Longitudinal automated brain volumetry versus expert visual assessment of atrophy progression on MRI: an exploratory study by Max Gebest, Christel Weiß, Chang-Gyu Cho, Lucrezia Hausner, Lutz Frölich, Alex Förster, Nandhini Santhanam, Johann Fontana, Christoph Groden, Holger Wenz, Máté E. Maros

“…AVA-delta and EVA showed significant global associations for the right hippocampus (pKW = 0.035), left temporal lobe (pKW = 0.0092), ventricle volume (pKW = 0.0091) and a weak association for the parietal lobe (pKW = 0.067). Post hoc testing revealed additional significant link for the left hippocampus (pWSRT = 0.039). …”
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Extending Investigations of miR‐126‐5p on the Regulation of CYP2A6, the Major Nicotine‐Inactivating Enzyme by Weilong Gu, Alec W. R. Langlois, Haidy Giratallah, Katrina G. Claw, Bhagwat Prasad, Kenneth E. Thummel, Rachel F. Tyndale

“…A published molecular study of microRNA‐126‐5p, the microRNA‐126 functional arm, showed it decreased CYP2A6 expression post‐transcriptionally; it also showed that higher CYP2A7 mRNA competed for microRNA‐126‐5p binding, mitigating the CYP2A6 reduction. …”
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Die Kooperation zwischen Regel- und sonderpädagogischen Lehrpersonen in der Praxis verstehen – Ein multimethodischer Blick auf Kooperation im Kontext schulischer Inklusion by Nicole Reinsdorf, Antje Ehlert

“…Die Datenerhebung erfolgte über standardisierte Fragebögen (Prä-Post-Design), acht leitfaden­gestützte Interviews und 18 Protokolle der Teammeetings. …”
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The ejection fraction and the cardiac index in the perioperative period of coronary artery bypass grafting: what is worth relying on? by Konstantin V. Paromov, Ayyaz Hussain, Lyudmila A. Neledova, Mikhail Y. Kirov

“…Methods: We performed a post hoc analysis of two consequential randomized studies. …”
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Association between Maternal Obesity and Large for Gestational Age Infants in Pre- Eclampsia: A Prospective Cohort Study, Bahawalpur by Zaib Un Nisa, Shamsa Iqbal, Mirza Sijeel Ahmad, Reema Gul, Shagufta Parveen, Zahra Wasim

“…Outcome transformers like Age, gestational Age, parity, gravidity, and socioeconomic status were precisely stratified, and post-stratification chi-square was used to observe the result on consequence. …”
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Protein lysine acetylation regulates oral microorganisms by Yuanchao Yang, Yuanchao Yang, Hailun He, Bingshi Liu, Bingshi Liu, Zhuoyue Li, Zhuoyue Li, Jiaman Sun, Jiaman Sun, Zhili Zhao, Yan Yang, Yan Yang

“…Post-translational modifications (PTMs) are integral to the regulation of protein function, stability, and cellular processes. …”
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A Multicenter Retrospective Study Evaluating IL-5-Targeted Biologic Therapies for the Treatment of Asthma and Allergic Bronchopulmonary Aspergillosis in Adults With Cystic Fibrosis... by Sameer Desai, PhD, Sophia Shen, MD, Zosia Gryz, BSc, Elizabeth Tullis, MD, Anne L. Stephenson, MD, PhD, Bradley S. Quon, MD, MSc

“…There was no statistical difference in ppFEV1 from baseline to 12-months postbiologic initiation, but the rate of change in ppFEV1 improved in the 12 months postbiologic vs prebiologic with a pre-to-post difference of 3.7% (95% CI, 1.2%-6.3%). SCS dose and frequency of PExs requiring hospitalization did not differ significantly in the 12 months before biologic vs after biologic initiation. …”
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Integrative transcriptomic and proteomic analyses reveal that carbon metabolism and complement system of Madin Darby Bovine Kidney cells are affected by bovine coronavirus infectio... by Hui Zhang, Qisheng Yu, Rui Guo, Qing Zhu, Jin Yu, Zhaohui Zhang, Lan Lan, Cheng Tang, Changqing Yu, Bin Zhang

“…Results In this study, a BCoV isolate, BCoV/SUWN/XHD-5, had cytopathogenic effects in Madin Darby bovine kidney (MDBK) cells and showed a high viral titer at 24 and 48 h post infection (hpi). Gene expression profiling using RNA sequencing and protein network mapping using the Tandem Mass Tag-based quantitative proteomics approach were performed in MDBK cells with BCoV infection at 24 and 48 hpi, respectively. …”
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Evaluation of inflammatory markers in patients with confirmed bacterial infection according to the type of isolated pathogen by Jelena Micik, Evgenija Mihajloska, Aleksandar Dimkovski, Georgina Gorgieva Atanasova, Aleksandar Dimovski, Ljubica Shuturkova, Zoran Sterjev, Aleksandra Grozdanova

“…Frequent bacterial infections in intensive care demand routine microbiological screening and antimicrobial management to effectively address potential Gram-positive and Gram-negative pathogens causing post-surgical infections. This study aimed to assess whether serum levels of leukocytes, C-reactive protein, and procalcitonin — biomarkers commonly used in daily clinical practice to predict postoperative outcomes — differ between infections caused by Gram-positive or Gram-negative bacteria in adult patients admitted to a cardiac surgical intensive care unit (CICU), in order to support treatment decisions. …”
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Mental and Physical Health in Wilson Disease Patients With SARS‐CoV‐2 Infection and Relevance of Long‐COVID by Isabelle Mohr, Maximilian Brand, Christophe Weber, Andrea Langel, Jessica Langel, Patrick Michl, Viola Yuriko Leidner, Alexander Olkus, Sebastian Köhrer, Uta Merle

“…A large proportion of WD patients experience LC symptoms, reduced life quality, and sleeping disorders after SARS‐CoV‐2 infection. WD patients post‐infection should be well monitored and supported if they develop persisting symptoms or neuro‐psychological problems.…”
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Transcriptomic analysis reveals vector attraction to potato virus Y is mediated through temporal regulation of TERPENE SYNTHASE 1 (TPS1) by Chad T. Nihranz, Prakriti Garg, Junha Shin, Madeleine Dumas, Sunnie Grace McCalla, Sushmita Roy, Clare L. Casteel

“…We show that settlement and fecundity of the aphid vector, Myzus persicae, is increased on potato virus Y (PVY)-infected Nicotiana benthamiana plants two weeks post inoculation but not after six weeks. RNA-seq analysis revealed that transcripts related to plant defense and amino acid biosynthesis are upregulated in response to PVY infection and down regulated in response to aphid herbivory, and these patterns changed over time. …”
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An experimental study of resveratrol effect on neurotrophic and structural changes in retinal ischemia by T. N. Kiseleva, A. V. Chudin, N. V. Balatskaya, A. I. Shchipanova, I. P. Khoroshilova-Maslova, M. S. Zaytsev, A. M. Maybogin, K. V. Lugovkina

“…The histological examination of the retina on day 3 showed reduced retinal ischemic lesions and signs of inflammation, decrease of the apoptosis of ganglion cells and zones of preserved retina with intact nuclear layers and a layer of photoreceptors in late post-ischemic period (after 30 days). Conclusions. …”
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Investigating the association between recorded smoking cessation interventions and smoking cessation in people living with cardiovascular disease using UK general practice data by Angela Difeng Wu, Nicola Lindson, Rafael Perera, Min Gao, Paul Aveyard, Rachna Begh, Jamie Hartmann-Boyce

“…Logistic regression assessed the relationship between recorded interventions and smoking abstinence rates within the one-year post-index event, considering QOF incentives and mental illness presence. …”
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Association of antioxidant markers (SOD, GSH, NO, Catalase) with ischemic stroke severity and recovery outcomes by Haonan Chen, Shuhan Zang, Runlei Zhang, Peilin Chen, Shengxian Wu

“…Stroke severity was evaluated using the modified Rankin Scale (mRS) and NIH Stroke Scale (NIHSS), with follow-up assessments at 2, 4, and 6 months post-treatment. Results: Among the 364 participants, 203 (55.7%) were male, and 161 (44.3%) were female, with a mean age of 67.3±12.2 years. …”
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Healthcare-Seeking Behaviour for Obstetric Complications in Ethiopia: A Multilevel Mixed-Effect Analysis by Alehegn Bishaw Geremew, Claire T. Roberts, Shahid Ullah, Jacqueline H. Stephens

“…Overall healthcare-seeking at health facilities for obstetric complication symptoms during the maternity continuum was 62% (95%CI: 59.6-64.3), with 47.8% (95%CI: 45.0-50.5), 64.5% (95%CI: 61.3-67.5), and 52% (95%CI: 48.3-55.6) seeking healthcare from health facilities during pregnancy, childbirth, and the immediate post-partum period, respectively. Antenatal care attendance (aOR = 3.43, 95%CI: 2.4-5.0), nulliparity (aOR = 2.1; 95%CI: 1.0-4.4), household access to media (aOR = 1.5, 95%CI: 1.0-2.1), no intimate partner violence (IPV) during pregnancy (aOR = 1.8, 95%CI: 1.1-3.1), high community wealth status (aOR = 1.2, 95%CI: 1.1-2.4), community encouragement of facility childbirth (aOR = 2.2, 95%CI: 1.1-4.3), community non-acceptance of the traditional birth attendant (TBA; aOR = 2.4, 95%CI: 1.6-3.7), and high community participation in health developmental army (HDA; aOR = 2.1, 95%CI: 1.1-3.9) were significantly associated with healthcare seeking behaviour. …”
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Effect of Plastics (Geotextiles) on Heavy Metal Accumulation by Industrial Hemp Plants Cultivated in Polluted Mediterranean Soils by Dimitrios Alexiadis, John Bethanis, Sotiria G. Papadimou, Edoardo Barbieri, Rafaella Vogia, Eftihia Tatsi, Pavlos Tziourrou, Eleni Tsaliki, Evangelia E. Golia

“…The experiments are particularly encouraging as they prove that simple and habitual practices in cultivated soils that lead to post-weather erosion of the geotextile may contribute positively in terms of remediation methods for heavy-metal-laden soils, as they indirectly help the plant to remove larger amounts of metal elements. …”
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Nosocomial infections in HIV-infected and HIV-uninfected children hospitalised for tuberculosis by Ann Robinson, Etienne D. Nel, Peter R. Donald, Hendrik S. Schaaf

“…Their impact could be reduced by the earlier introduction of antiretroviral treatment and by immunisation against certain of the infecting agents. Post-exposure prophylaxis for varicella could prevent or alleviate disease.…”
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Beyond the homozygous paradigm: symptomatic partial biotinidase deficiency in a heterozygous child—first case report from Nepal by Jagdish Kunwar, Bijay Kunwar, Anup Ghimire, Aramva Bikram Adhikari, Binay Aryal, Sachchu Thapa, Bina Prajapati Manandhar

“…Follow-up assessments at 3, 6, and 12 months post-treatment showed remarkable improvement. Conclusions This case highlights the clinical and diagnostic challenges of biotinidase deficiency (BTD) in resource-limited settings like Nepal, where the absence of newborn screening and limited molecular diagnostic capacity delay timely intervention. …”
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Effect of Android-based Mobile Diabetic Foot Early Self-assessment on Diabetic Foot Prevention Behaviors of Indonesian Patients With Type 2 Diabetes by Ni Wayan Suniyadewi, Nursalam Nursalam, Yuni Sufyanti Arief, Ninuk Dian Kurniawati, Ni Luh Putu Inca Buntari Agustini, I Dewa Ayu Rismayanti, Virgianti Nur Farida, Arifal Aris, Resti Utami

“…Materials and Methods: This is a quasi-experimental study with a pre-test/post-test design that was conducted on 60 Indonesian patients with type 2 DM (30 in intervention group and 30 in control group) who met the inclusion criteria and were purposively selected from August to October 2021. …”
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Targeting SLC7A5 in lung squamous cell carcinoma: implications for cancer metabolism shift and boron neutron capture therapy resistance by Yen-Ju Lin, Yu-Cheng Wu, Yu-Jui Liu, Wei-Chen Yeh, Yi-Chen Huang, Shen-Ao Zhang, Alvin Chen, Ming-Yi Zheng, Hong-Ming Liu, Fong-In Chou, Shien-Tung Pan, Min-Yuan Chou, Yu-Ting Chou

“…Furthermore, SLC7A5 knockout LUSC cells demonstrate resistance to BPA-BNCT but sensitivity to the autophagy inhibitor chloroquine. Post-BPA-BNCT treatment, surviving wild-type LUSC cells exhibit reduced SLC7A5 levels and increased sensitivity to chloroquine, highlighting a vulnerability in BPA-BNCT-resistant cells. …”
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