Comparison of efficacy and safety between surgical and conservative treatments for hemorrhoids: a meta-analysis by Longfang Quan, Xuelian Bai, Fang Cheng, Jin Chen, Hangkun Ma, Pengfei Wang, Ling Yao, Shaosheng Bei, Xiaoqiang Jia

“…Conclusion Surgical treatments provide superior symptom relief, faster recovery, and lower recurrence but with some specific post-treatment complications, while conservative treatments are safer and less invasive but with provides slower symptom relief and higher recurrence rates. …”
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Choice of optimal therapeutic sequence in treatment of patients with progressive / metastatic squamous cell cancer of the head and neck in the light of TPEx study results by A. M. Mudunov

“…Pembrolizumab as a monotherapy gives positive effect only in patients with certain level of PD-L expression (CPS >20) in total population. Post-hoc analysis of TPExtreme study demonstrated the most benefit results until now for patients who received consequently cetuximab contained chemotherapy regimens as a first line followed by immunotherapy for the second line in this patients group (overall survival 19.4 months for EXTREME arm and 21.9 months for TPEx arm).Thus TPExtreme study results demonstrates opportunity for better disease control in patients receiving cetuximab in first line and immunotherapy as second line treatment in total population for patients with recurrent / metastatic SCCHN.…”
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Umbilicoplastia: experiência com a técnica do minicírculo de pele Umbilicaplasty: experience with the skin mini-circle technique by José Carlos Daher, Alberto Benedik, César Augusto Daher Ceva Faria, Jefferson Di Lamartine Galdino Amaral, Jose Nava Rodrigues Neto, Ognev Meireles Cosac, Marcela Caetano Cammarota

“…RESULTS: The obtained results were considered satisfactory by the surgical team and the patients, without post operative problems that had require special care. …”
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Risk prediction model for waitlist mortality in patients with left ventricular assist devices by Anjan Tibrewala, MD, MS, Duc Thinh Pham, MD, Mo Hu, MS, Lucia C. Petito, PhD, Jonathan D. Rich, MD, Finn Gustafsson, MD, PhD, Theo M.M.H. de By, MBA, PhD, Kevin Veen, MD, PhD, Donald M. Lloyd-Jones, MD, ScM, Sanjiv J. Shah, MD

“…We considered 41 candidate predictors at 3 months post-implant. Univariate Fine-Gray models and 4 logistic regression techniques (logistic, LASSO, random forest, gradient boosting) were used to select variables for a final survival model using the Fine-Gray method. …”
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Struktur Mikroanatomi Hati dan Kadar Kolesterol Total Plasma Darah Tikus Putih Strain Wistar Pasca Suplementasi Minyak Lemuru dan Minyak Sawit by Ngudy Jaka Surasa, Nur Rahayu Utami, Wiwi Isnaeni

“…This study aimed to determine the micro-anatomy structure of liver and blood plasma total cholesterol level of white rats Wistar strain by post-oil supplementation of lemuru and palm oil. …”
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Is a wound drain needed routinely after anterior cervical discectomy and fusion? by Jude Geldart, BSc (Hons), MBChB, Katie Mathieson, MBChB (c), Sayan Biswas, MBChB (Hons), MRes (Dist), Ella Snowdon, BSc (Hons), MBChB, Ved Sarkar, BSc (c), Callum Tetlow, BSc, K. Joshi George, MBBS, MD, FRCS (Neurosurgery), FEBNS, FISS

“…Conclusions: Our study found no significant differences in the incidence of POHs or SSIs between post-ACDF patients with drains and those without, nor was there any difference in postoperative length of stay between the groups. …”
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Antiviral Activity of Double-Stranded Ribonucleic Acid and Interferon Alpha Composition in the Model of Experimental Influenza Infection of Mice by S. G. Gamaley, М. O. Skarnovich, E. V. Makarevich, О. Yu. Mazurkov, L. N. Shishkina, О. S. Ivanova, G. M. Levagina, Е. D. Danilenko

“…The study compositions were intranasally administered 3 hours before infection with influenza virus, as well as 1 and 3 days post infection. The doses of active components in the administered compositions were as follows: for dsRNA — 2.5 mg/kg, for IFN-alpha-2b — 500 IU/kg, 2500 IU/kg, or 5000 IU/kg. …”
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Prognostic factors for stent restenosis in patients with coronary artery disease undergoing percutaneous coronary intervention by M. А. Meshkova, I. A. Starodubtseva, A. A. Pashkova

“…In CAD patients 1-2 months post-PCI for ACS, restenosis development is associated with longer CAD duration, CKD stage 3A, use of BMS, and elevated Lp(a) levels >30 mg/dL, irrespective of achieving the target LDL-C level <1.4 mmol/L. …”
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Current status of nurses’ public health emergency response capacity for emerging infectious disease: a cross-sectional study by Qin Qiu, Qin Qiu, Yuntong Liu, Fanping Meng, Fanping Meng, Xinhua Wang, Chunxiang Su

“…ObjectivesThis study aimed to assess the current status of nurses’ public health emergency response capacity for emerging infectious diseases (EIDs) in tertiary hospitals in Beijing, explore the deficiencies of nurses’ emergency response capacity, and analyze the influencing factors in the post-epidemic era.MethodsA convenience sampling method was utilized to recruit registered nurses in 3 tertiary hospitals in Beijing from 27 August and 2 September 2024. …”
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High-temperature dolomite in the Lower Cretaceous Cupido Formation, Bustamante Canyon, northeast Mexico: petrologic, geochemical and microthermometric constraints by Gabriela Sara Guzzy-Arredondo, Gustavo Murillo-Muñetón, Dante Jaime Morán-Zenteno, José Manuel Grajales-Nishimura, Ricardo Martínez-Ibarra, Peter Schaaf

“…Similar homogenization temperatures were determined in dolomite and post- dolomite calcite cement of the Cupido Formation from southern locations including Potrero Chico and Potrero Minas Viejas. …”
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Pharmacokinetics and Safety with Bioequivalence of Isosorbide Mononitrate Sustained-Release Tablets in Chinese Healthy Volunteers: Bioequivalence Study by Wu B, Wang W, Zhang Q, Yu G, Lin J, Zhang T, Ye L, Wang K, Zhang W, Wu X

“…Serial blood samples were collected over 36 hours post-dose (Days 1 and 6). The plasma concentrations of isosorbide mononitrate were measured using a high-performance liquid chromatography-tandem mass spectrometry method, and pharmacokinetic parameters were determined using noncompartmental methods.Results: Fifty-six healthy subjects were enrolled. …”
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Digitising the on-call medical team's patient list system: a QIP by Fahad-Bin Zahid

“…Feedback was collected after each cycle to address challenges and refine functionality, including: • Removal of unnecessary columns • Removal of the ‘low-priority’ category (eg, falls, social issues), because such patients were delayed for extended periods, raising clinical safety concerns; • Improved navigation by fixing headers and introducing alternate row colouring to support dyslexic users1–3; • Enhanced visibility for same-day emergency care department (SDEC) and patients who were post-take; • Created a video guide for staff and clarified the log-in process; • Created a secure folder for archived spreadsheets to improve data storage; • Developed an automatic timestamp for when details were entered.Efficiency gains: • Reduced handover times by 13.5 min (on average) per handover; • 73% of registrars reported improved workflow efficiency; • Features, such as live updates and centralised tracking, minimised information loss and streamlined referral management.Environmental impact: • Eliminated 100% of official paper-based referral list, aligning with NHS sustainability goalsUser satisfaction: • 91% of registrars preferred the electronic system. • 73% rated the system 8–10 for usabilityEquality impact: • The project had no adverse effects on any protected characteristic groups. …”
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Real-World Treatment Efficacy and Safety Profile of Sofosbuvir- and Velpatasvir-Based HCV Treatment in South Korea: Multicenter Prospective Study by Jae Hyun Yoon, Chang Hun Lee, Hoon Gil Jo, Ju-Yeon Cho, Jin Dong Kim, Jin Won Kim, Ga Ram You, Sung Bum Cho, Sung Kyu Choi

“…The primary endpoint was a sustained virological response at 12 weeks post-treatment (SVR12). Results: Among 101 patients treated with SOF/VEL, the mean age was 64.71 years, and 40.9% were male. …”
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A novel glycogene-related signature for prognostic prediction and immune microenvironment assessment in kidney renal clear cell carcinoma by Xuyan Zhao, Hanxiao Cui, Mingjing Zhou, Xueting Ren, Zihao Li, Peinan Liu, Danni Zhao, Shuai Lin, Huafeng Kang

“…Glycosylation is a key post-translational modification that is essential in cancer progression. …”
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Epidemiological Situation on Cholera in the Russian Federation in 2023 and Forecast for 2024 by A. Yu. Popova, A. K. Noskov, E. B. Ezhlova, V. D. Kruglikov, E. V. Monakhova, O. S. Chemisova, A. A. Lopatin, S. M. Ivanova, O. A. Podoynitsyna, A. S. Vodop’yanov, D. A. Levchenko, I. V. Savina

“…It was established that the toxigenic strains isolated from patients belonged to the currently dominant in the world “post-Haitian” group, including in India and Bangladesh, with the genotype ctxB7 tcpACIRS rtxA4a VSP-IIΔ0495-0512. …”
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Characteristics and dynamics of cognitive impairment in patients with primary and recurrent cerebral ischemic hemispheric stroke by A. A. Kozyolkin, А. А. Kuznietsov, L. V. Novikova

“…Cognitive impairment, t hat significantly disrupt daily activities and life of the patient, is one of the most significant post-stroke complications that have social, medical and biological significance. …”
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Astrocyte induction of disease-associated microglia is suppressed by acute exposure to fAD neurons in human iPSC triple cultures by Alexandra M. Lish, Nancy Ashour, Richard V. Pearse, II, Paige C. Galle, Gwendolyn A. Orme, Sarah E. Heuer, Courtney R. Benoit, Kellianne D. Alexander, Elyssa F.L. Grogan, Gizem Terzioglu, Allegra Scarpa, Andrew M. Stern, Nicholas Seyfried, Vilas Menon, Tracy L. Young-Pearse

“…This model leverages cryopreserved cells, enabling co-cultures within 20 days post-thaw. Comparing monocultures and tricultures, we demonstrate how cell-cell interactions shape transcriptional and functional states across all three cell types. …”
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Functional Imaging of Liver Cancer (FLIC): Study protocol of a phase 2 trial of 18F-DCFPyL PET/CT imaging for patients with hepatocellular carcinoma. by Esther Mena, Joanna Shih, Joon-Yong Chung, Jennifer Jones, Atoosa Rabiee, Cecilia Monge, Baris Turkbey, Liza Lindenberg, Kilian E Salerno, Michael Kassin, Brad Wood, Jonathan Hernandez, Roberto Maass-Moreno, Babak Saboury, Neha Jakhete, Jason K Molitoris, Keith R Unger, Peter L Choyke, Freddy E Escorcia

“…Participants with histopathologic confirmation of HCC and a positive baseline 18F-DCFPyL-PET/CT will undergo a post-treatment 18F-DCFPyL-PET/CT during the first routine follow-up, typically within 4-8 weeks. …”
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A comparative study in the functional outcomes after conventional Deltopectoral approach vs. anterior deltoid split approach for fixation of proximal humerus fractures by Shradha A. Kulkarni, MS Orthopaedics, DNB Orthopaedics, Mansoor Malnas, Postgraduate Student-MS Orthopaedics (final year- 3rd year), Karan Bhanushali, MS Othopaedics, DNB Orthopaedics, Parag K. Munshi, MS Orthopedics, Dorth, DNB, MchOrth, FRCS (Gen Surg), FRCS (Orth)

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PRE-SURGERY STATUS AND IN-HOSPITAL COMPLICATIONS OF CORONARY BYPASS GRAFTING IN PREDIABETES AND TYPE 2 DIABETES PATIENTS by A. N. Sumin, N. A. Bezdenezhnykh, A. V. Bezdenezhnykh, A. V. Osokina, A. A. Kuzmina, О. V. Gruzdeva, О. L. Barbarash

“…Totally, 708 consecutive patients included, post coronary bypass grafting (CBG) in 2011-2012 in the SRI CICVS. …”
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