Using machine learning algorithms to predict risk factors of heart failure after complete mesocolic excision in colorectal cancer patients by Yuan Liu, Yuankun Liu, Yu Zhang, Pengpeng Zhang, Jiaheng Xie, Ning Zhao, Yi Xie, Chao Cheng, Songyun Zhao

“…The HF prediction model post-CME, derived from the XGBoost machine learning algorithm in this study, attests to its elevated predictive accuracy and clinical utility.…”
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Living therapeutics of nonpathogenic bacteria as biosynthesis factory and active carriers for enhancing tumor-targeted therapy by Mengna Dong, Xinhui Yang, Wenqian Zhang, Yuzhi Qiu, Peng Song, Hongfang Liu, Yajiang Yang, Xiangliang Yang, Qin Wang

“…Our systematic studies reveal that FeS@SRB has excellent biosafety and tumor targeting capabilities, achieving over 50% tumor delivery efficiency in female mice post-intravenous injection, which is 17 times higher than that of conventional chemically-synthesized FeS@BSA nanoparticles. …”
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High-intensity resistance and impact training for patients with hormone-sensitive prostate cancer and bone metastases—study protocol of a randomized clinical trial by Anne-Mette Ragle, Marta Kramer Mikkelsen, Anders Vinther, Bo Zerahn, Carsten Bogh Juhl, Susann Theile, Kasper Madsen, Dorte Lisbet Nielsen, Peter Busch Østergren

“…Data will be collected at baseline, midway intervention (16 weeks), post-intervention (32 weeks), and follow-up (44 weeks). …”
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Integrated transcriptomic and immune enzymatic analyses uncover coordinated immunometabolic responses in large yellow croaker (Larimichthys crocea) to Metanophrys sp. infection by Ruiling Zhou, Kangshuai Sun, Xiao Xie, Fei Yin, Jorge Galindo-Villegas

“…Antioxidant and immune enzyme activities, including SOD, CAT, and MDA in the skin, gill, and liver, and LYZ and Na+/K+-ATPase in the skin and gill were monitored from 0 to 72 hours post-infection (hpi). The results revealed tissue- and time-specific significant changes, indicating increased oxidative stress and activation of compensatory antioxidant and mucosal immune defenses. …”
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A comparative analysis of imaging-based algorithms for detecting focal cortical dysplasia type II in children by Jan Šanda, Zuzana Holubová, David Kala, Kateřina Jiránková, Martin Kudr, Tomáš Masák, Anežka Bělohlávková, Pavel Kršek, Jakub Otáhal, Martin Kynčl

“…Their performance was assessed using adult and pediatric healthy controls templates, with validation against both predictive radiological ROIs (PRR) and post-resection cavities (PRC). The junction algorithm achieved the highest median dice score (0.028, IQR 0.038, p < 0.01 when compared with other algorithms) and detected relevant clusters even in MRI-negative cases. …”
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Evaluation of the in vivo antidiabetic, in vitro antioxidant and alpha amylase inhibitory effects of Ocimum lamiifolium Hochst ex Benth leaf hydromethanolic crude extract in strept... by Gedefaw Getie Mengistu, Kefyalew Ayalew Getahun, Markeshaw Tiruneh, Hiwot Tezera, Meseret Derbew Molla

“…Data analysis was performed via one-way analysis of variance, followed by Tukey’s post hoc test, via the Statistical Package for Social Science software version 26. …”
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Impact of Early Mobilization Versus Immobilization on Pain and Mobility After Total Hip Replacement by Rizwan Khan Lodhi, Imran Manzoor, Muhammad Moueen, Jehanzeb Khan, Imanullah Riaz

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Demoralization in breast cancer survivors by Annekathrin Sender, Andreas Hinz, Laura Broemer, Anja Mehnert-Theuerkauf, Bernhard Strauß, Susanne Briest, Jenny Rosendahl

“…Demoralization was highly correlated with the experience of meaning and peace (r = –0.79), sense of existential vacuum (r = −0.78), anxiety (r = 0.72), and depression (r = 0.70), while the correlations were lower for distress (r = 0.37) and post-traumatic growth (r = −0.19). The mean scores of the breast cancer survivors were markedly higher than those of the general population on both subscales distress and coping (d = 0.71) and meaning and purpose (d = 0.34).DiscussionThe results show that demoralization is prevalent in cancer survivors and should be understood as a proper construct that has multiple relationships with other variables of mental health. …”
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Machine learning model for predicting recurrence following intensity-modulated radiation therapy in nasopharyngeal carcinoma by Mi Wang, Qingxiu Yao, Weiliu Zhu, Nianci Xiao, Libo Dai

“…This study aims to construct a reliable model for predicting post-treatment recurrence by integrating high-accuracy machine learning (ML) models. …”
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Tirzepatide mitigates Stroke-Induced Blood-Brain barrier disruption by modulating Claudin-1 and C/EBP-α pathways by Duozi Wang, Jianhong Wang, Binghu Li, Shu Yang, Fuqiang Guo, Bo Zheng, Jian Wang

“…Tirzepatide (TZP), a dual GLP-1 and GIP receptor agonist, has demonstrated neuroprotective effects, but its role in BBB restoration post-stroke remains unclear. Objective This study aims to evaluate the potential of TZP in preventing BBB dysfunction and restoring its integrity in ischemic stroke models. …”
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Pore multi-fractal characteristics of coal under true triaxial tetrahydrofuran hydraulic injection by Sheng XUE, Feilin HAN, Chunshan ZHENG, Shuaili LIU, Bingjun LIU

“…The generalized fractal dimension spectrum and multifractal singularity spectrum of the pore structures in both the original and post-injection coal samples conformed to the laws of multifractal theory, demonstrating that their pore structures possessed multifractal characteristics. …”
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Application of AI-assisted multi-advisor system combined with BOPPPS teaching model in clinical pharmacy education by Qianqian Ye, Shu Wang, Yufeng Liu, Jinque Luo, Ziwei Deng, Shao Liu, Yueping Jiang

“…To address this issue, a hybrid teaching model combining an AI-assisted multi-advisor system with the BOPPPS (bridge, objective, pre-assessment, participatory learning, post-assessment, summary) teaching method was applied in clinical pharmacy education. …”
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Outcomes of Early Weightbearing Following Open Reduction and Internal Fixation of Unstable Ankle Fractures in a Geriatric Population by Valerie Carbajal MD, Daniel Choi MD, Brent Kokobun MD, Arash Aminian MD, David Lee MD, Thomas Harris MD

“…We considered major complications to include: hardware failure, gross loss of reduction, need for revision ORIF, and accelerated post traumatic arthritis. Four patients were noted to have delayed wound healing. …”
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Recovery effects of slow-tempo preferred music on brain activity, physiological and psychological responses following high-intensity interval exercise in healthy male adults by Siwaporn Sreepetch, Papatsorn Ramyarangsi, Sujira Mukda, Vorasith Siripornpanich, Amornpan Ajjimaporn

“…Methods: Fifteen male university students (age: 21 ± 1 years) completed a 30-min HIIE session, involving alternating 1-min intervals at 60 % and 90 % V̇O2peak. Post-exercise, participants completed 15 min of passive recovery in one of three randomized conditions: PF, non-preferred music (NF), or no music (control; CN). …”
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Metastasis of Squamous Cell Carcinoma of the Larynx to the Right Adrenal Gland—A Case Report by Eliza Działach, Michał Simlot, Karolina Osowiecka, Elżbieta Nowara, Jarosław Markowski, Mateusz Grajek

“…Chemotherapy was discontinued due to hematological complications. Post-treatment monitoring included CT and PET-CT imaging, leading to the detection of a large adrenal mass. …”
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Evaluation of model-simulated tropical cyclone response on the biogeochemical parameters using profiling float observations in the Arabian Sea by V. P. Thangaprakash, M. S. Girishkumar, N. Sureshkumar, S. K. Baliar Singh, Kunal Chakraborty, R. U. V. N. Satish, T. V. S. Udaya Bhaskar, E. Pattabhi Rama Rao, M. Ravichandran

“…Although the ROMS model exhibited a similar temporal evolutions as apparent in observations, it consistently overestimated the near-surface chlorophyll and DO throughout the study period, except during the peak enhancement phase due to post-TC impact, where it showed slight underestimation (2 mg m-3). …”
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Quality approaches and standards of 3D printing in orthopedic and traumatological settings: a systematic review by Tanja Neussl, Richard Lindtner, Lukas Kampik, Sieglinde Pal, Michael Schirmer, David Putzer, Rohit Arora, Johannes Dominikus Pallua

“…Each phase of the production process—from image acquisition and segmentation to material selection and post-processing—affects the safety and performance of the final product. …”
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Organoid-based in vitro system and reporter for the study of Cryptosporidium parvum sexual reproduction by Bethany R. Korwin-Mihavics, Emmett A. Dews, Peter Miller, Alexandra Cameron, Bruno Martorelli di Genova, Christopher D. Huston

“…Use of this reporter in ODMs can help investigate the Cryptosporidium life cycle post-sexual differentiation in a physiologically relevant in vitro system.IMPORTANCEOrganoid-derived monolayers enable the study of previously inaccessible aspects of Cryptosporidium’s biology. …”
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Treatment of IL-10RA deficiency of pediatric patients with very early onset inflammatory bowel disease by allogeneic haematopoietic stem cell transplantation by Yafeng Wang, Dandan Liu, Haili Gao, Wei Liu, Yanna Mao

“…All VEO-IBD patients demonstrated weight gain following HSCT, with substantial improvements observed in severe malnutrition and growth retardation associated with IL-10RA deficiency post-transplantation. Allo-HSCT is thus identified as the optimal curative therapy for VEO-IBD patients with IL10-RA deficiency. …”
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Integrating Conservative kidney management Options and advance care Planning Education (COPE) into routine CKD care: a protocol for a pilot randomised controlled trial by Scott D Halpern, Michael K Paasche-Orlow, Nwamaka D Eneanya, Taylor L Stallings, Tamar A Klaiman, Margarita Alegria, Ann O’Hare, Nina O’Connor, Laura M Dember

“…We will assess outcomes at baseline, immediately post-education and at 2 and 12 weeks.Ethics and dissemination This protocol has been approved by the Institutional Review Board at the University of Pennsylvania. …”
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