Beyond industrial standards: crafting quality bread with heritage wheat in Walloon alternative bread supply chains by Lou Chaussebourg, Florian Baijot, Noémie Maughan, Marjolein Visser, Kevin Maréchal

“…These flours were sourced from six heritage wheat varieties, two variety mixes (one field-based, one post-harvest), and one modern variety bred for organic agriculture, all grown on the same field and milled under the same conditions. …”
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Comparison Of The Effect Of Moderate And High-Intensity Interval Training On Lactate Concentration, Some Inflammatory, And Oxidative Indicators Of Goalball Players by A Abdulelah Abbas Al-Hadeethi, F Taghian, Z Jawad Mohammed Al-Jawad, Kh Jalali Dehkordi

“…Therefore, the present study compared and investigated the effects of eight weeks of moderate and high-intensity interval training on the physiological indicators of goalball players.Methods:24 male goalball players in a semi-experimental study with a pre-test-post-test design randomly divided into three groups, including control, high-intensity interval training (intermittent running for 30 seconds with an intensity of 100-200% of the heart rate reserve (HRR), 30 seconds of active recovery at a speed of 50% HRR), and moderate-intensity interval training (including 25 minutes with an intensity of 40-50% HRR and the last four weeks 30 to 35 minutes with an intensity of 60-65% HRR). …”
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Challenges and lessons learned from a long-term postauthorisation safety study programme of rivaroxaban in Europe by Luis Alberto García Rodríguez, Montse Soriano-Gabarró, Pareen Vora, Yanina Balabanova, Gunnar Brobert, Kiliana Suzart-Woischnik, Ana Ruigomez, Leif Friberg, Ron Herings, Karin M A Swart, Tania Schink, Elisabeth Smits, Annemarie Voss, Christine Tarenz, Martin Homering, Tomasz Dyszynski, Gerd Nagel, Pablo Amaya

“…Objectives To describe opportunities and challenges experienced from the four pharmacoepidemiological database studies included in the rivaroxaban post authorisation safety study (PASS) programme and propose ways to maximise the value of population-based observational research when addressing regulatory requirements.Design PASS programme of rivaroxaban carried out as part of the regulatory postapproval commitment to the European Medicines Agency.Setting Clinical practice in Germany, the Netherlands, Sweden and the UK (electronic health records)—undertaken by pharmacoepidemiology research teams using country-specific databases with different coding structures.Participants 355 152 patients prescribed rivaroxaban and 338 199 patients prescribed vitamin K antagonists.Results Two major challenges that were encountered throughout the lengthy PASS programme were related to: (1) finalising country-tailored study designs before the extent of rivaroxaban uptake was known, and (2) new research questions that arose during the programme (eg, those relating to an evolving prescribing landscape).Recommendations We advocate the following strategies to help address these major challenges (should they arise in any future PASS): conducting studies based on a common data model that enable the same analytical tools to be applied when using different databases; maintaining early, clear, continuous communication with the regulator (including discussing the potential benefit of studying drug use as a precursor to planning a safety study); consideration of adaptive designs whenever uncertainty exists and following an initial period of data collection; and setting milestones for the review of study objectives.…”
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The Impact of Preventive Protocols on Oral Health Outcomes in Cancer Patients Undergoing Chemotherapy or Radiotherapy: A Systematic Review and Meta-Analysis by Carol Moussa, Laurent Estrade, Jeremy Glomet, Gael Y. Rochefort, Frédéric Denis, Maha H. Daou

“…Eligible studies included randomized trials, cohort studies, and pre–post intervention studies evaluating preventive dental care in patients receiving CT or RT. …”
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Effects of helminths and anthelmintic treatment on cardiometabolic diseases and risk factors: A systematic review. by Khanh Pham, Anna Mertelsmann, Keith Mages, Justin R Kingery, Humphrey D Mazigo, Hyasinta Jaka, Fredrick Kalokola, John M Changalucha, Saidi Kapiga, Robert N Peck, Jennifer A Downs

“…Eleven studies examined anthelmintic treatment, of which 9 (82%) reported post-treatment increases in dyslipidemia, metabolic syndrome, and diabetes or glucose levels. …”
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B-cell phenotype and IgD-CD27- memory B cells are affected by TNF-inhibitors and tocilizumab treatment in rheumatoid arthritis. by Rita A Moura, Cláudia Quaresma, Ana R Vieira, Maria J Gonçalves, Joaquim Polido-Pereira, Vasco C Romão, Nádia Martins, Helena Canhão, João E Fonseca

“…TACI, CD95, CD5, HLA-DR and TLR9 expression on B-cells significantly increased after treatment with either TNF-inhibitors and/ or tocilizumab, but no significant changes were observed in BAFF-R, BCMA, CD69, CD86, CXCR5, CD23, CD38 and IgM expression on B-cells when comparing baseline with post-treatment follow-ups. Alterations in B-cell gene expression of BAFF-R, TACI, TLR9, FcγRIIB, BCL-2, BLIMP-1 and β2M were found in ERA and established RA patients, but no significant differences were observed after TNF-inhibitors and tocilizumab treatment when comparing baseline and follow-ups. …”
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The Effect of PNF Stretching and Lower Extremity Strengthening Programs on Knee Joint Range of Before and After Local Fatigue of the Quadriceps Muscle in Male Athletes with Patello... by F Rostamizalani, M Sahebozamani, A.H Daneshjoo, M Zarei

“…Additionally, the exercise program significantly increased the strength of quadriceps muscles (ES=0/65 and P<0/05). The comparison and post-test showed a significant difference (ES=0/75). …”
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The global burden of depression in adolescents and young adults, 1990–2021: systematic analysis of the global burden of disease study by Zhuo Liu, Mengni Kuai

“…Conclusions The burden of depression among young people has risen substantially over the past three decades, with disproportionate impacts on females, post-2000 birth cohorts, and those in high-SDI regions. …”
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Clinical Characteristics and Analysis of Risk Factors Associated with Rhabdomyolysis in Snakebite Victims by Wang FZ, Xiang SH, Lin SQ, Qian FQ, Zhang QX, Geng MH, Deng JX, Wu SC

“…Notably, visitation beyond 6 hours post-bite and hemoglobin levels below 90 mg/dl emerged as independent risk factors for those with RM following snakebites, while female gender and albumin levels > 40 g/L were identified as protective factors against such occurrences.Conclusion: Snakebite victims with RM have more severe clinical conditions, necessitating prolonged treatment duration, and exhibit heightened mortality rates in comparison to those without RM.Keywords: acute kidney injury, clinical features, rhabdomyolysis, risk factors, snakebite…”
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Incidence of thyroid adverse events following immune checkpoint inhibitor treatment in patients with baseline positive thyroid antibodies: a systematic review and meta-analysis by Hui Yu, Qichao Chen, Wenbing Hu, Yuanhao Chen, Hui Ming

“…Meta-analysis was conducted using RevMan 5.4 and Stata 16.0 software, with adherence to PRISMA 2020 guidelines.ResultsA total of 13 studies involving 2,059 patients treated with ICIs for malignancies were included, with 594 cases of thyroid irAEs reported post-treatment. Meta-analysis revealed that the incidence of thyroid irAEs in patients with baseline positive thyroid antibodies was 66.7% (95% CI: 45.1%, 85.5%; Z=7.825, p&lt;0.001). …”
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Effects of Willow Bark (Salix Extract) on Pain and Stress Following Disbudding of Organic Dairy Calves by Madison E. Bacon, Marcia I. Endres, Bradley J. Heins

“…Neither LID nor WB alleviated the pain of calves throughout the post-disbudding period. The results highlighted the need to discover suitable options for pain mitigation of calves in organic livestock production.…”
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Polydopamine/polyvinyl alcohol/graphene oxide transition layer for enhancing adhesive performance of HA coating on Cf/C composites prepared by hydrothermal electrodeposition/hydrot... by Shaoqing Chen, Caiqin Liang, Pengyin Li, Chun Liu, Xierong Zeng, Xinbo Xiong, Xinye Ni

“…To address this, a polydopamine (PDA)-polyvinyl alcohol (PVA)-graphene oxide (GO) transition layer was introduced to reinforce and toughen HA coatings on Cf/C composites (PDA-PVA-GO/Cf/C) via hydrothermal electro-deposition/post-hydrothermal treatment. For comparison, the PDA and PDA/PVA transition layers were also prepared on Cf/C, designated as PDA/Cf/C and PDA-PVA/Cf/C, respectively. …”
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Las TIC como herramientas cognitivas de inclusión en clases de física para estudiantes de enseñanza secundaria by Samuel Sanhueza Haro, Alicia Bravo Escobar, Claudio Faúndez Araya, Eduardo Utreras Cofré

“…La técnica de recolección de información consistió en un pre- y post- de afinidad, aprendizaje significativo y de conocimientos de la disciplina. …”
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Effect of different administration methods of dexamethasone on postoperative pain and swelling following implant flap surgery: A randomized controlled trial of patient-centered out... by Feng He, Panpan Ming, Hong Zhu, Wenqing Zhu

“…Pain and swelling levels were measured and recorded within 72 h post-operation, along with potential influencing factors including gender, age, number of implants, duration of surgery, oral hygiene status, preoperative anxiety level, and pain sensitivity score using Pain Sensitivity Questionnaire (PSQ). …”
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Reliability of arterial spin labeling derived cerebral blood flow in periventricular white matter by Sudipto Dolui, Audrey P. Fan, Moss Y. Zhao, Ilya M. Nasrallah, Greg Zaharchuk, John A. Detre

“…ASL protocols used pseudocontinuous labeling (pCASL) with background-suppressed 3-dimensional readouts, and included both single and multiple post labeling delay (PLD) acquisitions, each acquired twice, with the latter providing both CBF and arterial transit time (ATT) maps. …”
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Unraveling gestational diabetes in Ethiopia: Insights from a cross-sectional study on prevalence and risk factors among Sidama’s pregnant population by Girma Tenkolu Bune

“…Results: The study, comprising 685 participants, attained a 92.4 % response rate, indicating a 16.1 % prevalence of GDM overall and an average post-glucose load level of 0.99 mmole/L. Factors such as living in urban areas (AOR = 1.69, 95 % CI (1.011, 2.82)), being widowed (AOR = 2.23,95 % CI (1.00,5.08)), history of previous abortions (AOR = 2.59,95 %CI(1.50,4.50)), prior caesarean section(AOR = 0.14,95 % CI (0.07,0.27)), gravidity (AOR = 0.77,95 % CI (0.64,0.94)), parity (AOR = 1.93, 95 % CI (1.54, 2.42)), and HIV/AIDS status (AOR = 4.06, 95 % CI (2.18, 7.58)) were independently associated with GDM. …”
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Physiotherapy in improving the interincisal mouth opening in oral submucous fibrosis: Meta-analysis by Ashish Bodhade, Alka Dive, Monal Yuwanati, Amol Gadbail, Dhara Dwivedi

“…Studies evaluating the effectiveness of physiotherapy alone or in combination in improvement of IMO pre-post intervention in OSMF patients were included. …”
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High-intensity interval training modulates thrombotic susceptibility in metabolic syndrome: Attenuation of plasma PAI-1 and fibrinogen via ameliorated metabolic dysfunction by Niyousha Ghazbani, Arezoo Razmdideh, Amin Alimohammadi, Danial Bagherzadeh, Ehsan Rezaee Moeini, Mohammad Reza Mozaffari, Mohammad Sadra Roshani Koosha

“…Fasting plasma PAI-1, fibrinogen, insulin resistance (HOMA-IR), body composition, and lipid profiles were assessed pre/post-intervention. HIIT significantly reduced PAI-1 (−30.7%, p<0.001) and fibrinogen (−21.8%, p<0.001) versus controls. …”
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Negative association between body roundness index and constipation: insights from NHANES by Lingting Chen, Huirong Xiao, Xuchao Yu, Bingbin Huang, Sirong Guo, Ting Yuan, Siyang Deng

“…Subgroup analyses identified significant interaction effects of BRI with age, alcohol consumption status, and hypertension on constipation risk (interaction P < 0.05). Post PSM, constipation patients demonstrated higher BRI levels than non-constipation counterparts (P = 0.013). …”
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Corticosteroid effectiveness among hospitalised COVID-19 patients in Malaysia by Najma Kori, Farida Islahudin, Muhammad Yusuf Zawir Abd Rahim, Petrick Periyasamy, Noraida Mohamed Shah, Ernieda Md Hatah, Lau Chee Lan

“…Methodology: Retrospective data on hospitalised COVID-19 patients were collected for this study, and the primary outcome measure was the patients’ clinical status based on the World Health Organization’s (WHO) Ordinal Scale for Clinical Improvement (OSCI) on Day-5 and Day-10 post-steroid.  Results: The results demonstrated that using steroids significantly improved patients’ clinical outcomes from a WHO OSCI level of 4 (0.1) on Day-1 to 2.6 (2.5) on Day-5 (p < 0.001). …”
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