: Murf-1 and Atrogin-1 gene expression significantly increased and fiber diameter of gastrocnemius muscle decreased in D group compared to C group (p=0.0001). …”
Get full text

Different Patterns of Oral Mucositis and Microbiota Injury After Total Body Irradiation- Versus Chemotherapy-Based Myeloablative Allogeneic Hematopoietic Cell Transplantation by Maryam Ebadi, MD, Hakan Gem, PhD, DDS, Gale Sebastian, DDS, Rania Abasaeed, DDS, Michele Lloid, RDH, Yolanda D. Tseng, MD, Omar Y. Mian, MD, PhD, Samuel Minot, PhD, David R. Dean, DDS, Armin Rashidi, MD, PhD

“…Although the cohorts were similar in plaque microbiota composition at baseline, they became significantly different at all post- hematopoietic cell transplantation timepoints. …”
Get full text

Effects of endurance exercise and dietary protein intake on osteokine, bone turnover, and inflammatory markers in endurance runners: A narrative review by Sofia Valente Ferreira, Silar Gardy, Tyler A. Churchward-Venne, Andrea R. Josse, Jenna C. Gibbs

“…Adequate dietary protein ingestion habitually and pre-, during, and post-exercise may attenuate bone resportion and pro-inflammatory markers in endurance athletes.…”
Get full text

The Effect of Multidimensional Sexual Education-Counseling on Sexual Knowledge and Attitudes of Couples Preparing for Marriage by Soghra Khani, Armin Firouzi, Mahmood Moosazadeh, Seyyed Hossein Hosseini Karnami, Zahra karimian, Fatemeh Seyri

“…Online questionnaires were completed before the intervention, immediately after, and three months post-intervention. Data analysis was performed using SPSS version 25. …”
Get full text

Uncovering injury-specific proteomic signatures and neurodegenerative risks in single and repetitive traumatic brain injury by Sarah Mantash, Soulaimane Aboulouard, Hassan Dakik, Yanis Zirem, Lydia Ziane-Chaouche, Ali Nehme, Khalil Mallah, Marya El-Kurdi, Naify Ramadan, Isabelle Fournier, Kazem Zibara, Firas Kobeissy, Michel Salzet

“…We assessed motor and cognitive outcomes at 2-, 7-, and 30-days post-injury to explore functional impairments associated with observed molecular changes. …”
Get full text

Correlation Between COVID-19 Recovery, Executive Function Decline, and Emotional State by Velásquez Cabrera DM, De la Roca-Chiapas JM, Hernández-González MA, Reyes Pérez V, Villada C

“…We also evaluate the emotional state of post-COVID-19 patients.Patients and Methods: We assessed patients between 18 and 50 years old, who had a history of COVID-19 with mild, moderate, or severe illness. …”
Get full text

Integration of mRNA and miRNA Analysis Reveals the Regulation of Salt Stress Response in Rapeseed (<i>Brassica napus</i> L.) by Yaqian Liu, Danni Li, Yutong Qiao, Niannian Fan, Ruolin Gong, Hua Zhong, Yunfei Zhang, Linfen Lei, Jihong Hu, Jungang Dong

“…These results provide novel insights into the post-transcriptional regulation of salt tolerance in <i>B. napus</i>, offering potential targets for genetic improvement.…”
Get full text

Association of myeloid-derived suppressor cells with hematopoietic recovery after high-dose chemotherapy in multiple myeloma by V. S. Anmut, T. V. Tyrinova, E. V. Batorov, T. A. Aristova, S. A. Sizikova, G. Yu. Ushakova, V. V. Denisova, E. R. Chernykh

“…Thus, the obtained results indicate the association of a higher number of M-MDSCs with a shorter duration of leukopenia after high-dose chemotherapy with autologous stem cell transplantation and indicate a positive role of M-MDSCs in hematopoietic recovery in the early post-transplant period in patients with MM.…”
Get full text

Mosquito- and tick-borne orthoflaviviruses cross an in vitro endothelial-astrocyte barrier by Felix Schweitzer, Felix Schweitzer, Lara-Jasmin Schröder, Lara-Jasmin Schröder, Alina Friedrichs, Alina Friedrichs, Viktoria Gudi, Thomas Skripuletz, Imke Steffen, Imke Steffen, Martin Palus, Martin Palus, Daniel Růžek, Daniel Růžek, Daniel Růžek, Albert Osterhaus, Albert Osterhaus, Chittappen Kandiyil Prajeeth

“…Nevertheless, virus replication did not affect the barrier function of endothelial cells as demonstrated by sustained TEER and absence of leakage of high molecular weight dextran molecules through the endothelial barrier even at several hours post infection.DiscussionOur findings indicate that orthoflaviviruses can infect the endothelial cells, replicate within them without affecting the cells and its barrier function. …”
Get full text

Influence of crouch angle on lower-extremity kinetic gait profile and walk distance in children with cerebral palsy: a cross-sectional study by Rajani Mullerpatan, Triveni Shetty, Sailakshmi Ganesan, Ashok Johari

“…Bonferroni adjustment was made for post-hoc analyses (p ≤ 0.01). Results Gait speed, cadence and 2-minute walk distance decreased from Group I to II to III(p ≤ 0.01). …”
Get full text

Extraction and purification of total flavonoids from Zanthoxylum planispinum Var. Dintanensis leaves and effect of altitude on total flavonoids content by Jiyue Wang, Xianqi Huang, Zhenyu Chen, Nian Chen, Mingli Yang, Chenggang Liang, Yanghua Yu, Denghong Shi

“…The antioxidant activity of the extracts was also assessed pre- and post-purification. Findings indicated that water was a more effective solvent than ethanol for flavonoid extraction, yielding optimal results at 70 °C, with a solid-to-liquid ratio of 1:70, 30 min, and 480 W. …”
Get full text

Usability, safety and tolerability of CUE1 vibrotactile device as promising therapeutic approach in orthostatic tremor by Viktoria Azoidou, Alexandra Zirra, Thomas Boyle, David Gallagher, Alastair John Noyce, Cristina Simonet

“…Compliance and tolerability were excellent (100 %), with only mild, transient skin irritation reported in two cases. Immediate post-intervention improvements were observed in TUG [-1.22 s (95 % CI: −2.03, −0.26), p = 0.020], tandem stance [+1.41 s (0.00, 6.13), p = 0.025], tandem walk [+0.50 steps (0.00, 2.50), p = 0.042], and heel raise hold [+1.62 s (1.00, 3.32), p = 0.020]. …”
Get full text

Transoral Incisionless Fundoplication for patients with Gastroesophageal Reflux Disease after Peroral Endoscopic Myotomy: a prospective cohort by Eduardo Guimarães Hourneaux de Moura, Matheus Ferreira de Carvalho, Victor Lira de Oliveira, Mateus Bond Boghossian, Antonio Afonso Miranda Neto, Eduardo Turiani Hourneaux de Moura, André Orsini Ardengh, Ary Nasi, Kenneth Chang, Mateus Pereira Funari

“…PATIENTS AND METHODS This was a pilot single-center prospective cohort study including ten patients with post-POEM GERD refractory to clinical management who underwent endoscopic treatment with the TIF procedure between February and November 2021. …”
Get full text

TM4SF1 overexpression in tumor-associated endothelial cells promotes microvascular invasion in hepatocellular carcinoma by Junwu Guo, Liangrui Chen, Binghua Dai, Chengjun Sui, Zhitao Dong, Keji Chen, Kecai Duan, Kunpeng Fang, Aijun Li, Kui Wang, Li Geng

“…BackgroundMicrovascular invasion (MVI) is linked to poor prognosis, early recurrence and post-surgical intrahepatic metastasis of hepatocellular carcinoma (HCC) but roles of tumor-associated endothelial cells (TECs) remain unclear. …”
Get full text

The effectiveness of e-learning in focused cardiac ultrasound training: a prospective controlled study by Johannes Ruppert, Rebecca Krüger, Sebastian Göbel, Susanna Wolfhard, Liv-Annebritt Lorenz, Andreas Michael Weimer, Roman Kloeckner, Elias Waezsada, Holger Buggenhagen, Julia Weinmann-Menke, Johannes Matthias Weimer

“…Materials and methods This prospective, controlled study assessed competency development among medical students attending a FOCUS workshop (study group) at two time points: T1 (pre-training) and T2 (post-training, after completing e-learning). The competence gain of the group was compared to a reference group (control group) of physicians who had also used the e-learning in preparation for a certified FOCUS workshop. …”
Get full text

Alpha-synuclein inclusions reduced by PIKfyve inhibition in Parkinson disease cell models by Sara Lucas-Del-Pozo, Giuseppe Uras, Federico Fierli, Veronica Lentini, Sofia Koletsi, Carlos Lazaro-Hernandez, Kai-Yin Chau, Derralynn A. Hughes, Anthony H.V. Schapira

“…Results: PIKfyve inhibition by YM201636 resulted in a lysosomal-dependant reduction of alpha-synuclein inclusions as early as 24 h post-treatment. YM201636 induced an increase in nuclear translocation of TFEB, and an increase in lysosomal markers LAMP1 and HEXA. …”
Get full text

RT-QuIC Reactivity in the Brain and Other Organs and Tissues in Early, Middle-early, Middle-late and Terminal Stages of Scrapie Agent 263K Intracerebral Infection in Hamsters by Donglin Liang, Chumou Liu, Kang Xiao, Yuan Wang, Donghua Zhou, Xiaoxi Jia, Yuezhang Wu, Xiaoping Dong, Qi Shi

“…-- named anchor --> </a> <h5 class="section-title" id="d1447294e225">Methods:</h5> <p dir="auto" id="d1447294e227">Brain, skin and other organ specimens were collected at approximately 20, 40, 60 and 80 (terminal stage) days post-inoculation, and homogenates were prepared. …”
Get full text

Single-cell transcriptomics reveals cellular dynamics and chemokine CXCL2-mediated smooth muscle cell proliferation in arterial repair by Xingxiao Huang, Xingxiao Huang, Yan Ping, Yan Ping, Qiuli Sun, Qiuli Sun, Mingjun Yu, Mingjun Yu, Chao Yang, Xiao Liu, Long Wang, Jinyu Huang, Jinyu Huang

“…BackgroundPercutaneous coronary intervention (PCI) remains the primary treatment for coronary artery disease (CAD), yet post-procedural arterial injury triggers cellular change and pathological inflammation, leading to thrombosis and restenosis. …”
Get full text

Indonesian Geriatrics Society Consensus on COVID-19 Management in Older Adults by IGP Suka Aryana, Siti Setiati, Roza Mulyana, Noto Dwimartutie, Aulia Rizka, Bayu Basuki Wijaya, Nur Riviati, Rensa Rensa, Dina Aprilia Ariestine, Bambang Joni Karjono, Eko Aribowo, Hildebrand Hanoch Victor Watupongoh, Ridzqie Dibyantari, Wayan Giri Semara Putra, Fandi Triansyah, Rahmi Istanti, Dian Daniella

“…In this consensus, we also discuss about management of older adults with special condition such as diabetes mellitus, kidney disease, malignancy, frailty, delirium, immobilization and dementia. In post COVID-19 phase, we believe that physical rehabilitation is important as it is done to improve fitness. …”
Get full text