A study on the prediction of targeted therapy efficacy in advanced lung adenocarcinoma patients with EGFR mutations using CT-based delta-radiomics model by Zekai Wu, Zekai Wu, Peiyan Hua, Xiuying Chen, Jie Lei, Laian Zhang, Peng Zhang

“…We segmented tumor regions on pre-and post-treatment CT scans using ITK-SNAP, then extracted radiomic features and applied mRMR-LASSO (Minimum Redundancy Maximum Relevance–Least Absolute Shrinkage and Selection Operator). …”
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Intervention Strategies to Overcome HPV Vaccine Hesitancy Among Hispanic Immigrants in the USA: A Video-Based Approach by Isaiah Aduse-Poku, Diego A. Ardon, Alexis B. Call, Spencer C. Davis, Preston Evans, Spencer Johanson, Ruth J. Larson, James Rencher, Isaac A. Woolley, Brian D. Poole, Jamie L. Jensen

“…Notably, females exhibited less favorable post-intervention attitudes compared to males. Additionally, perceived care from video creators was a strong predictor of normalized gains in vaccine attitudes (β = 0.270, <i>p</i> < 0.001). …”
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Combined sequential hypothermic oxygenated and normothermic machine perfusion for liver transplant from an expanded criteria donor: first clinical application in Russia by S. V. Gautier, N. V. Grudinin, A. R. Monakhov, M. A. Boldyrev, V. K. Bogdanov, D. M. Bondarenko, S. I. Zubenko, N. P. Mozheiko, M. G. Minina, O. M. Tsirulnikova

“…Preservation times were: SCS – 260 minutes, D-HOPE – 124 minutes, NMP – 480 minutes, with a total preservation time of 884 minutes. Post-transplant peak levels of AST, ALT, and total bilirubin in the recipient were 922.5 U/L, 613 U/L, and 63.3 μmol/L, respectively. …”
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Sex-specific effects of gastrointestinal microbiome disruptions on Helicobacter pylori-induced gastric carcinogenesis in INS-GAS mice by Chao Peng, Xin Li, Yu Li, Xinbo Xu, Yaobin Ouyang, Nianshuang Li, Nonghua Lu, Yin Zhu, Cong He

“…Notably, we found gender disparities in the alterations of gastric and intestinal microbiota in mice post H. pylori infection. While the enrichment of Bifidobacterium and Lachnospiraceae was observed in female mice, Escherichia_Shigella and Akkermansia were more abundant in males. …”
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Antisense oligonucleotides targeting the SARS-CoV-2 nucleocapsid gene decrease viral titers in hamsters by Christopher Fitzpatrick, Nicolas Meunier, Sophie Lepoder, Sophie Dhorne-Pollet, Bruno Da Costa, Bernard Klonjkowki, Jean-François Eléouët, Verónica A. Burzio, Bernard Delmas, Eric Barrey

“…ASO-N1 induced a sustained reduction in viral RNA and inflammatory cytokine expression in the nasal mucosa and efficiently decreased infectious viral titers in nasal swabs at day 3 post infection. Further optimization of the ASO-N1 sequence with a combination of RNase-H1-dependent and steric blockage chemistries synergistically increased the antiviral efficacy in vitro. …”
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From inconsistency to sustainability: ICU night huddle compliance improvement through a structured QI approach by Prasobh PV Mukundan, Alisha Karki

“…Materials and methods: This QI project followed a plan–do–study–act (PDSA) cycle over two phases: (1) initial QIP (September 2023–March 2024): a structured Night Shift Briefing Checklist was implemented to ensure standardised communication and that compliance was monitored; (2) re-audit (September 2024–December 2024): targeted interventions were implemented to address compliance gaps:• Phase 1: Checklist placed in Doctors’ Hub (22 September 2024)• Phase 2: WhatsApp group reminders to doctors (1 October 2024)• Phase 3: Message of the Week in Morning Huddle (14 October 2024)• Phase 4: Nursing In-Charge Involvement (15 November 2024)Weekly compliance rates were recorded and analysed pre- and post-interventions. Results and discussion: Compliance improved from 32.8% (initial QIP) to 70.7% (re-audit), a 37.9% increase (Fig 1).The impact of each intervention was assessed as follows: • Phase 1: Checklist in Doctors’ Hub (22 September 2024): initial compliance was low, with inconsistent adherence. • Phase 2: WhatsApp reminders (1 October 2024): compliance increased to ∼57%, but some nights were still missed due to lack of structured accountability. • Phase 3: Message of the Week in Morning Huddle (14 October 2024): reinforcement through daily reminders resulted in a boosted compliance of ∼71%. • Phase 4: Nursing In-Charge Involvement (15 November 2024): sustained compliance of ∼75% was achieved by actively engaging nursing staff, ensuring a shared responsibility rather than relying solely on doctors.Challenges: night huddle non-compliance persisted due to: • Workload pressure – If ICU was busy, staff may have skipped the huddle; • Forgetting/skipping: some days were missed even with reminder; • No direct accountability: night huddle often relied on motivated individuals; • Staff rotation issues: new staff may not have been fully aware of the expectation; • Nursing–doctor coordination issues: some shifts lacked direct interaction.What can be done to sustain and improve compliance? …”
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Intimate partner violence among lesbian, bisexual, and queer women students on campuses in South Africa: a qualitative study exploring context, drivers, and impacts by Pinky Mahlangu, Carrie Brooke-Sumner, Yandisa Sikweyiya, Kristin Dunkle, Ntlotleng Mabena, Rachel Jewkes, Sinegugu Duma, Nelisiwe Khuzwayo, Elizabeth Dartnall, Managa Pillay, Mercilene Tanyaradzwa Machisa

“…Data were analyzed inductively using a thematic analysis approach. We drew from the post-structural feminist theory to understand the relationship dynamics in same sex relationships of LBQ women. …”
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Anti-BCL2 therapy eliminates giant congenital melanocytic nevus by senolytic and immune induction by Boxuan Wei, Qingxiong Yu, Jiamin Jin, Danli Zhu, Bohan Lai, Jieyu Gu, Ran Yang, Huailiang Huang, Hongzhan Lin, Liang Zhang, Tao Zan, Feng Xie, Kang Zhang, Qingfeng Li

“…Neutrophil depletion and immunosuppression reduce treatment efficacy, highlighting the crucial role of the immune response post-BCL2i treatment. Long-term follow-up showed no recurrence, with neutrophils and T cells residing in the dermis, indicating memory immune reactions. …”
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La transformation de l’ancien centre de détention secrète de Derb Moulay Cherif en musée des « années de plomb » (Casablanca, Maroc) by Anissa Habane

“…The first concerns the establishment of former secret detention centers in the post-independent Moroccan kingdom, enabling us to grasp this painful, shameful and dark period in the country’s history. …”
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Which novel teaching strategy is most recommended in medical education? A systematic review and network meta-analysis by Shuai-Long Zhang, Si-Jing Ren, Dong-Mei Zhu, Tian-Yao Liu, Lian Wang, Jing-Hui Zhao, Xiao-Tang Fan, Hong Gong

“…Therefore, this systematic review and network meta-analysis aims to evaluate and prioritize various teaching strategies in medical education, including simulation-based learning (SBL), flipped classrooms (FC), problem-based learning (PBL), team-based learning (TBL), case-based learning (CBL), and bridge-in, objective, pre-assessment, participatory learning, post-assessment, and summary (BOPPPS). Methods We conducted a comprehensive systematic search of PubMed, Embase, Web of Science, the Cochrane Library, and some key medical education journals up to November 31, 2023. …”
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A Culturally Tailored mHealth Intervention (MobileMen App) to Promote Physical Activity in African American Men: Protocol for a Comparative Effectiveness Trial by Kayla Nuss, Amanda Brice, Callie Hebert, Phillip Nauta, April J Stull, Damon L Swift, Derek M Griffith, David B Buller, Robert L Newton Jr

“…Participants will complete assessments at baseline and at 6 months post randomization. Assessments include objective measurements of daily steps and minutes of moderate to vigorous PA, quality of life, dietary measures, self-efficacy for fruit and vegetable consumption and PA, and autonomous motivation for PA. …”
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Transcriptome sequencing–based analysis of the molecular mechanism underlying the effect of lncRNA AC003090.1 on osteoporosis by Huafeng Zhuang, Yongjun Lin, Chengye Lin, Miao Zheng, Yizhong Li, Xuedong Yao, Youjia Xu

“…The expression levels of Runx2, Opn, and Ocn in spongy and cortical bone samples, as well as in post-infection cells, were assessed through RT-qPCR. …”
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Static stress triggering of Morocco M 6.9 earthquake on 9 September 2023 by WANG Runyan, WAN Yongkui, GUAN Zhaoxuan, HUANG Shaohua, GU Peiyuan, SONG Zeyao, ZHOU Mingyue

“…Therefore, an in-depth exploration of earthquake triggering is of great significance for strengthening post-earthquake scientific research and improving society's ability to respond to earthquakes.…”
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Resistance training as a modulator of inflammation and cognition by Jacqueline Goodrich, Jamie L. Tartar, Jonathan Banks, Francesca Leon, Jose Antonio

“…Participants n = 15 female (18.2 ± .36) untrained undergraduate students completed a baseline assessment, engaged in twice-weekly full-body resistance training, and underwent a post-training assessment. Baseline measures included cognitive performance tasks (Flanker Squared, Simon Squared, and Stroop Squared), saliva collection for IL-6, CRP, and cortisol analysis, body composition testing via InBody, a sleep quality index, and lifestyle assessment. …”
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Evidence for the stabilization of FeN4 sites by Pt particles during acidic oxygen reduction by Nicolas A. Ishiki, Keyla Teixeira Santos, Nicolas Bibent, Kavita Kumar, Ina Reichmann, Yu-Ping Ku, Tristan Asset, Laetitia Dubau, Michel Mermoux, Hongxin Ge, Sandrine Berthon-Fabry, Viktoriia A. Saveleva, Vinod K. Paidi, Pieter Glatzel, Andrea Zitolo, Tzonka Mineva, Hazar Guesmi, Serhiy Cherevko, Edson A. Ticianelli, Frédéric Maillard, Frédéric Jaouen

“…The Pt addition strongly reduces the H2O2 production and Fe leaching rate during ORR, while post mortem Mössbauer spectroscopy reveals that the highly active but unstable Fe(III)N4 site is partially stabilized. …”
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Comparison of Patient Acceptance and Caregiver Satisfaction of Glass-Ionomer Cement vs. Silver Fluoride/Potassium Iodide Application to Manage Molar Incisor Hypomineralisation Hype... by Ramiar Karim, Walaa Ahmed, Mohamed Baider, Christian H. Splieth, Julian Schmoeckel

“…Caregivers in both groups (AgF + KI and GIC + glaze) answered a questionnaire (5-Point Likert Scale) regarding the perception of the treatment immediately (15 min post application) and in the 12 weeks follow-up. …”
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Development and validation of a nomogram model for predicting the occurrence of necrotizing enterocolitis in premature infants with late-onset sepsis by Min Tao, Ling Yan, Yu Lang, Leilei Shen, Sheng Chen, Na Cai

“…Abstract Background Necrotizing enterocolitis (NEC), a devastating gastrointestinal disease in preterm infants, is strongly linked to sepsis, and 34–57% of NEC cases develop post-sepsis. However, the risk factors for sepsis-associated NEC are still unclear. …”
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Interobserver and intra-observer variability in bowel preparation scoring for colon capsule endoscopy: impact of AI-assisted assessment, interim analysis by Ian Io Lei, Daniel Gaya, Alexander Robertson, Benedicte Schelde-Olesen, Alice Mapiye, Anirudh Bhandare, Ursula Valentiner, Pablo Laiz, Santi Segui, Anastasios Koulaouzidis, Ramesh Arasaradnam

“…Introduction: Colon capsule endoscopy (CCE) has gained prominence post-coronavirus 2019 (COVID-19) as a non-invasive alternative for lower gastrointestinal investigations. …”
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In-depth analysis of the risk factors for persistent severe acute respiratory syndrome coronavirus 2 infection and construction of predictive models: an exploratory research study by Jia Zhang, Weihua Zhu, Piping Jiang, Feng Ma, Yulin Li, Yuwei Cao, Jiaxin Li, Zhe Zhang, Xin Zhang, Wailong Zou, Jichao Chen

“…Abstract Background Persistent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection differs from long coronavirus disease (COVID-19) (acute symptoms ≥ 12 weeks post-clearance). The Omicron BA.5 variant has a shorter median clearance time (10–14 days) than the Delta variant, suggesting that the traditional 20-day diagnostic threshold may delay interventions in high-risk populations. …”
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Effects of simultaneous intervention of aerobic training and berberine supplementation on AMPK and GLUT4 gene expression in the quadriceps muscle of diabetic male rats by Mahboobe Zaefarani Arani, Javad Ramezani, Saeid Naghibi

“…One-way analysis of variance and Tukey's post hoc test were employed for between-group comparisons of the data.   …”
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