A China-Based exploration of surgical timing for polytrauma with a focus on fracture reconstruction by Chenning Ding, Mingwang Jia, Xing Han, Jiahui Zhang, Xin Zhao, Xiguang Sang

“…Given China’s healthcare context, this study will assess injury severity and perform definitive fracture reconstruction at specified post-trauma intervals. Postoperative infection rates, including wound infections, other complication incidences, hospital stay duration, treatment costs, and long-term outcomes will be observed and compared to identify the optimal timing for surgical intervention. …”
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Architecture and the Time of Space by Deborah Hauptman

“…Reflecting on this history, that post-war moment of theory, one cannot help but be struck by the complexity and the ambiguity of the adventure; qualities most evident in the fact that new spaces and new means of writing and drawing, of thinking and making emerged. …”
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Bridging radiotherapy before chimeric antigen receptor T cells for B-cell lymphomas: an ILROG multicenter study by Nikhil Yegya-Raman, John P. Plastaras, Christopher M. Wright, Monica Chelius, Siqi Zhang, Jonathan A. Baron, Harper Hubbeling, Austin J. Sim, Timothy J. Robinson, Michael D. Jain, Brandon Imber, Beatrice Fregonese, Joachim Yahalom, Colton Ladbury, Savita Dandapani, Chelsea C. Pinnix, Jillian R. Gunther, Penny Q. Fang, Susan Y. Wu, Bouthaina S. Dabaja, Joanna C. Yang, Jessica Chew, Steve Braunstein, Sumi Sinha, Nathan M. Delinger, Susan Sun, Stephanie A. Terezakis, Gukan Sakthivel, Louis S. Constine, Amit K. Chowdhry, Patrick M. Reagan, Skyler Burke, Yolanda D. Tseng, Michael J. LaRiviere, Amit Maity, Stephen J. Schuster, Elise A. Chong, Nicholas B. Figura

“…Patients with lactate dehydrogenase (LDH) normalization after Br-RT (high pre-Br-RT LDH, normal post-Br-RT LDH) had superior PFS and OS compared with those with high post-Br-RT LDH and similar PFS and OS compared with those with normal baseline LDH. …”
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Extracellular vesicle digital scoring assay for assessment of treatment responses in hepatocellular carcinoma patients by Chen Zhao, Yi-Te Lee, Andrew Melehy, Minhyung Kim, Jacqueline Ziqian Yang, Ceng Zhang, Jina Kim, Ryan Y. Zhang, Junseok Lee, Hyoyong Kim, Yong Ju, Yuan-Jen Tsai, Xianghong Jasmine Zhou, Steven-Huy B. Han, Saeed Sadeghi, Richard S. Finn, Sammy Saab, David S. Lu, Jason Chiang, Jae-Ho Park, Todd V. Brennan, Steven A. Wisel, Manaf Alsudaney, Alexander Kuo, Walid S. Ayoub, Hyunseok Kim, Hirsh D. Trivedi, Yun Wang, Aarshi Vipani, Irene K. Kim, Tsuyoshi Todo, Justin A. Steggerda, Georgios Voidonikolas, Kambiz Kosari, Nicholas N. Nissen, Rola Saouaf, Amit G. Singal, Myung Shin Sim, David A. Elashoff, Sungyong You, Vatche G. Agopian, Ju Dong Yang, Hsian-Rong Tseng, Yazhen Zhu

“…Results HCC EV TR Scores, calculated from pre- and post-treatment plasma samples in the phase-2 case–control study, accurately differentiated post-treatment viable from nonviable HCC in the training (area under the ROC curve [AUROC] of 0.90, n = 49) and validation set (AUROC of 0.88, n = 51). …”
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The efficacy, safety and clinical feasibility of a percutaneous atrial septal shunt device for pulmonary arterial hypertension: a single-center cohort study by Mingfei Li, Dandan Chen, Jianing Fan, Dan Tian, Lei Zhang, Xiaochun Zhang, Shasha Chen, Yuan Zhang, Wenzhi Pan, Lihua Guan, Daxin Zhou, Junbo Ge

“…The Short Form-36 (SF-36) score and the 6-minute walking distance (6MWD) at 12 months post-operation were significantly improved compared to baseline, with scores of 47.6 ± 19.5 versus 64.7 ± 24.6 (P = 0.029) and distances of 239.5 ± 137.8 m versus 401.7 ± 129.6 m (P = 0.045), respectively. …”
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Minimal residual ascites 3 months after TIPS implantation implicates worse clinical outcomes in patients with cirrhosis by Jim Benjamin Mauz, Lukas Hartl, Andrea Kornfehl, Sarah Lisa Schütte, Paul Hemetsberger, Theresa Müllner-Bucsics, Mathias Jachs, Anja Tiede, Hannah Rieland, Michael Schwarz, Nina Dominik, Georg Kramer, Bernhard Meyer, Lukas Reider, Michael Trauner, Heiner Wedemeyer, Mattias Mandorfer, Benjamin Maasoumy, Thomas Reiberger, Tammo Lambert Tergast

“…These findings suggest that patients with minimal residual ascites will benefit from enhanced post-TIPS clinical monitoring. Further research is warranted to uncover the underlying mechanisms and investigate the potential of targeted interventions to improve outcomes in this vulnerable group.…”
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An adaptive multiarm randomised trial of biomedical and psychosocial interventions to improve convalescence following severe acute malnutrition in sub-Saharan Africa: Co-SAM trial... by Paul Kelly, Lisa Langhaug, Marko Kerac, Helen Jones, Robert Ntozini, Laura Mwalekwa, Mutsa Bwakura-Dangarembizi, Beatrice Amadi, Deophine Ngosa, Nivea Chulu, Ellen Besa, Kuda Mutasa, Andrew J Prendergast, Virginia Sauramba, Eddington Mpofu, Bernard Chasekwa, Andreck Tembo, Gwendolyn Nayame, Sophreen Mwaba, Lydia Kazhila, Babak Choodari-Oskooei, Philip Ayieko, Batsirai Mutasa, Indi Trehan, Florence D Majo, Naume V Tavengwa, Thomas Jaki, Kirkby D Tickell, Benson O Singa, Dalton Wamalwa, Gerard Bryan Gonzales, Judd Walson, Doreen Rwigi, Melanie Smuk, Tim Brown, James Berkley, Sunhurai Mukwambo, Gertrude Tawodzera, Kavita Datta, Wedu Ndebele, Chishala Chabala, Churchil Nyabinda, James M Njunge, Julius Nyaoke, Eric Ochola, Molly Timbwa, Narshion Ngao, Sofia Muyemayema, Louisa Mudawarima, Shepherd Mudzingwa, Mukumbi Mutenda, Lucia K Keter, Tracy Naomi Phiri, Evans Mudibo, Aaron Tembo, Chris Oduol, Isabella Cordani, Sekai Chaparira, Athel Kamuti, Dorothy Murungu, Grace Gerema, Lovemore Chingonda, Courage Chiorera, Brenda Chivare, Gladys Ushe, Winmore Chiroodza, Melody Magonde, Hazel Zifesho, Simbarashe Mukorera, Perpetual Ngalande, Mary Phiri, Andrew Chisanga, Susan Kawinga, Martha Chola, Salia Kanunga, Nasilele Namatama, Florence Zulu, Chambah Ilunga, Catherine Achieng Otieno, Phlona Anyango Amam, Charles Mutinda Nganga, Emmanuel Odhiambo, Eveline Okado, Mary Nyathi, Edward Chabu

“…The primary composite outcome is death, hospitalisation or failed nutritional recovery within 24 weeks post-randomisation. An interim analysis will allow unpromising arms to be dropped, while the final analysis will be conducted when 1266 children have completed the study. …”
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Effects of community action on animal vaccination uptake, antimicrobial usage, and farmers’ wellbeing in Ghana: study protocol for a cluster-randomized controlled trial by Francis Sena Nuvey, Günther Fink, Jan Hattendorf, Daniel T. Haydon, Gilbert Fokou, Kennedy Kwasi Addo, Jakob Zinsstag, Clemence Esse-Dibby, Bassirou Bonfoh

“…The main idea is the platforms enabling information exchange on livestock vaccines, enhancing service scheduling, and sharing vaccination costs among farmers living in the same locality. …”
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Improved Sleep Associated With Triamcinolone Acetonide Extended-Release Injections for Knee Osteoarthritis: Use of a New Real-World Registry by Michael A. Mont, MD, Jennifer H. Lin, PhD, Andrew I. Spitzer, MD, Vinod Dasa, MD, Adam Rivadeneyra, MD, David Rogenmoser, DO, Andrew L. Concoff, MD, Mitchell K. Ng, MD, Mary DiGiorgi, PhD, MPH, Stan DySart, MD, Joshua Urban, MD, William M. Mihalko, MD, PhD

“…Sleep disturbance was assessed via least-square-means relative to the average population, with multivariate linear regressions used to assess changes pretherapy/post-therapy. Results: Patients administered IA-TA-ER had decreased sleep disturbance relative to other cohorts (least-square-means 52.3; 95% confidence interval: 50.5-54.0; P < .03). …”
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The Ethical Significance of Brain-Computer Interfaces as Enablers of Communication by Toma Gruica

“…These include enhanced consent protocols addressing phenomenological shifts, mandatory plans for post-trial access, and contingency measures against commercial abandonment. …”
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Tração cutânea intraoperatória para fechamento de ferida após mastectomia bilateral higiênica: relato de caso Intraoperative skin traction for closure of hygienic bilateral mastect... by Jason César Abrantes de Figueiredo, Rodrigo Gouvea Rosique, Patricia Jackeline Maciel

“…<br>INTRODUCTION: The post-mastectomy chest wall defects require reconstruction by a safe and efficient procedure. …”
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Implikasi terhadap Status Kepemilikan Hak atas Tanah dalam Transformasi UMKM Menjadi Perseroan Terbatas Perorangan by Dewinta Sukma Wijaya, Diyan Isnaeni

“…For instance, farmers or small-scale producers using their residential land for business must navigate land status conversion procedures, which can be complex and costly. This study, through a normative juridical approach, reveals a regulatory gap that may affect the operational continuity of MSMEs post-conversion. …”
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In vivo Confocal Microscopy for Corneal and Ocular Surface Pathologies: A Comprehensive Review by Ramirez-Miranda A, Guerrero-Becerril J, Ramirez M, Vera-Duarte GR, Mangwani-Mordani S, Ortiz-Morales G, Navas A, Graue-Hernandez EO, Alio JL

“…However, limitations include operator dependency, high costs, and the need for further technological refinements, such as wide-field imaging and non-contact modalities.Conclusion: IVCM represents a transformative tool in ophthalmology, bridging the gap between clinical evaluation and cellular-level diagnostics. …”
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“Take-home” functional electrical stimulation for depression: protocol for a prototype development and proof of concept randomized controlled trial by Fatemeh Gholamali Nezhad, Vanessa K. Tassone, Ilya Demchenko, Jia Xi Mary Chen, Stephanie N. Iwasa, Josh Martin, Naaz Desai, Hani E. Naguib, Milos R. Popovic, Venkat Bhat

“…More effective neurostimulation treatments are difficult to access and are associated with high hospital delivery costs. Patients would benefit from more efficacious and well-tolerated home-based neurostimulation treatments, which could be self-administered at a frequency required to treat MDD, maintain response, and reduce relapse. …”
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East Asian Welfare Regimes 東アジア福祉制度 by Joseph Wong, Andrew DeWit, Ito Peng

“…The pressure is also being ramped up by the apparently inexorable post-peak oil rise in conventional energy and other resource costs, not to mention the increasingly unstable US dollar-based global financial architecture. …”
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Nanomedicine-Based Ophthalmic Drug Delivery Systems for the Treatment of Ocular Diseases by Lin X, Zhou Y, Lv K, Wu W, Chen C

“…Additionally, a liposomal formulation of verteporfin, approved for the treatment of neovascular AMD, administered intravenously and activated by laser photodynamic therapy, demonstrates a durable response, with a marked reduction in treatment frequency from an average of 3.5 sessions in the first year to only 0.1 by the fifth year post-diagnosis. Despite these advantages, challenges such as manufacturing costs, potential toxicity, and limited clinical translation persist. …”
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Aquificae overcomes competition by archaeal thermophiles, and crowding by bacterial mesophiles, to dominate the boiling vent-water of a Trans-Himalayan sulfur-borax spring. by Nibendu Mondal, Subhajit Dutta, Sumit Chatterjee, Jagannath Sarkar, Mahamadul Mondal, Chayan Roy, Ranadhir Chakraborty, Wriddhiman Ghosh

“…While members of this phylum accounted for 80% of all 16S rRNA-encoding reads within the metagenomic dataset, 14% of such reads were attributed to Proteobacteria. Post assembly, only 25% of all protein-coding genes identified were attributable to Aquificae, whereas 41% was ascribed to Proteobacteria. …”
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Kidney transplant program in Irkutsk Region by A. V. Novozhilov, S. E. Grigoriev, O. Yu. Yakovleva, S. A. Yezhikeev

“…Kidney transplantation (KT) is often considered the best option for renal replacement therapy (RRT), significantly improving patient outcomes. Post-transplant, life expectancy doubles, and mortality decreases more than 4-fold compared to other RRT modalities. …”
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Prevalence and determinants of abortion among married women of reproductive age in rural and urban areas of the Southeastern Zone of Tigray, Ethiopia, 2024 a postwar study by Abrehaley Teklemariam Gebremariam, Girmatsion Fisseha Abreha, Kinfe Abraha Gebre-Egziabher, Awtachew Berhe Weldu

“…Comprehensive abortion care (CAC) includes safe services and post-abortion care, including modern techniques, medications, contraceptive counseling, emotional support, and community connections. …”
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Histone serotonylation promotes pancreatic cancer development via lipid metabolism remodeling by Sang Lin, Sheng Tan, Yonglin Peng, Aziguli Tulamaiti, Wenfei Du, Keshuo Ding, Changyu Chen, Jun Wu, Hua Li, Wei Xu, Jielin Sun, Xue-Li Zhang, Zhi-gang Zhang, Xiaodong Zhao

“…Apart from receptor-mediated signaling transduction pattern, serotonin can be covalently integrated into histone (the post-translational modification known as histone serotonylation) and serve as an epigenetic mark associated with permissive gene expression. …”
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