Brincidofovir is a robust replication inhibitor against African swine fever virus in vivo and in vitro by Shibang Guo, Yibo Zhang, Zhankui Liu, Daozhong Wang, Hui Liu, Liang Li, Qichao Chen, Dan Yang, Qingyun Liu, Huihui Guo, Shuang Mou, Huanchun Chen, Xiangru Wang

“…Time-of-addition assays suggest that the compound interferes with the post-invasion stage of the viral infection cycle. …”
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Intrinsic capacity, functional and psychosocial aspects of older adults participating in a multicomponent physical exercise program by Sarah Giulia Bandeira Felipe, Clarisse Bielh Printes, Fabiane de Oliveira Brauner, Douglas Katusohi Sato, Rafael Reimann Baptista, Rafael Reimann Baptista

“…This study aimed to evaluate the effects of such a program on IC, functional, and psychosocial aspects in older adults.MethodsThis pre- and post-study assessed older adults in Brazil enrolled in a multicomponent training program, evaluating IC as the main outcome using specific tests for each domain. …”
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Syndromic Testing in the Pandemic Era and Beyond: Rapid Detection for Respiratory Infections in Istanbul by Mustafa Onel, Hayriye Kırkoyun Uysal, Arat Hulikyan, Yasemin Ayse Ucar, Gizem Yapar, Aytaj Allahverdiyeva, Serra Zeynep Akkoyunlu, Eray Yurtseven, Mehmet Demirci, Sevim Mese, Ali Agacfidan

“…In light of our findings showing high rates of SARS-CoV-2 and RV/EV detection, along with diverse patterns of coinfection in clinical samples, such comprehensive testing not only assists in rapid diagnosis but also informs public health strategies by reflecting the evolving landscape of respiratory infections in the pandemic and post-pandemic era.…”
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Structural disadvantage and HIV risk – comparing risk factors between trans women’s partnerships with cis men and trans women sexual partners by Erin C. Wilson, Bow Suprasert, Dillon Trujillo, Sofia Sicro, Christopher J. Hernandez, Caitlin M. Turner, Willi McFarland, Sean Arayasirikul

“…Interventions focused on economic stability, workforce development and post incarceration re-entry housing and employment support for trans women and their cisgender men partners may have the most impact on reducing HIV risk and incidence.…”
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Characteristics of second primary malignancies following bispecific antibodies therapy by Dan Liu, Tong Li, Liang Wang, Jia Guo, Xinyu Zhou, Hongsheng Zhou, Xiaojie Liang, Baiwei Luo, Bingyu Lin, WeiXiang Lu, Shengyu Tian, Zihong Cai, Zhihao Jin, Keren Chen

“…TTO and SPM patterns were statistically similar between the two therapies.Conclusion Our study provides the first detailed characterization of SPMs post-BsAb, underscoring the need for continued pharmacovigilance and individualized risk management to mitigate SPM risks in patients undergoing BsAb therapy.…”
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Mapping of the Antinuclear Autoantibodies in Sudanese patients infected with Human Immunodeficiency Virus after HAART receiving: A cross-sectional study by Nooh Mohamed Hajhamed, Salahaldeen Ismail Mohammed, Waleed Abdelateif Hussein, Abdullah M. Bakheit, Nouh Saad Mohamed, Ayman Azhary, Abdallah Elssir Ahmed, Abualgasim Elgaili Abdalla, Abubakar Abdelbagi, Hassan Babieker Said Khalf Allah, Mahjoob Osman Mahjoob Ali, Mohammed Elfatih Hamida

“…This study represent the first investigation in Sudan designed to evaluate and determine the prevalence of Antinuclear autoantibody (ANA) among people living with HIV/AIDS by systematically charaterizing ANA staining patterns; distribution, frequency and their correlation with estimated endpoint titers and interplay of age -sex specific ANA patterns in the context of HIV infection post antiretroviral therapy era. Using Serum samples of one hundred and sixteen (116) HIV-infected patients admitted to two major Voluntary Testing and Counseling (VTC), of the HIV clinical centers at the Military Hospital and Bahri Hospital in Khartoum, Sudan, have been assessed for ANA screening. …”
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Association of sociodemographic factors and television food advertisements with junk food consumption among a sample of adolescents aged 13 to 17 in Magura district, Bangladesh: a... by Shammy Akter, Md. Hasan Al Banna, Justice Kanor Tetteh, Trisha Mallick, Bably Sabina Azhar, Joytun Nahar, Masuma Chowdhury, Addah Graham Gilbert Wilfred, Sumaia Sahrin

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Factors Associated with Efficient Harvesting and Engraftment of Auto-Transplants in Multiple Myeloma Patients by II Kostroma, AA Zhernyakova, ZhV Chubukina, NYu Semenova, IM Zapreeva, SA Tiranova, SS Bessmeltsev, AV Chechetkin, SV Gritsaev

“…All patients received subcutaneous injections of G-CSF in post-transplantation period. Transplant engraftment was assessed according to absolute neutrophil count of ≥ 0.5 × 109/L, and thrombocyte count of ≥ 20 × 109/L. …”
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Microbiota composition-based donor selection affects FMT efficacy in a murine colitis model by Zhongming Dai, Wen Cheng, Huan Peng, Xiaokui Qiu, Jiawen Sun, Xiaoqiang Liu, Xianjiu Sun, Jinwei Cai, Jincui Wang, Guolong Li, Yongling Lv, Shaobo Chen, Zhongying Zhong

“…LEfSe identified 24 genera distinguishing IBD and control mice; post-FMT microbiota of high-abundance donor recipients more closely resembled controls, correlating with therapeutic success.ConclusionFMT ameliorated IBD symptoms in murine models, with therapeutic efficacy associated with the relative abundance of health-associated microbial genera in donor microbiota.…”
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Health related quality of life of tuberculosis patients in South India: A longitudinal assessment study. by Vasantha Mahalingam, Muniyandi Malaisamy, Bella Devaleenal Daniel, Adhin Bhaskar, Lavanya Jayabal, Lakshmi Murali, Bharadhidasan Palani, Kavi Mathiyazhagan, Sai Madhu Yadla, Padmanaban Srinivasan, Ponnuraja Chinnaiyan

“…<h4>Background</h4>In India, there is no information on health related quality of life (HRQoL) of patients with drug sensitive tuberculosis (TB) using a longitudinal design that includes post- treatment period. This study is the first of its kind in India to assess HRQoL of TB patients from a longitudinal prospective and to identify the factors associated with changes in HRQoL.…”
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Chemical and Biological Properties of C-Point Obturation Cones by Marina Angélica Marciano, Paulo Jorge Palma, Ana Cristina Padilha Janini, Brenda Fornazaro Moraes, Thiago Bessa Marconato Antunes, Ribamar Lazanha Lucateli, Bruno Martini Guimarães, Mariza Akemi Matsumoto, Diana Bela Sequeira, Talita Tartari, Brenda Paula Figueiredo Almeida Gomes, Marco Antonio Hungaro Duarte

“…Histological evaluation of inflammatory infiltrate intensity was performed at 30 and 60 days post-implantation, with statistical analysis (significance set at <i>p</i> < 0.05). …”
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Impact of antidote quantity, timing and prehospital strategies in nerve agent mass casualty events: a simulation study by Ruben De Rouck, Mehdi Benhassine, Michel Debacker, Filip Van Utterbeeck, Jan Vaes, Isabell Meskens, Ives Hubloue

“…To address these gaps, this study uses Discrete Event Simulation to evaluate the impact of advanced medical stabilization (AMS) team arrival time, antidote availability, and evacuation policy on patient survival during an urban chemical-traumatic MCI with a subway sarin release scenario.MethodsA validated simulation model (SIMEDIS) was adapted to represent the full prehospital response chain, including triage, antidote administration, AMS, dry decontamination, further on-site stabilization in the forward medical post and transport to categorized hospitals. Two transport policies were modeled: Scoop&amp;Run (rapid transport of victims to hospitals) and Stay&amp;Play (on-site stabilization before transport). …”
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Phosphoglycerate dehydrogenase stabilizes protein kinase C delta type mRNA to promote hepatocellular carcinoma progression by Bin Cheng, Pai Peng, Shi Chen, Rui Liu, Xiaosong Li, Ke Wang, Jing Ma, Kai Wang, Ni Tang, Ailong Huang

“…However, the non-catalytic post-transcriptional regulatory functions of metabolic enzymes in hepatocellular carcinoma (HCC) remain largely unexplored. …”
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Total and subregional thalamic volumes before and after cognitive behavioral therapy in obsessive-compulsive disorder by Vilde Brecke, Anders Lillevik Thorsen, Chaim Huyser, Niels de Joode, Bjarne Hansen, Kristen Hagen, Gerd Kvale, Chris Vriend, Odile A. van den Heuvel, Olga Therese Ousdal

“…Repeated measures ANCOVAs and linear models were used to investigate pre-post changes in total or subregional thalamic volumes and their associations with clinical response. …”
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The Effectiveness of Deep Learning in the Differential Diagnosis of Hemorrhagic Transformation and Contrast Accumulation After Endovascular Thrombectomy in Acute Ischemic Stroke Pa... by Mehmet Beyazal, Merve Solak, Murat Tören, Berkutay Asan, Esat Kaba, Fatma Beyazal Çeliker

“…The study included 556 images of 52 patients (21 female and 31 male) who underwent EVT due to AIS, with hyperdense areas observed in the NCCT examination within the first 24 h post-EVT. The evaluated images were labeled as ‘contrast accumulation’ and ‘hemorrhagic transformation’. …”
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Ischemic Preconditioning Confers Epigenetic Repression of Mtor and Induction of Autophagy Through G9a‐Dependent H3K9 Dimethylation by Olof Gidlöf, Andrea L. Johnstone, Kerstin Bader, Bohdan B. Khomtchouk, Jiaqi J. O'Reilly, Selvi Celik, Derek J. Van Booven, Claes Wahlestedt, Bernhard Metzler, David Erlinge

“…Background Ischemic preconditioning (IPC) protects the heart from prolonged ischemic insult and reperfusion injury through a poorly understood mechanism. Post‐translational modifications of histone residues can confer rapid and drastic switches in gene expression in response to various stimuli, including ischemia. …”
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Ectopic ULBP2 Is Associated with Decreased NKG2D Expression in CD8⁺ T Cells Under T Cell-Modulatory Conditions in a Murine Tumor Model by Yasuhiko Teruya, Kosuke Yamaguchi, Kohei Yamane, Naomi Miyake, Yuji Nakayama, Takafumi Nonaka, Hiroki Chikumi, Akira Yamasaki

“…Tumor growth was uniformly assessed on day 21 post-transplantation, and TIL analysis was performed in groups with evaluable residual tumors. …”
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Protective effect of exercise induced metabolite-3 in ischemia-reperfusion injury by Zijie CHENG, Xuejun WANG, Zimu WANG, Juying QIAN

“…ResultsPlasma levels of EIM-3 were elevated post-exercise. EIM-3 was characterized as a phospholipid small-molecule compound with a partition coefficient (logP) of 5.58 and a solubility (logS) of −7.6, indicating favorable lipophilicity and cell membrane permeability. …”
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Impact of Hemoglobin Glycation Index on Complications Following Orthopedic Surgery: A Retrospective Comparative Propensity Score‐Matched Study by Yuhua Xiao, Bochen Sun, Guoyu Yu, Long Chen, Fenqi Luo, Jie Xu, Jun Luo, Ting Xue, Yiyang Xu

“…ABSTRACT Objective Patients with impaired glucose metabolism have an increased incidence of post‐operative complications. The best marker for glycemic control prior to elective orthopedic surgery remains unclear. …”
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Smoking cessation treatment prior to psychotherapy for patients with diagnosed mental disorders: study protocol for a randomized controlled trial by Esra Teresa Sünkel, Marie Neubert, Alla Machulska, Tim Klucken

“…Attitudes toward online interventions will be measured once at baseline, while all other measures will be assessed before the intervention, post-treatment, and at 6-week and 6-month follow-up sessions. …”
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