Managing cancer pain at the end of life with multiple strong opioids: a population-based retrospective cohort study in primary care. by Wei Gao, Martin Gulliford, Michael I Bennett, Fliss E M Murtagh, Irene J Higginson

“…The dip significantly affected the correlation of the complex cases with persistent increasing background opioid prescribing (weighted correlation coefficients pre-, post-Shipman periods: 0.98(95%CI: 0.67-1.00), p = 0.011; 0.14 (95%CI: -0.85 to 0.91), p = 0.85). …”
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Impact of impaired intrinsic capacity on postoperative frailty in elderly patients undergoing colorectal surgery: study protocol for a single-center, prospective, cohort study by Jirun Wang, Shaoqi Tian, Lei Zhang, Jia Liu, Yuefang Liu, Lei Zhu, Peipei Shan, Ping Zhao, Yang Zhao, Youzhuang Zhu, Youzhuang Zhu

“…All assessments will be conducted at predetermined intervals through face-to-face interviews during hospitalization and via telephone follow-up post-discharge.DiscussionThis study aims to clarify the risk of postoperative frailty in older patients with impaired intrinsic capacity. …”
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Computational screening of phytochemicals targeting mutant KRAS in colorectal cancer by Muskan Arooj, Rana Muhammad Mateen, Mohsin Javed, Muhammad Ali, Muhammad Irfan Fareed, Rukhsana Parveen, Ali Bahadur, Shahid Iqbal, Sajid Mahmood, Salah Knani, Fadi Jaber, KK Mujeeb Rahman, Meznah M. Alanazi, Randa A. Althobiti, Ibrahim Jafri, Lamiaa Galal Amin

“…The protein-ligand complex was also subjected to molecular dynamics (MD) simulation. Post simulation analysis, such as RMSD, RMSF, Rg, and no of hydrogen bonds, indicated a stable protein-ligand complex.…”
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Relationship between intraperitoneal volume and intraperitoneal pressure during peritoneal dialysis—a pilot study in adult patients by Fansan Zhu, Laura Rosales Merlo, Lela Tisdale, Maricar Villarama, Jun Yi, Zahin Haq, Xiaoling Wang, Nadja Grobe, Karsten Fischer, Kulwinder Plahey, Richard A. Lasher, Paul Chamney, Brigitte Schiller, Peter Kotanko

“…The density (ρ) of the PD dialysate was measured using a meter, and the creatinine and glucose concentrations in both dialysate (D) and serum (P) were measured pre‐ and post‐PD dwell. A physical model (IPP = ρ × g × h), was used to describe the relationship between IPP and IPV, where h is the apparent dialysate height and g is the gravitational acceleration. …”
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Tyrosine 67 Phosphorylation Controls Respiration and Limits the Apoptotic Functions of Cytochrome <i>c</i> by Junmei Wan, Paul T. Morse, Matthew P. Zurek, Alice A. Turner, Asmita Vaishnav, Arthur R. Salomon, Brian F. P. Edwards, Tasnim Arroum, Maik Hüttemann

“…Cytochrome <i>c</i> (Cyt<i>c</i>) is a multifunctional protein, essential for respiration and intrinsic apoptosis. Post-translational modifications of Cyt<i>c</i> have been linked to physiological and pathophysiologic conditions, including cancer. …”
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Treatment of Radiation Lesions with Mesenchymal Stem Cells by Já. Lakota

“…The aim of the work is to introduce a new method of post-radiation treatment – the use of allogeneic mesenchymal stem cells (MSCs).   …”
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A Constraint on Superheavy Elements of the GRB–Kilonova AT 2023vfi by Zhengyan Liu, Ji-an Jiang, Wen Zhao

“…We find that the temporal evolution of AT 2023vfi is similar to AT 2017gfo in the first week post-burst. Additionally, the r -process nuclide abundances of lanthanide-rich ejecta, derived from numerical relativity simulations of BNS mergers, can also successfully interpret the temporal evolution of the KN with the lanthanide-rich ejecta mass of 0.02 M _⊙ , which is consistent with the mass range of dynamical ejecta from numerical simulations in the literature. …”
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Benefits of Kombucha Consumption: A Systematic Review of Clinical Trials Focused on Microbiota and Metabolic Health by Gabriela Macedo Fraiz, Dandara Baia Bonifácio, Rayanne Santos de Paulo, Carolynne Martins Teixeira, Hércia Stampini Duarte Martino, Frederico Augusto Ribeiro de Barros, Fermín I. Milagro, Josefina Bressan

“…Results: Eight clinical trials were included (two pre- and post-interventions and six randomized controlled trials) with durations ranging from 10 days to 10 weeks. …”
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Evaluating breast cancer screening performance without registries using medico-administrative data by Emilien Jemelen, Francisco Orchard, William Madie, Bernard Valentin, Josine Belin, Enora Laas, Guillaume Jeannerod, Pierre Mares, Sandrine Katsahian, Agathe Guilloux

“…Women were followed for 24 months post-screening. Screen-detected cancers and those identified with the SNDS were included. …”
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Clinical and genetic characteristics of type 3 lissencephaly caused by a mutation in the TUBA1A gene (OMIM: 611603) by D. M. Guseva, T. V. Markova, L. A. Bessonova, S. S. Nikitin, E. L. Dadali, O. A. Shchagina

“…Lissencephaly (LIS) is a spectrum of malformations of the cerebral cortex that occur as a result of impaired migration of neuronal precursors to the cortical plate and the formation of furrows and convolutions in the post‑migration period of embryonic development. In recent years, a significant role of hereditary factors in the occurrence of LIS has been shown due to the improvement of methods of molecular genetic diagnostics. …”
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Socio-demographic correlates of health behaviors of children and adolescents during the COVID-19 pandemic: a cross-sectional study by Viviane Richard, Elsa Lorthe, Roxane Dumont, Andrea Loizeau, Hélène Baysson, María-Eugenia Zaballa, Julien Lamour, Rémy P. Barbe, Klara M. Posfay-Barbe, Idris Guessous, Silvia Stringhini, SEROCoV-KIDS study group

“…Continuous monitoring and targeted interventions are crucial to promoting healthy lifestyles among youth in the post-pandemic period.…”
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Additive friction stir deposition vs. friction surfacing: Comparison of friction stir-based approaches for groove repair of high strength aluminum alloys by Zina Kallien, Victor A. Rojas, Pietro Aspes, Adam N. Swinney, Trevor J. Fleck, J. Brian Jordon, Paul G. Allison, Benjamin Klusemann

“…The AFSD deposits present a sound metallurgical bonding, whereas the FS repair presents some unbonded regions; however, this is significantly improved when hybrid friction diffusion bonding (HFDB) is applied as post-processing technique to the FS deposit. A homogeneous average grain size is obtained in the AFSD deposits, whereas FS deposits present slight variations along layer thickness. …”
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Effect of Ultrasound Combined with Dry Needling on Myofascial Pain in the Upper Trapezius : a Controlled Randomised Study by Rahmat Nugraha, Rahmatika Rahmatika, Sudaryanto Sudaryanto, Hasbiah Hasbiah, Tiar Erawan

“…This type of research is a quasi-experiment with a randomized pre-test-post-test control group design that uses 2 sample groups, where the treatment group is given Ultrasound Therapy and Dry needling intervention, and the control group is given Dry needling intervention only. …”
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The risk of venous thromboembolism in adult patients with diffuse glioma: a nationwide population-based study by Frederik R. Hovman, Frantz R. Poulsen, Steinbjørn Hansen, Rikke H. Dahlrot

“…Increasing age (HR 1.03, 95%CI 1.01–1.04), male sex (HR 1.47, 95%CI 1.09–1.99), poor performance status (HR 1.57, 95%CI 1.10–2.25), and post-operative long-course radiochemotherapy (HR 2.10, 95%CI 1.19–3.72) were predictors of VTE in patients with glioma WHO grade 4. …”
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Impact of the COVID-19 pandemic on the mental and physical health of Indian working women: A cross-sectional study of District Rajkot, Gujarat by Thakur Dev PANDEY, Jyoti PATHAK

“…Results: Pre-COVID-19 data indicated stable employment rates across the talukas, with significant portions facing financial strain and mental health issues. Post-COVID-19 data revealed a substantial increase in unemployment, challenges, and the need for psychological counseling. …”
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Randomized clinical trial of thrice-weekly 4-month moxifloxacin or gatifloxacin containing regimens in the treatment of new sputum positive pulmonary tuberculosis patients. by Mohideen S Jawahar, Vaithilingam V Banurekha, Chinnampedu N Paramasivan, Fathima Rahman, Rajeswari Ramachandran, Perumal Venkatesan, Rani Balasubramanian, Nagamiah Selvakumar, Chinnaiyan Ponnuraja, Allaudeen S Iliayas, Navaneethapandian P Gangadevi, Balambal Raman, Dhanaraj Baskaran, Santhanakrishnan R Kumar, Marimuthu M Kumar, Victor Mohan, Sudha Ganapathy, Vanaja Kumar, Geetha Shanmugam, Niruparani Charles, Murugesan R Sakthivel, Kannivelu Jagannath, Chockalingam Chandrasekar, Ramavaram T Parthasarathy, Paranji R Narayanan

“…Clinical and bacteriological assessments were done monthly during treatment and for 24 months post-treatment. The Data and Safety Monitoring Board recommended termination of the trial due to high TB recurrence rates in the G and M regimens.…”
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Characterisation of morbidity in a COPD hospital cohort by A. Duarte-de-Araújo, P. Teixeira, V. Hespanhol, J. Correia-de-Sousa

“…Frequent acute exacerbations were reported by 38.0% of patients. The mean post-bronchodilator FEV1 was 53.2%. The distribution of patients according to GOLD 2017 stage and classification was respectively 9.9%, 41.9%, 35.0% and 13.2% from 1 to 4 and 23.1%, 39.6%, 2.3% and 35.0% from GOLD A to D. …”
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Patients Prefer Being Offered a Mirror to See Their Cervix and External Genitalia During Well-Exams while Clinician Perceptions May Create Barriers to Offering a Mirror: A Mixed Me... by Luci Olewinski, Stephanie Hartmann, Savannah McKenzie, Shannon Lewis, Grace Saxon, Robert Eric Heidel, Fatima Ahmed

“…Patients took a presurvey, were offered a mirror to see their external genitalia and/or their cervix during the exam, and then took a post-survey. The clinician portion was a mixed-methods survey given at the initiation of the study and after the four-month patient survey period. …”
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Influences of Diet Quality, Nursery‐Habitat Complexity and Sex on Brain Development and Cognitive Performance of Brown Trout (Salmo trutta L.) by J. Peter Koene, Libor Závorka, Matthias Pilecky, Kathryn R. Elmer, Colin E. Adams

“…Brown trout were raised from egg for 7 months post‐hatch on either a high (8.91%) or low (1.79%) n‐3 LC‐PUFA diet; for the final 3 months, trout were further divided into complex (heavily ornamented tanks with small, dynamic, populations) or simple habitats (bare tanks with many, constant, inhabitants). …”
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Early experience with percutaneous photodynamic nails for sacral metastatic disease and insufficiency fractures: a retrospective cohort analysis of functionality and pain relief by Marilee J. Clunk, Marcos R. Gonzalez, Sonia E. Ubong, Alisha Sodhi, Joseph O. Werenski, Hayley M. Denwood, Daniel G. Tobert, Santiago A. Lozano-Calderon

“…Primary outcomes included post-operative complications, pain relief, opioid consumption, and function. …”
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