The Efficacy of Fractional CO2 Laser in the Treatment of Genitourinary Syndrome of Menopause: A Large Prospective Observational Study by Violante Di Donato, Ottavia D'Oria, Andrea Giannini, Maria Scudo, Carmel Sher, Margherita Fischetti, Giorgia Perniola, Innocenza Palaia, Marco Monti, Ludovico Muzii, Pierluigi Benedetti Panici

“…Results: Data indicated a significant improvement of MBS (vaginal itching (p < 0.0001), post-coital vaginal bleeding (p < 0.002), vaginal dryness (p < 0.0001), dyspareunia (p < 0.0001) and dysuria (p < 0.0001), higher Vaginal Health Index Score (VHIS) (4.1 ± 1.21; 95% CI = 3.84–4.35) and reduces pH (–0.53 ± 0.24; 95% CI = 0.48–0.58) after CO2 laser treatment. …”
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Exercise-induced irisin ameliorates cognitive impairment following chronic cerebral hypoperfusion by suppressing neuroinflammation and hippocampal neuronal apoptosis by Weiping Xiao, Yibing Yang, Lu Bai, Peixuan Yang, Runze Li, Daizhi Yang, Fanying Li, Lingzhi Quan, Qiupeng Liang, Yan Yan, Tiewei Qi, Feng Liang

“…Additionally, expression of integrins αV and β5 in hippocampal neurons, microglia, and astrocytes decreased post-CCH. FAE effectively enhanced both peripheral and central irisin expression. …”
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Investigation of SiC MOSFET Structures for Surge Robustness in the Third Quadrant Under Various <inline-formula><tex-math notation="LaTeX">$V_{\text{GS}}$</tex-math></inline-formul... by Xinbin Zhan, Yanjing He, Xi Jiang, Hao Yuan, Qingwen Song, Xiaoyan Tang, Xiaowu Gong, Yuming Zhang

“…SiC JBSFET operates in a unipolar conduction mode prior to the surge current density threshold of 998.3 <inline-formula><tex-math notation="LaTeX">$\mathbf {A}/\mathbf {cm}^{\mathbf {2}}$</tex-math></inline-formula>, after which it transitions to a post-bipolar conduction mode, similar to SiC JBS diode. …”
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Knockout of thyroid hormone receptor alpha a (thraa) enhances cardiac regeneration in zebrafish through metabolic and hypoxic regulation by Man Yee Cheung, Chunmei Jiang, Imtiaz Ul Hassan, Hui Wang, Donghao Guo, Daniel Wuyang Dio, Huan Yan, Jianmin Sun, Xufeng Qi, Dongqing Cai, Wei Ge, Sheue-yann Cheng, Wai-Yee Chan, Hui Zhao

“…However, a comprehensive understanding of TH and its receptors, thyroid hormone receptors (TRs), orchestrating with other regulatory processes for heart regeneration, such as the hypoxia signaling pathway and post-injury metabolic switches, remains elusive. …”
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Effectiveness and Safety of DLBS3233 in Newly Diagnosed Type 2 Diabetes Mellitus: A 12-week Clinical Trial by Heri Nugroho, Nurmilawati Nurmilawati, Diana Novitasari, Lidia Rombeallo, Rambu Farah Effendi, Reski Reski, Intan Surayya, Nugroho Agung Daryanto, Solomon Putera, Raymond Rubianto Tjandrawinata

“…Various metabolic parameters, including fasting and post-meal plasma glucose levels at two hours, fasting insulin level, HOMA-IR, adiponectin level, lipid profile, superoxide dismutase (SOD) activity, GLUT-4 concentrations, and body weight measurements, were assessed at baseline, Week 6, and Week 12. …”
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Acute suicidal ideation in context: highlighting sentiment-based markers through the diary entries of a clinically depressed sample by Damien Lekkas, Amanda C. Collins, Michael V. Heinz, Tess Z Griffin, Arvind Pillai, Subigya K. Nepal, Daniel M. Mackin, Andrew T. Campbell, Nicholas C. Jacobson

“…Entry results were grouped based on phase trajectory type, and the Kruskal-Wallis test was employed with post-hoc multiple hypothesis correction to statistically compare SEANCE features between all group pairs. …”
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Dexmedetomidine protects against N-Nitrosodiethylamine induced acute hepatic damage by modulating autophagy and apoptosis through SIRT1 by Ruixin Wu, Sailan Tang, Aoxue Xu, Qi Xue, Shuwen He, Qizhi Liao, Chanjuan Chen, Dachen Zhou, Xianwen Hu, Nianliang Zhang, Gang Li, Ye Zhang, Chunxia Huang

“…Histopathological changes, inflammatory and oxidative responses were assessed 24 h post-DEN exposure. The roles of autophagy and SIRT1 were further examined using hepatocyte-specific SIRT1 knockout mice (SIRT1f/fALBcre+/−). …”
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Antimicrobial Susceptibility Patterns of Haemophilus influenzae and Streptococcus pneumoniae in Respiratory Tract Infections: A Retrospective Observational Real-world Database Stud... by V Balaji, Vishal Singh, Puja Nijhara, Krunal Dalal, Sanket Sawant, Sebin Thomas, Lindsey Teichman, Shilpa Patkar

“…The susceptibility patterns of both organisms remained consistent during the pre- and post Coronavirus Disease-2019 (COVID-19) pandemic periods, except for H. influenzae to cefixime {94.0% (n=252) to 63.7% (n=137)}. …”
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Randomised trial of assessing diagnostic yield in transbronchial biopsy with a guide sheath by Hao-Chun Chang, Yao-Wen Kuo, Ching-Kai Lin, Lih-Chyun Chang, You-Yi Chen, Ching-Yao Yang, Jung-Yien Chien, Chia-Lin Hsu, Tzu-Hsiu Tsai, Chao-Chi Ho, Jin-Yuan Shih, Chong-Jen Yu

“…The histopathology, cytology and microbiology yield rates, as well as procedure time and post-procedure adverse events, of the two groups were compared. …”
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A systematic review of histopathological assessments in Peste des petits ruminants by Saira Awaz, Iram Maqsood, Hanif Ur Rahman, Baitullah Khan, Gul Muhammad, Imtiaz Ali Shah, Asima Azam, Ayesha Hidayat, Almas Faryal Nizam

“…Information were the authors and publication year, research methodology and histopathological results linked to PPR, factors influencing these outcomes (including treatment type, immunisation technique, and time post-infection), and the authors' conclusions and recommendations. …”
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Effects of rapid maxillary expansion and functional orthodontic treatment in children with sleep disordered breathing: a systematic review by Magdalena Piełunowicz, Jacek Kotuła, Krzysztof Kotuła, Mieszko Więckiewicz, Joanna Lis, Beata Kawala, Anna Ewa Kuc, Michał Sarul

“…The study design was defined in the PICO format—Population (P): non-syndromic prepubertal and adolescent patients requiring orthodontic treatment, who additionally have coexisting sleep disorders; Intervention (I): Orthodontic treatment of malocclusion with differentiated appliances; Comparison (C): evaluation of Apnea Hypopnea Index (AHI) and sleep questionnaires pre and post treatment; Outcome (O): effect of orthodontic treatment on sleep quality. …”
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Neutrophil- and Endothelial Cell-Derived Extracellular Microvesicles Are Promising Putative Biomarkers for Breast Cancer Diagnosis by Thayse Batista Moreira, Marina Malheiros Araújo Silvestrini, Ana Luiza de Freitas Magalhães Gomes, Kerstin Kapp Rangel, Álvaro Percínio Costa, Matheus Souza Gomes, Laurence Rodrigues do Amaral, Olindo Assis Martins-Filho, Paulo Guilherme de Oliveira Salles, Letícia Conceição Braga, Andréa Teixeira-Carvalho

“…In addition, the MVs of BC patients were analyzed before treatment and 6, 12, and 24 months post-treatment. Machine learning approaches were employed to determine the performance of MVs to identify BC and to propose BC classifier algorithms. …”
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Rationale and protocol of the LEAD 2.0 study: a randomized controlled trial assessing the feasibility of a virtually delivered 6-month exercise and nutrition intervention in older... by Bobby Neudorf, Noah Koblinsky, Krista Power, Malcom Binns, Alexandra J. Fiocco, Shlomit Rotenberg, Susan Marzolini, Paul Oh, Jane Thornton, Fatim Ajwani, Kylie Sullivan, Stéphanie Chevalier, Caryl Russell, Guylaine Ferland, Nicole D. Anderson, Laura E. Middleton

“…Assessments will be performed virtually at baseline, 6 months (post-intervention), and 12 months. Feasibility will be measured by recruitment rate, adherence, and retention. …”
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Combination of Whole Body MRI and MY-RADS: A Promising Standardised Approach for Treatment Response Evaluation in Multiple Myeloma Patients by Dipu Bhuyan, Hrishikesh Choudhury, Baloy Jyoti Talukdar, Subhosree Dey, Sushant Agarwal, Aditi Das, Rishabh

“…All participants adhered to a standardised MRI protocol employing uniform sequence parameters utilising the 3T Siemens Magnetom Skyra technology both pre-and post-treatment, with a burden score allocated to reflect the extent and severity of the disease. …”
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‘Super Rehab’: can we achieve coronary artery disease regression? A feasibility study protocol by David Murphy, Charalambos Antoniades, John Graby, Fiona Gillison, Amardeep Dastidar, Dylan Thompson, Theresa Smith, Oliver Peacock, Ali Khavandi, Hugh McLeod, Jonathan Carl Luis Rodrigues

“…However, many patients with coexistent cardiovascular risk factors, particularly those with metabolic syndrome (MetS), remain at heightened risk of future MACE despite current management.Cardiac rehabilitation is offered to patients post-revascularisation, however, there is no definitive evidence demonstrating its benefit in a primary prevention setting. …”
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Variation in Arterial CO2 is a Stronger Determinant of Brain Tissue Oxygenation Than its Synchronous Value in Critically Ill Patients With Acute Brain Injury by Joanie Martineau, MD, MSc, Francis Bernard, MD, Alexandrine Gagnon, MD, Virginie Williams, PhD, Sabrina Araujo de Franca, BSN, David Williamson, BPharm, PhD, Yiorgos Alexandros Cavayas, MD, Msc

“…DESIGN:. We performed a post hoc analysis of a prospective cohort study collecting arterial blood gas (ABG) values alongside synchronous neuromonitoring variables. …”
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Advanced 4-chamber echocardiography techniques enable clinically matched precise characterization of heart disease progression in mice by Ege Kacira, Mariam F. Oueis, Nawal H. Tamimi, Sarah L. Sturgill, Xianyao Xu, Thomas J. Hund, Mark T. Ziolo, Yuchi Han, Isabelle Deschênes, Ji-dong Fu

“…Results: Here we show that LAX-BP echocardiography demonstrates volumetric accuracy comparable to cardiac magnetic resonance (CMR) and detects significant LV functional decline within the first week post-TAC–changes that are not clearly captured by M-mode imaging. …”
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The enhanced integration of proven techniques to quantify the uncertainty of forecasting extreme flood events based on numerical weather prediction models by Mitra Tanhapour, Jaber Soltani, Hadi Shakibian, Bahram Malekmohammadi, Kamila Hlavcova, Silvia Kohnova, Peter Valent

“…A Multi-Model Ensemble (MME) system was developed using the Group Method of Data Handling (GMDH) and Weighted Average-Weighted Least Square Regression (WA-WLSR) models to post-process raw precipitation forecasts. We thereupon proposed an approach that combined the Hydrologiska Byråns Vattenbalansavdelning (HBV) hydrological model with the Long-Short Term Memory (LSTM) network (HBV-LSTM model) to enhance flood forecasting. …”
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Surgical effect and prognostic factors of myasthenia gravis with thymomas by Wenxin Tian, Xiao Li, Hongfeng Tong, Wenhan Weng, Fan Yang, Guanchao Jiang, Jun Wang

“…A total of 162 patients were evaluated for post intervention MG status. A total of 55 patients achieved complete stable remission; the overall effective rate was 84.5%. …”
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Single-Bout Strength: Acute Mental Health Responses to Resistance Training in Active Adults by Manuel Amore, Adolfo Alfarano, Vincenzo Sorgente, Giulia Panconi, Sara Guarducci, Riccardo Bravi, Diego Minciacchi

“…A Quade ANCOVA confirmed that group assignment is significantly predictive for post-intervention anxiety levels (F(1, 54) = 8.46, <i>p</i> = 0.005), controlling for baseline values. …”
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