Decreased Effectiveness of a Novel Opioid Withdrawal Protocol Following the Emergence of Medetomidine as a Fentanyl Adulterant by Kory S. London, Philip Durney, TaReva Warrick-Stone, Karen Alexander, Jennifer L. Kahoud

“…The primary outcome was a change in Clinical Opioid Withdrawal Scale (COWS) score from pre- to post-treatment. Secondary outcomes included rates of discharge against medical advice (AMA) and ICU admission, as well as the impact of a revised treatment protocol. …”
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Geochemistry of Neoproterozoic shales of the Rabanpalli Formation, Bhima Basin, Northern Karnataka, southern India: implications for provenance and paleoredox conditions by Ramasamy Nagarajan, Jayagopal Madhavaraju, Raghavendra Nagendra, John Selvamony Armstrong-Altrin, Jacques Moutte

“…La/Sc, Th/Sc, Th/Co, Th/Cr, and Cr/Th ratios of shales were compared with those of sediments derived from felsic and basic rocks (fine fraction), upper continental crust (UCC) and post-Archean Australian average shale (PAAS) ratios, which reveal that these ratios are within the range of felsic rocks. …”
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Theory-Driven EEG Indexes for Tracking Motor Recovery and Predicting the Effects of Hybridizing tDCS With Mirror Therapy in Stroke Patients by Chia-Lun Liu, Ken-Hsien Su, Yi-Shiung Horng, Chia-Ling Chen, Shou-Hsien Huang, Ching-Yi Wu

“…The EEG indexes used in this study focused on the functional involvement for motor generation: alpha power at temporal regions (inhibiting non-motor activity) and central-frontal regions (releasing motor regions from inhibition). Results showed that post-training benefits, measured by Fugl-Meyer Assessment (FMA), were similar across 3 tDCS interventions (premotor, primary motor, sham). …”
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THE EFFECT OF CORIANDER LEAF EXTRACT TOWARDS KIDNEY HISTOPATHOLOGICAL FEATURES ON WISTAR RAT INDUCED BY ORALLY ADMINISTERED MERCURY by Manda Petrina, Ika Pawitra Miranti, Nani Maharani, Intan Rahmania Eka Dini

“…Objective: To examine the nephroprotective activity of coriander leaf extract towards Wistar rat’s proximal tubules induced with orally administered mercury Methods: : Experimental study with post test only control group design using 20 male Wistar rats divided randomly into 4 groups as samples. …”
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Dynamics of Serum Cytokines During Resection Surgery for Malignant Neoplasms in the Lungs by A. O. Soloviev, V. T. Dolgikh, O. N. Novichkova, N. V. Govorova, O. V. Leonov, O. V. Sokolova

“…In Group II (the comparison group, n=12), a combined general anesthesia including mechanical lung ventilation followed by morphine analgesia was used. 4 study points were determined: prior to induction, and one, 12, and 24 hours post-surgery.Results. 12 hours after surgery completion, the concentration of TNFα in the main group was lesser by 57.1% vs. the comparison group; by the end of the first 24 hours, it fell down by 64.3%. …”
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Effect of Microencapsulated Medium-Chain Fatty Acids, Lignocellulose, and Heat-Killed <i>Lactobacillus plantarum</i> L-137 Supplementation on Lactating Sow Performance, and Nutriti... by Nithat Wichasit, Wandee Tartrakoon, Rangsun Charoensook, Riantong Singanusong, Juan J. Loor, Gaku Shoji, Satoru Onoda, Tossaporn Incharoen

“…Supplements were daily added to the morning meal for 21 days (day 100 of gestation to day 7 post-farrowing). Compared with CON, the S1 and S4 groups had improvements (<i>p</i> < 0.01) in live-born piglet numbers, and colostrum yield. …”
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The first UK case of congenital Zika syndrome by Dominic A Haigh, Lynne Warrander, Philip Bullen, Philip Veal, Christina Petridou

“…Placental histopathology was unremarkable, and post-mortem was declined. Results: A blood sample was tested for Zika virus (ZIKV) at the Rare and Imported Pathogens Laboratory (RIPL), Porton Down; the ZIKV PCR result was indeterminate, and the IgG was positive. …”
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Construction and evaluation of a nomogram prediction model for the risk of epistaxis following nasotracheal intubation: a single-center retrospective cohort study by Jie Chen, Hao Fan, Yuxing Wang, Yuhang Zhu, Ren Zhou, Hua Kang, Hong Jiang

“…Abstract Background and objective Nasotracheal intubation (NTI) is a common procedure in oral and maxillofacial surgery; however, it is associated with a significant risk of post-procedural epistaxis. This study aims to identify risk factors for epistaxis following NTI and develop a nomogram-based prediction model to provide clinicians with a reliable risk assessment tool. …”
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Congenital Anomalies in Neonates: Findings from Six Baghdad Hospitals by Bassam M. Al-Musawi, Ali M. Khalid, Nadin A. Kamal, Maha Z. Muneer

“… Background: Birth defects are the leading cause of both neonatal and post-neonatal deaths, as an estimated 240,000 neonates die in their first month of life worldwide each year. …”
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The effects of kappa opioid agonist RU-1205 on local field potentials and behavior in the discriminative stimulus paradigm by K. Yu. Kalitin, O. Yu. Mukha, A. A. Spasov

“…Electrophysiological changes observed include an increase in power of theta frequencies (4–8 Hz) in F, P and mPFC leads, along with a reduced power of delta frequencies (0.5–4 Hz) in O and Hipp leads, and a suppression of gamma activity (30–50 Hz) in F and mPFC leads, all with statistical significance (p &lt;0.05). Post-administration of RU-1205 resulted in a decreased coherence between pairs of electrodes: P–O, P–F, F–O, and mPFC–Hipp (all p &lt;0.05). …”
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Biomarkers for sarcopenia, muscle mass, muscle strength, and physical performance: an umbrella review by Gaoming Liu, Shide Jiang, Wenqing Xie, Xu Liu, Guang Yang, Wenhao Lu, Hengzhen Li, Zhi Liu, Wenfeng Xiao, Yusheng Li

“…Patients with sarcopenia exhibited elevated interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor-alpha (TNF-α) levels compared to controls, with these markers showing post-intervention improvement. Some metabolic and amino acid biomarkers were found to be lower in patients with sarcopenia than in the control group. …”
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Pedals possible: a pilot study of adaptive cycling as a school-based rehabilitation intervention for students with disabilities by Julia S. Brennan, Everette Keller, Elizabeth Humanitzki, Jessica Nichole Wade, Chad Catledge, Stephen Houston, Jonathan Beall, Cynthia B. Dodds

“…During an eight-week intervention, students had a goal of riding adaptive cycles three times a week for twenty minutes. Using a pre-and post-test design, primary outcomes included individualized goal attainment scaling (GAS) linked to students' individualized education plans (IEP) and the 6-minute cycling test (6MCT) measuring cycling distance. …”
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Green construction as the way to ecologization of the economy and sustainable development of Ukraine by Oksana Drebot, Мariia Vysochanska, Valentyna Bilotil, Oleh Yaremko

“…Besides, the Russian-Ukrainian war has become a real challenge for Ukraine, and caused a number of additional problems: negative impact on the environment, socio-economic damage, damage and destruction of buildings, thousands of civilian and military casualties, the largest flow of refugees in Europe since the Second World War, etc. Given that the post-war recovery and development of Ukraine should be green in order to ensure sustainable development, the principles of green construction become necessary in the transformation of the construction industry. …”
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Posterior Wall Involvement During Pulmonary Vein Isolation Using the Farapulse System by Maria Teresa Izquierdo de Francisco, Josep Navarro‐Manchon, Oscar Cano Perez, Javier Navarrete Navarro, Carmen Arveras Martinez, Fransciso Javier Chorro Gasco, Luis Martinez‐Dolz, Joaquin Osca Asensi

“…We arbitrarily defined a narrow corridor as one that measured < 20 mm of healthy tissue (voltage > 0.5 mV). Results Post‐PVI mapping revealed an unexpected narrow corridor in the posterior wall in 12 (15%) and fusion in 18 (23%) patients. …”
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Comparing GLIM and SGA Nutritional Criteria for Malnutrition Assessment and Prognosis in Chronic Heart Failure Patients by Zhou YQ, He WM, Jing S, Xie YQ, Chen S, Li JN

“…The primary outcome was the occurrence of adverse events (worsening heart failure, readmission, or all-cause mortality) within 90 days post-discharge. Statistical analyses included Cohen’s kappa for agreement, Receiver Operating Characteristic (ROC) curves for predictive value, and multivariate logistic regression to identify independent risk factors for adverse outcomes.Results: The agreement between SGA and GLIM criteria was good (Cohen’s Kappa = 0.8). …”
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A study protocol for a randomized controlled feasibility trial of behavioural therapy for interepisode bipolar symptoms (STABILISE) by Kim Wright, Fiona Warren, Sandra Bucci, Barnaby D. Dunn, Steven Jones, Heather O’Mahen, Rod S. Taylor, Antonieta Medina-Lara

“…Follow up points will be at 14, 30 and 52 weeks post eligibility confirmation, with 30 weeks as the primary end point. …”
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Transcriptomic characterisation of acute myeloid leukemia cell lines bearing the same t(9;11) driver mutation reveals different molecular signatures by Elise Georges, William Ho, Miren Urrutia Iturritza, Lel Eory, Kamila Malysz, Ulduz Sobhiafshar, Alan L. Archibald, Daniel J. Macqueen, Barbara Shih, David Garrick, Douglas Vernimmen

“…Genome-wide studies have identified genes that are commonly mutated in AML, including many epigenetic regulators involved in either DNA methylation (DNMT3A, TET2, IDH1/2) or histone post-translational modifications (ASXL1, EZH2, MLL1). …”
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Enhanced Immunogenicity of Chicken H9N2 Influenza Inactivated Vaccine Through a Novel Dual-Targeting Fusion Protein Strategy by Hai Xu, Bihua Deng, Erzhong Wu, Yalu Zhu, Qiurong Qi, Yaming Feng, Yu Lu

“…For parallel comparison, control groups included H9N2 avian influenza vaccines containing the inactivated virus alone, the inactivated virus with the immune enhancer CVCVA5, and a commercial H9N2 avian influenza inactivated vaccine. Results: At 4 weeks post-immunization, chickens vaccinated with the inactivated H9N2 virus combined with the GRFT-VHH74 fusion protein (1/2 H9+GRFT-VHH74) exhibited significantly enhanced humoral, mucosal, and cellular immune responses compared to those vaccinated with the inactivated H9N2 virus alone or the commercial H9N2 vaccine (<i>p</i> < 0.05). …”
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Tranexamic acid impairs plasmin generation on human mesenchymal stem cells and derived membrane microvesicles, halting pericellular proteolysis by Ramy Abou Rjeily, Christina Mrad, Fatiha Z. El-Ghazouani, Florence Toti, Audrey Cras, Audrey Cras, Eduardo Angles-Cano

“…Our findings provide the first demonstration that TXA efficiently inhibits MSC-driven plasmin generation by competitively blocking plasminogen binding to the uPA•uPAR complex at the cell plasma membrane.DiscussionWe propose that plasmin formation on MSCs may be involved in pathological processes such as endometrial hemorrhage (metrorrhagia and Post-Partum Hemorrhage), autoimmune and ischaemic diseases, as well as cancer. …”
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Testicular extracellular matrix/gelatin-based scaffold using gas foaming to support spermatogonial stem cells by Maryam Momeni, Mohammad Kazemi Ashtiani, Zahra Bashiri, Zohreh Bagher, Hamid Reza Asgari, Morteza Koruji

“…Masson’s trichrome, Alcian blue, and orcein staining were conducted to ensure the maintenance of ECM components post-decellularization. Porous scaffolds were fabricated using gelatin incorporation with various concentrations of extracted ECM via the gas foaming method. …”
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