Transcriptomic Signature of Frailty in Older Patients With Cardiovascular Disease Undergoing Cardiac Surgery or TAVI by Omar Baritello, Simon H. Sündermann, Kristian Espinosa‐Garnica, Jörg Kempfert, Markus Jähnert, Nick L. Beetz, Dominik Geisel, Jasmin Gaugel, Julia Rominger, Ursula Müller‐Werdan, Catrin Herpich, Kristina Norman, Alexandra Chadt, Hadi Al‐Hasani, Heinz Völler, Annett Salzwedel, Heike Vogel

“…ABSTRACT Background Deterioration of functional capacity mostly determinates frailty in older patients with cardiovascular disease (CVD). …”
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Statin-induced risk of diabetes does not reduce cardiovascular benefits in primary prevention: a 6-year propensity-score matched study in a large population by Maria Lembo, Valentina Trimarco, Raffaele Izzo, Daniela Pacella, Stanislovas S. Jankauskas, Paola Gallo, Roberto Piccinocchi, Carmine Morisco, Gaetano Piccinocchi, Luca Bardi, Stefano Cristiano, Giovanni Esposito, Giuseppe Giugliano, Fahimeh Varzideh, Maria Virginia Manzi, Bruno Trimarco, Gaetano Santulli

“…Abstract Background The long-term risk of cardiovascular (CV) events in individuals who develop new-onset type 2 diabetes (T2D) after having received statin therapy in primary prevention is mostly unknown. Methods We designed a population-based cohort study in individuals without T2D and atherosclerotic CV disease (ASCVD), divided in two groups according to the presence of statin therapy. …”
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Potency of all-D amino acid antimicrobial peptides derived from the bovine rumen microbiome on tuberculous and non-tuberculous mycobacteria by Céline Boidin-Wichlacz, Marc Maresca, Isabelle Correia, Olivier Lequin, Vanessa Point, Magali Casanova, Alexis Reinbold, Olga Iranzo, Sharon A. Huws, Priscille Brodin, Linda B. Oyama, Aurélie Tasiemski, Stéphane Canaan, Jean-François Cavalier

“…Membrane permeabilization and monolayer lipid insertion assays suggested that these peptides mostly act by insertion into the mycobacterial membrane resulting in a rapid membranolytic effect. …”
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Comparative abundance and diversity of populations of the Pseudomonas syringae and Soft Rot Pectobacteriaceae species complexes throughout the Durance River catchment from its Fren... by Morris, C.E., Lacroix, C., Chandeysson, C., Guilbaud, C., Monteil, C., Piry, S., Rochelle Newall, E., Fiorini, S., Van Gijsegem, F., Barny, M.A., Berge, O.

“…In contrast, SRP strains were detected in 98 of the samples, mostly from the southern part of the river, at population densities that did not exceed 3 ´ 104 bacteria L-1. …”
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Adjunctive IgM-enriched immunoglobulin therapy with a personalised dose based on serum IgM-titres versus standard dose in the treatment of septic shock: a randomised controlled tri... by Giacomo Grasselli, Patrizia Murino, Emanuela Biagioni, Martina Tosi, Giorgio Berlot, Giacomo Castiglione, Alberto Corona, Maria Giovanna De Cristofaro, Abele Donati, Paolo Feltracco, Francesco Forfori, Fiorentino Fragranza, Ornella Piazza, Livio Tullo

“…Immunoglobulin preparations enriched with the IgM component have largely been used in sepsis, mostly at standard dosages (250 mg/kg per day), regardless of clinical severity and without any dose adjustment based on immunoglobulin serum titres or other biomarkers. …”
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A worldwide event-based debris flow barrier dam dataset from 1800 to 2023 by H. Cheng, H. Cheng, K. Hu, K. Hu, S. Liu, S. Liu, X. Zhang, X. Zhang, H. Li, H. Li, Q. Zhang, Q. Zhang, L. Ning, L. Ning, M. R. Gouli, M. R. Gouli, P. Li, P. Li, A. Yang, A. Yang, P. Zhao, P. Zhao, J. Liu, J. Liu, L. Wei, L. Wei

“…The understanding of debris flow barrier dams (DFBDs) is poor, mostly due to existing studies focusing on individual events and a lack of summarization of multiple DFBD events. …”
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CRISPR/Cas9-mediated knockout of SLC15A4 gene involved in the immune response in bovine rumen epithelial cells by Mao-cheng JIANG, Zi-xuan HU, Ke-xin WANG, Tian-yu YANG, Miao LIN, Kang ZHAN, Guo-qi ZHAO

“…Meanwhile, the down-regulated genes were mostly enriched in the nuclear factor κB (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways. …”
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Integrating anamnestic and lifestyle data with sphingolipid levels for risk-based prostate cancer screening by Caterina Peraldo-Neia, Paola Ostano, Melissa Savioli, Maurizia Mello-Grand, Ilaria Gregnanin, Francesca Guana, Francesca Crivelli, Francesco Montagnani, Michele Dei-Cas, Rita Paroni, Antonella Sinopoli, Francesco Ferranti, Nicolò Testino, Marco Oderda, Andrea Zitella, Chiara Fiameni, Amedeo Gagliardi, Alessio Naccarati, Luca Clivio, Paolo Gontero, Stefano Zaramella, Giovanna Chiorino

“…Univariable logistic regression was applied to identify ananmestic and lifestyle variables mostly associated with PCa. Penalized logistic regression models predictive of PCa or ISUP > 1 PCa were built both using the 814 subjects with complete information for such variables, applying a 10-fold cross validation approach, and dividing the dataset into a training (n = 445: 132 PCa, 313 non-PCa) and a test (n = 369: 147 PCa, 222 non-PCa) set. …”
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Real-World Analysis of Short-Term Effectiveness of Oral Semaglutide: Impact on Glycometabolic Control and Cardiovascular Risk by Sara Palazzi, Federica Sentinelli, Antonella Zugaro, Sara Morgante, Livia Santarelli, Sandra Melanzi, Annamaria De Mutiis, Deamaria Piersanti, Barbara Macerola, Marco Iezzi, Pietro Mercuri, Alessandro Ferranti, Daniele Tienforti, Maria Gisella Cavallo, Arcangelo Barbonetti, Marco Giorgio Baroni

“…<b>Results</b>: Among 167 participants (mean age 66.5 years, mostly obese, baseline HbA1c 8.4% ± 1.5), 83.2% received a 7 mg dose. …”
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Utilization of cervical cancer screening and its associated factors among women living with HIV in East Africa: a systematic review and meta-analysis by Gebrie Getu Alemu, Getaneh Awoke Yismaw, Habtamu Abebe Getahun, Habtamu Wagnew Abuhay, Mekuriaw Nibret Aweke, Meron Asmamaw Alemayehu, Nebiyu Mekonnen Derseh, Tigist Kifle Tsegaw, Tilahun Yemanu Birhan, Banchlay Addis, Berhanie Addis Ayele, Emebet Birhanu Lealem, Eyob Akalewold Alemu, Fetlework Gubena Arage

“…Abstract Background Women living with HIV (WLHIV), mostly in East Africa, are six times more likely to develop cervical cancer and are a priority population for secondary prevention. …”
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Spinal metastases at the thoracolumbar junction – Influencing factors for surgical decision-making according to a multicentric registry by Vanessa Hubertus, Arthur Wagner, Arian Karbe, Leon-Gordian Leonhardt, Beate Kunze, Susanne Borchert, Fatma Kilinc, Michelle Mariño, Nitzan Nissimov, Charlotte Buhre, Marcus Czabanka, Marc Dreimann, Sven O. Eicker, Lennart Viezens, Hanno S. Meyer, Peter Vajkoczy, Bernhard Meyer, Julia S. Onken

“…Reoperations were necessary in 65 cases (16%), mostly due to SSI (n = 19, 29%), local recurrence (n = 15, 23%), and hardware failure (HWF) during follow-up (n = 9, 18%, i-iii, p = 0.7853). …”
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Piloting a team-based telemedicine care for hypertension focused on Black patients by Srista Manandhar, Sunit Chhetri, Danielle Sutton, Animita C. Saha, Suneet Kaur, Josh Brown, Jeff Williamson, Kathryn E. Callahan, Justin B. Moore, Yhenneko J. Taylor, Hayden B. Bosworth, Yashashwi Pokharel

“…We provided social support to 11 patients 19 times including support at home visits by CHWs, mostly for food and medications. There were challenges in supporting other social needs like housing. …”
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Efficient delivery of anlotinib and radioiodine by long circulating nano-capsules for active enhanced suppression of anaplastic thyroid carcinoma by Linlin Zhang, Chuanying Zhu, Shuo Huang, Miaomiao Xu, Chao Li, Hongliang Fu, Yafu Yin, Sheng Liang, Hui Wang, Zhilei Cui, Lei Huang

“…The Anlotinib-BSA nano-capsule (nBSA) showed a mostly uniform size distribution centering at 21–23 nm, and the nano-drug had a characteristic absorption peak at the wavelength of 325 nm. …”
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Comparison of the efficacy and safety of various anti-inflammatory drugs in urate-lowering therapy initiation in patients with gout (preliminary data) by M. N. Chikina, M. S. Eliseev, O. V. Zhelyabina

“…Nasonova Research Institute of Rheumatology, 97 (94%), mostly men, entered a single-center prospective study. …”
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Mutations in the “hot spots” of the <i>FLT3</i>, <i>NPM1</i>, <i>IDH1</i>, <i>IDH2</i> and <i>DNMT3A</i> genes in acute myeloid leukemia by E. N. Voropaeva, M. V. Burundukova, A. A. Lyzlova, I. A. Chukhontseva, V. N. Maksimov, T. I. Pospelova

“…Publications such as “letters to the editor” and “comments” on published works, animal and cell model studies, as well as works on secondary AML, AML/myelodysplastic syndrome were excluded from the analysis. Mostly more recent works with the full text of the publication available in Russian or English were used. …”
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Review of Research on Supercritical Carbon Dioxide Axial Flow Compressors by Yong Tian, Dexi Chen, Yuming Zhu, Peng Jiang, Bo Wang, Xiang Xu, Xiaodi Tang

“…As for performance characteristics, currently, sCO₂ axial-flow compressors are mostly designed with large mass flow rates (>100 kg/s), near-critical inlet conditions, multistage configurations with relatively low stage pressure ratios (1.1–1.2), and high isentropic efficiencies (87–93%). …”
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Pengembangan Aplikasi Sistem Informasi Pendataan Bangunan (SIPBANG) pada Dinas Pekerjaan Umum dan Penataan Ruang (DPUPR) Kota Malang Menggunakan Framework Scrum by Muhamad Rifky, Yusi Tyroni Mursityo, Bondan Sapta Prakoso

“…While the tested result of compatibility that was used to determine the ability of the system to be accessed mostly positive, with the exception of the category of important issues which is negative because the site does not use a secure protocol. …”
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Achievement of minimal disease activity in psoriatic arthritis according to the time of administration of synthetic disease-modifying antirheumatic drugs, a comparative analysis of... by T. V. Korotaeva, E. Yu. Loginova, E. E. Gubar, Yu. L. Korsakova, M. V. Sedunova, I. N. Pristavsky, I. N. Kushnir, I. F. Umnova, S. S. Kudishina

“…Among sDMARDs, preference is mostly given to the use of MTX in real clinical practice; the treatment with the latter enables 16.5% of patients to achieve MDA. …”
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Determination of polychlorinated biphenyls in water by gas chromatography-electron capture detector combined with automated liquid-liquid extraction and dispersive solid phase extr... by HU Hongmei, GUO Yuanming, HAO Qing, SUN Xiumei, JIN Yanjian, ZHONG Zhi, ZHANG Xiaojun

“…It may be because PSA could effectively remove carbohydrates, fatty acids, organic acids, polyphenols, sugar and polar pigments on the objective compounds, while C18 was mostly used to remove some non-polar disruptors such as fat and esters. …”
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Lecanemab in clinical practice: real-world outcomes in early Alzheimer’s disease by Noa Bregman, Talya Nathan, Dror Shir, Nurit Omer, Mori Hai Levy, Aya Bar David, Orna Aizenstien, Eyal Lotan, Yifat Alcalay, Anan Abu Awad, Avi Gadoth, Elissa Ash, Tamara Shiner

“…ARIA occurred in 18.6% of patients, mostly asymptomatic. One patient experienced symptomatic ARIA, required hospitalization with intravenous treatment, and discontinued therapy. …”
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