Inflammatory changes in early dementia with Lewy bodies by Talene A. Yacoubian, Hongwei Qin, Amy Amara, Natividad Stover, Lauren Ruffrage, Yue Zhang, Richard Kennedy, David Geldmacher, Adam Gerstenecker, David G. Standaert, Etty N. Benveniste

“…An extensive number of studies have documented inflammatory changes in Parkinson’s disease (PD), but much less is known about DLB. Post-mortem DLB brains show T-cell infiltration, and flow cytometry and cytokine/chemokine measures in DLB subjects have suggested the presence of inflammatory responses in DLB. …”
Get full text

The Effectivity MultiModality Treatment on Rehabilitation Management of Diabetic Foot Disease Patients for Improvement of Clinical Efficacy & Hemorheological Status by Li S, Liu Y, Chen Y

“…Key outcome measures included: (1) clinical efficacy; (2) hemorheological indicators—whole blood low-shear viscosity (WBLSV), high-shear viscosity (WBHSV), fibrinogen (FIB), and erythrocyte deformability index (EDI); (3) vascular endothelial function indicators—endothelin (ET), basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF), and calcitonin gene-related peptide (CGRP); (4) self-management ability—Adult Health Self-Management Scale (AHSMSRS), General Self-Efficacy Scale (GSES); and (5) nursing satisfaction—Newcastle Nursing Service Satisfaction Scale (NSNS).Results: The intervention group had a significantly higher total treatment efficacy rate (92.06% vs 77.78%, P < 0.05). Post-intervention hemorheological parameters (WBLSV, WBHSV, FIB, EDI) and endothelial markers (ET, bFGF, VEGF, CGRP) showed greater improvement in the intervention group (P < 0.05). …”
Get full text

Exploring the use of physical rehabilitation for sepsis survivors: a scoping review by Michelle E Kho, Bram Rochwerg, Jenna Smith-Turchyn, Christopher Farley, Jordon L Hvizd, Anastasia N L Newman, Heather O’Grady, Sophia Werdens Abram, Neeraja Nannapaneni, Shannon McKenney

“…Future research should report details of intervention parameters and evaluate rehabilitation post-hospital discharge to maximise impact on function and quality of life for sepsis survivors.Registration The protocol was registered on Open Science Framework Registries (Registration DOI: https://doi.org/10.17605/OSF.IO/2EPJ6).…”
Get full text

Evaluation of Antibacterial Activity of Ethanolic Extract of Portulaca Oleracea against Periodontal Pathogens: An In-vitro Study by Mitaj Pandharinath Anvekar, Shruti Virupaxi, Sadanand Kulkarni, Preeti Ingalagi, Ramya Pai, Viplavi Chavan Patil

“…A crude extract from the aerial parts of Portulaca oleracea was prepared by the Soxhlet extraction method using ethanol as a solvent at KAHER’s Shri BM Kankanawadi Ayurveda Mahavidyalaya Post Graduate Studies and Research Centre, Belagavi, Karnataka. …”
Get full text

Análise das urgências odontológicas durante a pandemia da covid-19 by Thiago de Albuquerque e Silva, Maria Ercília de Araújo, Fernanda Campos de Almeida Carrer, Antônio Carlos Frias

“…O ano de 2019 foi o ano de controle (não pandêmico) e 2020-21 os de exposição. Os testes Friedman e Post-Hoc de Durbin-Conover utilizaram nível de significância de 5%. …”
Get full text

Polycyclic Aromatic Hydrocarbons as an Extraterrestrial Atmospheric Technosignature by Dwaipayan Dubey, Ravi Kopparapu, Barbara Ercolano, Karan Molaverdikhani

“…To account for the historical decline in PAH production post the industrial revolution, we explore varying PAH concentrations to assess instrumental capabilities of detecting civilizations resembling modern Earth. …”
Get full text

Effect of disease progression on CSF-directed AAV gene therapy in a large brain animal model of lysosomal storage disease by Jacqueline E. Hunter, Caitlyn M. Molony, Wojciech K. Panek, Charles H. Vite, Sanjeev Chawla, Harish Poptani, John H. Wolfe

“…Significant improvements in clinical parameters were observed, and partial correction was documented pre mortem by non-invasive magnetic resonance spectroscopy and diffusion tensor imaging. Post mortem analysis demonstrated that higher levels of lysosomal alpha-mannosidase activity in animals treated at 12 weeks of age did not translate into increased correction of lysosomal storage lesions throughout the brain when compared with animals treated at earlier time points. …”
Get full text

Gastrointestinal function outcomes following radical and conservative colorectal surgery for deep endometriosis: A systematic review and meta‐analysis by Ezgi Darici, Attila Bokor, Daria Pashkunova, Birgit Senft, Nilüfer Cimşit, Gernot Hudelist

“…Conclusions Segmental resection seems to be associated with higher rates of post‐operative constipation and lower GIQLI scores when compared to conservative surgery. …”
Get full text

Identification of potential pathogenic genes associated with the comorbidity of rheumatoid arthritis and renal fibrosis using bioinformatics and machine learning by Jiao Qiu, Yalin Xu, Luyuan Tong, Xingchun Yang, Xiao Wu

“…The constructed miRNA-TF-mRNA regulatory network provided a comprehensive overview of the post-transcriptional and transcriptional regulatory mechanisms. …”
Get full text

Sejm konny. Rzecz o funkcjonowaniu ideologii demokracji szlacheckiej w dawnej Polsce by Henryk Olszewski

“…W wielu innych przypadkach nazwy poszczególnych sejmów albo wcale nie znajdowały podstawy w zwodach prawa stanowionego, pojawiając się w toku obrad sejmików i sejmów lub w literaturze politycznej, towarzyszącej kampaniom sejmowym, albo uzyskiwały sankcję ustawodawcy dopiero ex post. Wymieńmy tylko niektóre z nich: sejm sprawiedliwości (conventus iustitiae — 1520)1, sejm inkwizycyjny (1592) 2, sejm ratyfikacyjny (1629) 3, sejm abdykacyjny (1668), sejm cere- monialis (1717), sejm correctionis (1733)4, a także sejm egzekucyjny (1562-1563) , sejmy pacyfikacyjne (1589, 1673, 1698 - 1699, sejmy tzw. delegacyjne (1767-1768 i 1773-1775) 5, liczne sejmy exorbitantiarum. …”
Get full text

Active Seizures Predict Worse Instrumental Activities of Daily Living in Individuals With Normal Cognition and Dementia by Ifrah Zawar, Jaideep Kapur, Meghan M. Mattos, Carol Manning, Syeda Amrah Hashmi, Mark Quigg

“…ANOVA compared the rate of longitudinal FAQ decline across seizure groups. Post hoc analyses identified group differences. Results Among 20,486 cognitively normal participants (average age = 69.7 years, female = 65% [N = 13,370]), IADLs were worse among 114 active seizure participants (adjusted‐mean‐difference [95% confidence interval (CI)]: active vs. remote = 0.69 (0.23, 1.14), p = 0.0011, active vs. controls = 0.85 (0.46, 1.24), p < 0.001). …”
Get full text

Effectiveness and immune responses of focused ultrasound ablation for cervical intraepithelial neoplasia by Hongmin Zeng, Maoyu Liu, Linlin Xiao, Xiaoyuan Zhang, Qing Feng, Shufang Chang

“…Purpose To investigate the safety, efficacy, and the immune responses of focused ultrasound in cervical intraepithelial neoplasia (CIN).Methods Patients with biopsy-confirmed CIN were recruited for focused ultrasound treatment and asked to return during 3–6 and 6–12 months post-treatment to receive cervical cytology, high-risk human papilloma virus (HPV) detection, and colposcopy. …”
Get full text

A study of cord blood alkaline phosphatase as a predictor of neonatal hyperbilirubinemia in a tertiary hospital by Vijay Baburao Sonawane, Rajdeep Agarwal, Mariya Maksud, Amit Saxena, Veeranna Kotrashetti

“…During follow-up, hyperbilirubinemia (serum bilirubin >13 mg/dL at 72 h post-birth) was observed in 15 neonates with high ALP levels, compared with only two cases in the low ALP group. …”
Get full text

COMPARISON OF POROSITY PREDICTION FROM SEISMIC DATA IN THE F3 BLOCK, NETHERLANDS USING MACHINE LEARNING by Urip Nurwijayanto Prabowo, Sudarmaji Sudarmaji, Jarot Setyowiyoto, Sismanto Sismanto

“…The data from the F3 block consists of six post-stack seismic lines with an inline spacing of 40 meters and three wells. …”
Get full text

Radiation-induced skin regeneration: A comparative efficacy and safety analysis of alpha, beta, and gamma modalities in murine models by Madyan Ahmed Khalaf, Marwan Noori Mohammed, Baida M. Ahmed, Sahar A. H. Al-Sharqi

“…Following surgical induction of full-thickness wounds (8 mm diameter), irradiation groups received 15 min of exposure at four intervals post-surgery using americium-241 (alpha), strontium-91 (beta), and cesium-137 (gamma). …”
Get full text

Multiscale End-point Screening with Extended Tight-binding Hamiltonians by Xiaohui Wang, Sai Li, Zuoyuan Zhang, Linqiong Qiu, Zhaoxi Sun

“…Methods: We investigated the integration of xTB Hamiltonians (GFN0, GFN1, and GFN2) with post-simulation implicit-solvent models [Poisson−Boltzmann (PB), generalized Born (GB), and the most recent CPCM-X] for end-point free energy calculations. …”
Get full text

Therapeutic Approaches of Viral Gene Silencing by Small Interfering RNA: Strategies to Prevent the Emergence of Antiviral Resistant Escape Mutants by Hara Kang, Yun Ji Ga, Jung Won Kim, Chaeyeon Kim, Se-Hwan Son, Chaeeun Gwak, Jung-Yong Yeh

“…RNA interference (RNAi) was originally regarded as a mechanism of eukaryotic post-transcriptional gene regulation mediated by small interfering RNA (siRNA)-induced sequence-specific RNA degradation. …”
Get full text

Leptin receptor signaling mediates the distinct tendon–bone interface reconstruction in rotator cuff tears and osteoporosis-comorbid rotator cuff tears by Dongxu Zhu, Xinrui Zhu, Yingze Zhang, Xiaohong Huang

“…Conclusions This study demonstrated the role of Lep and Angptl4 in TBI reconstruction, via activating Lepr-mediated Stat3–Sox9 and Stat3–Runx2 signaling pathways, differentially regulating osteogenesis and chondrogenesis, and leading to the distinct clinical outcomes post-ARCR in RCTs and osteoporosis-comorbid RCTs. …”
Get full text

An Application of Deep Learning Models for the Detection of Cocoa Pods at Different Ripening Stages: An Approach with Faster R-CNN and Mask R-CNN by Juan Felipe Restrepo-Arias, María José Montoya-Castaño, María Fernanda Moreno-De La Espriella, John W. Branch-Bedoya

“…The accurate classification of cocoa pod ripeness is critical for optimizing harvest timing, improving post-harvest processing, and ensuring consistent quality in chocolate production. …”
Get full text

Comparison of Hormonal, Inflammatory, Muscle Damage and Oxidative Stress Biomarkers Changes in Response to High-Intensity Interval, Circuit and Concurrent Exercise Bouts by Francisco Javier Martínez-Noguera, Linda H. Chung, Amelia Guadalupe-Grau, Silvia Montoro-García, Pedro E. Alcaraz

“…Purpose: Although chronic resting hormonal changes were traditionally considered to modulate muscle tissue remodeling and growth, our knowledge of exercise on the acute post-exercise hormonal response is limited. Moreover, the type of exercise protocol may trigger different hormonal profiles. …”
Get full text