Ultrasmall nanoparticles for co-delivery of antisense oligonucleotides targeting miR-21 and miR-210 to treat glioblastoma by Ravi Raj Singh, Ritu Kulshreshtha, Amirali Popat

“…With the current strategy, we report significant cellular uptake of microRNAs in the 2D cellular model (LN229 cells) 1 h post-transfection as well as significant penetration of oligonucleotides deep within the hypoxic core of 3D GBM spheroids. …”
Get full text

Multifaceted health coaching intervention for cardiovascular risk prevention – exploratory qualitative study of Chinese clients' perspectives by Xue Yang, Gengcong Qu, Lawrence Luk, Phoenix K. H. Mo, Benjamin H. K. Yip, Samuel Y. S. Wong, Carmen K. M. Wong

“…Methods Eighteen participants were recruited from the We WATCH project, a health coaching program for cardiovascular disease prevention in middle-aged adults (35–59 years) at post-program. Purposive sampling was used regarding gender, age and lifestyle domains. …”
Get full text

Provision of long‐acting reversible contraception at surgical abortion—A cross‐sectional nationwide register study by Sara Hogmark, Niklas Envall, Anna Wikman, Charlotte Skoglund, Helena Kopp Kallner, Susanne Hesselman

“…In the study population, 2624/6251 (42.0%) patients had a pre‐ or post‐abortion psychiatric disorder, a factor associated with an increased likelihood of LARC provision compared with women with no such disorders (adjusted odds ratio 1.21; 95% CI 1.08–1.34). …”
Get full text

Treatment outcomes of pulpotomy versus pulpectomy in vital primary molars diagnosed with symptomatic irreversible pulpitis: protocol for a non-inferiority randomised controlled tri... by Nebu Philip, Joe Mathew Cherian, Mebin George Mathew, Abi M. Thomas, Sunaina Jodhka, Nino John, Bharat Suneja, Mandeep Duggal

“…The secondary outcome evaluated will be the immediate (24 h and 7 d) post-operative pain relief afforded by the two treatment interventions. …”
Get full text

Isolation and Genomic Analysis of <i>Escherichia coli</i> Phage AUBRB02: Implications for Phage Therapy in Lebanon by Tasnime A. Abdo Ahmad, Samar A. El Houjeiry, Antoine Abou Fayad, Souha S. Kanj, Ghassan M. Matar, Esber S. Saba

“…Treatment with AUBRB02 significantly reduced post-formation <i>E. coli</i> biofilms, as indicated by lower OD values compared with the positive control. …”
Get full text

Interpretable machine learning for early predicting the risk of ventilator-associated pneumonia in ischemic stroke patients in the intensive care unit by Heshan Cao, Junying Wei, Ping Hua, Songran Yang, Songran Yang

“…The primary outcome was the incidence of VAP post-ICU admission. The Boruta algorithm was used to select features prior to developing 10 ML models. …”
Get full text

Intralobar pulmonary sequestration combined with pulmonary mucoepidermoid carcinoma in an adolescent: A case report by Brooklynne A.S. Dilley-Maltenfort, John Roebel, Todd Boyd, Rachael Courtney, Daniel Evans, Anne Mackow

“…A chest computerized tomography (CT) revealed a 2.7-cm non-calcified mass in the left lower lobe with post-obstructive changes. He was admitted to our institution with worsening symptoms but improved on IV antibiotics and was discharged home shortly thereafter. …”
Get full text

Exploring the Landscape of Operating Room Scheduling: A Bibliometric Analysis of Recent Advancements and Future Prospects by Md Al Amin, Majed Hadid, Adel Elomri, Rabah Ismaen, Ismail Dergaa, Hind Alashi, Amal Jobran Al-Hajaji, Moustafa Alkhalil, Omar M Aboumarzouk, Abdelfatteh EL Omri

“…Results: ORS publications steadily rose, notably post-2013, led by developed nations like the UK, Australia, the US, France, and Germany. …”
Get full text

Effect of sodium-glucose co-transporter 2 inhibitor on contrast-induced acute kidney injury and prognosis in type 2 diabetes patients undergoing percutaneous coronary intervention by Shicheng Yang, Huifang Hao, Xiufeng Zhai, Peng Zhang, Naikuan Fu

“…Renal function was assessed before PCI, 48 h, and 1 week post-PCI, measuring serum creatinine, estimated glomerular filtration rate, cystatin C, and neutrophil gelatinase-associated lipocalin. …”
Get full text

Comparison of the effects of zoledronic acid versus denosumab on bone metabolism, inflammatory response, and immunoglobulins in breast cancer patients with bone metastases by Zhang Xian, Tong Jinfeng, Wang Zhi, Yang Hailong, Shi Pei

“…No significant difference was observed in post-treatment BMD between the two groups (P > 0.05). …”
Get full text

The Impact of Palliative and End-of-Life Care Educational Intervention in Emergency Departments in Singapore: An Interrupted Time Series Analysis by Rakhee Yash Pal, Mui Teng Chua, Liang Guo, Ranjeev Kumar, Luming Shi, Win Sen Kuan

“…The study had three phases: Phase 1—5 pre-intervention surveys, Phase 2—intervention with an online training course, and Phase 3—5 post-intervention surveys. The impact of the intervention was scored based on staff perceptions of end-of-life care in 3 domains: 1. …”
Get full text

The effect of mobile application-based education on illness perception in patients undergoing percutaneous coronary intervention: a randomized controlled trial by Khatereh Salavati, Nahid Rejeh, Farhad Rohani

“…Abstract Introduction Illness perception (IP) significantly influences recovery and self-care in patients undergoing percutaneous coronary intervention (PCI), particularly in managing post-intervention complications. Although effective education is acknowledged as a way to enhance IP, using novel technologies such as mobile apps in this area has received less attention. …”
Get full text

Ex vivo Liver Autotransplantation for Alveolar Echinococcosis with Brain and Lung Metastases: A Case Report by Abdikarimov A, Shayakhmetov Y, Kalina V, Saberbekov S, Ilyassov N, Nurgaliev E, Omarov Y

“…Empirical antibiotic therapy was initiated as follows: meropenem 1000 mg three times a day for 10 days, omeprazole 40 mg once a day for 14 days, anticoagulant therapy was not administered in the first post-operation day due to high risk of bleeding. …”
Get full text

Critical care nurses role and scope of practice during a global crisis: a qualitative study by Ina Thon Aamodt, Dag-Gunnar Stubberud, Anne Eikeland, Kristin Westgaard Sunde, Frigg Johanne Jahren Petersen, Sandra Karoliussen Hammer, Kristin Halvorsen

Get full text

Impact of Nasopharyngeal FilmArray Respiratory Panel Results on Antimicrobial Decisions in Hospitalized Patients by Kenneth K. Sakata, Natalya Azadeh, Anjuli Brighton, M’hamed Temkit, Christine L. Klassen, Thomas E. Grys, Holenarasipur R. Vikram

“…The inpatient records were reviewed 48 hours after the NP-FARP for the following data: demographic information; NP-FARP, serum procalcitonin, and methicillin-resistant Staphylococcus aureus nasal swab (MRSA NS) results; antibiotics prior and post-48 hours of the NP-FARP result; and the current immunosuppression status. …”
Get full text

Predicting exploratory thoracotomy in non-small cell lung cancer: a computed tomography based nomogram approach by Fuqiang Dai, Chengyi Mao, Guangkuo Guo, Longyong Mei, Yonggeng Feng, Zipeng Hao, Xintian Wang, Letian Zhang, Bo Deng

“…Conclusion CT imaging at the critical slice post-neoadjuvant therapy is crucial for predicting the risk of exploratory thoracotomy and postoperative survival in patients with central NSCLC.…”
Get full text

Spine Fractures in Ankylosing Spondylitis Patients: Analysis of Fracture Pattern, Clinical, and Radiological Outcome: A Retrospective Observational Study by Shreya P Shenoy, Delhibabu B Thamba, Subhadeep Ghosh, CS Vishnu Prasath, V Venkatasujith

“…Injury mechanism, method of diagnosis, the location and the type of the fracture, neurological status pre and postoperatively (post-op), and management and clinical outcome were studied. …”
Get full text

Allelic Variants of NRF2 and TLR9 Genes in Critical Illness by A. G. Chumachenko, A. E. Myazin, A. N. Kuzovlev, A. M. Gaponov, A. V. Tutelyan, L. N. Porokhovnik, A. M. Golubev, V. M. Pisarev

“…Materials and methods. DNA from 86 post#operative patients and oncologic patients was genotyped in an allelespecific fashion using tetra#primer polymerase chain reaction followed by gel electrophoresis analysis of products.Results. …”
Get full text

Investigating the effect of mindfulness-based art therapy on self-efficacy of multiparous and nulliparous women: A randomized controlled trial by Ashraf Beirami, Zahra Rahemi

“…Results: The mean self-efficacy scores for expectations during the active stage of labor immediately after the intervention were 162.07±11.28 (nulliparous), 163.07±12.02 (multiparous), and 145.77±27.50 (control group). Four weeks post-intervention, the scores were 162.07±11.98 (nulliparous), 163.07±12.02 (multiparous), and 145.77±27.50 (control group). …”
Get full text

Deproteinization with Papain enzyme improves the bonding performance of self-etch adhesives to eroded dentin by Pharsiri Sirirangsee, Junji Tagami, Kittisak Sanon, Raju Botta, Thitaphat Ngernsutivorakul, Citra Kusumasari, Noriko Hiraishi, Yasushi Shimada, Pasiree Thongthai

“…Statistical analysis was performed using three-way ANOVA with Tukey’s post hoc tests, and t-tests (p < 0.05). Pretreatment with papain enzyme slightly increased the initial µTBS of SEB, while significantly increasing the initial µTBS of UBQ (p < 0.05). …”
Get full text