Developing a new cleavable crosslinker reagent for in-cell crosslinking by Fränze Müller, Bogdan R. Brutiu, Iakovos Saridakis, Thomas Leischner, Micha J. Birklbauer, Manuel Matzinger, Mathias Madalinski, Thomas Lendl, Saad Shaaban, Viktoria Dorfer, Nuno Maulide, Karl Mechtler

“…Crosslinkers which are amenable to post-linking backbone cleavage simplify peptide identification, aid in 3D structure determination and enable system-wide studies of protein-protein interactions (PPIs) in cellular environments. …”
Get full text

The Enhancement of Immunity Gained from Feline Trivalent Vaccines in Mice Using Feline IL-15, IL-23 and Metabolic Regulatory Molecules by Ruichen Gao, Wei Sun, Danning Zhang, Linhan Zhang, Dafang He, Mengxi Li, Yi Wei, Junjie Peng, Gang Wang

“…The results showed that Group A had significantly higher neutralizing antibody titers against calicivirus post-booster immunization, while both Groups A and B exhibited enhanced antibody responses against the herpesvirus and panleukopenia viruses. …”
Get full text

COVID-19 pandemic impact on antibiotics sensitivity of E. coli and K. pneumoniae from urine specimens: a retrospective study by Mohammad A Abu Lubad, Munir A Abu-Helalah, Tahany S Al-Hajaia, Kholoud A Al-Hutaibat, Amin A Aqel, Hamed Alzoubi

“…Our results highlight the need for revising and updating the antimicrobial stewardship programs post-COVID pandemic utilizing local data. …”
Get full text

Macají Lourdes by Christiam Aguirre-Merino, Edison Chango-Agama, Fausto Sarmiento, Jorge Córdova-Lliquín, Ángel Caizaguano-Buñay, Lady Parra-Ordonez, José Herrera

“… El artículo presenta los primeros resultados de las investigaciones realizadas en el sitio Macají Lourdes (Riobamba, Chimborazo), discutiendo para ello las características del registro arqueológico, la materialidad cultural, los datos cronológicos y los procesos post-deposicionales que lo perturbaron. La evidencia recuperada mediante una prospección arqueológica que incluyó reconocimientos superficiales, apertura de pruebas de pala y una exploración estratigráfica con cuatro unidades de excavación (3 m x 1 m), reveló la existencia de un sitio arqueológico en la Unidad 01. …”
Get full text

Machine Learning-Driven Optimization of Machining Parameters Optimization for Cutting Forces and Surface Roughness in Micro-Milling of AlSi10Mg Produced by Powder Bed Fusion Additi... by Zihni Alp Cevik, Koray Ozsoy, Ali Ercetin, Gencay Sariisik

“…Although additive manufacturing enables complex geometries and minimizes material waste, challenges remain in reducing surface roughness and cutting forces during post-processing. Micro-milling experiments were conducted using spindle speeds up to 60,000 rpm, with varied feed rates and cutting depths. …”
Get full text

Latissimus dorsi muscle for functional reconstruction surgery of the triceps surae following soft tissue sarcoma resection by Daniela Kristina Carolino, Keiichi Muramatsu, Yasuhiro Tani, Masaya Ueda

“…Neurovascular anastomoses of the subscapular artery with the posterior tibial artery, thoracodorsal vein with the comitant vein, and thoracodorsal nerve with the tibial motor nerve branch was completed using a microscope. Seven years post-surgery, there is no evidence of local recurrence of metastasis. …”
Get full text

Cyber Security Awareness on Social Media: Knowledge Sharing Among Orang Asli Students by Palaniappan Shamala, Muruga Chinniah, Shamsatun Nahar binti Ahmad, Lee Chang Kerk, Abd Malik Mohd Rick

“…In each phase, sets of questionnaires with pre and post-tests were distributed to assess the program’s impact. …”
Get full text

Identifying Causal Risk Factors for Violence among Discharged Patients. by Jeremy W Coid, Constantinos Kallis, Constantinos Kallis, Mike Doyle, Jenny Shaw, Simone Ullrich

“…Measures were taken at baseline (pre-discharge), 6 and 12 months post-discharge using the Historical, Clinical and Risk-20 items version 3 (HCR-20v3) and Structural Assessment of Protective Factors (SAPROF). …”
Get full text

Improving soybean (Glycine max (L.) Merr.) growth and soil health with Gyttja biochar: insights into plant biochemical attributes and soil chemical properties by Vedat Beyyavaş

“…., chlorophyll index, stomatal conductance, proline, malondialdehyde contents, and antioxidant enzyme activity) were analyzed. Post-harvest soil samples were analyzed for chemical properties including pH, electrical conductivity, and activities of catalase, urease, and dehydrogenase enzymes. …”
Get full text

Clinical Sports Medicine by Wilhelm A, 4, Herbsleb M, Dittmar C, Rüdrich P, Schürer A, Wüstenfeld J, 5, Kastner T, 5, Wolfarth B, 4, 5

“…BLC obtained from both settings were compared at given HR, obtained from each of the four loops during PFR.Results: A two-way 4 x 2 repeated measures analysis of variance (ANOVA) showed a statistically significant main effect of stage (p< .001) and test protocol (p< .001), as well as a significant interaction effect between these two factors (p<.001). Post-hoc calculated paired-samples t-test showed significantly lower BLC from ITR compared to that obtained from PFR at any loop/HR level. …”
Get full text

The Learning Curve for Laparoscopic Sacrocolpopexy Based on Dissection Skills if Structured Teaching and Standardized Surgery are Applied by Studer AM, Krebs J, Brambs C, Christmann-Schmid C

“…A high subjective and objective success rate was reported post-operatively. Differences in overall time were clearly correlated with overall dissection time.Conclusion: We demonstrated that a stepwise, structured, and standardized intraoperative surgical program facilitated safe and efficient laparoscopic SCP performance in the analyzed situation. …”
Get full text

Temporal dynamics of chicken host’s molecular response against Fowl adenovirus serotype 8b infection via RNA-sequencing by Bahiyah Azli, Nur Farhana Salim, Mohd Hair-Bejo, Abdul Rahman Omar, Norfitriah Mohamed Sohaimi, Ugwu Chidozie Clifford, Nor Asilah Wati Abdul Hamid, Nurulfiza Mat Isa

“…Results The harvested chicken livers were subjected to biological pooling and transcriptomic profiling via RNA-sequencing, according to the days of post-infections (dpi). A total of 21,662 genes were identified in both control and infected groups, enriched in various biological processes and pathways, displaying patterns of disease progressions. …”
Get full text

Investigation of potential relationship between glucagon-like peptide 1 receptor agonists with suicide/self-injury: disproportionality analysis using WHO-VigiBase by Ye Young Kim, Ju Hwan Kim, Ju-Young Shin

“…Conclusion Given the differences in results by indication, this study highlights the need for post-marketing surveillance of the suicide/self-injury risk in non-T2DM populations using GLP-1 RAs for simple weight loss.…”
Get full text

Effects of Forced Exercise on Withdrawal Syndrome, Brain Hippocampus Neurons Count and Level of Serum Corticosterone in Morphine Addicted Male Rats by Alireza Sarkaki, Maryam Mohammadian, Marzieh Panahi, Akram Ahangarpour, Fakher Rahim

“…The data were analyzed with one-way ANOVA that followed by LSD post hoc test. The differences between groups were accepted as significant with P value less than 0.05.Results: Addiction to morphine increased withdrawal signs and corticostrone secretion significantly and reduced hipocampal neurons in brain, All off which were significant. …”
Get full text

Stakeholder engagement in European research and innovation: An investigation into how and why EU R&I projects develop engagement tools [version 1; peer review: 2 approved, 1 approv... by Luka Gudek, Jacqueline Broerse, Madhura Rao

“…Results Tools developed within projects take up shape within distinct phases, denominated as Purpose, Prototyping, Praxis, and Post-project continuity. Each of these phases comes with distinct challenges and opportunities. …”
Get full text

Efficacy of Cannabis Oil in Improving Subjective Sleep Quality in Systemic Sclerosis: A Prospective Placebo-Controlled Study by Apichart So-ngern, Bungon Sripanichkulchai, Ajanee Mahakkanukrauh, Siraphop Suwannaroj, Patnarin Pongkulkiat, Tippawan Onchan, Somdej Kanokmedhakul, Chingching Foocharoen

“…The mean difference in PSQI scores decreased more in the treatment group than in the placebo group from baseline to post-treatment, but this difference was not statistically significant (<i>p</i> = 0.09). …”
Get full text

Circulating chemokines and leukocytes and their impact on breast cancer prognosis by Rogério Agenor de Araújo, Felipe Andrés Cordero da Luz, Eduarda da Costa Marinho, Camila Piqui Nascimento, Ana Cristina Araújo Lemos da Silva, Maria Luíza Gonçalves dos Reis Monteiro, Marcelo José Barbosa Silva

“…NLR was prognostic during follow-up, with lower OS observed in patients with NLR > 3 at 12 months post-diagnosis. Significant correlations were identified among 8 CC/CXC chemokines. …”
Get full text

Evaluation of the infectivity of three porcine reproductive and respiratory syndrome virus (PRRSV) variants by Claudio Marcello Melini, Mariana Kikuti, Montserrat Torremorell, Kimberly VanderWaal, Stephanie Rossow, Jerry Torrison, Cesar A. Corzo

“…Blood, rectal, and nasal swabs were collected at different time points up to 28 days post-inoculation (dpi) and tested via RT-PCR. Two animals per group were euthanized on 11 dpi and tissue samples were assessed by histopathology. …”
Get full text

Cohort study on Medical-Integrated holistic nursing’s impact on intensive care unit patients’ outcomes, complications, and comprehensive health care by Fang Cao

“…The key outcomes measured included mortality within 28 days, ICU length of stay, hospital infection rate, incidence of adverse reactions, quality of life at 3 months post-discharge, rate of re-admission to the ICU, and the difference of collaboration scores involving the two groupings.Within 28 days, the RG showed significantly lower mortality than the CG (10.00% vs. 23.00%; χ²=6.133, P < 0.05) and shorter ICU stays (t = 4.026, P < 0.05). …”
Get full text

Evaluation of intradialytic hypoxemia development in intensive care patients by Uğur Uzun, Sibel Ersan, Işıl Köse Güldoğan, Aykut Sarıtaş, Nimet Şenoğlu

“…Patients’ arterial and central venous blood gas values were measured before dialysis (baseline), at the third hour of dialysis (3rd hour), and one-hour post-dialysis (5th hour). The study evaluated PaO₂, partial pressure of carbon dioxide (PaCO₂), central venous oxygen saturation (ScvO₂), mean arterial pressure (MAP), perfusion index (PI) and the temperature gradient between the forearm and fingertip. …”
Get full text