Mesenchymal Stromal Cells Do Not Increase the Risk of Viral Reactivation Nor the Severity of Viral Events in Recipients of Allogeneic Stem Cell Transplantation by Giovanna Lucchini, Erica Dander, Fabio Pavan, Irene Di Ceglie, Adriana Balduzzi, Paolo Perseghin, Giuseppe Gaipa, Alessandra Algarotti, Martino Introna, Alessandro Rambaldi, Attilio Rovelli, Andrea Biondi, Ettore Biagi, Giovanna D'Amico

“…In our experience MSC infusion did not prove to trigger more frequent or severer viral reactivations in the post transplantation setting.…”
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Recent Advances in Mpox Epidemic: Global Features and Vaccine Prevention Research by Xinling Zhang, Dong-Ang Liu, Yuting Qiu, Ruiyao Hu, Shiyu Chen, Yue Xu, Keyi Chen, Jinghua Yuan, Xiaoping Li

“…Due to the incomplete development of a vaccine specifically for MPXV, the smallpox vaccine remains in use for preventing mpox or for emergency vaccination post-exposure. Therefore, the persistent spread of mpox is still a major concern, requiring greater awareness and vaccination efforts in populations at high risk. …”
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Leaf area estimation in small-seeded broccoli using a lightweight instance segmentation framework based on improved YOLOv11-AreaNet by Yaben Zhang, Yifan Li, Xiaowei Cao, Zikun Wang, Jiachi Chen, Yingyue Li, Zhibo Zhong, Ruxiao Bai, Peng Yang, Feng Pan, Xiuqing Fu

“…A total of 6,192 germination-stage images were captured using a custom phenotyping system, from which 2,000 were selected and augmented to form a 5,000-image training set. Post-processing techniques—including morphological optimization, edge enhancement, and watershed segmentation—were employed to refine leaf boundaries and compute geometric area.ResultsCompared to the original YOLOv11 model, YOLOv11-AreaNet achieves comparable segmentation accuracy while significantly reducing the number of parameters by 57.4% (from 2.84M to 1.21M), floating point operations by 25.9% (from 10.4G to 7.7G), and model weight size by 51.7% (from 6.0MB to 2.9MB), enabling real-time deployment on edge devices. …”
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FCGR1A Alleviates Ischemic Stroke-induced Injury by Promoting Anti-Inflammatory Microglial Polarization via the AMPK–mTOR Signaling Pathway by Meng Liu, Xuhui Fan, Dongya Chen, Huibin Yao, Zhihui Huang, Heng Li, Qing Zhang, Yuqi Wang, Haihan Song, Yufeng Yan

“…Background: Ischemic stroke triggers inflammatory responses that lead to neuronal damage, with microglial polarization significantly influencing post-stroke inflammation. This study explores the role of Fc gamma receptor Ia (FCGR1A) in microglial polarization and its regulatory mechanisms in ischemic stroke. …”
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Spray-induced gene silencing enables the characterization of gene function during pre-penetration stages in Blumeria graminis f. sp. tritici by Meihui Zhang, Meijiao Zhou, Meijiao Zhou, Yunmeng Jia, Yunmeng Jia, Xipeng Li, Xipeng Li, Aolin Wang, Taiguo Liu, Yilin Zhou, Wei Liu, Jieru Fan

“…BgtActin silencing predominantly induced abnormal appressoria and reduced disease severity when dsRNA was applied at 6 and 10 hours post-inoculation (hpi). In contrast, BgtActin was almost not silenced when dsRNA was applied at 2 hpi. …”
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Acute kidney injury as a risk factor for atrial fibrillation after coronary artery bypass grafting — effects of sodium-glucose cotransporter-2 inhibitors by L. V. Kremneva, L. A. Arutyunyan, L. I. Gapon, S. N. Suplotov, S. V. Shalaev

“…The number of patients with pAF after CABG was 29,3%, AKI — 16,3%. Post-CABG pAF predictor was postoperative AKI. The use of SGLT-2 inhibitors was associated with a lower incidence of pAF after intervention. …”
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Ruxolitinib stopped before transplantation does not induce cytokine release in myelofibrosis by Sara Villar, Emmanuel Curis, Marie-Hélène Schlageter, Nelly Bosselut, Amandine Charbonnier, Marie-Thérèse Rubio, Pascal Turlure, Hélène Labussière, Jacques-Olivier Bay, Jérome Cornillon, Laure Vincent, Corentin Orvain, Jean-Jacques Kiladjian, David Michonneau, Gérard Socié, Marie Robin

“…At baseline, MF patients without ruxolitinib had increased inflammatory cytokine levels (CD25, REG3A, IL18 and ST2) as compared to MF patients on ruxolitinib. On day 0 and week 1 post-transplantation, levels of these cytokines were similar with and without ruxolitinib. …”
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Liposomal Delivery of a Biotechnological <i>Lavandula angustifolia</i> Miller Extract Rich in Rosmarinic Acid for Topical Herpes Simplex Therapy by Federica Fulgheri, Fabrizio Angius, Matteo Perra, Ilenia Delogu, Silvia Puxeddu, Milen I. Georgiev, Renáta Novotná, Jana Franková, Misia Lobina, Aldo Manzin, Maria Manconi, Maria Letizia Manca

“…Furthermore, these preliminary results highlighted promising antiviral activity against HSV-1 of the obtained formulations, particularly when applied during or post-infection. Overall, these phospholipid vesicles offer a dual therapeutic approach, combining antioxidant, anti-inflammatory, and antiviral effects, positioning them as promising candidates for the treatment of HSV-induced skin lesions and related inflammatory conditions.…”
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Genetic and computational analysis of AKR1C4 gene rs17134592 polymorphism in breast cancer among the Bangladeshi population by Md. Akeruzzaman Shaon, Farzana Ansari, Zimam Mahmud, Sonia Tamanna, Abdullah Al Saba, Rushafi Sikder, Tabassum Howlader, Md. Zakir Hossain Howlader

“…CC + CG) also showed an enhanced risk of susceptibility to breast malignancy (p < 0.0001, OR = 3.25, 95% CI = 1.78 to 6.08). In the subgroup of post-menopausal women, the risk of developing breast cancer was significantly higher for carriers of the GG genotype, with relative risks of 4.02 and 3.92, in the additive model 2 and recessive model, respectively. …”
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Genetics, sex and the use of platelet‐rich plasma influence the development of arthrofibrosis after anterior cruciate ligament reconstruction by Mikel Sánchez, Izarbe Yarza, Cristina Jorquera, Jose María Aznar, Leonor López deDicastillo, Cristina Valente, Renato Andrade, João Espregueira‐Mendes, David Celorrio, Beatriz Aizpurua, Juan Azofra, Diego Delgado

“…The combination of patient and genetic variants of a patient allows the development of a prognostic algorithm for the risk of post‐surgical arthrofibrosis. Level of Evidence level III.…”
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Microenvironment-adaptive nanomedicine MXene promotes flap survival by inhibiting ROS cascade and endothelial pyroptosis by Ningning Yang, Rongrong Hua, Yingying Lai, Peijun Zhu, Jian Ding, Xianhui Ma, Gaoxiang Yu, Yiheng Xia, Chao Liang, Weiyang Gao, Zhouguang Wang, Hongyu Zhang, Liangliang Yang, Kailiang Zhou, Lu Ge

“…This study is the first to confirm MXene's biological effects on the ischaemic microenvironment post-skin flap transplantation. Findings indicated that MXene significantly decreased the necrotic area in ischaemic flaps (37.96% ± 2.00%), with reductions of 30.40% ± 1.86% at 1 mg/mL and 20.19% ± 2.11% at 2 mg/mL in a concentration-dependent manner. …”
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SUMOylation-related genes define prognostic subtypes in stomach adenocarcinoma: integrating single-cell analysis and machine learning analyses by Kaiping Luo, Kaiping Luo, Donghui Xing, Donghui Xing, Xiang He, Yixin Zhai, Yanan Jiang, Hongjie Zhan, Zhigang Zhao

“…BackgroundStomach adenocarcinoma (STAD) exhibits high molecular heterogeneity and poor prognosis, necessitating robust biomarkers for risk stratification. While SUMOylation, a post-translational modification, regulates tumor progression, its prognostic and immunological roles in STAD remain underexplored.MethodsPrognostic SUMOylation-related genes (SRGs) were screened via univariate Cox regression, and patients were stratified into molecular subtypes using unsupervised consensus clustering. …”
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Treatment of Medication-Related Osteonecrosis of the Jaw Without and With the Use of Advanced Platelet-Rich Fibrin: A Retrospective Clinical Study by Paulina Adamska, Marcin Stasiak, Natalia Kobusińska, Michał Bartmański, Adam Zedler, Michał Studniarek

“…The presence of growth factors may enhance healing and reduce post-procedure complications. There are no studies examining the effect of A-PRF on the healing of patients with MRONJ. …”
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Graph theory-based analysis of functional connectivity changes in brain networks underlying cognitive fatigue: An EEG study. by Yabing Lou, Rui Pi, Ruifeng Sun, Jilin Wu, Wei Wang, Ziman Zhu, Tengteng Dai, Weijun Gong

“…<h4>Results</h4>Statistical analysis revealed significant post-fatigue elevations in global average PSD across all examined frequency bands: α (p < 0.001), θ (p < 0.001), and β (p = 0.004). …”
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The Incidence, Associated Factors and in‐Hospital Outcomes of Cardiac‐Surgery‐Associated Acute Kidney Injury Among Children Undergoing Cardiac Surgery at Jakaya Kikwete Cardiac Ins... by Joyce Gimonge, David Muhunzi, Zawadi Edward, Rodrick Kisenge

“…Despite the advances in the care and increased survival of children post‐cardiac surgery, CSA‐AKI is still a big problem with considerable morbidity and mortality in high‐risk children. …”
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Degradation behaviour and damage mechanisms of carbon fibre reinforced polymer composite laminates subjected to laser irradiation by Patrick K. Kamlade, Jojibabu Panta, Max Mammone, Richard (Chunhui) Yang, Richard P. Mildren, John Wang, Matthew Ibrahim, Rodney Thomson, Y.X. Zhang

“…For the 98 W cases, the larger beam diameter required a 53 % longer exposure time to achieve perforation, highlighting the role of power density in damage progression. Post-irradiation analysis using scanning electron microscopy (SEM), ultrasonic C-scans, and micro-focused X-ray computed tomography (micro-CT) revealed fibre sublimation, matrix decomposition, cone-shaped perforations, and interlaminar cracking. …”
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The scopes, outcomes, and limitations of health trials on oral sex practices: a global scoping review by Kafayat Aminu, Timothy Olukunle Aladelusi, Afeez Abolarinwa Salami, Semeeh Akinwale Omoleke, Chiamaka Norah Ezeagu, Julienne Murererehe, Charles Adetokunbo Olomo, Jimoh Amzat, Peace Uwambaye, Akinyele Olumuyiwa Adisa, Kehinde Kazeem Kanmodi

“…Regarding behavioural modifications post-intervention, findings from the review mostly noted modification to sexual behaviours in the intervention groups, signifying intervention efficacy. …”
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Prediction of 90 day mortality in elderly patients with acute HF from e‐health records using artificial intelligence by Joconde Weller, Johann Gutton, Guillaume Hocquet, Leïla Pellet, Marie‐José Aroulanda, Amélie Bruandet, Didier Theis, Fabio Boudis, Romain Cador, Pierre Zweigenbaum, Anne Buronfosse, Pascal deGroote, Michel Komajda

“…This study aimed to construct a model automatically predicting 90 day post‐discharge mortality using electronic health record (EHR) data 48 h after admission and artificial intelligence. …”
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Features of Celiac Disease in children and adolescents with Down syndrome: a single-center experience of annual screening by Martina Lattuada, Paola Rebora, Paola Rebora, Chiara Fossati, Alessandra Lazzerotti, Lucia Paolini, Alessandro Cattoni, Alessandro Cattoni, Roberto Panceri, Maria Grazia Valsecchi, Maria Grazia Valsecchi, Andrea Biondi, Andrea Biondi, Giovanna Zuin

“…Follow-up was 6-, 12- and 24-months post-diagnosis.ResultsThe prevalence of CD in 770 children with DS was 7.5% (95% CI: 5.8%–9.6%). 57 children with CD and DS were compared with 114 CD NS matched controls (total sample size = 171). …”
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A comprehensive analysis of health-related quality of life in thyroid cancer patients using the THYCA-24 questionnaire by Thi Huyen Dinh, Hoang-Bac Nguyen, Thi Bang-Suong Nguyen, Hong Tuan-Nam Pham, Lam Doan-Van, Trung-Thong Luu-Nguyen, Thi Hoe Nguyen, Hoang-Quan Pham, Thi Xuan-Thao Le, Kim-Hai Nguyen

“…No statistically significant difference was observed in overall QoL scores between the pre-operative baseline and the 3-month post-operative assessment across most physical symptoms. …”
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