Polymerized laminin-modified microcapsules improve pancreatic islet resilience towards cytokine induced inflammatory stress and lower chemoattractant cytokine secretion by Isaura Beatriz Borges Silva, Theo Borghuis, Tian Qin, Mari Cleide Sogayar, Paul de Vos

“…This study explores modifying the intracapsular environment with extracellular matrix (ECM) molecules – chondroitin sulfate (ChS), laminin (LN), and polymerized laminin (pLN) – to enhance islet cell resilience against cytokine-induced stress, associated with the post-transplantation environment. Encapsulated mouse insulinoma β-cells (MIN6) and human islets were exposed to pro-inflammatory cytokines (IL-1β, IFN-γ, TNF-α) over 1, 3, and 5 days. …”
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Systematic review and meta-analysis of L1-VLP-based human papillomavirus vaccine efficacy against anogenital pre-cancer in women with evidence of prior HPV exposure. by Ada Miltz, Huw Price, Maryam Shahmanesh, Andrew Copas, Richard Gilson

“…<h4>Findings</h4>Three RCT reports and two post-trial cohort studies were eligible, comprising data from 13,482 women who were included in the vaccine studies but had evidence of HPV infection at study entry. …”
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An investigation of fentanyl and methamphetamine use among first-time arrestees from 25 county jails across the U.S. in 2023 by Joseph E. Schumacher, Abdullah Ahsan, Amber H. Simpler, Adam P. Natoli, Bradley J. Cain, Peter S. Chindavong, Aren Yarcan

“…This study highlights the significant prevalence of methamphetamine and/or fentanyl use among first-time arrestees, underscoring the urgent need for targeted interventions, improved in-jail substance use treatment, and post-release support to mitigate overdose risks and enhance public health outcomes.…”
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Long-Term Engraftment and Satellite Cell Expansion from Human PSC Teratoma-Derived Myogenic Progenitors by Zahra Khosrowpour, Nivedha Ramaswamy, Elise N. Engquist, Berkay Dincer, Alisha M. Shah, Hossam A. N. Soliman, Natalya A. Goloviznina, Peter I. Karachunski, Michael Kyba

“…A dynamic population of PAX7⁺ human satellite cells was established, initially expanding post-transplantation and declining moderately between 4 and 8 months as fibers matured. …”
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Lablab purpureus: Evaluation and Selection of Drought-tolerant - High-yielding Accessions in Dry Farming Systems Based on Drought Tolerance Indices and Multi-environmental Yield Tr... by Julius Missanga, Patrick Ndakidemi, Pavithravani Venkataramana

“…The responses of the accessions to TMS conditions were quantified through ten developed indices whose correlation coefficients were computed from the mean of the seed yield plant-1 under MSF and TMS conditions. ANOVA and post-hoc tests were used to analyze the variation among the accessions and their field parameters as well as to compare their means, respectively. …”
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Timing Matters: An Observational Study on Circadian Effects of Spinal Anesthesia in Cesarean Delivery by Evangelia Nikouli, Nikoleta Koutlaki, Kostas Anagnostopoulos, Soultania Anna Toubalidou, Christina Tsigalou, Pelagia Chloropoulou

“…Blood samples for CRP and cortisol were collected preoperatively and at 2, 4, 24, and 48 h post operation. <b>Results:</b> Group C showed shorter sensory and motor blockade than Groups A and B (<i>p</i> < 0.05). …”
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A novel framework for seasonal affective disorder detection: Comprehensive machine learning analysis using multimodal social media data and SMOTE by Md. Shamshuzzoha, Tazkia Tasnim Bahar Audry, Md. Jahangir Alam, Zaheed Ahmed Bhuiyan, Md Motaharul Islam, Mohammad Mehedi Hassan

“…We apply the Synthetic Minority Over-sampling Technique (SMOTE) in two distinct ways—on the training dataset post-splitting and the entire dataset—to assess its impact on model generalization. …”
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SARS-CoV-2 neutralizing antibody determination after vaccination using spectrophotometric measurement of lateral flow immunochromatography by Jianqiang Ma, Scott Kaniper, Yuliya Vabishchevich, Nana Nyantakyi, Dorret Lynch, Fan Chun, Hai-Lung Dai, Glenn S. Gerhard

“…This retrospective single-center cross-sectional study compared the performance of a lateral flow immunochromatography assay coupled with a spectrophotometric measurement system for detecting SARS-CoV-2 neutralizing antibodies against an enzyme-linked immunosorbent assay (ELISA) neutralization antibody assay in the context of post-vaccination responses. The limit of detection was similar to the ELISA with strong linearity throughout the measuring interval. …”
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Prevalence of cardiac arrhythmias among patients undergoing chronic hemodialysis by O. V. Likhachev-Mishchenko, A. A. Kornienko, N. A. Kornienko, E. G. Kadyan, L. A. Khaisheva, S. V. Shlyk

“…PVCs were more common on dialysis days, while tachyarrhythmias were more common during dialysis and in the immediate post- dialysis period. Older age (odds ratio (OR) 10 years older, 1,53; 95% confidence interval (CI): 1,15-2,03; P=0,003), lower cardiac output (OR 1 L/min more, 0,66; 95% CI: 0,44-1,00; P=0,05) were independently associated with clinically relevant arrhythmias.Conclusion. …”
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Exploring the predictive value of carotid Doppler ultrasound and clinical features for spinal anesthesia-induced hypotension: a prospective observational study by Esmée C. de Boer, Joris van Houte, Catarina Dinis Fernandes, Tom Bakkes, Jens Muehlsteff, R. Arthur Bouwman, Massimo Mischi

“…Abstract Background The induction of spinal anesthesia is often followed by hypotension, which has been associated with post-operative end-organ damage. A timely prediction of spinal anesthesia-induced hypotension (SAIH) paired with appropriate interventions may reduce the risk of adverse outcomes. …”
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Deciphering novel enzymatic and non-enzymatic lysine lactylation in Salmonella by Chuanzhen Zhang, Tao Zhou, Chengxi Li, Danni Wang, Jing Tao, Xiaocen Zhu, Jie Lu, Jinjing Ni, Yu-Feng Yao

“…Lysine lactylation, a novel post-translational modification, is involved in multiple cellular processes. …”
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FlexO2: A patient-controlled oxygen flow selector improving autonomy and daily function in long-term oxygen therapy (LTOT) by Michael Runold, Ingegerd Karlsson, Magda Borén

“…Methods In a consecutive, non-randomized pre-post intervention proof-of-concept study at Karolinska University Hospital, 26 patients on LTOT (median age 77; 69% COPD) used FlexO2 for three months. …”
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Neuro-Inflammatory and Behavioral Changes Are Selectively Reversed by <i>Sceletium tortuosum</i> (Zembrin^®) and Mesembrine in Male Rats Subjected to Unpredictable Chroni... by Johané Gericke, Stephan F. Steyn, Francois P. Viljoen, Brian H. Harvey

“…Sucrose preference, open field, Barnes maze, and forced swim tests were performed, with cortico-hippocampal monoamines, inflammatory and oxidative stress markers analyzed post-mortem. Male, but not female rats, presented with increased anhedonia and anxiety but not despair. …”
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Beta and alpha electroencephalographic activity changes after acute exercise Alterações eletrencefalográficas nas bandas de frequência alfa e beta após exercício de esforço máximo... by Helena Moraes, Camila Ferreira, Andréa Deslandes, Mauricio Cagy, Fernando Pompeu, Pedro Ribeiro, Roberto Piedade

“…Log transformation and paired student's t-test compared the pre and post exercise values (p<0.05). Results indicated a significant absolute power increase in beta after exercise at frontal (Fp1, F3 and F4) and central (C4) areas, which might be related to increased cortical activation.…”
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Unveiling molecular mechanisms and candidate genes for goss’s bacterial wilt and leaf blight resistance in corn through RNA-Seq analysis by Mohammad Sayari, Sara Victoria Good, Dimitri Trubetskoy, Mohamed El-Shetehy, Aria Dolatabadian, Atta Soliman, Arash Kheirodin, Fouad Daayf

“…The two selected corn lines were subjected to inoculation with two isolates of C. nebraskensis exhibiting distinct levels of aggressiveness: DOAB232 (DOAB), a weakly aggressive isolate and Cn14-5-1 (BACT), a highly aggressive one, or were left untreated (CTL) Total RNA was isolated from leaf tissue in three biological replicates for each hybrid x treatment combination five days post-inoculation (dpi), a timepoint selected to capture the early transcriptional response to pathogen infection. …”
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Failure and constitutive behavior of a Li-ion pouch cell under mechanical loading by Andreas Trondl, Benjamin Schaufelberger, Thomas Kisters, Clemens Fehrenbach, Anja Steiert, Dong-Zhi Sun

“…For investigating the failure of a whole pouch-cell, interrupted flat-punch and hemispherical-punch indentation tests were performed. Post-mortem CT analysis revealed that crack development is rather gradual than abrupt. …”
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Regulation of plant immunity through histone H3 β-hydroxybutyrylation-mediated transcriptional control by Qiutao Xu, Zhengting Chen, Rui Wang, Xuan Ma, Yuhang Duan, Du Hai, Jing Chen, Zhongyi Cheng, Lu Zheng, Junbin Huang, Jisen Zhang, Yu Zhao, Xiaoyang Chen

“…This research advances our understanding of plant epigenetic regulation by establishing Kbhb as a cellular post-translational modification with the potential to regulate plant immune responses.…”
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Development and validation of survival prediction tools in early and late onset colorectal cancer patients by Wanling Li, Jinshan Liu, Yuntong Lan, Dongling Yu, Bingqiang Zhang

“…These tools estimate survival probabilities for EOCRC and LOCRC patients under various treatment strategies and display the corresponding survival curves post-treatment over the 1- to 8-year period. This study successfully developed online calculators using machine learning algorithms to predict 1- to 8-year survival probabilities for EOCRC and LOCRC patients under various treatment strategies.…”
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Detection of immune-mediated tumour cell death in vivo using Zirconium-89-labeled APOMAB® by Vasilios Liapis, Nicole L. Wittwer, William Tieu, Tessa Gargett, Michael P. Brown, Alexander H. Staudacher

“…La/SSB only becomes accessible to APOMAB binding in post-apoptotic necrotic tumour cells. Methods We assessed the ability of APOMAB to detect dead tumour cells after immune-mediated cell death. …”
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LLMs Have Rhythm: Fingerprinting Large Language Models Using Inter-Token Times and Network Traffic Analysis by Saeif Alhazbi, Ahmed Hussain, Gabriele Oligeri, Panos Papadimitratos

“…However, these techniques are susceptible to adversarial attacks, operate in a post-hoc manner, and may require access to the model weights to inject a verifiable fingerprint. …”
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