An enigma of hypocalcaemia: unveiling the interaction between denosumab and intravenous iron when co-administered by Sabyasachi Roy, Anand Velusamy, Muhammed Russal Latheef

“…Avoiding close co-administration of denosumab and iron (separate by >4 weeks), preferring lower-risk iron (iron sucrose) and monitoring calcium, phosphate and magnesium levels for 4 weeks post-treatment are also recommended. Conclusion: Although no large trials specifically address this drug combination, the accumulating case series underscore a real safety signal.7…”
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Copper Pyrithione Induces Hepatopancreatic Apoptosis and Metabolic Disruption in <i>Litopenaeus vannamei</i>: Integrated Transcriptomic, Metabolomic, and Histopathological Analysis by Jieyu Guo, Yang Yang, Siying Yu, Cairui Jiang, Xianbin Su, Yongfeng Zou, Hui Guo

“…Metabolomic analysis identified numerous significantly different metabolites (SDMs) at both 3 and 48 h post-exposure, with most SDMs associated with energy metabolism, fatty acid metabolism, and related pathways. …”
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Application of dental pulp stem cell-conditioned medium combined with deep cryopreservation of autologous cranial flaps by Ye Liu, Yonghao Liu, Zhifei Ye, Xinxin Wang, Junyi Li, Peter L. Mei, Li Duan, Ben Wang, Chun Xu, Wei Xiong, Yan He, Qingsong Ye

“…Objectives This study investigates optimized preservation protocols for autologous cranial flaps to mitigate post-cranioplasty complications, while evaluating the preservative efficacy and clinical translation potential of dental pulp stem cell-conditioned medium (DPSC-CM) as a novel osteogenic storage solution. …”
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Quantitative electroencephalography characteristics in delirium with various etiologies: A multicenter study by Julia van der A, Robert Fleischmann, Annerose Mengel, Lisette Vernooij, Cornelis Stam, Sophie Leroy, Pauline Schneider, Johannes Ehler, Arjen Slooter, Edwin van Dellen

“…Etiology-based delirium subtypes included post-stroke, medical and postoperative delirium diagnosed by staff physicians based on the Diagnostic and Statistical Manual of Mental Disorders-IV or 5 criteria. …”
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Sensitive detection of minimal residual disease and immunotherapy targets by multi-modal bone marrow analysis in high-risk neuroblastoma – a multi-center study by Nina U. Gelineau, Eva Bozsaky, Lieke M. J. van Zogchel, Fikret Rifatbegovic, Daria Lazic, Andrea Ziegler, Ahmad Javadi, Lily Zappeij-Kannegieter, Ulrike Pötschger, Marta Fiocco, Peter F. Ambros, Inge M. Ambros, Bernd Bodenmiller, Ellen C. van der Schoot, Ruth Ladenstein, Marie Bernkopf, Godelieve A. M. Tytgat, Sabine Taschner-Mandl

“…RT-qPCR-MES, despite lower sensitivity, identified 37 additional cases and showed delayed clearance of MES markers post-chemotherapy, with increases prior to relapse. …”
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Difference-making factors for successful implementation of a multicomponent colorectal cancer screening program in rural clinics (SMARTER CRC) by Amanda F. Petrik, Brittany Badicke, Melinda M. Davis, Melinda M. Davis, Melinda M. Davis, Edward J. Miech, Jennifer Coury, Erin S. Kenzie, Erin S. Kenzie, Jennifer L. Schneider, Robert Durr, Anna C. Edelmann, Anders Herreid-O’Neill, Emily Myers, Gloria D. Coronado

“…Factors included in the analysis were collected through qualitative interviews, practice facilitation notes, and project datasets.ResultsA total of 14 intervention clinics were included in our analysis. Post-intervention, overall clinic-level screening rates for CRC ranged from 12.6 to 22.0%, while FIT completion rates among patients who were mailed a kit ranged from 12.3 to 41.7%. …”
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UFMylation of NLRP3 Prevents Its Autophagic Degradation and Facilitates Inflammasome Activation by Jiongjie Jing, Fan Yang, Ke Wang, Mintian Cui, Ni Kong, Shixi Wang, Xiaoyue Qiao, Fanyu Kong, Dongyang Zhao, Jinlu Ji, Lunxian Tang, Jiaxin Gao, Yu‐Sheng Cong, Deqiang Ding, Kun Chen

“…Aberrant activation of NLRP3 inflammasome is closely related to various inflammatory diseases. Post‐translational modifications are critical for NLRP3 inflammasome regulation. …”
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Impact of antihypertensive drug classes on cardiovascular outcomes: insights from the STEP study by Xinyi Peng, Michael Hecht Olsen, Manan Pareek, Jingjing Bai, Yang Liu, Qirui Song, Jun Cai

“…The HRs for ARBs per-unit increase in relative time remained consistently lower than those of CCBs across the primary outcome, MACE, and stroke (all P < 0.05). Conclusions This post hoc analysis suggested that ARBs and CCBs might be more favourable for composite cardiovascular outcomes than diuretics and beta-blockers. …”
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Evaluating the contribution of operation triple zero to HIV viral load suppression and retention among the adolescents in TASO Uganda using RE-AIM framework: a before and after imp... by Bonniface Oryokot, Abraham Ignatius Oluka, David Kagimu, Yunus Miya, Saadick Mugerwa Ssentongo, Catherine Achola, Abubaker Kawuba, Twaha Mafabi, Charles Odoi, Baker Bakashaba, Kenneth Mugisha, Michael Bernard Etukoit, Eleanor Namusoke-Magongo

“…Results Out of the original 533 ALHIV, 510 were considered for the post-intervention analysis, 53.1% females, mean age of 15.27 (Standard deviation = 2.15). …”
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SARS-CoV-2 outbreak in lions, tigers, and hyenas at Denver Zoo by Emily N. Gallichotte, Laura Bashor, Katelyn Erbeck, Lara Croft, Katelyn Stache, Jessica Long, Sue VandeWoude, James C. Johnson, Kristy L. Pabilonia, Gregory D. Ebel

“…Infectious virus was correlated with high levels of vRNA and was more likely to be detected earlier during infection. Four months post-infection, all tested animals generated robust neutralizing antibody titers. …”
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Effect of mild posterior capsule opacification on visual outcomes in trifocal diffractive pseudophakic eyes: A multicenter prospective study by Limei Zhang, Runhan Shi, Xuanzhu Chen, Xuefen Gu, Jiying Shen, Aijun Wang, Shuang Ni, Lei Cai, Haike Guo, Jin Yang

“…However, in patients with PCO grade 1 (mild), post-capsulotomy UNVA, DLI, medium and high spatial frequency CS under photopic condition and VF-14 scores were significantly improved compared with pre-capsulotomy values (all P ​< ​0.05). …”
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Low Skeletal Muscle Radiodensity Predicts Response to CDK4/6 Inhibitors Plus Aromatase Inhibitors in Advanced Breast Cancer by Hyunwook Kim, Seungjin Baek, Sookyeong Han, Gun Min Kim, Joohyuk Sohn, Yumie Rhee, Namki Hong, Min Hwan Kim

“…Strong associations between low SMD and poor PFS were observed in groups with pre‐menopause status (HR, 3.04 vs. 1.19 in post‐menopause; 95% CI: 1.54–5.99, p for interaction < 0.05) and without visceral metastases (HR, 2.95 vs. 1.19 in with visceral metastases; 95% CI: 1.59–5.49, p for interaction < 0.05). …”
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Effects of protein supplementation during pilates training on body composition, core muscle endurance, and joint flexibility in trained women: a randomized controlled trial by Christina Karpouzi, Antigoni Kypraiou, Vassilis Mougios, Anatoli Petridou

“…The common BIA and DXA variables were highly correlated (r > 0.78, p < 0.001) and did not differ pre-intervention (p > 0.1), although they differed post-intervention (p < 0.001), with BIA overestimating lean mass compared with DXA. …”
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Associations Between Female Sex Hormones and Skeletal Muscle Ageing: The Baltimore Longitudinal Study of Aging by Annabel J. Critchlow, Sarah E. Alexander, Danielle S. Hiam, Luigi Ferrucci, David Scott, Séverine Lamon

“…ABSTRACT Background To date, most research investigating the influence of circulating sex hormones on ageing female skeletal muscle has been cross‐sectional and focused only on dichotomised young and old, or pre‐ versus post‐menopausal groups. This excludes an important transitional period from high to low circulating oestrogen. …”
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Moderate-intensity training has a better effect on growth factors than high-intensity training in rats by Laily Mita Andriana, Adi Pranoto, Greta Ahmad Bukhori, Joseph Kenoly Nugroho, Irmantara Subagio, Nining Widyah Kusnanik, Bayu Agung Pramono, Dany Pramuno Putra, Muhamad Fauzi Antoni, Bekir Erhan Orhan

“…The data were analyzed by using one way-ANOVA and Tukey’s HSD post hoc test with significant levels of 5%. Results: We observed GH levels in CON (4.30 ± 0.29) pg/mL, MIT (4.55 ± 0.17) pg/mL, HIT (4.09 ± 0.28) pg/mL and (p < 0.001). …”
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The therapeutic effect of leucogen in treating alcoholic liver cirrhosis with thrombocytopenia or leukopenia by Min Su, Mengwen He, Jia-Liang Liu, Wu-Cai Yang, Jian-Jun Wang, Chang Guo, Yi-Ming Fu, Chun-Yan Wang, Shuyao Li, Dong Ji, Hong-Yan Chen

“…SAMPLE SIZE: 413 patients (320 patients in the final analysis) RESULTS: In this retrospective study, 320 patients were analyzed post-propensity score matching: 160 patients each in the leucogen and non-leucogen groups. …”
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Effect of sodium-reduced potassium-enriched salt substitutes on stomach cancer: the Salt Substitute and Stroke Study (SSaSS) by Xinyi Zhang, Xuejun Yin, Mei Ling Yap, Qiang Li, Liping Huang, Yishu Liu, Bo Zhou, Zhifang Li, Yi Zhao, Jixin Sun, Yan Yu, Lijing L. Yan, Yangfeng Wu, Bruce Neal, Maoyi Tian

“…Methods The primary analyses of the Salt Substitute and Stroke Study (SSaSS) defined the effects of sodium-reduced potassium-enriched salt substitutes compared to regular salt on the risk of stroke. This post-hoc investigation explored effects on stomach and other cancers. …”
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From transition management towards just transition and place-based governance. Τhe case of Western Macedonia in Greece by Lefteris Topaloglou, Lefteris Ioannidis

“…This region has all the characteristics of a coal-dependent locality, under an urgent need to design and implement a post-lignite, just, transition strategy. FINDINGS: Given that transition implies a profound and long-lasting societal, economic, and environmental transformation, new and pioneering modes of governance are necessary to tackle such a multifaceted challenge. …”
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Venous Sinus Stenting Using a Ledge‐Reducing Catheter, 0.088‐in. Catheter‐Extender With an External Single Point of Control: Technique and Multicenter Clinical Experience by Oded Goren, Fabio Settecase, George Luh, Tareq Kass‐Hout, Rami Morsi, Coleman O. Martin, Ahmad K. Almekkawi, Nicholas A. Telischak, Matthew D. Alexander, Michael G. Abraham, Sivani Lingam, Ramesh Grandhi, M. Shazam Hussain, Tudor G. Jovin, Priyank Khandelwal, Thanh T. Nguyen, Piers Klein, Joey D. English, Mohamad K. Abdalkader

“…Median stenosis decreased from 80% (interquartile range 75–87) to 0% (interquartile range 0–0) post stenting (P<0.001). There were no Monopoint‐related complications. compared with the operators’ typical VSS catheter setup/technique, MS was rated “better” in 93% and “slightly better” in 6%; operators cited ease of crossing the stenosis, improved trackability and support, as well as lack of stent‐catheter length incompatibilities. …”
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Long-term biological and behavioural impact of an adolescent sexual health intervention in Tanzania: follow-up survey of the community-based MEMA kwa Vijana Trial. by Aoife M Doyle, David A Ross, Kaballa Maganja, Kathy Baisley, Clemens Masesa, Aura Andreasen, Mary L Plummer, Angela I N Obasi, Helen A Weiss, Saidi Kapiga, Deborah Watson-Jones, John Changalucha, Richard J Hayes, MEMA kwa Vijana Trial Study Group

“…A further impact evaluation survey in 2007/8 ( approximately 9 years post-intervention) tested this hypothesis.<h4>Methods and findings</h4>This is a cross-sectional survey (June 2007 through July 2008) of 13,814 young people aged 15-30 y who had attended trial schools during the first phase of the MEMA kwa Vijana intervention trial (1999-2002). …”
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